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ClinicalTrials.gov public records Last synced Oct 14, 2026, 5:16 AM EDT

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Showing 265–288 of 299 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Degenerative Spine Disease Clear all
Completed No phase listed Observational

Osteocel® Plus in Posterior Lumbar Interbody Fusion (PLIF)

NCT00941980
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
Osteocel Plus
Biological
Lead sponsor
NuVasive
Industry
Eligibility
18 Years to 70 Years · Female only
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated Dec 24, 2025 · Synced Oct 14, 2026, 5:16 AM EDT
Not listed Not applicable Interventional

A Prospective Study of Clinical Outcomes Following a Single Intradiscal Injection of Bone Marrow Aspirate Concentrate (BMAC) for Single Level Discogenic Low Back Pain

NCT03912454
View directory record Official record
Conditions
Degenerative Disc Disease, Spine Degeneration
Interventions
Autologous Bone Marrow Aspirate Concentrate (BMAC) Injection
Other
Lead sponsor
Bone and Joint Clinic of Baton Rouge
Other
Eligibility
18 Years to 60 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Baton Rouge, Louisiana
Source: ClinicalTrials.gov public record
Updated Mar 16, 2022 · Synced Oct 14, 2026, 5:16 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Safety and Effectiveness Study of the TOPS System, a Total Posterior Arthroplasty Implant Designed to Alleviate Pain Resulting From Moderate to Severe Lumbar Stenosis

NCT00405691
View directory record Official record
Conditions
Low Back Pain, Leg Pain, Spondylolisthesis, Lumbar Spinal Stenosis
Interventions
"TOPS System" - Total Posterior Arthroplasty Implant
Device
Lead sponsor
Impliant, Ltd.
Industry
Eligibility
40 Years to 75 Years
Enrollment
450 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 2006
U.S. locations
16
States / cities
Beverly Hills, California • Daly City, California • New Haven, Connecticut + 12 more
Source: ClinicalTrials.gov public record
Updated May 18, 2011 · Synced Oct 14, 2026, 5:16 AM EDT
Terminated No phase listed Observational

RAMP Study: A Study Comparing Two Lumbar Fusion Procedures

NCT01716182
View directory record Official record
Conditions
Spinal Stenosis, Spondylolisthesis, Degenerative Disc Disease
Interventions
Not listed
Lead sponsor
Baxano Surgical, Inc.
Industry
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
11
States / cities
Fullerton, California • Los Angeles, California • Carmel, Indiana + 8 more
Source: ClinicalTrials.gov public record
Updated Jul 9, 2014 · Synced Oct 14, 2026, 5:16 AM EDT
Not listed No phase listed Observational

InterFuse® S and T for the Treatment of Scoliosis, Spondylolisthesis and Degenerative Disc Disease (DDD)

NCT02659722
View directory record Official record
Conditions
Scoliosis, Back Pain
Interventions
InterFuse
Device
Lead sponsor
Vertebral Technologies, Inc.
Industry
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2019
U.S. locations
1
States / cities
Syracuse, New York
Source: ClinicalTrials.gov public record
Updated Nov 2, 2016 · Synced Oct 14, 2026, 5:16 AM EDT
Terminated Phase 3 Interventional

A Clinical Study of the Dynesys(R) Spinal System

NCT00759057
View directory record Official record
Conditions
Degenerative Spondylolisthesis or Retrolisthesis, Spinal Stenosis, Stenosing Lesion.
Interventions
Posterior Pedicle Screw System
Device
Lead sponsor
Zimmer Biomet
Industry
Eligibility
20 Years to 80 Years
Enrollment
399 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2015
U.S. locations
26
States / cities
Scottsdale, Arizona • Tucson, Arizona • Los Angeles, California + 23 more
Source: ClinicalTrials.gov public record
Updated Jun 28, 2012 · Synced Oct 14, 2026, 5:16 AM EDT
Active, not recruiting No phase listed Observational

Long-term Assessment of the Safety and Performance of the NuVasive Simplify Disc

NCT05258435
View directory record Official record
Conditions
Cervical Disc Disease, Degenerative Disc Disease
Interventions
NuVasive Simplify Cervical Artificial Disc
Device
Lead sponsor
NuVasive
Industry
Eligibility
Not listed
Enrollment
131 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2028
U.S. locations
10
States / cities
Orange, California • Santa Monica, California • Thornton, Colorado + 7 more
Source: ClinicalTrials.gov public record
Updated Dec 22, 2025 · Synced Oct 14, 2026, 5:16 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Spine Patient Outcomes Registry for Biomet/EBI (Electro-Biology, Inc)

NCT00726284
View directory record Official record
Conditions
Degenerative Disc Disease, Spinal Stenosis
Interventions
Not listed
Lead sponsor
Zimmer Biomet
Industry
Eligibility
Not listed
Enrollment
651 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2007
U.S. locations
5
States / cities
Little Rock, Arkansas • Orange City, Florida • Akron, Ohio + 2 more
Source: ClinicalTrials.gov public record
Updated Feb 24, 2020 · Synced Oct 14, 2026, 5:16 AM EDT
Terminated Not applicable Interventional

Effectiveness of Lumbar Fusion When NanOss Bioactive Is Used With Posterolateral Gutter Fusions

NCT01452516
View directory record Official record
Conditions
Degenerative Disc Disease, Spinal Stenosis, Spondylolisthesis
Interventions
nanOss Bioactive Bone void filler, Interbody FCage
Device
Lead sponsor
Pioneer Surgical Technology, Inc.
Industry
Eligibility
18 Years and older
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
7
States / cities
Beverly Hills, California • La Jolla, California • Chicago, Illinois + 4 more
Source: ClinicalTrials.gov public record
Updated Dec 7, 2016 · Synced Oct 14, 2026, 5:16 AM EDT
Completed Not applicable Interventional

Lumbar Spine Muscle Degeneration Inhibits Rehabilitation-Induced Muscle Recovery

NCT03442374
View directory record Official record
Conditions
Disc Degeneration, Low Back Pain
Interventions
Exercise
Other
Lead sponsor
University of California, San Diego
Other
Eligibility
21 Years to 85 Years
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Nov 28, 2023 · Synced Oct 14, 2026, 5:16 AM EDT
Recruiting No phase listed Observational

OssDsign® Spine Registry Study ("Propel")

NCT05329129
View directory record Official record
Conditions
Degenerative Disc Disease, Spinal Stenosis
Interventions
OssDsign® Catalyst
Device
Lead sponsor
OssDsign
Industry
Eligibility
21 Years and older
Enrollment
450 participants
Timeline
2022 – 2030
U.S. locations
15
States / cities
Fresno, California • Long Beach, California • San Diego, California + 12 more
Source: ClinicalTrials.gov public record
Updated Jun 8, 2026 · Synced Oct 14, 2026, 5:16 AM EDT
Completed Phase 2 Interventional

Safety and Preliminary Efficacy Study of NeoFuse in Subjects Undergoing Multi-Level Anterior Cervical Discectomy

NCT01097486
View directory record Official record
Conditions
Cervical Degenerative Disc Disease, Degenerative Spondylolisthesis, Spinal Stenosis
Interventions
NeoFuse, Allograft
Biological · Procedure
Lead sponsor
Mesoblast, Ltd.
Industry
Eligibility
18 Years to 70 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
8
States / cities
Sacramento, California • Santa Monica, California • Denver, Colorado + 5 more
Source: ClinicalTrials.gov public record
Updated Aug 16, 2019 · Synced Oct 14, 2026, 5:16 AM EDT
Withdrawn Phase 1Phase 2 Interventional

Safety and Efficacy Study of NeoFuse in Subjects Requiring Posterolateral Lumbar Fusion

NCT00810212
View directory record Official record
Conditions
Degenerative Disc Disease, Degenerative Spondylolisthesis, Spinal Stenosis
Interventions
PLF with autograft, PLF with NeoFuse
Procedure · Biological
Lead sponsor
Mesoblast, Ltd.
Industry
Eligibility
18 Years to 70 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
1
States / cities
Plano, Texas
Source: ClinicalTrials.gov public record
Updated Jun 2, 2020 · Synced Oct 14, 2026, 5:16 AM EDT
Completed Not applicable Interventional Results available

OsteoStrux™ Collagen Ceramic Scaffold in Instrumented Lumbar Spine Fusion

NCT01873586
View directory record Official record
Conditions
Degenerative Changes, Stenosis, Spondylosis
Interventions
Posterolateral Fusion
Procedure
Lead sponsor
SeaSpine, Inc.
Industry
Eligibility
18 Years and older
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
1
States / cities
Kenmore, New York
Source: ClinicalTrials.gov public record
Updated Jun 17, 2019 · Synced Oct 14, 2026, 5:16 AM EDT
Completed Not applicable Interventional

Telehealth Activity Intervention After Lumbar Spine Surgery

NCT04968821
View directory record Official record
Conditions
Spinal Degenerative Disorder
Interventions
Physical activity intervention, Usual care
Behavioral · Other
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated May 29, 2024 · Synced Oct 14, 2026, 5:16 AM EDT
Active, not recruiting Not applicable Interventional

Transforaminal Lumbar Interbody Fusion (TLIF)

NCT04073563
View directory record Official record
Conditions
Degenerative Disease of the Lumbosacral Spine
Interventions
Infuse™ Bone Graft (Infuse™), Intervertebral body fusion device and Medtronic posterior Fixation Systems
Device
Lead sponsor
Medtronic Spinal and Biologics
Industry
Eligibility
18 Years and older
Enrollment
600 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2028
U.S. locations
43
States / cities
Phoenix, Arizona • Tucson, Arizona • Irvine, California + 35 more
Source: ClinicalTrials.gov public record
Updated Feb 4, 2026 · Synced Oct 14, 2026, 5:16 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Open Access Database of Standing Full Body Radiographs in Asymptomatic Volunteers

NCT03076658
View directory record Official record
Conditions
Intervertebral Disc Degeneration, Osteoarthritis, Spine
Interventions
EOS imaging
Radiation
Lead sponsor
University of Colorado, Denver
Other
Eligibility
21 Years to 85 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2031
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Sep 28, 2023 · Synced Oct 14, 2026, 5:16 AM EDT
Not listed Phase 3 Interventional

Wallis Mechanical Normalization System for Low Back Pain

NCT00134537
View directory record Official record
Conditions
Low Back Pain
Interventions
Interspinous process and dynamic stabilization, Conservative Care
Device
Lead sponsor
Zimmer Spine
Industry
Eligibility
18 Years to 60 Years
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2012
U.S. locations
17
States / cities
Phoenix, Arizona • Beverly Hills, California • Santa Monica, California + 13 more
Source: ClinicalTrials.gov public record
Updated Oct 4, 2011 · Synced Oct 14, 2026, 5:16 AM EDT
Completed No phase listed Observational

XLIF® vs. MAS®TLIF for the Treatment of Symptomatic Lumbar Degenerative Spondylolisthesis With or Without Central Stenosis.

NCT01024699
View directory record Official record
Conditions
Spondylolisthesis
Interventions
Not listed
Lead sponsor
NuVasive
Industry
Eligibility
18 Years and older
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2015
U.S. locations
9
States / cities
Jacksonville, Florida • Kissimmee, Florida • Savannah, Georgia + 6 more
Source: ClinicalTrials.gov public record
Updated Dec 24, 2025 · Synced Oct 14, 2026, 5:16 AM EDT
Recruiting Not applicable Interventional

The NOTICE Study: Neurosurgery and OrThopedIcs Communication Evaluation Study Following Lumbar Fusions

NCT04140344
View directory record Official record
Conditions
Lumbar Spine Degeneration, Lumbar Spine Instability, Lumbar Spondylosis
Interventions
Text Message Group
Other
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
224 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated May 8, 2026 · Synced Oct 14, 2026, 5:16 AM EDT
Completed No phase listed Observational

Osteocel® Plus in eXtreme Lateral Interbody Fusion (XLIF®)

NCT00948532
View directory record Official record
Conditions
Degenerative Disc Disease, Back Pain
Interventions
biologic, Osteocel Plus
Biological
Lead sponsor
NuVasive
Industry
Eligibility
18 Years to 80 Years
Enrollment
104 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
13
States / cities
La Jolla, California • Hollywood, Florida • Miami Beach, Florida + 10 more
Source: ClinicalTrials.gov public record
Updated Dec 24, 2025 · Synced Oct 14, 2026, 5:16 AM EDT
Completed Not applicable Interventional

Comparison of nanOss Bioactive With Autograft and Bone Marrow Aspirate to Autograft in the Posterolateral Spine

NCT01968993
View directory record Official record
Conditions
Degenerative Disc Disease, Spinal Stenosis, Spondylolisthesis
Interventions
nanOss Bioactive - posterolateral gutter
Device
Lead sponsor
Pioneer Surgical Technology, Inc.
Industry
Eligibility
18 Years and older
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2015
U.S. locations
3
States / cities
La Jolla, California • San Francisco, California • Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Nov 8, 2016 · Synced Oct 14, 2026, 5:16 AM EDT
Enrolling by invitation No phase listed Observational Accepts healthy volunteers

Adjacent Level Anterior Cervical Fusion: SeaSpine Shoreline Versus Removal of Previously Implanted Plate and Replating

NCT06415136
View directory record Official record
Conditions
Degenerative Disc Disease, Disc Herniation
Interventions
SeaSpine Shoreline
Device
Lead sponsor
Research Source
Network
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Southfield, Michigan
Source: ClinicalTrials.gov public record
Updated Aug 22, 2025 · Synced Oct 14, 2026, 5:16 AM EDT
Withdrawn Not applicable Interventional

Single Center Study Comparing MOBIS II ST vs MOBIS PEEK

NCT02852187
View directory record Official record
Conditions
Lumbar Disc Disease
Interventions
SIGNUS MOBIS PEEK Cage, SIGNUS MOBIS II ST Cage
Device
Lead sponsor
Signus Medizintechnik GmbH
Industry
Eligibility
18 Years to 89 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
East Syracuse, New York
Source: ClinicalTrials.gov public record
Updated Mar 19, 2020 · Synced Oct 14, 2026, 5:16 AM EDT