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Showing 1–14 of 14 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Filters: Condition: Delayed Onset Muscle Soreness (DOMS) Clear all
Completed Phase 2 Interventional Accepts healthy volunteers

Study to Assess the Safety, Tolerability, and Effects of CHI-202 to Support Recovery From Physical Activity

NCT05026164
View directory record Official record
Conditions
Delayed Onset Muscle Soreness (DOMS)
Interventions
CHI-202, CHI-101
Dietary Supplement
Lead sponsor
Canopy Growth Corporation
Industry
Eligibility
18 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Boca Raton, Florida
Source: ClinicalTrials.gov public record
Updated Feb 15, 2022 · Synced Jun 25, 2026, 10:47 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Effects of a 5-Week Probiotic Supplementation Intervention on Markers of Delayed Onset Muscle Soreness

NCT07219498
View directory record Official record
Conditions
Exercise Induced Muscle Damage, Delayed Onset Muscle Soreness (DOMS)
Interventions
Lactobacillus casei, Placebo Capsule(s)
Dietary Supplement · Other
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 30 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated May 3, 2026 · Synced Jun 25, 2026, 10:47 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

An Investigator Initiated, Within-Subject, Proof of Concept Study to Assess the Efficacy and Safety of Voltaren Gel in Subjects With DOMS

NCT02087748
View directory record Official record
Conditions
Pain, Delayed Onset Muscle Soreness
Interventions
1% diclofenac sodium gel, Placebo
Drug
Lead sponsor
Lotus Clinical Research, LLC
Other
Eligibility
18 Years to 35 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014
U.S. locations
1
States / cities
Pasadena, California
Source: ClinicalTrials.gov public record
Updated Dec 9, 2014 · Synced Jun 25, 2026, 10:47 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Study of SST-0225 Topical Ibuprofen Cream in the Treatment of Delayed Onset Muscle Soreness (DOMS)

NCT02597634
View directory record Official record
Conditions
Delayed Onset Muscle Soreness, DOMS
Interventions
SST-0225, Placebo
Drug
Lead sponsor
Strategic Science & Technologies, LLC
Industry
Eligibility
16 Years to 65 Years
Enrollment
156 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
3
States / cities
Hollywood, Florida • South Miami, Florida • Springfield, Missouri
Source: ClinicalTrials.gov public record
Updated Oct 12, 2016 · Synced Jun 25, 2026, 10:47 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Topical CBD's Effects on Soreness and Performance

NCT06320327
View directory record Official record
Conditions
Muscle Soreness
Interventions
Cannabidiol cream, Placebo cream
Other
Lead sponsor
Joseph Pastina
Other
Eligibility
18 Years to 45 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
2
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Mar 19, 2024 · Synced Jun 25, 2026, 10:47 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

The Effect of Joint Hypermobility Syndrome on Delayed Onset of Muscle Soreness and Recovery Time

NCT04934267
View directory record Official record
Conditions
Hypermobility Syndrome
Interventions
Eccentric Exercise for subjects with JHS, Eccentric Exercise for Controls
Other
Lead sponsor
New York Institute of Technology
Other
Eligibility
18 Years to 35 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Old Westbury, New York
Source: ClinicalTrials.gov public record
Updated Nov 1, 2021 · Synced Jun 25, 2026, 10:47 PM EDT
Terminated Phase 2 Interventional Accepts healthy volunteers Results available

A Study to Evaluate the Efficacy and Safety of K-285 Compared With Menthol Gel for the Treatment of Delayed Onset Muscle Soreness (DOMS) in the Lower Extremity

NCT04484428
View directory record Official record
Conditions
Acute Pain
Interventions
K-285, Menthol
Drug
Lead sponsor
Kowa Research Institute, Inc.
Industry
Eligibility
18 Years to 35 Years
Enrollment
126 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Pasadena, California
Source: ClinicalTrials.gov public record
Updated Dec 26, 2024 · Synced Jun 25, 2026, 10:47 PM EDT
Completed Phase 3 Interventional Results available

A Within-subject Study to Evaluate the Efficacy and Safety of Diclofenac Sodium Topical Gel 1% Compared to Placebo in Subjects Experiencing Delayed Onset Muscle Soreness

NCT02271854
View directory record Official record
Conditions
Muscle Soreness
Interventions
Diclofenac sodium gel 1%, Placebo
Drug
Lead sponsor
Novartis
Industry
Eligibility
18 Years to 35 Years
Enrollment
102 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014
U.S. locations
1
States / cities
Pasadena, California
Source: ClinicalTrials.gov public record
Updated Apr 4, 2016 · Synced Jun 25, 2026, 10:47 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Controlled Study to Assess the Efficacy and Safety of S-Ibuprofen Topical Gel 5% (AP0302) in the Treatment of DOMS

NCT03852459
View directory record Official record
Conditions
Pain, Acute
Interventions
S-Ibuprofen, Vehicle
Drug
Lead sponsor
Aponia Laboratories, Inc.
Industry
Eligibility
18 Years to 55 Years
Enrollment
251 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Jan 24, 2022 · Synced Jun 25, 2026, 10:47 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Dosing Interval Study of SST-0225 Topical Ibuprofen Cream in the Treatment of Delayed Onset Muscle Soreness

NCT02339129
View directory record Official record
Conditions
Delayed Onset Muscle Soreness
Interventions
SST-0225, Placebo
Drug
Lead sponsor
Strategic Science & Technologies, LLC
Industry
Eligibility
16 Years to 65 Years
Enrollment
72 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
2
States / cities
South Miami, Florida • Springfield, Missouri
Source: ClinicalTrials.gov public record
Updated Sep 8, 2016 · Synced Jun 25, 2026, 10:47 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

A Study Comparing the Efficacy and Safety of Orally Administered Ibuprofen and Placebo in Delayed Onset Muscle Soreness

NCT02113566
View directory record Official record
Conditions
Delayed Onset Muscle Soreness
Interventions
Acetaminophen 1000mg
Drug
Lead sponsor
Jean Brown Research
Other
Eligibility
18 Years to 55 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Dec 1, 2015 · Synced Jun 25, 2026, 10:47 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Pilot Study Comparing the Efficacy and Safety of a New Pain Patch and Placebo in Delayed Onset Muscle Soreness (DOMS)

NCT02602353
View directory record Official record
Conditions
Delayed Onset Muscle Soreness
Interventions
Loxoprofen Pain Patch, Placebo Patch, No Treatment
Drug
Lead sponsor
Lead Chemical Co., Ltd.
Industry
Eligibility
18 Years to 40 Years
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Oct 27, 2016 · Synced Jun 25, 2026, 10:47 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Palmar Cooling on the Human Immune System

NCT07215338
View directory record Official record
Conditions
Human Immune Response
Interventions
Muscle Temperature Control
Other
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
22 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Nov 3, 2025 · Synced Jun 25, 2026, 10:47 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Etodolac-lidocaine Patch in Subjects Experiencing Acute Delayed Onset Muscle Soreness

NCT02695381
View directory record Official record
Conditions
Acute Delayed Onset Muscle Soreness (DOMS)
Interventions
Etodolac-lidocaine topical patch, Placebo
Drug
Lead sponsor
MEDRx USA, Inc.
Industry
Eligibility
18 Years to 35 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016
U.S. locations
1
States / cities
Pasadena, California
Source: ClinicalTrials.gov public record
Updated Sep 11, 2016 · Synced Jun 25, 2026, 10:47 PM EDT