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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Delirium Treatment Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Prophylactic Olanzapine Versus Placebo for Prevention of Postoperative Delirium After Joint Replacement Surgery

NCT00699946
View directory record Official record
Conditions
Delirium
Interventions
olanzapine, placebo
Drug
Lead sponsor
The New England Baptist Hospital
Other
Eligibility
65 Years and older
Enrollment
495 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2007
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 20, 2009 · Synced Sep 27, 2026, 8:20 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Positive Imagery Therapy and the Incidence of Emergence Reactions With the Use of Ketamine

NCT04746079
View directory record Official record
Conditions
Procedural Sedation, Emergence Delirium
Interventions
Positive Imagery Therapy
Behavioral
Lead sponsor
Mercy Health Ohio
Other
Eligibility
18 Years and older
Enrollment
180 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Youngstown, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 22, 2022 · Synced Sep 27, 2026, 8:20 PM EDT
Completed No phase listed Observational

Sound Levels in the Pediatric Cardiac Critical Care Unit and Their Correlation With Sedation Administration, Delirium Scores and Patient Heart Rate

NCT04777695
View directory record Official record
Conditions
Noise Exposure, Sedative Withdrawal Delirium, Sedative Toxicity
Interventions
Decibel Monitor
Other
Lead sponsor
Children's National Research Institute
Other
Eligibility
Up to 22 Years
Enrollment
64 participants
Timeline
2021
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Sep 30, 2021 · Synced Sep 27, 2026, 8:20 PM EDT
Completed No phase listed Observational

Ketamine Infusion as Sedative Analgesic in Severe ARDS

NCT04818827
View directory record Official record
Conditions
Intensive Care Unit Syndrome, Mechanical Ventilation Complication, Sedatives and Hypnotics Causing Adverse Effects in Therapeutic Use, Delirium
Interventions
Not listed
Lead sponsor
Interfaith Medical Center
Other
Eligibility
18 Years to 90 Years
Enrollment
124 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 25, 2021 · Synced Sep 27, 2026, 8:20 PM EDT
Withdrawn Phase 4 Interventional

RCT: Trazodone vs Quetiapine vs Placebo for Treating ICU Delirium (TraQ)

NCT05085808
View directory record Official record
Conditions
Delirium, Morality, Quality of Life, Psych, Treatment Side Effects
Interventions
Trazodone, Quetiapine, Placebo
Drug
Lead sponsor
University of Southern California
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2028 – 2030
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated May 3, 2026 · Synced Sep 27, 2026, 8:20 PM EDT
Terminated Phase 4 Interventional Results available

Valproic Acid for Treatment of Hyperactive or Mixed Delirium in ICU

NCT02343575
View directory record Official record
Conditions
Hyperactive Delirium, Mixed Delirium
Interventions
Valproic Acid, Placebo, Haloperidol
Drug
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Jun 25, 2019 · Synced Sep 27, 2026, 8:20 PM EDT
Completed No phase listed Observational

Neurocognitive Functioning in Patients With Newly Diagnosed Upper Aerodigestive Tract Cancer Receiving Treatment at Henry-Joyce Cancer Clinic

NCT00533884
View directory record Official record
Conditions
Neurocognitive Impairment, Delirium, Esophageal Cancer, Head and Neck Cancer, Lung Cancer
Interventions
Assessment of therapy complications, Neurocognitive assessment, Quality-of-life assessment
Other
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
21 Years and older
Enrollment
86 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2013
U.S. locations
4
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Apr 6, 2017 · Synced Sep 27, 2026, 8:20 PM EDT
Completed No phase listed Observational

A Study of the Experience of Music Therapy in Cancer Patients With Delirium

NCT04104217
View directory record Official record
Conditions
Cancer Patients With Delirium
Interventions
Music therapy, Interviews
Behavioral
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Eligibility
18 Years to 75 Years
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 21, 2023 · Synced Sep 27, 2026, 8:20 PM EDT
Completed Not applicable Interventional

Decreasing Delirium Through Music

NCT03095443
View directory record Official record
Conditions
Delirium
Interventions
Music Therapy - Personalized Playlist, Music Therapy - Standard Playlist, Attention Control
Other
Lead sponsor
Indiana University
Other
Eligibility
18 Years and older
Enrollment
56 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Apr 16, 2019 · Synced Sep 27, 2026, 8:20 PM EDT
Completed Not applicable Interventional Results available

Improving the Recovery and Outcome Every Day After the ICU

NCT03095417
View directory record Official record
Conditions
Delirium, Alzheimer Disease
Interventions
Physical Exercise Intervention, Cognitive Training Intervention, Stretching Control, Cognitive Control
Behavioral
Lead sponsor
Indiana University
Other
Eligibility
50 Years and older
Enrollment
249 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
6
States / cities
Avon, Indiana • Carmel, Indiana • Fishers, Indiana + 1 more
Source: ClinicalTrials.gov public record
Updated Mar 26, 2024 · Synced Sep 27, 2026, 8:20 PM EDT
Recruiting Not applicable Interventional

Clinical Effectiveness of the "PICU Up!" Multifaceted Early Mobility Intervention for Critically Ill Children

NCT04989790
View directory record Official record
Conditions
Child, Intensive Care Unit Acquired Weakness, Critical Illness, Hospital Acquired Pressure Ulcer
Interventions
PICU Up!
Other
Lead sponsor
Johns Hopkins University
Other
Eligibility
Up to 18 Years
Enrollment
1,440 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
11
States / cities
Madera, California • Orlando, Florida • Louisville, Kentucky + 8 more
Source: ClinicalTrials.gov public record
Updated Aug 23, 2026 · Synced Sep 27, 2026, 8:20 PM EDT
Withdrawn Phase 4 Interventional

Efficacy and Safety of Risperidone and Trazodone Monotherapy and Combination Therapy in Critically Ill Patients With Delirium

NCT02118688
View directory record Official record
Conditions
Delirium, Agitation
Interventions
Risperidone, Trazodone, Placebo
Drug
Lead sponsor
Rochester General Hospital
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2016
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Sep 9, 2019 · Synced Sep 27, 2026, 8:20 PM EDT
Terminated No phase listed Observational

Trazodone vs. Quetiapine for the Treatment of ICU Delirium

NCT05307003
View directory record Official record
Conditions
Delirium, Delirium of Mixed Origin, Delirium, Sepsis Associated, Delirium in Old Age, Delirium Confusional State, Psych, Morality, Treatment Side Effects
Interventions
Trazodone, Quetiapine
Drug
Lead sponsor
University of Southern California
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated May 3, 2026 · Synced Sep 27, 2026, 8:20 PM EDT
Completed Phase 2 Interventional Results available

Randomized Controlled Trial of Dexmedetomidine for the Treatment of Intensive Care Unit (ICU) Delirium

NCT00351299
View directory record Official record
Conditions
Delirium, Agitation
Interventions
Dexmedetomidine, Standard of Care
Drug · Other
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years and older
Enrollment
53 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2012
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 8, 2017 · Synced Sep 27, 2026, 8:20 PM EDT
Withdrawn Phase 4 Interventional

Ziprasidone vs Standard Therapy for Agitated Patients in the ED

NCT00786318
View directory record Official record
Conditions
Psychosis, Agitation, Delirium
Interventions
ziprasidone, Standard therapy
Drug
Lead sponsor
George Washington University
Other
Eligibility
18 Years to 100 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Sep 24, 2017 · Synced Sep 27, 2026, 8:20 PM EDT
Completed No phase listed Observational

Treatment of Alcohol Withdrawal Syndrome With Alpha-2 Agonists and/or Anticonvulsants

NCT05438641
View directory record Official record
Conditions
Alcohol Withdrawal Syndrome
Interventions
BZDP-Sparing Protocol, BZDP-Based Protocol
Drug
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Jun 29, 2022 · Synced Sep 27, 2026, 8:20 PM EDT
Not listed Phase 4 Interventional

Phenobarbital vs Ativan for Alcohol Withdrawal in the Intensive Care Unit

NCT04156464
View directory record Official record
Conditions
Alcohol Withdrawal, Alcohol Withdrawal Delirium
Interventions
Phenobarbital, Lorazepam
Drug
Lead sponsor
OSF Healthcare System
Other
Eligibility
18 Years and older
Enrollment
142 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Peoria, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 7, 2020 · Synced Sep 27, 2026, 8:20 PM EDT
Recruiting Not applicable Interventional

Delirium in Neurodegenerative Disease Patients: A Music Therapy Intervention for Hospital Care

NCT07137949
View directory record Official record
Conditions
Delirium
Interventions
Music therapy
Behavioral
Lead sponsor
Boston Medical Center
Other
Eligibility
60 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 31, 2026 · Synced Sep 27, 2026, 8:20 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Rivastigmine in the Treatment of Postoperative Delirium: a Pilot Clinical Trial

NCT00835159
View directory record Official record
Conditions
Delirium, Postoperative Cognitive Dysfunction
Interventions
Rivastigmine Patch, Placebo Patch
Drug · Other
Lead sponsor
NYU Langone Health
Other
Eligibility
65 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2010
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 8, 2015 · Synced Sep 27, 2026, 8:20 PM EDT
Completed No phase listed Observational

Stress Biomarkers Among Patients Undergoing Treatment for Excited Delirium and Severe Pain in the Emergency Department

NCT01747824
View directory record Official record
Conditions
Agitation, Excited Delirium, Pain
Interventions
Not listed
Lead sponsor
Hennepin Healthcare Research Institute
Other
Eligibility
18 Years and older
Enrollment
1,322 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Dec 22, 2015 · Synced Sep 27, 2026, 8:20 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

YOOMI: Effect of Gamified Physical Therapy Exercise Software on Inpatient Mobility

NCT05815017
View directory record Official record
Conditions
Weakness, Muscle, Delirium in Old Age, Muscle Atrophy or Weakness, Muscle Loss, Hospital Acquired Condition, Physical Disability, Physical Inactivity
Interventions
Yoomi Physical Therapy Software
Device
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
65 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
New Brunswick, New Jersey
Source: ClinicalTrials.gov public record
Updated Aug 6, 2026 · Synced Sep 27, 2026, 8:20 PM EDT
Completed Phase 3 Interventional Results available

The Prevention of Delirium and Complications Associated With Surgical Treatments Multi Center Clinical Trial

NCT01690988
View directory record Official record
Conditions
Delirium
Interventions
Ketamine (0.5 mg/kg), Normal Saline (placebo), Ketamine (1 mg/kg)
Drug
Lead sponsor
Washington University School of Medicine
Other
Eligibility
60 Years and older
Enrollment
746 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jun 5, 2018 · Synced Sep 27, 2026, 8:20 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effect of Music Therapy on Delirium

NCT03980782
View directory record Official record
Conditions
Delirium
Interventions
Music Therapy
Other
Lead sponsor
Geisinger Clinic
Other
Eligibility
65 Years and older
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Scranton, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 1, 2020 · Synced Sep 27, 2026, 8:20 PM EDT
Recruiting Not applicable Interventional

TaVNS for Delirium

NCT07258082
View directory record Official record
Conditions
Delirium Treatment, Delirium
Interventions
Transauricular Vagus Nerve Stimulation
Device
Lead sponsor
Stony Brook University
Other
Eligibility
22 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Stony Brook, New York
Source: ClinicalTrials.gov public record
Updated Apr 21, 2026 · Synced Sep 27, 2026, 8:20 PM EDT