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Showing 1–24 of 213 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Dental Caries Clear all
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluate the Effectiveness of an Experimental Urethane Dimethacrylate Resin Based Dental Composite Material

NCT02018822
View directory record Official record
Conditions
Dental Caries, Restorative Material
Interventions
urethane dimethacrylate, TPH3, Esthet-X HD
Device
Lead sponsor
University of Rochester
Other
Eligibility
18 Years to 85 Years
Enrollment
85 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2017
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Aug 27, 2018 · Synced Sep 12, 2026, 10:02 AM EDT
Completed Phase 3 Interventional Results available

Prevention of Adult Caries Study (PACS)

NCT00357877
View directory record Official record
Conditions
Caries, Dental
Interventions
10% w/v chlorhexidine acetate coating FDA IND #45466, Placebo
Drug · Other
Lead sponsor
Tufts University
Other
Eligibility
18 Years and older
Enrollment
983 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2010
U.S. locations
4
States / cities
Tuba City, Arizona • Boston, Massachusetts • Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Jun 13, 2017 · Synced Sep 12, 2026, 10:02 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Waukesha Smiles: Dental Outreach to Low-income Waukesha Children

NCT00703001
View directory record Official record
Conditions
Dental Caries
Interventions
Educational Intervention, Referral Intervention
Behavioral
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
Not listed
Enrollment
400 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2010
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Sep 5, 2010 · Synced Sep 12, 2026, 10:02 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Nutrition Knowledge for Spanish-speaking Parents

NCT01296945
View directory record Official record
Conditions
Obesity, Dental Caries
Interventions
Kiosk, paper, Kiosk PLUS paper, Kiosk PLUS web
Other
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
160 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 29, 2012 · Synced Sep 12, 2026, 10:02 AM EDT
Completed Not applicable Interventional

Multi-Media Parent-based Intervention to Promote Dental Hygiene Among Young Children: BeReady2Smile

NCT03637309
View directory record Official record
Conditions
Dental Caries in Children
Interventions
BeReady2Smile Video and App
Behavioral
Lead sponsor
Oregon Research Behavioral Intervention Strategies, Inc.
Industry
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Eugene, Oregon
Source: ClinicalTrials.gov public record
Updated Nov 23, 2021 · Synced Sep 12, 2026, 10:02 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Treatment of Interproximal Cavities on Primary Molar Teeth With Silver Diamine Fluoride

NCT03770286
View directory record Official record
Conditions
Dental Caries in Children, Dental Caries Class II, Dental Caries
Interventions
5% Fluoride Varnish, 38% Silver diamine fluoride, Super Floss
Device
Lead sponsor
Children's Hospital Los Angeles
Other
Eligibility
3 Years to 12 Years
Enrollment
51 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Oct 14, 2024 · Synced Sep 12, 2026, 10:02 AM EDT
Completed Phase 3 Interventional

Xylitol Adult Caries Trial (X-ACT)

NCT00393055
View directory record Official record
Conditions
Dental Caries
Interventions
xylitol, inactive lozenge
Dietary Supplement
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
25 Years to 80 Years
Enrollment
709 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2011
U.S. locations
3
States / cities
Birmingham, Alabama • Chapel Hill, North Carolina • San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Sep 11, 2011 · Synced Sep 12, 2026, 10:02 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

BEhavioral EConomics for Oral Health iNnovation Trial

NCT03576326
View directory record Official record
Conditions
Toothbrushing, Dental Plaque, Parent-Child Relations, Oral Hygiene, Dental Caries
Interventions
Drawing Incentive
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
6 Months to 47 Months
Enrollment
244 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2021
U.S. locations
1
States / cities
Santa Monica, California
Source: ClinicalTrials.gov public record
Updated Sep 18, 2025 · Synced Sep 12, 2026, 10:02 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Older Adult Effectiveness of 2 Treatments

NCT03916926
View directory record Official record
Conditions
Dental Caries
Interventions
A "simple medical strategy" consisting of silver diamine fluoride (SDF), B "typical dental strategy" consisting of atraumatic restorative treatment (ART) with glass ionomer cement + Fluoride varnish (FV)
Device
Lead sponsor
Case Western Reserve University
Other
Eligibility
62 Years and older
Enrollment
568 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2024
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 12, 2025 · Synced Sep 12, 2026, 10:02 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Clinical Trial NuSmile Crowns

NCT04975321
View directory record Official record
Conditions
Primary Dental Caries, Multisurface Origin (Diagnosis)
Interventions
Nu Smile Zirconia crown, Nu Smile Pre Veneered crown, Composite strip crown
Device
Lead sponsor
University of Washington
Other
Eligibility
Up to 5 Years
Enrollment
97 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2019
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated May 8, 2022 · Synced Sep 12, 2026, 10:02 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

Safety Evaluation of Advantage Anti-Caries Varnish

NCT02645617
View directory record Official record
Conditions
Dental Caries
Interventions
Varnish
Drug
Lead sponsor
Advantage Dental Services, LLC
Industry
Eligibility
36 Months to 60 Months
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jan 20, 2020 · Synced Sep 12, 2026, 10:02 AM EDT
Recruiting Not applicable Interventional

Clinical Evaluation of Full Contour Zirconia Chairside CAD/CAM Crowns

NCT06173167
View directory record Official record
Conditions
Dental Disorders Hard Tissues of Teeth, Dental Diseases
Interventions
Crowns self-adhesively luted, Crowns conventionally cemented
Device
Lead sponsor
Ivoclar Vivadent AG
Industry
Eligibility
18 Years and older
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Mar 27, 2024 · Synced Sep 12, 2026, 10:02 AM EDT
Completed Phase 4 Interventional Results available

The Effect of Silver Diamine Fluoride (SDF) on Bacteria Involved in Root or Cervical Carious Lesions

NCT02953886
View directory record Official record
Conditions
Caries
Interventions
Silver Diamine Fluoride (SDF)
Device
Lead sponsor
Heba Mitwalli
Other
Eligibility
18 Years and older
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Sep 27, 2018 · Synced Sep 12, 2026, 10:02 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

A Study to Evaluate the Microbiology, Safety and Tolerability of C16G2 Dental Strip Application

NCT03052842
View directory record Official record
Conditions
Dental Caries
Interventions
C16G2 Strip, Placebo Strip
Drug · Other
Lead sponsor
Armata Pharmaceuticals, Inc.
Industry
Eligibility
12 Years to 75 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
3
States / cities
Kalispell, Montana • Bedford, Texas • Irving, Texas
Source: ClinicalTrials.gov public record
Updated Dec 21, 2022 · Synced Sep 12, 2026, 10:02 AM EDT
Completed Phase 1 Interventional

Study of Viral Load Decay Rates in HIV Infected Participants Starting Treatment With Raltegravir (RAL) and Emtricitabine/Tenofovir Disoproxil Fumarate (TDF)

NCT00660972
View directory record Official record
Conditions
HIV Infections
Interventions
Raltegravir, Emtricitabine/tenofovir disoproxil fumarate
Drug
Lead sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
NIH
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
15
States / cities
San Diego, California • Aurora, Colorado • Chicago, Illinois + 10 more
Source: ClinicalTrials.gov public record
Updated Oct 31, 2021 · Synced Sep 12, 2026, 10:02 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Promoting Behavioral Change for Oral Health in American Indian Mothers and Children

NCT01116726
View directory record Official record
Conditions
Early Childhood Dental Caries
Interventions
Motivational interviewing, Enhanced community services
Behavioral
Lead sponsor
University of Colorado, Denver
Other
Eligibility
15 Years to 44 Years
Enrollment
1,134 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2017
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Jul 7, 2021 · Synced Sep 12, 2026, 10:02 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Cold Plasma for Dental Restoration and Caries Prevention

NCT01529606
View directory record Official record
Conditions
Dental Restoration, Caries
Interventions
Composite restoration and tooth cleaning, Plasma treatment
Other · Procedure
Lead sponsor
Nanova, Inc
Industry
Eligibility
18 Years to 35 Years
Enrollment
102 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2014
U.S. locations
1
States / cities
Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Apr 15, 2020 · Synced Sep 12, 2026, 10:02 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Healthy Hydration Pilot in Elementary Schools

NCT06132763
View directory record Official record
Conditions
Hydration, Dental Caries, Body Mass Index
Interventions
Hydration Intervention, Control - Assessments Only
Behavioral · Other
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
4 Years and older
Enrollment
563 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Oct 30, 2025 · Synced Sep 12, 2026, 10:02 AM EDT
Completed Not applicable Interventional Results available

Short-term Disulfiram Administration to Accelerate the Decay of the HIV Reservoir in Antiretroviral-treated HIV Infected Individuals

NCT01286259
View directory record Official record
Conditions
HIV-1 Infection
Interventions
Disulfiram
Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
2
States / cities
San Francisco, California • Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 29, 2020 · Synced Sep 12, 2026, 10:02 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effectiveness of a Nutritional Counseling Tool in Reducing the Amount and Frequency of Sugar Intake

NCT06673342
View directory record Official record
Conditions
Dental Cavity, Caries,Dental
Interventions
Nutritional Counseling
Behavioral
Lead sponsor
Loma Linda University
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Mar 12, 2025 · Synced Sep 12, 2026, 10:02 AM EDT
Completed Not applicable Interventional Results available

Resin Infiltration to Arrest Early Tooth Decay

NCT01584024
View directory record Official record
Conditions
Dental Caries
Interventions
Resin infiltration, Sham treatment
Device
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 24 Years
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
West Point, New York
Source: ClinicalTrials.gov public record
Updated Feb 11, 2019 · Synced Sep 12, 2026, 10:02 AM EDT
Completed Phase 1 Interventional

Chlorhexidine Gel Therapy for Cariogenic Oral Microflora

NCT01036412
View directory record Official record
Conditions
Head and Neck Cancer
Interventions
1% Chlorhexidine Gluconate Gel, Surveys
Drug · Behavioral
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 18, 2016 · Synced Sep 12, 2026, 10:02 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Evaluation of a Brief Tailored Motivational Intervention to Prevent Early Childhood Caries

NCT01123330
View directory record Official record
Conditions
Dental Caries
Interventions
Motivational Interviewing
Behavioral
Lead sponsor
Temple University
Other
Eligibility
Up to 5 Years
Enrollment
2,042 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2001 – 2007
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated May 13, 2010 · Synced Sep 12, 2026, 10:02 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Saving Lives at Birth: Primary Prevention of Periodontal Disease in Relation to Preterm Birth in Malawi

NCT02333227
View directory record Official record
Conditions
Preterm Birth, Periodontal Disease, Caries, Dental
Interventions
Xylitol gum
Dietary Supplement
Lead sponsor
Baylor College of Medicine
Other
Eligibility
18 Years to 64 Years · Female only
Enrollment
10,069 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2021
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jan 7, 2024 · Synced Sep 12, 2026, 10:02 AM EDT