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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Dental Caries Clear all
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Birth to Three - Cavity Free

NCT05756413
View directory record Official record
Conditions
Caries,Dental
Interventions
Self-determination theory
Behavioral
Lead sponsor
University of Iowa
Other
Eligibility
18 Years to 45 Years
Enrollment
1,268 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
16
States / cities
Anamosa, Iowa • Belle Plaine, Iowa • Cedar Rapids, Iowa + 11 more
Source: ClinicalTrials.gov public record
Updated Jul 20, 2026 · Synced Jul 21, 2026, 12:09 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Clinical Study to Assess an Experimental Dentifrice in an Experimental Model of Early Stage Caries

NCT06949072
View directory record Official record
Conditions
Dental Caries
Interventions
Test Dentifrice, Reference Dentifrice, Negative Control Dentifrice
Drug
Lead sponsor
HALEON
Industry
Eligibility
18 Years to 85 Years
Enrollment
47 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Sep 23, 2025 · Synced Jul 21, 2026, 12:09 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Pilot Study to Promote Maternal and Infant Oral Health

NCT00719238
View directory record Official record
Conditions
Dental Caries
Interventions
Nutrition plus education, Education only
Behavioral
Lead sponsor
UConn Health
Other
Eligibility
18 Years and older · Female only
Enrollment
121 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2008
U.S. locations
1
States / cities
Farmington, Connecticut
Source: ClinicalTrials.gov public record
Updated Jul 20, 2008 · Synced Jul 21, 2026, 12:09 PM EDT
Completed Not applicable Interventional

Using Video Modeled Social Stories to Improve Oral Hygiene in Children With Autism Spectrum Disorder

NCT02003820
View directory record Official record
Conditions
Autism Spectrum Disorder, Dental Caries
Interventions
video modeled social story
Behavioral
Lead sponsor
Yale University
Other
Eligibility
5 Years to 14 Years
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
2
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Aug 7, 2016 · Synced Jul 21, 2026, 12:09 PM EDT
Completed Phase 3 Interventional

Postoperative Hypersensitivity Randomized Comparative Effectiveness Research Trial

NCT01268605
View directory record Official record
Conditions
Dental Caries
Interventions
Restoration with a dentin bonding agent (DBA), Restoration with a resin modified glass ionomer liner (RMGI)
Procedure
Lead sponsor
Pearl Network
Network
Eligibility
15 Years to 60 Years
Enrollment
341 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
41
States / cities
Phoeniz, Arizona • Newport Beach, California • Boulder, Colorado + 37 more
Source: ClinicalTrials.gov public record
Updated Sep 18, 2014 · Synced Jul 21, 2026, 12:09 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

ETT Rotation During Nasal Fiberoptic Intubation

NCT02405546
View directory record Official record
Conditions
Dental Caries
Interventions
Pre-Rotated (Group R), No pre-rotation
Other
Lead sponsor
Nemours Children's Clinic
Other
Eligibility
2 Years to 17 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2015
U.S. locations
1
States / cities
Wilmington, Delaware
Source: ClinicalTrials.gov public record
Updated Mar 22, 2016 · Synced Jul 21, 2026, 12:09 PM EDT
Completed Phase 3 Interventional

The Children's Amalgam Trial

NCT00065988
View directory record Official record
Conditions
Dental Caries
Interventions
Dispersed phase amalgam restoration /composite restoration
Device
Lead sponsor
Carelon Research
Other
Eligibility
6 Years to 10 Years
Enrollment
534 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1997 – 2005
U.S. locations
1
States / cities
Watertown, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 27, 2010 · Synced Jul 21, 2026, 12:09 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Interactive Parent-Targeted Text Messaging in Pediatric Clinics to Reduce Caries Among Urban Children

NCT03294590
View directory record Official record
Conditions
Caries, Dental, Health Behavior
Interventions
OHT Parent targeted text messages, CWT Parent targeted text messages
Other
Lead sponsor
Boston University
Other
Eligibility
0 Months to 7 Years
Enrollment
754 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 23, 2023 · Synced Jul 21, 2026, 12:09 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Maximal Use Study to Determine the Pharmacokinetics of L-arginine After Exaggerated Oral Use of COL101

NCT06182267
View directory record Official record
Conditions
Caries,Dental
Interventions
L Arginine, Sodium Fluoride
Drug
Lead sponsor
Colgate Palmolive
Industry
Eligibility
18 Years to 65 Years
Enrollment
29 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Fair Lawn, New Jersey
Source: ClinicalTrials.gov public record
Updated Jan 1, 2024 · Synced Jul 21, 2026, 12:09 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Nutrition Knowledge for Spanish-speaking Parents

NCT01296945
View directory record Official record
Conditions
Obesity, Dental Caries
Interventions
Kiosk, paper, Kiosk PLUS paper, Kiosk PLUS web
Other
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
160 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 29, 2012 · Synced Jul 21, 2026, 12:09 PM EDT
Completed Not applicable Interventional Results available

Resin Infiltration to Arrest Early Tooth Decay

NCT01584024
View directory record Official record
Conditions
Dental Caries
Interventions
Resin infiltration, Sham treatment
Device
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 24 Years
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
West Point, New York
Source: ClinicalTrials.gov public record
Updated Feb 11, 2019 · Synced Jul 21, 2026, 12:09 PM EDT
Terminated Not applicable Interventional Results available

Lithium Disilicate Crowns Study

NCT05070416
View directory record Official record
Conditions
Caries, Dental Trauma
Interventions
Lithium disilicate crowns
Device
Lead sponsor
Ivoclar Vivadent AG
Industry
Eligibility
18 Years and older
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Oct 22, 2025 · Synced Jul 21, 2026, 12:09 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Decision Aids for the Management of Suspicious Occlusal Caries Lesions

NCT02340767
View directory record Official record
Conditions
Dental Caries
Interventions
Spectra Device, DIAGNOdent
Device
Lead sponsor
The National Dental Practice-Based Research Network
Network
Eligibility
6 Years and older
Enrollment
3,085 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
6
States / cities
Birmingham, Alabama • Gainesville, Florida • Minneapolis, Minnesota + 3 more
Source: ClinicalTrials.gov public record
Updated Apr 2, 2019 · Synced Jul 21, 2026, 12:09 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

DPBRN Longitudinal Study of Questionable Occlusal Caries Lesions

NCT01309971
View directory record Official record
Conditions
Dental Caries
Interventions
Not listed
Lead sponsor
Dental Practice-Based Research Network
Network
Eligibility
6 Years and older
Enrollment
2,624 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2011
U.S. locations
6
States / cities
Birmingham, Alabama • Gainesville, Florida • Minneapolis, Minnesota + 1 more
Source: ClinicalTrials.gov public record
Updated Feb 18, 2014 · Synced Jul 21, 2026, 12:09 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Prevention of Enamel Demineralization by Use of K18-smooth Surface Sealant

NCT03306433
View directory record Official record
Conditions
Dental Caries
Interventions
UDMA-K18 smooth surface sealant
Device
Lead sponsor
University of Colorado, Denver
Other
Eligibility
12 Years to 89 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Oct 6, 2021 · Synced Jul 21, 2026, 12:09 PM EDT
Completed Not applicable Interventional Results available

In Vivo Assessment of the Tooth-Resin Composite Interface Using Optical Coherence Tomography

NCT05145322
View directory record Official record
Conditions
Cavity, Cavities of Teeth
Interventions
Composite with 90 degree cavosurface angle, Composite with wide bevel
Device
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 27, 2024 · Synced Jul 21, 2026, 12:09 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

Safety Evaluation of Advantage Anti-Caries Varnish

NCT02645617
View directory record Official record
Conditions
Dental Caries
Interventions
Varnish
Drug
Lead sponsor
Advantage Dental Services, LLC
Industry
Eligibility
36 Months to 60 Months
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jan 20, 2020 · Synced Jul 21, 2026, 12:09 PM EDT
Completed Not applicable Interventional Results available

Composites and Urinary Bisphenol-A Study

NCT01484132
View directory record Official record
Conditions
Dental Caries
Interventions
Restoration of dental caries with dental composite
Procedure
Lead sponsor
Carelon Research
Other
Eligibility
3 Years to 17 Years
Enrollment
113 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Watertown, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 9, 2015 · Synced Jul 21, 2026, 12:09 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Enamel Remineralization Potential of Dentifrices in Situ

NCT01128946
View directory record Official record
Conditions
Dental Caries
Interventions
NaF, SnF, NaMFP
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years to 80 Years
Enrollment
83 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2010
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Dec 31, 2014 · Synced Jul 21, 2026, 12:09 PM EDT
Completed Phase 4 Interventional Results available

The Effect of Silver Diamine Fluoride (SDF) on Bacteria Involved in Root or Cervical Carious Lesions

NCT02953886
View directory record Official record
Conditions
Caries
Interventions
Silver Diamine Fluoride (SDF)
Device
Lead sponsor
Heba Mitwalli
Other
Eligibility
18 Years and older
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Sep 27, 2018 · Synced Jul 21, 2026, 12:09 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Development and Evaluation of a Medical Intervention for Early Childhood Caries

NCT00464009
View directory record Official record
Conditions
Early Childhood Dental Caries
Interventions
Continuing medical education
Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
Not listed
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2001 – 2007
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 28, 2010 · Synced Jul 21, 2026, 12:09 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Esthetics of Dental Composite and Adhesive System

NCT03716349
View directory record Official record
Conditions
Cavities of Teeth
Interventions
Pulp vitality testing, Photos, local and/or topical anesthetic, rubber dam, tooth surface cleaned, enamel margins, Adhesive Systems, cavity preparation, Shade selection using Easy Shade 5, Light Curing, Contoured and polished, Consent, Health Questionnaire, xray, Release of medical information signed, Oral Exam, Teeth Assessment, Clinical Assessment, Tokuyama Universal Bond, ScotchBond
Diagnostic Test · Other · Drug + 3 more
Lead sponsor
Erica Teixeira
Other
Eligibility
18 Years and older
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2025
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Apr 30, 2026 · Synced Jul 21, 2026, 12:09 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Microbial Testing for Caries Risk Assessment

NCT03389373
View directory record Official record
Conditions
Dental Caries
Interventions
GC Strep Mutans Saliva Sampling
Device
Lead sponsor
University of Colorado, Denver
Other
Eligibility
24 Months to 96 Months
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Jul 15, 2018 · Synced Jul 21, 2026, 12:09 PM EDT
Terminated Phase 3 Interventional Results available

Effectiveness of Silver Diamine Fluoride (SDF) in Arresting Cavitated Caries Lesions

NCT03649659
View directory record Official record
Conditions
Cavities of Teeth
Interventions
Silver Diamine Fluoride, Placebo
Drug
Lead sponsor
University of Michigan
Other
Eligibility
12 Months to 71 Months
Enrollment
830 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2023
U.S. locations
3
States / cities
Iowa City, Iowa • Ann Arbor, Michigan • New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 6, 2025 · Synced Jul 21, 2026, 12:09 PM EDT