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Showing 1–24 of 41 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Dental Caries in Children Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Promoting Behavioral Change for Oral Health in American Indian Mothers and Children

NCT01116726
View directory record Official record
Conditions
Early Childhood Dental Caries
Interventions
Motivational interviewing, Enhanced community services
Behavioral
Lead sponsor
University of Colorado, Denver
Other
Eligibility
15 Years to 44 Years
Enrollment
1,134 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2017
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Jul 7, 2021 · Synced Sep 28, 2026, 4:11 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Clinical Trial Comparing Isolite® vs. Cotton Roll Isolation in the Placement of Dental Sealants

NCT02668874
View directory record Official record
Conditions
Dental Caries on Pit and Fissure Surface
Interventions
Isolite System, Cotton Roll Technique
Device · Other
Lead sponsor
University of Iowa
Other
Eligibility
6 Years to 16 Years
Enrollment
104 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Jan 31, 2022 · Synced Sep 28, 2026, 4:11 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

QI Study of a Practice Facilitator's Impact in Working With Clinics on Improving Dental, Lead & Obesity Measures for Children

NCT01739166
View directory record Official record
Conditions
Lead Poisoning, Obesity, Dental Decay
Interventions
Practice-tailored intervention to increase rates of targeted services
Other
Lead sponsor
University Hospitals Cleveland Medical Center
Other
Eligibility
Not listed
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2012
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Dec 2, 2014 · Synced Sep 28, 2026, 4:11 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

3D Scanning as an Advanced Tool for Identifying Tooth Lesions in Children

NCT06829550
View directory record Official record
Conditions
Dental Caries in Children, Tooth Erosion, Fluorosis, Dental, Dental Caries
Interventions
indirect- 3D digital scanning
Diagnostic Test
Lead sponsor
Indiana University
Other
Eligibility
3 Years to 12 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated May 5, 2026 · Synced Sep 28, 2026, 4:11 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Arrest of Proximal Caries Using Orthodontic Bands and Glass Ionomer Cement

NCT04538963
View directory record Official record
Conditions
Dental Caries Class II, Dental Caries in Children, Dental Caries on Smooth Surface Limited to Enamel
Interventions
Orthodontic Band affixed with Glass Ionomer Cement
Device
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
5 Years to 209 Months
Enrollment
38 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
2
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Sep 4, 2021 · Synced Sep 28, 2026, 4:11 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Livionex on Reducing Plaque Accumulation and Improving Oral Health in Children

NCT04368533
View directory record Official record
Conditions
Plaque, Dental, Caries, Dental, Oral Hygiene
Interventions
Livionex Dental Gel, A standard children's toothpaste containing 1500 ppm fluoride
Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
9 Months to 12 Years
Enrollment
78 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Oct 15, 2024 · Synced Sep 28, 2026, 4:11 PM EDT
Completed Not applicable Interventional

Using Video Modeled Social Stories to Improve Oral Hygiene in Children With Autism Spectrum Disorder

NCT02003820
View directory record Official record
Conditions
Autism Spectrum Disorder, Dental Caries
Interventions
video modeled social story
Behavioral
Lead sponsor
Yale University
Other
Eligibility
5 Years to 14 Years
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
2
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Aug 7, 2016 · Synced Sep 28, 2026, 4:11 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Predicting Caries Risk in Underserved Toddlers in Primary Healthcare Settings

NCT01707797
View directory record Official record
Conditions
Dental Caries
Interventions
Not listed
Lead sponsor
University of Michigan
Other
Eligibility
9 Months to 15 Months
Enrollment
1,326 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2017
U.S. locations
3
States / cities
Indianapolis, Indiana • Iowa City, Iowa • Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 16, 2018 · Synced Sep 28, 2026, 4:11 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Medical Management of Caries in the Primary Dentition Using Silver Nitrate

NCT02604134
View directory record Official record
Conditions
Dental Caries
Interventions
Prophylaxis, Fluoride varnish, Silver Nitrate
Procedure · Drug
Lead sponsor
Arwa Owais
Other
Eligibility
2 Years to 11 Years
Enrollment
122 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2018
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Jul 10, 2019 · Synced Sep 28, 2026, 4:11 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

BEhavioral EConomics for Oral Health iNnovation Trial

NCT03576326
View directory record Official record
Conditions
Toothbrushing, Dental Plaque, Parent-Child Relations, Oral Hygiene, Dental Caries
Interventions
Drawing Incentive
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
6 Months to 47 Months
Enrollment
244 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2021
U.S. locations
1
States / cities
Santa Monica, California
Source: ClinicalTrials.gov public record
Updated Sep 18, 2025 · Synced Sep 28, 2026, 4:11 PM EDT
Completed Phase 3 Interventional

Health Effects of Silver-Mercury Dental Fillings

NCT00066118
View directory record Official record
Conditions
Caries, Dental
Interventions
Dental amalgam restorations
Device
Lead sponsor
University of Washington
Other
Eligibility
8 Years to 12 Years
Enrollment
507 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1996 – 2011
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jun 3, 2018 · Synced Sep 28, 2026, 4:11 PM EDT
Completed No phase listed Observational

Oral Alkali Production and Caries Prevention in Children (Cross-sectional Component)

NCT02368028
View directory record Official record
Conditions
Dental Caries
Interventions
Oral Samples
Other
Lead sponsor
University of Florida
Other
Eligibility
2 Years to 5 Years
Enrollment
131 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Sep 14, 2015 · Synced Sep 28, 2026, 4:11 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Dietary Analysis for Caries Prevention in Children Using a Computer Software

NCT02375763
View directory record Official record
Conditions
Dental Caries
Interventions
Software instruction
Other
Lead sponsor
Marquette University
Other
Eligibility
3 Years to 13 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Mar 23, 2017 · Synced Sep 28, 2026, 4:11 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Comparing Pediatric Dental Oral Sedation Outcomes With and Without Meperidine in Children Aged 3-7 Years

NCT04068948
View directory record Official record
Conditions
Dental Caries in Children, Pediatric Dental Sedation, Meperidine, Hydroxyzine, Midazolam
Interventions
Meperidine, Hydroxyzine, Midazolam
Drug
Lead sponsor
University of Washington
Other
Eligibility
3 Years to 7 Years
Enrollment
37 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jan 23, 2024 · Synced Sep 28, 2026, 4:11 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Effectiveness of Rubber Dam Isolation Versus Cotton Roll Isolation on Bonded Fissure Sealant Retention

NCT03886727
View directory record Official record
Conditions
Dental Caries in Children, Dental Caries on Pit and Fissure Surface, Dental Leakage
Interventions
Rubber Dam Set, Dental Cotton Roll
Device
Lead sponsor
Zafer Cavit Cehreli, DDS, PhD
Other
Eligibility
6 Years to 16 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
New Orleans, Louisiana
Source: ClinicalTrials.gov public record
Updated Nov 4, 2019 · Synced Sep 28, 2026, 4:11 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Caries Management by Risk Assessment in Children

NCT01310283
View directory record Official record
Conditions
Dental Caries
Interventions
xylitol mints and fluoride varnish
Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
5 Years to 9 Years
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2012
U.S. locations
2
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Nov 13, 2012 · Synced Sep 28, 2026, 4:11 PM EDT
Not listed No phase listed Observational

Everybody Brush: A Community-wide Toothpaste Distribution Campaign

NCT02327507
View directory record Official record
Conditions
Dental Caries
Interventions
Toothpaste & Telephone Support
Behavioral
Lead sponsor
Advantage Dental Services, LLC
Industry
Eligibility
6 Months to 20 Years
Enrollment
21,731 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Redmond, Oregon
Source: ClinicalTrials.gov public record
Updated Dec 29, 2014 · Synced Sep 28, 2026, 4:11 PM EDT
Completed Not applicable Interventional Results available

Xylitol for Caries Prevention in Inner-City Children

NCT01901250
View directory record Official record
Conditions
Dental Caries
Interventions
Xylitol gummy bears, Sugar free fiber gummy bears, Oral health education, Fluoride varnish, Dental sealant
Dietary Supplement · Behavioral · Device
Lead sponsor
Case Western Reserve University
Other
Eligibility
5 Years to 6 Years
Enrollment
562 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2011
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 11, 2014 · Synced Sep 28, 2026, 4:11 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

A Clinical Trial to Assess the Safety and the Anti-caries Efficacy of COL 101 (Arginine) Non-fluoride Dentifrices in Comparison With 0.24% Sodium Fluoride (1100 Ppm F) Dentifrice Control in 10 to 14-year-old Children

NCT04750902
View directory record Official record
Conditions
Dental Caries
Interventions
0.24% Sodium Fluoride Dentifrice, 1.5% Arginine Dentifrice, 4.0% Arginine Dentifrice, 8.0% Arginine Dentifrice
Drug
Lead sponsor
Colgate Palmolive
Industry
Eligibility
10 Years to 14 Years
Enrollment
2,025 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
8
States / cities
Loma Linda, California • Gainesville, Florida • Indianapolis, Indiana + 4 more
Source: ClinicalTrials.gov public record
Updated Jul 20, 2026 · Synced Sep 28, 2026, 4:11 PM EDT
Completed Phase 3 Interventional

The Children's Amalgam Trial

NCT00065988
View directory record Official record
Conditions
Dental Caries
Interventions
Dispersed phase amalgam restoration /composite restoration
Device
Lead sponsor
Carelon Research
Other
Eligibility
6 Years to 10 Years
Enrollment
534 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1997 – 2005
U.S. locations
1
States / cities
Watertown, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 27, 2010 · Synced Sep 28, 2026, 4:11 PM EDT
Completed No phase listed Observational

Oral Alkali Production and Caries Prevention in Children (Longitudinal)

NCT02398695
View directory record Official record
Conditions
Dental Caries
Interventions
Oral Samples
Other
Lead sponsor
University of Florida
Other
Eligibility
2 Years to 7 Years
Enrollment
232 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Nov 12, 2018 · Synced Sep 28, 2026, 4:11 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Tooth Smart Healthy Start: Oral Health Advocates in Public Housing

NCT01205971
View directory record Official record
Conditions
Dental Caries in Children
Interventions
Motivational Interviewing, Dental Preventive Services
Behavioral
Lead sponsor
Boston University
Other
Eligibility
15 Years and older
Enrollment
2,842 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2016
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 12, 2018 · Synced Sep 28, 2026, 4:11 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Study on Use of Xylitol-wipes to Prevent Dental Caries

NCT01468727
View directory record Official record
Conditions
Dental Caries
Interventions
xylitol wipe, placebo wipe
Dietary Supplement
Lead sponsor
University of California, San Francisco
Other
Eligibility
6 Months to 35 Months
Enrollment
88 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2008
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Nov 15, 2011 · Synced Sep 28, 2026, 4:11 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Gurney Journey: Virtual Reality Distraction

NCT06283108
View directory record Official record
Conditions
Dental Caries in Children, Dental Diseases, Gastrointestinal Surgery, Procedures Requiring Anesthesia
Interventions
Standard Child Life Preparation and Support + Meta Quest 2 VR headset with Gurney Journey (a mixed reality experience), Standard Child Life Preparation and Support
Device · Behavioral
Lead sponsor
Children's Hospital Colorado
Other
Eligibility
5 Years to 17 Years
Enrollment
58 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Jun 25, 2025 · Synced Sep 28, 2026, 4:11 PM EDT