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Showing 1–24 of 50 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Dental Malocclusion Clear all
Terminated Not applicable Interventional Accepts healthy volunteers

The Effect of OrthoPulse Photobiomodulation on the Rate of Tooth Movement During Alignment With Fixed Appliances

NCT03202355
View directory record Official record
Conditions
Malocclusion
Interventions
Fixed Appliance Orthodontic Treatment, OrthoPulse™
Device
Lead sponsor
Biolux Research Holdings, Inc.
Industry
Eligibility
11 Years to 60 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
3
States / cities
Chandler, Arizona • Peoria, Arizona • Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Apr 7, 2019 · Synced Sep 23, 2026, 3:27 AM EDT
Completed No phase listed Observational

Focused Registry to Collect Clinical Data on the MatrixWAVE System

NCT03405389
View directory record Official record
Conditions
Mandibular Fractures
Interventions
MatrixWAVE MMF System
Procedure
Lead sponsor
AO Innovation Translation Center
Other
Eligibility
18 Years and older
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2025
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 15, 2025 · Synced Sep 23, 2026, 3:27 AM EDT
Recruiting Not applicable Interventional

Bromelain for Post-surgery Facial Swelling

NCT07115212
View directory record Official record
Conditions
Malocclusion
Interventions
Bromelain
Dietary Supplement
Lead sponsor
Mohamed Bazina
Other
Eligibility
18 Years to 65 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Jun 4, 2026 · Synced Sep 23, 2026, 3:27 AM EDT
Completed Not applicable Interventional Results available

Accelerated Invisalign Therapy in Conjunction With Acceledent Aura

NCT02868554
View directory record Official record
Conditions
Malocclusion
Interventions
AcceleDent Aura, Accelerated Invisalign therapy
Device
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 99 Years
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 26, 2020 · Synced Sep 23, 2026, 3:27 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Effect of AcceleDent® Aura on Orthodontic Tooth Movement With Aligners

NCT01962012
View directory record Official record
Conditions
Malocclusion
Interventions
AcceleDent Aura, Sham Device
Device
Lead sponsor
OrthoAccel Technologies Inc.
Industry
Eligibility
18 Years to 40 Years
Enrollment
46 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2016
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Sep 27, 2016 · Synced Sep 23, 2026, 3:27 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Optimizing Orthodontic Appliances Efficiency With Remote Dental Monitoring and Artificial Intelligence Algorithms

NCT05573308
View directory record Official record
Conditions
Malocclusion, Misaligned Teeth
Interventions
Clear Aligners with Dental Monitoring, Clear Aligners
Device
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
12 Years to 70 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2029
U.S. locations
4
States / cities
Antioch, Illinois • Chicago, Illinois • Grayslake, Illinois + 1 more
Source: ClinicalTrials.gov public record
Updated Jul 7, 2026 · Synced Sep 23, 2026, 3:27 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

RCT Comparing Invisalign and Traditional Orthodontic Treatment

NCT04556448
View directory record Official record
Conditions
Malocclusion, Angle Class II
Interventions
Aligners, Clear braces
Other
Lead sponsor
Texas A&M University
Other
Eligibility
17 Years and older
Enrollment
78 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2019
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Sep 20, 2020 · Synced Sep 23, 2026, 3:27 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluation of a "Flash-free" Adhesive Resin for Orthodontic Bracket Bonding

NCT02030002
View directory record Official record
Conditions
Malocclusion
Interventions
APC Flash-Free Adhesive Coated Appliance System, APC II Adhesive Coated Appliance System
Device
Lead sponsor
University of Minnesota
Other
Eligibility
10 Years to 60 Years
Enrollment
49 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2019
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 11, 2021 · Synced Sep 23, 2026, 3:27 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

The Use of Clear Aligners With Movement Enhancement Techniques

NCT02087163
View directory record Official record
Conditions
Malocclusion
Interventions
Movement Enhancement Technique, Clear Aligner
Device
Lead sponsor
Align Technology, Inc.
Industry
Eligibility
16 Years to 46 Years
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2019
U.S. locations
1
States / cities
San Jose, California
Source: ClinicalTrials.gov public record
Updated Jan 30, 2020 · Synced Sep 23, 2026, 3:27 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Analysis of Orthodontic Tooth Movement Using 3D Imaging

NCT03398798
View directory record Official record
Conditions
Tooth Crowding, Dental Crowding, Malocclusion
Interventions
.014", .016", Twin brackets, Self-ligating brackets
Device
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
10 Years to 45 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
2
States / cities
Chapel Hill, North Carolina • Huntersville, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 30, 2020 · Synced Sep 23, 2026, 3:27 AM EDT
Recruiting No phase listed Observational

Orthognathic Speech Pathology: Phonetic Contrasts of Patients With Dental Discrepancies Pre- and Post-Treatment Analyses

NCT04117360
View directory record Official record
Conditions
Dentofacial Abnormalities, Dentofacial Deformities, Dentofacial Anomalies, Including Malocclusion, Malocclusion, Malocclusion in Children, Dentofacial Disharmony, Skeletal Malocclusion, Skeletal Malformation, Speech Sound Disorder, Speech Disorders
Interventions
Orthognathic surgery and Orthodontics
Other
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
15 Years to 40 Years
Enrollment
180 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2028
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 11, 2026 · Synced Sep 23, 2026, 3:27 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

A Comparison of the Alignment Achieved Using Computer-guided Indirect Bonding of Orthodontic Brackets to Conventional Appliance Placement

NCT02221856
View directory record Official record
Conditions
Malocclusion
Interventions
Motion View, Conventional Orthodontic Treatment
Procedure
Lead sponsor
Harvard School of Dental Medicine
Other
Eligibility
Up to 60 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 8, 2017 · Synced Sep 23, 2026, 3:27 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

One Week Aligner Evaluation

NCT02603289
View directory record Official record
Conditions
Malocclusion
Interventions
Invisalign
Device
Lead sponsor
Align Technology, Inc.
Industry
Eligibility
Not listed
Enrollment
287 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2020
U.S. locations
23
States / cities
Livermore, California • Napa, California • San Francisco, California + 20 more
Source: ClinicalTrials.gov public record
Updated Oct 19, 2020 · Synced Sep 23, 2026, 3:27 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluation of Clear Aligner Trays to Straighten Teeth

NCT03141788
View directory record Official record
Conditions
Malocclusion
Interventions
Clear Aligner
Device
Lead sponsor
Solventum Orthodontics Corporation
Industry
Eligibility
14 Years and older
Enrollment
52 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
9
States / cities
Denver, Colorado • Kennesaw, Georgia • Catonsville, Maryland + 5 more
Source: ClinicalTrials.gov public record
Updated Dec 1, 2024 · Synced Sep 23, 2026, 3:27 AM EDT
Completed Not applicable Interventional Results available

The Effects of Extraoral Photobiomodulation on the Rate of Orthodontic Alignment

NCT02267824
View directory record Official record
Conditions
Malocclusion
Interventions
Extraoral OrthoPulse® PBM, Fixed Orthodontic Appliance Treatment
Device · Other
Lead sponsor
Biolux Research Holdings, Inc.
Industry
Eligibility
11 Years to 40 Years
Enrollment
101 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
2
States / cities
Birmingham, Alabama • Suwanee, Georgia
Source: ClinicalTrials.gov public record
Updated Aug 26, 2018 · Synced Sep 23, 2026, 3:27 AM EDT
Not listed No phase listed Observational Accepts healthy volunteers

EXD-959 Orthodontic Brackets and EXD-961 Related Instruments Trial

NCT03606551
View directory record Official record
Conditions
Malocclusion
Interventions
EXD-959 Bracket System
Device
Lead sponsor
3M
Industry
Eligibility
11 Years and older
Enrollment
78 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
5
States / cities
Culver City, California • Wellington, Florida • Northfield, Minnesota + 2 more
Source: ClinicalTrials.gov public record
Updated Feb 20, 2021 · Synced Sep 23, 2026, 3:27 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Effect of Force Magnitude on Canine Retraction and Gingival Crevicular Fluid Proteome

NCT06668194
View directory record Official record
Conditions
Tooth Crowding
Interventions
Light Force (150g Niti Coil), Heavy Force (400 g Niti coil)
Device
Lead sponsor
UConn Health
Other
Eligibility
11 Years to 16 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2028
U.S. locations
1
States / cities
Farmington, Connecticut
Source: ClinicalTrials.gov public record
Updated Nov 25, 2024 · Synced Sep 23, 2026, 3:27 AM EDT
Suspended No phase listed Observational Accepts healthy volunteers

Premolar Extractions for Obstructive Sleep Apnea in Children With Overjet

NCT04946201
View directory record Official record
Conditions
Obstructive Sleep Apnea, Malocclusion
Interventions
Not listed
Lead sponsor
Mohamed Bazina
Other
Eligibility
10 Years to 15 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2026
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Dec 23, 2025 · Synced Sep 23, 2026, 3:27 AM EDT
Completed Not applicable Interventional Results available

Accelerated Tooth Movement With AcceleDent® and Aligners - a Pilot Project

NCT02438280
View directory record Official record
Conditions
Tooth Movement, Malocclusion
Interventions
AcceleDent, Vibrational Device
Device
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Oct 29, 2018 · Synced Sep 23, 2026, 3:27 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Pain and Activity Levels After Orthodontic Separators

NCT05615688
View directory record Official record
Conditions
Dental Malocclusion
Interventions
Pain Intensity following Placement of Orthodontic Separators
Procedure
Lead sponsor
Lina Sharab
Other
Eligibility
15 Years to 49 Years
Enrollment
94 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Oct 15, 2025 · Synced Sep 23, 2026, 3:27 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Clinical Effectiveness of Late Maxillary Protraction for Cleft Lip and Palate

NCT02789787
View directory record Official record
Conditions
Cleft Lip and Palate
Interventions
Maxillary Protraction, Orthognathic Surgery
Procedure
Lead sponsor
University of Southern California
Other
Eligibility
11 Years to 21 Years
Enrollment
117 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2021
U.S. locations
2
States / cities
Los Angeles, California • Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Oct 10, 2021 · Synced Sep 23, 2026, 3:27 AM EDT
Completed Not applicable Interventional Results available

Alveolar Microperforation for Inflammation-Enhanced Tooth Movement During Orthodontic Treatment

NCT01720797
View directory record Official record
Conditions
Malocclusion
Interventions
Micro-osteoperforation, Anesthestic, Chlorhexidine
Device · Drug · Other
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 55 Years
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jun 18, 2015 · Synced Sep 23, 2026, 3:27 AM EDT
Completed Not applicable Interventional Results available

OrthoPulse™ and Its Effect on the Rate of Orthodontic Tooth Alignment: A Pilot Feasibility Study

NCT02267837
View directory record Official record
Conditions
Malocclusion
Interventions
OrthoPulse™
Device
Lead sponsor
Biolux Research Holdings, Inc.
Industry
Eligibility
11 Years to 40 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Suwanee, Georgia
Source: ClinicalTrials.gov public record
Updated Aug 26, 2018 · Synced Sep 23, 2026, 3:27 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Assessment of the Efficacy of the Aerodentis System

NCT03421886
View directory record Official record
Conditions
Orthodontic Treatment, Tooth Crowding, Orthodontics
Interventions
Aerodentis system, Invisalign clear aligner system
Device
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
12 Years to 60 Years
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2020
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Nov 3, 2020 · Synced Sep 23, 2026, 3:27 AM EDT