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Showing 1–24 of 38 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Dental Pulp Diseases Clear all
Completed No phase listed Observational Accepts healthy volunteers

Accuracy of Electronic Apex Locators ProMark, RootZX II and NRG Rider on Working Length of Multi-rooted Teeth

NCT02521909
View directory record Official record
Conditions
Dental Pulp Diseases
Interventions
ProMark (Tooth Extraction for Assessment of Different Apex Locators), Root ZX II (Tooth Extraction for Assessment of Different Apex Locators), NRG Rider (Tooth Extraction for Assessment of Different Apex Locators)
Device
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jun 21, 2017 · Synced Sep 22, 2026, 1:02 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Treatment Outcome With a Revascularization Protocol Using the Triple Versus Double Antibiotic Paste

NCT00881491
View directory record Official record
Conditions
Pulp Necrosis
Interventions
Double Antibiotic Paste, Triple Antibiotic Paste, Mineral Trioxide Aggregate
Drug
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
7 Years to 60 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2015
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Feb 4, 2016 · Synced Sep 22, 2026, 1:02 PM EDT
Recruiting Not applicable Interventional

Bacterial Reduction After Supplementary Disinfection Procedures in Infected Root Canals

NCT06569329
View directory record Official record
Conditions
Dental Pulp Necroses
Interventions
GentleWave System Root Canal Therapy, EdgePro Laser Root Canal Therapy, The ProUltra Piezo Ultrasonic with EndoUltra Tips Root Canal Therapy
Device
Lead sponsor
Abhishek Parolia
Other
Eligibility
18 Years to 95 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Sep 9, 2026 · Synced Sep 22, 2026, 1:02 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Measurement of Bite Force in Humans

NCT00223327
View directory record Official record
Conditions
Dental Pulp Necrosis, Periapical Periodontitis
Interventions
Not listed
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
16 Years to 60 Years
Enrollment
89 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2008
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Mar 8, 2012 · Synced Sep 22, 2026, 1:02 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Pulp Capping With Two Different Agents

NCT00812877
View directory record Official record
Conditions
Dental Pulp Exposure
Interventions
Mineral Trioxide Aggregate, Calcium Hydroxide
Drug
Lead sponsor
Oregon Health and Science University
Other
Eligibility
7 Years and older
Enrollment
376 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2012
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated May 24, 2015 · Synced Sep 22, 2026, 1:02 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Regeneration of Pulp-Dentin Development in Teeth With Necrotic Pulps and Immature Roots

NCT01976065
View directory record Official record
Conditions
Pulp Necrosis, Regeneration
Interventions
Triple Antibiotic Paste, Standard Treatment
Drug · Other
Lead sponsor
Kenneth Hargreaves
Other
Eligibility
6 Years to 20 Years
Enrollment
125 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2018
U.S. locations
4
States / cities
Loma Linda, California • Baltimore, Maryland • Chapel Hill, North Carolina + 1 more
Source: ClinicalTrials.gov public record
Updated Sep 6, 2023 · Synced Sep 22, 2026, 1:02 PM EDT
Not listed Phase 4 Interventional Accepts healthy volunteers

Success and Color Stability of MTA Pulpotomized Primary Molars: an RCT

NCT02702505
View directory record Official record
Conditions
Reversible Pulpitis, Dental Pulp Diseases
Interventions
NeoMTA, ProRoot MTA
Biological · Other
Lead sponsor
Texas A & M University Baylor College Of Dentistry
Other
Eligibility
2 Years to 8 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2017
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Mar 7, 2016 · Synced Sep 22, 2026, 1:02 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Intentional Pulpotomy to Preserve Hopeless Molars

NCT04385693
View directory record Official record
Conditions
Pulpitis, Dental Pulp Diseases, Tooth Diseases
Interventions
Pulpotomy, Extraction and placement of space maintainer
Procedure
Lead sponsor
University of Florida
Other
Eligibility
5 Years to 10 Years
Enrollment
17 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jun 5, 2023 · Synced Sep 22, 2026, 1:02 PM EDT
Enrolling by invitation Phase 4 Interventional

Nanozymes in Endodontics

NCT07518901
View directory record Official record
Conditions
Apical Periodontitis, Endodontic Disease, Root Canal Infection
Interventions
Nanozyme treatment, Control (Standard treatment)
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 30, 2026 · Synced Sep 22, 2026, 1:02 PM EDT
Recruiting Not applicable Interventional

Bacterial Load Reduction by GentleWave and EdgePro Irrigation Systems in Mandibular Necrotic Molars

NCT06554366
View directory record Official record
Conditions
Pulp Necroses
Interventions
GentleWave, EdgePro laser irrigation, Irrisafe passive ultrasonic irrigation
Device
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Sep 4, 2025 · Synced Sep 22, 2026, 1:02 PM EDT
Terminated Not applicable Interventional

Efficacy of Solventum™ Vitrebond™ Pulp Protect Liner/Base Used as a Liner/Base Under Dental Restorations

NCT07261137
View directory record Official record
Conditions
Caries, Dental, Tooth Decay, Dental Decay, Tooth Sensitivity
Interventions
Vitrebond™ Pulp Protect Liner/Base, Vitrebond™ Plus (comparator)
Device
Lead sponsor
Solventum US LLC
Industry
Eligibility
7 Years to 89 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 5, 2026 · Synced Sep 22, 2026, 1:02 PM EDT
Withdrawn Not applicable Interventional

Endodontic Regenerative Procedure for Immature Non-vital Teeth

NCT03425123
View directory record Official record
Conditions
Tooth, Nonvital
Interventions
Regenerative Endodontic Procedure (REP)
Other
Lead sponsor
Boston University
Other
Eligibility
7 Years to 18 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 2, 2019 · Synced Sep 22, 2026, 1:02 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Effectiveness of GentleWave System in Endodontic Treatment

NCT06518304
View directory record Official record
Conditions
Pain, Postoperative, Root Canal Infection, Endodontically Treated Teeth
Interventions
GentleWave, Conventional Protocol
Other
Lead sponsor
University of Salamanca
Other
Eligibility
18 Years to 80 Years
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Manhattan, New York
Source: ClinicalTrials.gov public record
Updated Aug 20, 2024 · Synced Sep 22, 2026, 1:02 PM EDT
Completed No phase listed Observational

Diagnosis, Evaluation and Treatment of Patients in Need of Third Molar Removal

NCT00316485
View directory record Official record
Conditions
Wisdom Teeth
Interventions
Not listed
Lead sponsor
National Institute of Dental and Craniofacial Research (NIDCR)
NIH
Eligibility
18 Years to 50 Years
Enrollment
718 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2013
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 5, 2017 · Synced Sep 22, 2026, 1:02 PM EDT
Completed Not applicable Interventional Results available

Nanodiamond Modified Gutta Percha (NDGP) Composite for Non-surgical Root Canal Therapy (RCT) Filler Material

NCT02698163
View directory record Official record
Conditions
Dental Pulp Diseases, Dental Pulp Necrosis, Nerve Root Pain Nec
Interventions
Nanodiamond reinforced Gutta Percha, Gutta Percha
Device
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2021
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jan 20, 2022 · Synced Sep 22, 2026, 1:02 PM EDT
Recruiting Not applicable Interventional

Effect of Photobiomodulation on Pain and Healing of the Vertical Releasing Incision After Endodontic Microsurgery

NCT06574152
View directory record Official record
Conditions
Apical Periodontitis, Endodontically Treated Teeth, Endodontic Disease, Apical Cyst, Apical Granuloma, Periradicular Disease, Previous Endodontic Treatment
Interventions
PBM treatment, PBM sham treatment, EMS
Device
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Aug 16, 2026 · Synced Sep 22, 2026, 1:02 PM EDT
Terminated Not applicable Interventional

Clinical Study Evaluating Solventum™ Vitrebond™ Pulp Protect Liner/Base for Direct Capping of Pulpal Exposure

NCT07231237
View directory record Official record
Conditions
Dental Caries, Pulp Exposure, Dental, Tooth Decay, Dental Decay
Interventions
Vitrebond™ Pulp Protect Liner/Base
Device
Lead sponsor
Solventum US LLC
Industry
Eligibility
7 Years to 89 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 5, 2026 · Synced Sep 22, 2026, 1:02 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

A New Clinical Use of Ferumoxytol Nanoparticles: An Antibiofilm Treatment

NCT06110494
View directory record Official record
Conditions
Apical Periodontitis, Pulp Disease, Dental
Interventions
Iron oxide nanoparticles treatment Ferumoxytol/H2O2, NaOCl, NaCl, supplementary irrigation
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 27, 2024 · Synced Sep 22, 2026, 1:02 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Apical Size and Root Canal Treatment Success Trial (AS-RCT Trial)

NCT03053037
View directory record Official record
Conditions
Root Canal Therapy
Interventions
final apical size instrumentation
Procedure
Lead sponsor
University of Washington
Other
Eligibility
18 Years to 85 Years
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2022
U.S. locations
2
States / cities
San Antonio, Texas • Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Feb 23, 2022 · Synced Sep 22, 2026, 1:02 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Exploration of the Utility of Dental-dedicated MRI for Dentistry

NCT06948162
View directory record Official record
Conditions
Dental Crowding, Dental Occlusion, Traumatic, Endodontic Disease, Orthodontic Treatment, Endodontic Lesions, PeriodontalConditions, Oral Surgery Conditions, Tooth Extractions, Local Anesthesia, Traumatic Dental Pain, TMJ, Orthodontics, Endodontic Histopathology, Periodontal Diseases
Interventions
dental-dedicated MRI (ddMRI)
Device
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
500 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 24, 2026 · Synced Sep 22, 2026, 1:02 PM EDT
Recruiting No phase listed Observational

Bite Force Measurements

NCT06843525
View directory record Official record
Conditions
Irreversible Pulpitis, Apical Periodontitis, Pulpal Necrosis
Interventions
Not listed
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
18 Years to 89 Years
Enrollment
112 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Newark, New Jersey
Source: ClinicalTrials.gov public record
Updated Jul 23, 2025 · Synced Sep 22, 2026, 1:02 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Effect of Post-Operative Anesthetics on Post-Operative Pain in Patients Receiving Endodontic Treatment

NCT05338671
View directory record Official record
Conditions
Endodontic Disease, Post Operative Pain, Symptomatic Irreversible Pulpitis
Interventions
Local anesthetic
Drug
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated May 28, 2025 · Synced Sep 22, 2026, 1:02 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Tissue Characterization in Teeth Treated With a Regeneration Protocol

NCT00881907
View directory record Official record
Conditions
Pulp Necrosis
Interventions
Triple Antibiotic Paste
Drug
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
10 Years to 60 Years
Enrollment
1 participant
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2014
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Feb 4, 2016 · Synced Sep 22, 2026, 1:02 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Sodium Channel Expression in Human Teeth

NCT00575263
View directory record Official record
Conditions
Dental Pulp Disease
Interventions
Not listed
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
16 Years to 80 Years
Enrollment
250 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2015
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Sep 21, 2015 · Synced Sep 22, 2026, 1:02 PM EDT