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ClinicalTrials.gov public records Last synced Sep 10, 2026, 3:25 PM EDT

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Showing 1–24 of 43 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Conditions
Dental Caries, Tooth Decay
Interventions
Resin polymer (NuSmile Bioflx) crown, Stainless steel crown
Other
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
3 Years to 7 Years
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Richmond, Virginia
Completed Not applicable Interventional Accepts healthy volunteers Results available

Clinical Evaluation of Kerr SonicFill™ 2 vs 3M ESPE Filtek™ Supreme Ultra Universal Restorative

NCT03032705
Conditions
Dental Caries
Interventions
SonicFill™ 2, Filtek™ Supreme
Device
Lead sponsor
Tufts University
Other
Eligibility
18 Years and older
Enrollment
51 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2020
U.S. locations
1
States / cities
Boston, Massachusetts
Conditions
Dental Caries, Dental Restoration Failure
Interventions
Filtek One, Filtek Z250
Device
Lead sponsor
Louisiana State University Health Sciences Center in New Orleans
Other
Eligibility
18 Years and older
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
New Orleans, Louisiana
Conditions
Dental Caries
Interventions
Hall Technique (HT), Modified Hall Technique (MHT), Conventional Technique (CT)
Device
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
5 Years to 8 Years
Enrollment
132 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Houston, Texas
Conditions
Dental Caries
Interventions
Not listed
Lead sponsor
Dental Practice-Based Research Network
Network
Eligibility
6 Years and older
Enrollment
9,291 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2011
U.S. locations
6
States / cities
Birmingham, Alabama • Gainesville, Florida • Minneapolis, Minnesota + 1 more
Conditions
Caries, Unsatisfactory or Defective Restoration of Tooth
Interventions
Placement of restoration
Device
Lead sponsor
Heraeus Kulzer GmbH
Industry
Eligibility
18 Years and older
Enrollment
130 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2022
U.S. locations
1
States / cities
Portland, Oregon
Conditions
Fractured Tooth, Decayed Tooth, Unsatisfactory Restoration of Tooth
Interventions
Celtra Duo
Device
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
73 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
1
States / cities
Ann Arbor, Michigan
Completed No phase listed Observational Accepts healthy volunteers

DPBRN Reasons for Replacement or Repair of Dental Restorations

NCT01201876
Conditions
Dental Caries
Interventions
Not listed
Lead sponsor
Dental Practice-Based Research Network
Network
Eligibility
6 Years and older
Enrollment
6,368 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2010
U.S. locations
6
States / cities
Birmingham, Alabama • Gainesville, Florida • Minneapolis, Minnesota + 1 more
Active, not recruiting Not applicable Interventional

Celtra Quatro Crown Study

NCT04604301
Conditions
Fractured Tooth, Decayed Tooth, Unsatisfactory Restoration of Tooth
Interventions
Celtra Quatro
Device
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 110 Years
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2027
U.S. locations
1
States / cities
Ann Arbor, Michigan
Active, not recruiting No phase listed Observational Accepts healthy volunteers

Clinical Study of a 3D Shaded Zirconia for Chairside CAD/CAM Restorations

NCT06713577
Conditions
Dental Prosthesis Failure, Dental Prosthesis Complication
Interventions
CEREC Cercon 4D
Device
Lead sponsor
Dentsply Sirona Implants and Consumables
Industry
Eligibility
18 Years to 75 Years
Enrollment
82 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2031
U.S. locations
1
States / cities
Ann Arbor, Michigan
Conditions
Dental Restoration, Dental Veneers
Interventions
3MTM FiltekTM Supreme Flowable Composite
Device
Lead sponsor
New York University
Other
Eligibility
18 Years to 75 Years
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
New York, New York
Completed Not applicable Interventional Results available

Clinical Evaluation of a Bulk Fill Resin Composite

NCT04686422
Conditions
Dental Caries, Unsatisfactory or Defective Restoration of Tooth
Interventions
Tetric PowerFill
Device
Lead sponsor
Ivoclar Vivadent AG
Industry
Eligibility
19 Years to 90 Years
Enrollment
39 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
Birmingham, Alabama
Completed Not applicable Interventional Accepts healthy volunteers Results available

Clinical Performance of Incremental and Bulk Fill Composites in Class II Restorations

NCT02889835
Conditions
Dental Caries
Interventions
Supreme Universal Restorative, Supreme Flowable Restorative, Bulk Fill Flowable Restorative
Device
Lead sponsor
Solventum US LLC
Industry
Eligibility
19 Years to 90 Years
Enrollment
53 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2021
U.S. locations
1
States / cities
Birmingham, Alabama
Not listed No phase listed Observational Accepts healthy volunteers

Early Caries Lesion Management Observational Study

NCT04933331
Conditions
Initial Caries, Arrested Dental Caries, Cavitated Caries, Dental Caries, Dental Caries in Children
Interventions
Curodont Repair Fluoride Plus, Silver Diamine Fluoride, Glass Ionomer Sealant, Fluoride varnish, Fluoride toothpaste
Drug · Device
Lead sponsor
CareQuest Institute for Oral Health
Other
Eligibility
4 Years and older
Enrollment
744 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2024
U.S. locations
4
States / cities
Dothan, Alabama • Westborough, Massachusetts • Bend, Oregon + 1 more
Conditions
Dental Caries
Interventions
Restoration with a dentin bonding agent (DBA), Restoration with a resin modified glass ionomer liner (RMGI)
Procedure
Lead sponsor
Pearl Network
Network
Eligibility
15 Years to 60 Years
Enrollment
341 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
41
States / cities
Phoeniz, Arizona • Newport Beach, California • Boulder, Colorado + 37 more
Conditions
Dental Caries, Pulp Exposure, Dental, Tooth Decay, Dental Decay
Interventions
Vitrebond™ Pulp Protect Liner/Base
Device
Lead sponsor
Solventum US LLC
Industry
Eligibility
7 Years to 89 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Boston, Massachusetts
Completed No phase listed Observational Accepts healthy volunteers

DPBRN Longitudinal Study of Repaired or Replaced Dental Restorations

NCT01201395
Conditions
Dental Caries
Interventions
Not listed
Lead sponsor
Dental Practice-Based Research Network
Network
Eligibility
6 Years and older
Enrollment
9,813 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2011
U.S. locations
6
States / cities
Birmingham, Alabama • Gainesville, Florida • Minneapolis, Minnesota + 1 more
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Clinical Investigation of a New Bulk Fill Composite Resin in the Restoration of Posterior Teeth

NCT02572570
Conditions
Dental Restoration Failure of Marginal Integrity, Dental Caries, Unrepairable Overhanging of Dental Restorative Materials, Poor Aesthetics of Existing Restoration, Secondary Dental Caries Associated With Failed or Defective Dental Restorations, Fractured Dental Restorative Materials Without Loss of Materials, Fracture of Dental Restorative Materials With Loss of Material
Interventions
Filtek Bulk Fill Posterior, Filtek Supreme Ultra
Device
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 99 Years
Enrollment
27 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2019
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Conditions
Caries, Dental, Tooth Decay, Dental Decay, Tooth Sensitivity
Interventions
Vitrebond™ Pulp Protect Liner/Base, Vitrebond™ Plus (comparator)
Device
Lead sponsor
Solventum US LLC
Industry
Eligibility
7 Years to 89 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Boston, Massachusetts
Completed Not applicable Interventional Accepts healthy volunteers Results available

Comparative Effectiveness of School-based Caries Prevention

NCT03442309
Conditions
Dental Caries, Quality of Life
Interventions
Silver Diamine Fluoride, Fluoride Varnishes, Glass Ionomer
Device
Lead sponsor
NYU College of Dentistry
Other
Eligibility
5 Years to 12 Years
Enrollment
7,418 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
1
States / cities
New York, New York
Conditions
Dental Crowns
Interventions
IPS e.max® ZirCAD Prime Esthetic
Combination Product
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
40 participants
Timeline
2022 – 2026
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Completed Not applicable Interventional Results available

Clinical Performance of Chairside CAD/CAM Restorations

NCT04279574
Conditions
Dental Cements, Caries,Dental
Interventions
Lithium disilicate onlays (IPS emaxCAD/Ivoclar), Chairside zirconia crowns (3M)
Device
Lead sponsor
Solventum US LLC
Industry
Eligibility
18 Years to 89 Years
Enrollment
58 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
1
States / cities
Ann Arbor, Michigan
Completed No phase listed Observational Accepts healthy volunteers

DPBRN Patient Satisfaction With Dental Restorations

NCT01201421
Conditions
Patient Satisfaction
Interventions
Not listed
Lead sponsor
Dental Practice-Based Research Network
Network
Eligibility
13 Years and older
Enrollment
5,932 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2010
U.S. locations
6
States / cities
Birmingham, Alabama • Gainesville, Florida • Minneapolis, Minnesota + 1 more
Conditions
Partial Edentulism
Interventions
SLActive dental implant
Device
Lead sponsor
Institut Straumann AG
Industry
Eligibility
18 Years and older
Enrollment
266 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2010
U.S. locations
3
States / cities
Boca Raton, Florida • Indianapolis, Indiana • Philadelphia, Pennsylvania