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Showing 1–24 of 59 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Dentin Sensitivity Clear all
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Investigating the Efficacy of a Dentifrice in Providing Long Term Relief From Dentinal Hypersensitivity

NCT01827670
View directory record Official record
Conditions
Dentine Hypersensitivity
Interventions
Stannous fluoride, Sodium monofluorophosphate
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years to 65 Years
Enrollment
119 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Jan 25, 2015 · Synced Jul 22, 2026, 9:54 AM EDT
Completed Not applicable Interventional Results available

Test on a New Experimental Mouth Rinse for Relieving Tooth Sensitivity

NCT02113579
View directory record Official record
Conditions
Dentin Sensitivity
Interventions
Experimental Mouth Rinse 12027-033, Placebo Mouth Rinse
Device · Other
Lead sponsor
Johnson & Johnson Consumer and Personal Products Worldwide
Industry
Eligibility
18 Years and older
Enrollment
375 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014
U.S. locations
2
States / cities
Fort Wayne, Indiana • Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Jun 9, 2015 · Synced Jul 22, 2026, 9:54 AM EDT
Completed Phase 2 Interventional Results available

Exploratory Study to Evaluate an Occlusion Based Dentifrice in Relief of Dentinal Hypersensitivity

NCT01691560
View directory record Official record
Conditions
Dentine Hypersensitivity
Interventions
5% calcium sodium phosphosilicate/ sodium monofluorophosphate dentifrice, 0% calcium sodium phosphosilicate/sodium monofluorophosphate dentifrice, Sodium monofluorophosphate dentifrice, Sodium fluoride dentifrice
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years to 55 Years
Enrollment
140 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated May 28, 2014 · Synced Jul 22, 2026, 9:54 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

To Assess the Efficacy of a Toothpaste Containing 8% Arginine as Compared to Colgate Cavity Protection Toothpaste in the Reduction of Dentinal Hypersensitivity.

NCT07149376
View directory record Official record
Conditions
Sensitivity, Tooth
Interventions
TOMs of Maine Sensitive SLS Free Xtra Fresh, Colgate Cavity protection toothpaste
Device · Drug
Lead sponsor
Colgate Palmolive
Industry
Eligibility
18 Years to 70 Years
Enrollment
84 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Costa Mesa, California
Source: ClinicalTrials.gov public record
Updated Nov 4, 2025 · Synced Jul 22, 2026, 9:54 AM EDT
Completed Phase 2 Interventional Results available

Efficacy of Potassium Nitrate Solution in Reducing Dentinal Hypersensitivity

NCT01115452
View directory record Official record
Conditions
Dentine Hypersensitivity
Interventions
5% Potassium nitrate, 2.5% Potassium nitrate, Sterile water
Drug · Other
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years to 65 Years
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Jan 25, 2015 · Synced Jul 22, 2026, 9:54 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Lesion Progression After Icon Treatment in Young Adults

NCT01988337
View directory record Official record
Conditions
Caries, Salivary Function, Tooth Sensitivity
Interventions
Resin infiltration, Mock treatment
Device · Other
Lead sponsor
DMG Dental Material Gesellschaft mbH
Industry
Eligibility
19 Years and older
Enrollment
56 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2018
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Oct 3, 2022 · Synced Jul 22, 2026, 9:54 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

The Efficacy of a Toothpaste to Reduce Sensitivity

NCT00763269
View directory record Official record
Conditions
Dentin Hypersensitivity
Interventions
Triclosan, Silicon dioxide, fluoride, Triclosan, fluoride
Drug
Lead sponsor
Colgate Palmolive
Industry
Eligibility
12 Years to 80 Years
Enrollment
626 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008
U.S. locations
1
States / cities
Cedar Knolls, New Jersey
Source: ClinicalTrials.gov public record
Updated Mar 6, 2012 · Synced Jul 22, 2026, 9:54 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Study in Dentinal Hypersensitivity (DH) Participants to Assess the Efficacy of an Occluding Dentifrice.

NCT02753075
View directory record Official record
Conditions
Dentin Sensitivity
Interventions
Experimental Oral Rinse 1, Experimental Oral Rinse 2, Placebo Oral Rinse, Fluoride toothpaste
Device · Other · Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years to 55 Years
Enrollment
240 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Aug 26, 2018 · Synced Jul 22, 2026, 9:54 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Clinical Study to Assess the Effects of Various Dentifrice Technologies on Dentinal Hypersensitivity

NCT03965039
View directory record Official record
Conditions
Dentin Hypersensitivity
Interventions
Dipotassium oxalate toothpaste, Stannous fluoride toothpaste, Potassium nitrate toothpaste, Sodium monofluorophosphate toothpaste
Device · Drug
Lead sponsor
Procter and Gamble
Industry
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Oct 29, 2020 · Synced Jul 22, 2026, 9:54 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

A Clinical Trial to Evaluate the Effects of Larineco Remineralizing Gum on Oral Health, Breath Freshness, Tooth Sensitivity, and Gum Comfort

NCT07692581
View directory record Official record
Conditions
Bad Breath, Tooth Sensitivity
Interventions
Larineco Remineralizing Gum
Dietary Supplement
Lead sponsor
Larine C Corporation
Industry
Eligibility
18 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Jul 8, 2026 · Synced Jul 22, 2026, 9:54 AM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Efficacy and Safety Assessment of Experimental Bleaching Agents

NCT06802614
View directory record Official record
Conditions
Tooth Discoloration, Dentin Sensitivity, Patient Satisfaction
Interventions
BLEACHING GEL A, 5% NF_TiO2, BLEACHING GEL B, VISIBLE LIGHT IRRADIATION, Whiteness HP 35%, Whiteness HP Automixx 6%
Device · Radiation
Lead sponsor
University of Oklahoma
Other
Eligibility
18 Years to 65 Years
Enrollment
240 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Jan 30, 2025 · Synced Jul 22, 2026, 9:54 AM EDT
Completed Not applicable Interventional Results available

A Study of the Relief of Tooth Sensitivity of an Experimental Mouthrinse Device

NCT01345292
View directory record Official record
Conditions
Dentin Sensitivity
Interventions
Mouthwash, Potassium nitrate toothpaste, Sodium fluoride toothpaste
Device · Drug
Lead sponsor
Johnson & Johnson Consumer and Personal Products Worldwide
Industry
Eligibility
18 Years and older
Enrollment
226 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Jun 9, 2015 · Synced Jul 22, 2026, 9:54 AM EDT
Enrolling by invitation Not applicable Interventional

Using Calcium Hydroxylapatite To Treat Gum Recession and Tooth Hypersensitivity

NCT06826391
View directory record Official record
Conditions
Gingival Recession, Generalized, Gingival Recession Generalized Moderate, Gingival Recession Localized Moderate, Tooth Sensitivity
Interventions
Calcium hydroxylapatite
Device
Lead sponsor
American Academy of Facial Esthetics
Network
Eligibility
20 Years to 70 Years
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
1
States / cities
South Euclid, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 16, 2025 · Synced Jul 22, 2026, 9:54 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Clinical Study to Evaluate the Anti-Sensitivity Efficacy of a Stannous Fluoride Toothpaste in a Population of Dentin Hypersensitivity Sufferers

NCT06354270
View directory record Official record
Conditions
Dentin Sensitivity
Interventions
Stannous fluoride toothpaste, Regular fluoride toothpaste (Crest Cavity Protection)
Drug
Lead sponsor
HALEON
Industry
Eligibility
18 Years to 65 Years
Enrollment
115 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Melbourne, Florida
Source: ClinicalTrials.gov public record
Updated Jun 24, 2025 · Synced Jul 22, 2026, 9:54 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

To Evaluate the Efficacy of an Experimental Dissolvable Strip in Rapidly Relieving Dentinal Hypersensitivity (DH)

NCT02937623
View directory record Official record
Conditions
Dentin Sensitivity
Interventions
Dissolvable polymer strip containing Novamin (calcium sodium phosphosilicate)
Device
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years to 65 Years
Enrollment
126 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Jan 28, 2018 · Synced Jul 22, 2026, 9:54 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

The Efficacy of a Dentifrice in Providing Relief From the Pain of Dentinal Hypersensitivity

NCT01592864
View directory record Official record
Conditions
Dentine Hypersensitivity
Interventions
Stannous Fluoride, Sodium Monofluorophosphate
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years to 65 Years
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Mar 9, 2014 · Synced Jul 22, 2026, 9:54 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Efficacy of Sensi-IP Toothpaste in the Treatment of Dentinal Hypersensitivity Compared to a Sodium Fluoride Toothpaste

NCT06166745
View directory record Official record
Conditions
Dentinal Hypersensitivity
Interventions
Sensi-IP toothpaste, Sodium Fluoride Toothpaste
Device
Lead sponsor
IR Scientific Inc.
Industry
Eligibility
18 Years to 80 Years
Enrollment
46 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 18, 2024 · Synced Jul 22, 2026, 9:54 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

NUPRO Sensodyne Prophylaxis Paste With NovaMin Sensitivity Relief Study

NCT01669785
View directory record Official record
Conditions
Tooth Hypersensitivity
Interventions
Group C, Group A, Group B
Device
Lead sponsor
Dentsply International
Industry
Eligibility
18 Years to 70 Years
Enrollment
139 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Aug 20, 2014 · Synced Jul 22, 2026, 9:54 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Meta-analysis of Stannous Fluoride and the Effects on Enamel Erosion

NCT04006470
View directory record Official record
Conditions
Enamel Erosion
Interventions
Stannous fluoride dentifrice, Positive control dentifrice, Negative control dentifrice
Drug
Lead sponsor
Procter and Gamble
Industry
Eligibility
18 Years and older
Enrollment
172 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 4, 2019 · Synced Jul 22, 2026, 9:54 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effects of an Oxalate Containing Product on Dentinal Hypersensitivity With Dental Prophylaxis

NCT02481557
View directory record Official record
Conditions
Dentin Sensitivity
Interventions
Oxalate Salt Solution
Device
Lead sponsor
Procter and Gamble
Industry
Eligibility
18 Years and older
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Jun 10, 2019 · Synced Jul 22, 2026, 9:54 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Trial of Nano-hydroxyapatite-Containing Toothpastes for Relief of Dentin Hypersensitivity

NCT04590040
View directory record Official record
Conditions
Dentin Sensitivity
Interventions
Placebo, 15% nano-HAP toothpaste, 5% KNO3 toothpaste
Other · Device
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
20 Years to 80 Years
Enrollment
192 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Aug 15, 2023 · Synced Jul 22, 2026, 9:54 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Clinical Study to Determine the Safety and Effectiveness of Dentinal Hypersensitivity Treatment With Two Different Toothbrushes

NCT02513212
View directory record Official record
Conditions
Dentin Sensitivity
Interventions
Potassium Oxalate, Stannous fluoride paste, Manual toothbrush, Power toothbrush
Device · Drug
Lead sponsor
Procter and Gamble
Industry
Eligibility
18 Years and older
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015
U.S. locations
1
States / cities
Fresno, California
Source: ClinicalTrials.gov public record
Updated Aug 30, 2020 · Synced Jul 22, 2026, 9:54 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Clinical Efficacy in Relieving Dentin Hypersensitivity of Nanohydroxyapatite-Containing Toothpastes and Cream

NCT02918617
View directory record Official record
Conditions
Dentin Sensitivity
Interventions
Control toothpaste containing Novamin® technology, Control toothpaste containing 1500 ppm fluoride as MFP, Test toothpaste with nano-HAP (high concentration), Test toothpaste with nano-HAP (low concentration), Test toothpaste with nano-HAP and (Potassium Nitrate) KNO3, Control toothpaste without nano-HAP, Test toothpaste with nano-HAP (medium concentration), Test cream with nano-HAP (higher concentration), Control cream without nano-HAP
Drug
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
18 Years to 80 Years
Enrollment
203 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Nov 15, 2018 · Synced Jul 22, 2026, 9:54 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

NUPRO(r) Sensodyne Prophylaxis Paste With NovaMin(r)Sensitivity Relief Study

NCT01610167
View directory record Official record
Conditions
Tooth Hypersensitivity
Interventions
NUPRO Classic Prophy Paste, NUPRO Sensodyne Prophy Paste with Novamin with fluoride., NUPRO Sensodyne Prophy Paste with Novamin without fluoride.
Device
Lead sponsor
Dentsply International
Industry
Eligibility
18 Years to 70 Years
Enrollment
151 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Oct 13, 2013 · Synced Jul 22, 2026, 9:54 AM EDT