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Showing 1–24 of 60 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Dentin Sensitivity Clear all
Completed Not applicable Interventional Results available

Tooth Sensitivity Relief by Two Mouthrinses

NCT01133379
View directory record Official record
Conditions
Dentin Sensitivity
Interventions
12027-019, 12027-020, 12027-021
Device
Lead sponsor
Johnson & Johnson Consumer and Personal Products Worldwide
Industry
Eligibility
18 Years and older
Enrollment
174 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Jul 8, 2015 · Synced Sep 6, 2026, 2:54 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Study to Investigate Efficacy of Two Experimental Oral Rinses in Providing Long Term Relief From Pain Derived From Exposed Dentine in Response to Chemical, Thermal, Tactile, or Osmotic Stimuli.

NCT02651467
View directory record Official record
Conditions
Dentin Sensitivity
Interventions
Experimental Oral Rinse 1 (1.5% w/w KOX, 0ppm F, pH 7.0), Experimental Oral Rinse 2 (2.0% w/w KOX, 45ppm F, pH 4.5), Placebo Oral Rinse (0% w/w KOX 0ppm F, pH 4.5 )
Other
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years to 65 Years
Enrollment
221 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Aug 26, 2018 · Synced Sep 6, 2026, 2:54 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Clinical Evaluation of OBU When Used for Indirect Dental Restorations

NCT06002880
View directory record Official record
Conditions
Sensitivity, Tooth
Interventions
Optibond Universal
Device
Lead sponsor
Kerr Corporation
Industry
Eligibility
18 Years to 100 Years
Enrollment
13 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Fort Lauderdale, Florida
Source: ClinicalTrials.gov public record
Updated Feb 11, 2024 · Synced Sep 6, 2026, 2:54 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Clinical Efficacy of a Toothpaste in Providing Relief From the Pain of Dentinal Hypersensitivity

NCT01592851
View directory record Official record
Conditions
Dentine Hypersensitivity
Interventions
Stannous Fluoride, Sodium Monofluorophosphate
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years to 65 Years
Enrollment
113 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Jun 2, 2014 · Synced Sep 6, 2026, 2:54 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Real-World Study of a Calcium Sodium Phosphosilicate Anti-Sensitivity Toothpaste for Dentin Hypersensitivity Relief

NCT07300540
View directory record Official record
Conditions
Dentin Sensitivity
Interventions
Calcium sodium phosphosilicate (CSPS) Toothpaste
Other
Lead sponsor
HALEON
Industry
Eligibility
18 Years to 65 Years
Enrollment
500 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Jul 20, 2026 · Synced Sep 6, 2026, 2:54 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Dentin Hypersensitivity Reduction Efficacy Clinical

NCT07738198
View directory record Official record
Conditions
Dental Hypersensitivity
Interventions
0.454% stannous fluoride toothpaste, 5% potassium nitrate, 0.76% sodium monofluorophosphate
Drug
Lead sponsor
Colgate Palmolive
Industry
Eligibility
18 Years to 70 Years
Enrollment
116 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Costa Mesa, California
Source: ClinicalTrials.gov public record
Updated Jul 30, 2026 · Synced Sep 6, 2026, 2:54 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Comparison Study of Hypersensitivity Treatment

NCT05768373
View directory record Official record
Conditions
Dentin Hypersensitivity
Interventions
3M™ Clinpro™ Fluoride Aqueous Solution, 3M™ Vanish™
Device
Lead sponsor
Solventum US LLC
Industry
Eligibility
18 Years and older
Enrollment
101 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Feb 6, 2025 · Synced Sep 6, 2026, 2:54 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Meta-analysis of Stannous Fluoride Dentifrice and the Effects on Dentine Hypersensitivity

NCT04005417
View directory record Official record
Conditions
Dentine Hypersensitivity
Interventions
Stannous fluoride dentifrice, Positive control dentifrice, Negative control dentifrice
Drug
Lead sponsor
Procter and Gamble
Industry
Eligibility
18 Years and older
Enrollment
1,036 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 1, 2019 · Synced Sep 6, 2026, 2:54 PM EDT
Completed Not applicable Interventional Results available

Study of Root Coverage With Acellular Dermal Matrix: Puros® Dermis Versus Alloderm®

NCT00881959
View directory record Official record
Conditions
Gingival Recession
Interventions
Puros® Dermis versus Alloderm®
Device
Lead sponsor
Zimmer Biomet
Industry
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
4
States / cities
Birmingham, Alabama • Ann Arbor, Michigan • Newark, New Jersey + 1 more
Source: ClinicalTrials.gov public record
Updated May 26, 2015 · Synced Sep 6, 2026, 2:54 PM EDT
Completed Not applicable Interventional Results available

A Study of the Relief of Tooth Sensitivity of an Experimental Mouthrinse Device

NCT01345292
View directory record Official record
Conditions
Dentin Sensitivity
Interventions
Mouthwash, Potassium nitrate toothpaste, Sodium fluoride toothpaste
Device · Drug
Lead sponsor
Johnson & Johnson Consumer and Personal Products Worldwide
Industry
Eligibility
18 Years and older
Enrollment
226 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Jun 9, 2015 · Synced Sep 6, 2026, 2:54 PM EDT
Completed Not applicable Interventional Results available

Test on a New Experimental Mouth Rinse for Relieving Tooth Sensitivity

NCT02113579
View directory record Official record
Conditions
Dentin Sensitivity
Interventions
Experimental Mouth Rinse 12027-033, Placebo Mouth Rinse
Device · Other
Lead sponsor
Johnson & Johnson Consumer and Personal Products Worldwide
Industry
Eligibility
18 Years and older
Enrollment
375 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014
U.S. locations
2
States / cities
Fort Wayne, Indiana • Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Jun 9, 2015 · Synced Sep 6, 2026, 2:54 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Clinical Study to Evaluate the Anti-Sensitivity Efficacy of a Stannous Fluoride Toothpaste in a Population of Dentin Hypersensitivity Sufferers

NCT06354270
View directory record Official record
Conditions
Dentin Sensitivity
Interventions
Stannous fluoride toothpaste, Regular fluoride toothpaste (Crest Cavity Protection)
Drug
Lead sponsor
HALEON
Industry
Eligibility
18 Years to 65 Years
Enrollment
115 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Melbourne, Florida
Source: ClinicalTrials.gov public record
Updated Jun 24, 2025 · Synced Sep 6, 2026, 2:54 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Efficacy of Sensi-IP Toothpaste in the Treatment of Dentinal Hypersensitivity Compared to a Sodium Fluoride Toothpaste

NCT06166745
View directory record Official record
Conditions
Dentinal Hypersensitivity
Interventions
Sensi-IP toothpaste, Sodium Fluoride Toothpaste
Device
Lead sponsor
IR Scientific Inc.
Industry
Eligibility
18 Years to 80 Years
Enrollment
46 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 18, 2024 · Synced Sep 6, 2026, 2:54 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Lesion Progression After Icon Treatment in Young Adults

NCT01988337
View directory record Official record
Conditions
Caries, Salivary Function, Tooth Sensitivity
Interventions
Resin infiltration, Mock treatment
Device · Other
Lead sponsor
DMG Dental Material Gesellschaft mbH
Industry
Eligibility
19 Years and older
Enrollment
56 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2018
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Oct 3, 2022 · Synced Sep 6, 2026, 2:54 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Clinical Study to Determine the Safety and Effectiveness of Dentinal Hypersensitivity Treatment With Two Different Toothbrushes

NCT02513212
View directory record Official record
Conditions
Dentin Sensitivity
Interventions
Potassium Oxalate, Stannous fluoride paste, Manual toothbrush, Power toothbrush
Device · Drug
Lead sponsor
Procter and Gamble
Industry
Eligibility
18 Years and older
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015
U.S. locations
1
States / cities
Fresno, California
Source: ClinicalTrials.gov public record
Updated Aug 30, 2020 · Synced Sep 6, 2026, 2:54 PM EDT
Completed Phase 4 Interventional Results available

Dose Response of a Tubule Occlusion Agent

NCT01075256
View directory record Official record
Conditions
Dentine Hypersensitivity, Dental Pain
Interventions
5% calcium sodium phosphosilicate toothpaste, 7.5% calcium sodium phosphosilicate toothpaste, Placebo toothpaste
Device
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years to 50 Years
Enrollment
195 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Jun 2, 2013 · Synced Sep 6, 2026, 2:54 PM EDT
Completed Phase 2 Interventional

Phase 2 Study of KH001 in Long-term Relief From Dentin Hypersensitivity

NCT06464939
View directory record Official record
Conditions
Dentin Hypersensitivity
Interventions
KH001, Placebo
Drug
Lead sponsor
HysensBio Co., Ltd
Industry
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
2
States / cities
Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 12, 2026 · Synced Sep 6, 2026, 2:54 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effects of an Oxalate Containing Product on Dentinal Hypersensitivity With Dental Prophylaxis

NCT02481557
View directory record Official record
Conditions
Dentin Sensitivity
Interventions
Oxalate Salt Solution
Device
Lead sponsor
Procter and Gamble
Industry
Eligibility
18 Years and older
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Jun 10, 2019 · Synced Sep 6, 2026, 2:54 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

The Efficacy of a Toothpaste to Reduce Sensitivity

NCT00763269
View directory record Official record
Conditions
Dentin Hypersensitivity
Interventions
Triclosan, Silicon dioxide, fluoride, Triclosan, fluoride
Drug
Lead sponsor
Colgate Palmolive
Industry
Eligibility
12 Years to 80 Years
Enrollment
626 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008
U.S. locations
1
States / cities
Cedar Knolls, New Jersey
Source: ClinicalTrials.gov public record
Updated Mar 6, 2012 · Synced Sep 6, 2026, 2:54 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Study Assessing the Effects of an Experimental Dentifrice in Maintaining Tooth Color Following Tooth Bleaching

NCT06150573
View directory record Official record
Conditions
Dentin Sensitivity, Oral Hygiene
Interventions
Test Dentifrice, Reference Dentifrice (Aquafresh Cavity Protection)
Drug
Lead sponsor
HALEON
Industry
Eligibility
18 Years to 65 Years
Enrollment
160 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Jul 23, 2025 · Synced Sep 6, 2026, 2:54 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Clinical Efficacy in Relieving Dentin Hypersensitivity of Nanohydroxyapatite-Containing Toothpastes and Cream

NCT02918617
View directory record Official record
Conditions
Dentin Sensitivity
Interventions
Control toothpaste containing Novamin® technology, Control toothpaste containing 1500 ppm fluoride as MFP, Test toothpaste with nano-HAP (high concentration), Test toothpaste with nano-HAP (low concentration), Test toothpaste with nano-HAP and (Potassium Nitrate) KNO3, Control toothpaste without nano-HAP, Test toothpaste with nano-HAP (medium concentration), Test cream with nano-HAP (higher concentration), Control cream without nano-HAP
Drug
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
18 Years to 80 Years
Enrollment
203 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Nov 15, 2018 · Synced Sep 6, 2026, 2:54 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Investigating the Efficacy of an Occluding Dentifrice in Providing Relief From Dentinal Hypersensitivity

NCT02832375
View directory record Official record
Conditions
Dentin Sensitivity
Interventions
stannous fluoride, sodium monofluorophosphate
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years to 65 Years
Enrollment
242 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated May 24, 2017 · Synced Sep 6, 2026, 2:54 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluation of the Safety and Efficacy of an Oxalate Gel or Negative Control on Dentinal Hypersensitivity

NCT02189382
View directory record Official record
Conditions
Dentin Sensitivity
Interventions
Potassium Oxalate, Water
Device · Other
Lead sponsor
Procter and Gamble
Industry
Eligibility
18 Years and older
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Aug 19, 2018 · Synced Sep 6, 2026, 2:54 PM EDT
Recruiting No phase listed Observational

Multi-site Study to Look at Tooth Wear and Tooth Sensitivity and the Risk Factors Associated.

NCT07195357
View directory record Official record
Conditions
Dentin Hypersensitivity, Erosive Tooth Wear
Interventions
epidemiological
Other
Lead sponsor
Indiana University
Other
Eligibility
18 Years and older
Enrollment
2,500 participants
Timeline
2026 – 2027
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated May 4, 2026 · Synced Sep 6, 2026, 2:54 PM EDT