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Showing 1–24 of 36 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Denture Clear all
Completed No phase listed Observational Accepts healthy volunteers

Novel Coating to Minimize Bacterial Adhesions and Tooth Wear in Denture Acrylic

NCT02834832
View directory record Official record
Conditions
Denture Stomatitis, Wear of Denture Teeth
Interventions
PECVD coating
Device
Lead sponsor
University of Florida
Other
Eligibility
21 Years to 80 Years
Enrollment
17 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2019
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jul 22, 2020 · Synced Jul 23, 2026, 11:46 PM EDT
Completed Phase 4 Interventional Results available

A Study to Investigate Food Occlusion Efficacy of a Denture Adhesive in Denture Wearers

NCT03709810
View directory record Official record
Conditions
Denture Retention
Interventions
Marketed Denture Adhesive (Super Poligrip Max Seal), No Adhesive
Combination Product · Other
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years to 85 Years
Enrollment
49 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Mar 1, 2020 · Synced Jul 23, 2026, 11:46 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Removable Partial Denture Abutments Restored With Monolithic Zirconia Crowns

NCT03283709
View directory record Official record
Conditions
Crowns, Denture
Interventions
Full-contour monolithic zirconia abutment crowns, Conventional abutment crowns
Device
Lead sponsor
Hiroko Nagaoka
Other
Eligibility
25 Years to 70 Years
Enrollment
1 participant
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Mar 12, 2020 · Synced Jul 23, 2026, 11:46 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Conventionally vs. Digitally Fabricated Complete Dentures: Clinical Treatment Outcome Differences

NCT02521935
View directory record Official record
Conditions
Mouth, Edentulous
Interventions
Complete traditional dentures, Complete CADCAM dentures
Device
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 99 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2020
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 26, 2017 · Synced Jul 23, 2026, 11:46 PM EDT
Terminated Not applicable Interventional Results available

Lithium Disilicate (CAD/CAM) Fixed Partial Dentures (FPD) Clinical Study

NCT03036566
View directory record Official record
Conditions
Missing Tooth
Interventions
Lithium disilicate ceramic (Ivoclar)
Device
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2020
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jul 24, 2024 · Synced Jul 23, 2026, 11:46 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Biological Specifications for Denture Designs

NCT00018512
View directory record Official record
Conditions
Tooth Loss
Interventions
Implant-supported denture
Procedure
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
35 Years to 80 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
1999 – 2004
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jan 20, 2009 · Synced Jul 23, 2026, 11:46 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Study to Assess the Effectiveness of a Marketed Denture Adhesive in Real-World Setting

NCT07273149
View directory record Official record
Conditions
Denture Retention
Interventions
Poligrip Power Max Hold + Seal
Device
Lead sponsor
HALEON
Industry
Eligibility
18 Years and older
Enrollment
375 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 1, 2026 · Synced Jul 23, 2026, 11:46 PM EDT
Enrolling by invitation Not applicable Interventional

Microbiome Effects of Extended Use of MI Paste in Elderly Removable Denture Wearers

NCT06406751
View directory record Official record
Conditions
Dental Prosthesis
Interventions
MI Paste
Device
Lead sponsor
University of Iowa
Other
Eligibility
65 Years to 105 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Nov 9, 2025 · Synced Jul 23, 2026, 11:46 PM EDT
Terminated No phase listed Observational Accepts healthy volunteers

An Observational Clinical Case Series Study to Assess Fit and Quality of Full Dentures Fabricated by AM

NCT04023006
View directory record Official record
Conditions
Mouth, Edentulous
Interventions
Removable prostheses
Device
Lead sponsor
Dentsply International
Industry
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 9, 2021 · Synced Jul 23, 2026, 11:46 PM EDT
Completed Phase 2 Interventional

Clinical Investigation of Mandibular Implant Overdenture

NCT00066014
View directory record Official record
Conditions
Dental Implantation
Interventions
Implant Overdenture Treatment
Procedure
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
21 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1998 – 2007
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Feb 21, 2012 · Synced Jul 23, 2026, 11:46 PM EDT
Withdrawn Phase 3 Interventional Accepts healthy volunteers

A Clinical Study to Assess Force Required to Dislodge Upper Denture With and Without Use of a Novel Denture Adhesive

NCT04473521
View directory record Official record
Conditions
Denture Retention
Interventions
Investigational denture adhesive cream, Super Poligrip Free
Device
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years to 85 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Jan 21, 2021 · Synced Jul 23, 2026, 11:46 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Efficacy of an Oral Hygiene Implant Protocol

NCT04462341
View directory record Official record
Conditions
Peri-implant Mucositis
Interventions
Water Flosser, Manual Toothbrush
Device
Lead sponsor
Water Pik, Inc.
Industry
Eligibility
18 Years to 90 Years
Enrollment
6 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 26, 2021 · Synced Jul 23, 2026, 11:46 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Outcome Evaluation of Ceramic Crowns Using Two Different Dental Cements

NCT00591942
View directory record Official record
Conditions
Sensitivity to Dental Cements, Dental Crowns, Dental Three-unit Bridges
Interventions
Full ceramic crowns or 3-unit fixed partial dentures.
Device
Lead sponsor
Clark Stanford
Other
Eligibility
18 Years to 80 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2009
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Mar 7, 2018 · Synced Jul 23, 2026, 11:46 PM EDT
Withdrawn No phase listed Observational

A Descriptive, Prospective Clinical Study to Evaluate Full Dentures Fabricated by Additive Manufacturing

NCT03997604
View directory record Official record
Conditions
Mouth, Edentulous
Interventions
Full Dentures created by additive manufacturing
Device
Lead sponsor
Dentsply International
Industry
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
2
States / cities
Northglenn, Colorado • Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated Aug 16, 2022 · Synced Jul 23, 2026, 11:46 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Immediate Loading of 4 Guided Implants Supporting a Maxillary Overdenture Using a Novaloc TiN Retention System

NCT06083506
View directory record Official record
Conditions
Immediate Dental Implant Loading, Denture, Complete
Interventions
NOVALOC TiN retained maxillary overdenture
Device
Lead sponsor
West Virginia University
Other
Eligibility
21 Years and older
Enrollment
17 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
1
States / cities
Morgantown, West Virginia
Source: ClinicalTrials.gov public record
Updated Jul 19, 2025 · Synced Jul 23, 2026, 11:46 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Study to Determine the Efficacy of a Denture Adhesive to Seal Out Food Particles From Under the Mandibular Partial Denture

NCT05908890
View directory record Official record
Conditions
Partial Denture
Interventions
Experimental Denture Adhesive, Fixodent True Feel Denture Adhesive
Device
Lead sponsor
Procter and Gamble
Industry
Eligibility
18 Years and older
Enrollment
29 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Jun 17, 2023 · Synced Jul 23, 2026, 11:46 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Bite Force Study Comparing Two New Test Adhesives With Currently Marketed Denture Adhesive

NCT02937870
View directory record Official record
Conditions
Denture Retention
Interventions
Test Product 1, Test Product 2, Reference Product, Negative Control
Device · Other
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years to 85 Years
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
1
States / cities
Bloomfield, New Jersey
Source: ClinicalTrials.gov public record
Updated May 22, 2018 · Synced Jul 23, 2026, 11:46 PM EDT
Not yet recruiting Not applicable Interventional

Comparative Study of Denture Fabrication Techniques

NCT07525011
View directory record Official record
Conditions
Complete Edentulism
Interventions
Traditional Complete Denture Fabrication, Easdent Digital Complete Denture Fabrication
Procedure
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Newark, New Jersey
Source: ClinicalTrials.gov public record
Updated Apr 12, 2026 · Synced Jul 23, 2026, 11:46 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Oral and Dermal Tolerability Clinical Study of an Experimental Denture Wipe

NCT03478644
View directory record Official record
Conditions
Denture Cleansers
Interventions
Experimental Denture Wipe, Tap Water
Device · Other
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years to 80 Years
Enrollment
152 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Oct 14, 2018 · Synced Jul 23, 2026, 11:46 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Study to Investigate a Method to Measure Food Occlusion by Denture Adhesives in Denture Wearers

NCT03345108
View directory record Official record
Conditions
Denture Retention
Interventions
Denture Adhesive Cream (Conventional Application), Denture Adhesive (Continuous Strip Application), No Adhesive
Device · Other
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years to 85 Years
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Mar 28, 2019 · Synced Jul 23, 2026, 11:46 PM EDT
Recruiting Not applicable Interventional

Postural Perturbations Tracing to the Stomatognathic System

NCT06974591
View directory record Official record
Conditions
Posture
Interventions
Dental splints, Dentures
Other
Lead sponsor
Boston University
Other
Eligibility
30 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 3, 2025 · Synced Jul 23, 2026, 11:46 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluation of a Experimental Denture Adhesive to Prevent Food Ingress

NCT02928380
View directory record Official record
Conditions
Denture Retention
Interventions
Experimental Denture Adhesive, Reference (Marketed) Denture Adhesive
Device
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years to 85 Years
Enrollment
83 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Aug 26, 2018 · Synced Jul 23, 2026, 11:46 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Conventional, Overdenture and Palateless Overdenture Oral Health Impact Comparison Study

NCT02731703
View directory record Official record
Conditions
Jaw, Edentulous
Interventions
Overdenture treatment
Device
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 99 Years
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2023
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated May 14, 2023 · Synced Jul 23, 2026, 11:46 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

A Clinical Study to Evaluate the Maximum Maxillary Bite Force (BF) When Using Two Novel Denture Adhesives Compared to Using No-Adhesive

NCT05173974
View directory record Official record
Conditions
Denture Retention
Interventions
Super Poligrip Free, Experimental Denture Adhesive 1, Experimental Denture Adhesive 2
Device
Lead sponsor
HALEON
Industry
Eligibility
18 Years to 85 Years
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Feb 15, 2024 · Synced Jul 23, 2026, 11:46 PM EDT