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ClinicalTrials.gov public records Last synced Oct 31, 2026, 10:12 AM EDT

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Showing 289–312 of 4,837 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Depressed Clear all
Completed Phase 3 Interventional

Effects Of Antidepressants On Sexual Functioning In Adults

NCT00051272
View directory record Official record
Conditions
Major Depressive Disorder (MDD)
Interventions
Extended-release Bupropion Hydrochloride
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years and older
Enrollment
425 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2004
U.S. locations
24
States / cities
Phoenix, Arizona • Scottsdale, Arizona • Berkeley, California + 19 more
Source: ClinicalTrials.gov public record
Updated Mar 29, 2011 · Synced Oct 31, 2026, 10:12 AM EDT
Completed Not applicable Interventional

Building Resilience for Surgical Recovery

NCT06174701
View directory record Official record
Conditions
Psychosocial Functioning, Surgery, Older Adults, Physical Function, Postoperative Outcome, Depressive Symptoms
Interventions
Problem Solving Therapy (PST), Enhanced Usual Care
Behavioral
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
65 Years and older
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Aug 3, 2026 · Synced Oct 31, 2026, 10:12 AM EDT
Completed No phase listed Observational

Mapping Mood in the Subthalamic Nucleus in Parkinson's Disease (PD)

NCT00847431
View directory record Official record
Conditions
Parkinson's Disease, Depression, Anxiety
Interventions
Not listed
Lead sponsor
Washington University School of Medicine
Other
Eligibility
40 Years and older
Enrollment
81 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2015
U.S. locations
2
States / cities
St Louis, Missouri • Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated May 4, 2016 · Synced Oct 31, 2026, 10:12 AM EDT
Completed Not applicable Interventional Results available

Researching Resiliency in Stressful Experiences (RISE) Program for Men Leaving Incarceration

NCT04785677
View directory record Official record
Conditions
Stress Disorders, Traumatic, Stress Disorders, Traumatic, Acute, Depressive Symptoms, Anxiety, Substance Use, Aggression, Coping Skills, Impulsive Behavior, Housing Problems, Recidivism, Stress, Occupational Stress, Psychological Distress
Interventions
Resiliency in Stressful Experiences (RISE) Program
Behavioral
Lead sponsor
Florida State University
Other
Eligibility
18 Years to 35 Years · Male only
Enrollment
403 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Tallahassee, Florida
Source: ClinicalTrials.gov public record
Updated Aug 28, 2026 · Synced Oct 31, 2026, 10:12 AM EDT
Terminated Phase 2 Interventional Accepts healthy volunteers Results available

Effects of Estrogen and Hot Flashes on Mood in Postmenopausal Women

NCT01126801
View directory record Official record
Conditions
Menopausal Depression
Interventions
Estradiol, Placebo control
Drug · Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
40 Years and older · Female only
Enrollment
2 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2011
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 20, 2017 · Synced Oct 31, 2026, 10:12 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Effects of Barefoot Running vs. in Shoes on Physiology and Mood

NCT01733381
View directory record Official record
Conditions
Autonomic Nervous System (ANS) Functioning and Mood State
Interventions
Not listed
Lead sponsor
University of Arizona
Other
Eligibility
18 Years and older
Enrollment
22 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2014
U.S. locations
1
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated Jul 31, 2025 · Synced Oct 31, 2026, 10:12 AM EDT
Completed Phase 1 Interventional Results available

Psilocybin-assisted CBT for Depression

NCT05227612
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Psilocybin, Cognitive behavioral therapy
Drug · Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
21 Years to 60 Years
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated May 19, 2026 · Synced Oct 31, 2026, 10:12 AM EDT
Terminated Not applicable Interventional

iPad Use in Reducing Anxiety and Depression in Patients Undergoing Bone Marrow Transplant

NCT02378012
View directory record Official record
Conditions
Anxiety, Depression, Malignant Neoplasm
Interventions
Computer-Assisted Intervention, Questionnaire Administration
Other
Lead sponsor
Ohio State University Comprehensive Cancer Center
Other
Eligibility
18 Years and older
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 24, 2020 · Synced Oct 31, 2026, 10:12 AM EDT
Completed Not applicable Interventional

Pilot Study Assessing Computerized Cognitive Behavioral Therapy for Depression

NCT01990053
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Beating the Blues
Behavioral
Lead sponsor
Ohio State University
Other
Eligibility
18 Years and older
Enrollment
128 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 24, 2023 · Synced Oct 31, 2026, 10:12 AM EDT
Terminated Phase 3 Interventional Results available

Vortioxetine to Prevent Return of Symptoms in Children With Depression

NCT05014919
View directory record Official record
Conditions
Depression
Interventions
Vortioxetine, Placebo
Drug
Lead sponsor
H. Lundbeck A/S
Industry
Eligibility
7 Years to 11 Years
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
3
States / cities
Long Beach, California • Atlanta, Georgia • Plano, Texas
Source: ClinicalTrials.gov public record
Updated Jan 5, 2023 · Synced Oct 31, 2026, 10:12 AM EDT
Completed Not applicable Interventional

Effectiveness of HabitWorks and Symptom Tracking for Anxiety and Depression

NCT07025486
View directory record Official record
Conditions
Anxiety, Depression, Anxiety
Interventions
HabitWorks, Symptom TRacking
Behavioral
Lead sponsor
Mclean Hospital
Other
Eligibility
18 Years and older
Enrollment
340 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 30, 2026 · Synced Oct 31, 2026, 10:12 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Testing TRUST Depression Management Intervention

NCT03599141
View directory record Official record
Conditions
Depressive Symptoms, Quality of Life
Interventions
Trust-building Self-management Together, Depression Management
Behavioral
Lead sponsor
Case Western Reserve University
Other
Eligibility
14 Years to 17 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 9, 2024 · Synced Oct 31, 2026, 10:12 AM EDT
Completed Not applicable Interventional Results available

rTMS for MDD: 5.5cm Rule vs. F3 Targeting

NCT03378570
View directory record Official record
Conditions
Major Depressive Disorder, Depression
Interventions
Repetitive transcranial magnetic stimulation
Device
Lead sponsor
Nicholas Trapp
Other
Eligibility
18 Years to 90 Years
Enrollment
123 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Feb 3, 2025 · Synced Oct 31, 2026, 10:12 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Characterizing Psychological Consequences of Childhood Trauma

NCT00209105
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
DEX-CRF stimulation test, Psychosocial stress induction, Brain imaging of sad mood , self-reference, reward, Acoustic startle
Drug · Behavioral · Procedure
Lead sponsor
Emory University
Other
Eligibility
18 Years to 45 Years
Enrollment
113 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2011
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Nov 13, 2013 · Synced Oct 31, 2026, 10:12 AM EDT
Completed Not applicable Interventional Results available

Effectiveness of Depression Treatment Following Coronary Artery Bypass Surgery

NCT00091962
View directory record Official record
Conditions
Cardiovascular Diseases, Coronary Disease, Heart Diseases, Depression
Interventions
Psychoeducation; Treatment recommendations, Pharmacotherapy, Usual Care
Behavioral · Drug · Other
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years to 100 Years
Enrollment
453 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2009
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 14, 2016 · Synced Oct 31, 2026, 10:12 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Preventing Postpartum Depression in African American Home Visiting Clients

NCT01175603
View directory record Official record
Conditions
Depression
Interventions
Mothers and Babies Course (Adapted for Baltimore Home Visiting Programs)
Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
14 Years to 50 Years · Female only
Enrollment
82 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2010
U.S. locations
4
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 7, 2016 · Synced Oct 31, 2026, 10:12 AM EDT
Completed Not applicable Interventional

Telehealth Depression Treatments for Older Adults

NCT02600754
View directory record Official record
Conditions
Depression
Interventions
IT-PST, IT-SCM
Behavioral
Lead sponsor
University of Texas at Austin
Other
Eligibility
50 Years and older
Enrollment
277 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Apr 28, 2021 · Synced Oct 31, 2026, 10:12 AM EDT
Not yet recruiting Not applicable Interventional

Transcutaneous Vagus Nerve Stimulation for Attention and Memory

NCT06723743
View directory record Official record
Conditions
Traumatic Brain Injury (TBI) Patients
Interventions
Transcutaneous vagus nerve stimulation for attention in veterans with TBI, Soterix Medical Vagus Nerve Stimulation mini-CT
Other · Device
Lead sponsor
Baylor College of Medicine
Other
Eligibility
25 Years to 64 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Oct 5, 2026 · Synced Oct 31, 2026, 10:12 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Pain Neuroscience Education for Depression

NCT04023435
View directory record Official record
Conditions
Chronic Low-back Pain, Depression
Interventions
PNE edcuation
Other
Lead sponsor
St. Ambrose University
Other
Eligibility
18 Years to 90 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Davenport, Iowa
Source: ClinicalTrials.gov public record
Updated Jan 17, 2023 · Synced Oct 31, 2026, 10:12 AM EDT
Completed Not applicable Interventional Results available

Implementing Evidence in the Detection and Treatment of Post Stroke Depression

NCT00296140
View directory record Official record
Conditions
Mental Health, Neurology, Health Services
Interventions
self management of PSD symptoms, screening and treatment of PSD
Behavioral · Procedure
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2009
U.S. locations
2
States / cities
Gainesville, Florida • Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Aug 28, 2018 · Synced Oct 31, 2026, 10:12 AM EDT
Recruiting Not applicable Interventional

One-Day cTBS Over the Precuneus

NCT07758010
View directory record Official record
Conditions
Depressive Disorder, Treatment-Resistant, Treatment Resistant Depression (TRD), Treatment Resistant Major Depression Disorder
Interventions
Precuneus-targeted continuous theta-burst stimulation, Left dorsolateral prefrontal cortex intermittent theta-burst stimulation, Sham transcranial magnetic stimulation
Device
Lead sponsor
Mclean Hospital
Other
Eligibility
18 Years and older
Enrollment
69 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 11, 2026 · Synced Oct 31, 2026, 10:12 AM EDT
Active, not recruiting Not applicable Interventional

Voice Activated Personal Assistant for Depression Among Older Adults

NCT06114485
View directory record Official record
Conditions
Depression, Anxiety
Interventions
VIPA Treatment Program, Alexa with Guidebook
Behavioral
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 13, 2026 · Synced Oct 31, 2026, 10:12 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluating Behavioral Activation Efficacy in Depressed Spanish-Speaking Latinos

NCT01958840
View directory record Official record
Conditions
Depression
Interventions
Behavioral Activation for Depression Treatment, Supportive Counseling
Behavioral
Lead sponsor
University of Maryland, College Park
Other
Eligibility
18 Years and older
Enrollment
46 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
1
States / cities
College Park, Maryland
Source: ClinicalTrials.gov public record
Updated May 30, 2023 · Synced Oct 31, 2026, 10:12 AM EDT
Completed Phase 4 Interventional Results available

Duloxetine for Chronic Depression: a Double-blind Study

NCT00360724
View directory record Official record
Conditions
Dysthymic Disorder, Depressive Disorder NOS
Interventions
Duloxetine (Cymbalta)
Drug
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
20 Years to 75 Years
Enrollment
65 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2013
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 21, 2017 · Synced Oct 31, 2026, 10:12 AM EDT