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ClinicalTrials.gov public records Last synced Nov 4, 2026, 2:26 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 721–744 of 4,841 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Depressed Clear all

Conditions: Major Depressive Disorder
Interventions: Pregnenolone 500 mg, Pregnenolone 800 mg, Placebo; Drug
Lead sponsor: University of Texas Southwestern Medical Center; Other
Eligibility: 18 Years to 65 Years · Female only
Enrollment: 34 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2022
U.S. locations: 1
States / cities: Dallas, Texas

Conditions: Solid Tumor, Solid Tumor, Adult
Interventions: DESCANSO/Depresión/Depressed Mood, Cansancio/Fatigue, and Sueño/Sleep; Rest in English; Behavioral
Lead sponsor: Ponce Medical School Foundation, Inc.; Industry
Eligibility: 21 Years to 100 Years
Enrollment: 125 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2030
U.S. locations: 7
States / cities: Basking Ridge, New Jersey • Middletown, New Jersey • Montvale, New Jersey + 4 more

Conditions: Major Depressive Disorder
Interventions: Brainsway H-Coil Deep TMS System, Brainsway H-Coil Deep TMS System (Sham treatment); Device
Lead sponsor: Brainsway; Industry
Eligibility: 22 Years to 68 Years
Enrollment: 233 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2012
U.S. locations: 14
States / cities: Los Angeles, California • Sacramento and Davis, California • Santa Monica, California + 10 more

Conditions: Depression
Interventions: CarePartners for depression; Behavioral
Lead sponsor: University of Michigan; Other
Eligibility: 21 Years and older
Enrollment: 243 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2018
U.S. locations: 7
States / cities: Alpena, Michigan • Ann Arbor, Michigan • Canton, Michigan + 4 more

Conditions: Major Depressive Disorder
Interventions: TMS with Neurostar TMS Therapy System; Device
Lead sponsor: Johns Hopkins University; Other
Eligibility: 15 Years to 24 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2011
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Preterm Birth
Interventions: Implementation of social determinants of health screening and referral; Other
Lead sponsor: University of Massachusetts, Worcester; Other
Eligibility: 18 Years and older · Female only
Enrollment: 882 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2027
U.S. locations: 7
States / cities: Denver, Colorado • Jacksonville, Florida • Detroit, Michigan + 4 more

Conditions: Hepatitis C, Depressive Disorder, Major, Depressive Disorder, Depression, HIV Infections
Interventions: Hepatitis C educational support groups, Cognitive Behavioral Therapy skills based group sessions; Behavioral
Lead sponsor: Icahn School of Medicine at Mount Sinai; Other
Eligibility: 21 Years and older
Enrollment: 26 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2010
U.S. locations: 1
States / cities: New York, New York

Conditions: Major Depressive Disorder, Psychotic Disorders
Interventions: Mifepristone, matching placebo; Drug
Lead sponsor: Corcept Therapeutics; Industry
Eligibility: 18 Years to 75 Years
Enrollment: 257 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2006
U.S. locations: 23
States / cities: Pico Rivera, California • Riverside, California • San Diego, California + 20 more

Conditions: Major Depressive Disorder, Miscarriage, Stillbirth, Neonatal Death
Interventions: Group Interpersonal Psychotherapy (IPT-G), Coping with Depression (CWD); Behavioral
Lead sponsor: Brown University; Other
Eligibility: 18 Years to 50 Years · Female only
Enrollment: 62 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2014
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Stroke, Depression, Depressive Symptoms, Post-stroke Depression
Interventions: Dyadic (couples-based) positive psychology intervention; Behavioral
Lead sponsor: University of Utah; Other
Eligibility: 18 Years and older
Enrollment: 68 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2020
U.S. locations: 1
States / cities: Salt Lake City, Utah

Conditions: Bipolar Disorder
Interventions: magnetic seizure therapy (MST), electroconvulsive therapy (ECT); Device
Lead sponsor: Joao L. DeQuevedo; Other
Eligibility: 22 Years to 85 Years
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2027
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Major Depressive Disorder
Interventions: Tocilizumab, Placebo, Whole-Body Hyperthermia; Drug · Device
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years to 65 Years
Enrollment: 35 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2029
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Bipolar I Disorder, Mania, Depression
Interventions: Cariprazine, Placebo; Drug
Lead sponsor: AbbVie; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 901 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2022
U.S. locations: 46
States / cities: Little Rock, Arkansas • Rogers, Arkansas • Anaheim, California + 39 more

Conditions: Depressive Episode, Bipolar 1 Depression
Interventions: SEP-4199 200 mg, SEP-4199 400 mg, Placebo; Drug
Lead sponsor: Sumitomo Pharma America, Inc.; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 344 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2020
U.S. locations: 7
States / cities: Cerritos, California • Garden Grove, California • San Diego, California + 4 more

Conditions: Memory Deficits, Electroconvulsive Therapy
Interventions: Cognitive Intervention: Memory Training, Comparable general mental stimulation; Behavioral
Lead sponsor: New York State Psychiatric Institute; Other
Eligibility: 18 Years to 70 Years
Enrollment: 59 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2017
U.S. locations: 1
States / cities: New York, New York

Conditions: Major Depressive Disorder
Interventions: focal ECT; Device
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years to 90 Years
Enrollment: 17 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2016
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Depression, Insomnia
Interventions: Intensive Sleep Retraining, Sleep Hygiene; Behavioral
Lead sponsor: University of Michigan; Other
Eligibility: 18 Years to 65 Years
Enrollment: 13 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2018
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Major Depressive Disorder, Apathy
Interventions: Targeted Cognitive Training Intervention, General Cognitive Training Intervention; Behavioral
Lead sponsor: AdventHealth; Other
Eligibility: 60 Years and older
Enrollment: 84 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2028
U.S. locations: 1
States / cities: Orlando, Florida

Conditions: Depression
Interventions: Ketamine; Drug
Lead sponsor: Neurological Associates of West Los Angeles; Other
Eligibility: 18 Years to 70 Years
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020
U.S. locations: 1
States / cities: Santa Monica, California

Conditions: Changes in Brain Network Connectivity
Interventions: Anesthetics, Dissociative; Drug
Lead sponsor: University of Michigan; Other
Eligibility: 18 Years to 65 Years
Enrollment: 16 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2015
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Treatment Resistant Depression
Interventions: Vagus Nerve Stimulation (VNS); Device
Lead sponsor: LivaNova; Industry
Eligibility: 18 Years and older
Enrollment: 6,800 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2030
U.S. locations: 101
States / cities: Birmingham, Alabama • Huntsville, Alabama • Burlingame, California + 85 more

Conditions: Bipolar Disorder, Major Depression, Rumination
Interventions: Functional Magnetic Resonance Imaging (fMRI); Other
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years to 64 Years
Enrollment: 32 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2020
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Race-related Stress, Depression, Anxiety, Quality of Life, Stress Reaction
Interventions: ACT for SCD; Behavioral
Lead sponsor: Children's Hospital Los Angeles; Other
Eligibility: 14 Years to 21 Years
Enrollment: 66 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2029
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Major Depressive Disorder With Psychotic Features
Interventions: Quetiapine, escitalopram, Sertraline, Citalopram; Drug
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years to 85 Years
Enrollment: 32 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2013
U.S. locations: 1
States / cities: Boston, Massachusetts

Search by objective public record fields.

Development of Pregnenolone as a Treatment for Depression

DESCANSO, a Mental Health Intervention for Depression, Insomnia, and Fatigue Symptoms in Latino People With Cancer

Evaluation of the Brainsway Deep Transcranial Magnetic Stimulation (TMS) H-Coil in the Treatment of Major Depression Disorder

Telemonitoring Enhanced Support for Depression Self Management

rTMS for Adolescents and Young Adults

The Social Determinants of Health Screening and Referral Project

Prevention of Depression in HIV/HCV Co-infected Substance Abuse Patients

A United States Study of Corlux for Psychotic Symptoms in Psychotic Major Depression

Group Interpersonal Psychotherapy for Treatment of Major Depressive Disorder Following Perinatal Loss

Testing a Positive Psychology-based Intervention for Couples Coping With Stroke

Magnetic Seizure Therapy in Bipolar Depression (MST-BpD) and Treatment Resistant Depression (MST-TRD)

Mild-Intensity Whole Body Hyperthermia (WBH) for Major Depressive Disorder

A Cariprazine Study in the Prevention of Relapse in Bipolar I Disorder Patients Whose Current Episode is Manic or Depressive, With or Without Mixed Features

A Clinical Study to Test the Effectiveness of an Investigational Drug to Treat People That Have Major Depressive Episodes When They Have Bipolar 1 Depression

Cognitive Training for Memory Deficits Associated With Electroconvulsive Therapy

Focal Electroconvulsive Therapy for Depression

Sleep Therapy for Insomnia and Depression

Targeting Network Dysfunction in Apathy of Late-life Depression Using Digital Therapeutics

Intravenous Ketamine Effects on Functional Neuroanatomy

Anesthesia and Functional Connectivity: An Analysis of fMRI Changes

A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression

Self Focus in Bipolar Disorder: A Functional Magnetic Resonance Imaging (fMRI) Study

Acceptance and Commitment Therapy for Adolescents and Young Adults With Sickle Cell Disease

Seroquel Alone Versus Seroquel With an SSRI for Depression With Psychotic Symptoms