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ClinicalTrials.gov public records Last synced Nov 4, 2026, 7:16 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 793–816 of 4,841 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Depressed Clear all

Conditions: Schizophrenia, Schizophreniform Disorder
Interventions: Citalopram, Placebo, Psychoeducation, Cognitive Behavioral Therapy (CBT), Functional Magnetic Resonance Imaging (fMRI); Drug · Behavioral · Radiation
Lead sponsor: NYU Langone Health; Other
Eligibility: 16 Years to 40 Years
Enrollment: 95 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2018
U.S. locations: 1
States / cities: New York, New York

Conditions: Anxiety Depression, Disability Physical
Interventions: Rauha; Device
Lead sponsor: Toivoa Inc; Industry
Eligibility: 22 Years and older
Enrollment: 13 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: San Antonio, Texas

Conditions: Depression, Anxiety, Bipolar Disorder
Interventions: Not listed
Lead sponsor: National Institute of Mental Health (NIMH); NIH
Eligibility: 18 Years and older
Enrollment: 193 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2025
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Treatment Resistant Depression, Electroconvulsive Therapy, ECT, Ketamine, Psychiatric Disorder, Depression, Major Depressive Disorder, Major Depressive Episode, Unipolar Depression
Interventions: electroconvulsive therapy (ECT), Ketamine; Procedure · Drug
Lead sponsor: Bo Hu; Other
Eligibility: 21 Years to 75 Years
Enrollment: 403 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2022
U.S. locations: 5
States / cities: New Haven, Connecticut • Baltimore, Maryland • New York, New York + 2 more

Conditions: Depression
Interventions: Behavioral intervention (iCBT + TeleCoach), Internet-based cognitive behavioral therapy (I-CBT), Treatment as usual / Wait-list control; Behavioral
Lead sponsor: Northwestern University; Other
Eligibility: 19 Years and older
Enrollment: 102 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2012
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Depression, Menopause, Vasomotor Disturbance, Hot Flashes, Sleep
Interventions: vortioxetine; Drug
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 40 Years to 62 Years · Female only
Enrollment: 47 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2016
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Mild Cognitive Impairment, Major Depressive Disorder, Alzheimer's Disease
Interventions: es-citalopram, Memantine; Drug
Lead sponsor: New York State Psychiatric Institute; Other
Eligibility: 50 Years to 90 Years
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2010
U.S. locations: 1
States / cities: New York, New York

Conditions: Depression
Interventions: Cognitive-behavioral group, Cognitive-behavioral bibliotherapy; Behavioral
Lead sponsor: Oregon Research Institute; Other
Eligibility: 13 Years to 19 Years
Enrollment: 390 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2013
U.S. locations: 1
States / cities: Eugene, Oregon

Conditions: Sleep-disordered Breathing, Major Depressive Disorder
Interventions: Positive Airway Pressure (PAP); Device
Lead sponsor: University of Michigan; Other
Eligibility: 18 Years to 45 Years · Female only
Enrollment: 29 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2020
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Major Depressive Disorder (MDD), Suicidal Ideation
Interventions: TMS; Device
Lead sponsor: University of California, Davis; Other
Eligibility: 15 Years to 25 Years
Enrollment: 25 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Sacramento, California

Conditions: Affective Disorders
Interventions: Ziprasidone, Sertraline, Haloperidol; Drug
Lead sponsor: Duke University; Other
Eligibility: 18 Years to 75 Years
Enrollment: 72 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2003 – 2005
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Diabetes, Depression
Interventions: sertraline, Placebo; Drug
Lead sponsor: Charles Drew University of Medicine and Science; Other
Eligibility: 21 Years and older
Enrollment: 89 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2008
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Depression
Interventions: Not listed
Lead sponsor: National Institute of Mental Health (NIMH); NIH
Eligibility: 18 Years to 75 Years
Enrollment: 300 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2008
U.S. locations: 15
States / cities: Tuscaloosa, Alabama • Harbor City, California • Los Angeles, California + 12 more

Conditions: Menopause, Sleep Disturbance, Anxiety, Depression, Cognitive Function, Fatigue, Libido
Interventions: Radicle Revive Placebo Control Form 4.1, Radicle Revive Active Study Product 4.1 Usage; Dietary Supplement
Lead sponsor: Radicle Science; Industry
Eligibility: 21 Years to 105 Years · Female only
Enrollment: 500 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025
U.S. locations: 1
States / cities: Del Mar, California

Conditions: Bipolar Type II Disorder
Interventions: Venlafaxine, Lithium Carbonate; Drug
Lead sponsor: Stanley Medical Research Institute; Other
Eligibility: 18 Years and older
Enrollment: 90 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2002 – 2006
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Mood Disorders in Children and Adolescents
Interventions: Family-based treatment; Behavioral
Lead sponsor: Mayo Clinic; Other
Eligibility: 10 Years to 18 Years
Enrollment: 84 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2019
U.S. locations: 3
States / cities: Scottsdale, Arizona • Jacksonville, Florida • Rochester, Minnesota

Conditions: Depression, Suicide Risk
Interventions: Not listed
Lead sponsor: National Institute of Mental Health (NIMH); NIH
Eligibility: 18 Years to 99 Years
Enrollment: 1,000 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2028
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Major Depressive Disorder
Interventions: Dose-matched placebo, Vilazodone; Drug
Lead sponsor: Forest Laboratories; Industry
Eligibility: 18 Years to 70 Years
Enrollment: 518 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2013
U.S. locations: 14
States / cities: Beverly Hills, California • Encino, California • New Port Beach, California + 11 more

Conditions: Opioid-Related Disorders
Interventions: Treating Opioid Patients' Pain and Sadness (TOPPS), Health Education (HE); Behavioral
Lead sponsor: Boston University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 163 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2024
U.S. locations: 2
States / cities: Boston, Massachusetts • Fall River, Massachusetts

Conditions: Hypogonadism, Late Onset Hypogonadism, Low Testosterone
Interventions: Dihydrotestosterone (0.7%) in hydroalcoholic gel; Drug
Lead sponsor: ASCEND Therapeutics; Industry
Eligibility: 55 Years to 80 Years · Male only
Enrollment: 128 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2006
U.S. locations: 16
States / cities: Phoenix, Arizona • Torrance, California • Gainesville, Florida + 13 more

Conditions: Depression
Interventions: Neuroimaging with Magnetic Resonance Imaging (MRI); Other
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years to 65 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Treatment Resistant Depression
Interventions: Active TBS-DLPFC, TBS-DMPFC; Device
Lead sponsor: Stanford University; Other
Eligibility: 18 Years to 80 Years
Enrollment: 16 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2025
U.S. locations: 1
States / cities: Stanford, California

Conditions: Major Depressive Disorder, Traumatic Brain Injury
Interventions: Cognitive Behavioral Therapy for individuals with TBI, Waitlist Control; Behavioral · Other
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years and older
Enrollment: 62 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2022
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Depression
Interventions: BA (brief advice), SHE (supervised and home-based exercise), HE (health education), CBEX (cognitive-behavioral sessions focused on increasing and maintaining exercise); Behavioral
Lead sponsor: Butler Hospital; Other
Eligibility: 18 Years to 65 Years
Enrollment: 240 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2021
U.S. locations: 1
States / cities: Providence, Rhode Island

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DECIFER: Depression and Citalopram In First Episode Recovery

Exploratory Study for Toivoa-001 on Human Factors

Mental Health Impact of the COVID-19 Pandemic on Amish and Mennonite Participants in AMBiGen

ELEKT-D: Electroconvulsive Therapy (ECT) vs. Ketamine in Patients With Treatment Resistant Depression (TRD)

Effectiveness of a Technology Assisted Behavioral Intervention in Assisting People With Major Depressive Disorder

Vortioxetine for Menopausal Depression

Memantine Plus Es-citalopram in Elderly Depressed Patients With Cognitive Impairment

Testing the Effectiveness of Adolescent Depression Prevention Programs (The OregonBlues Study)

Sleep-Disordered Breathing and PAP in Perinatal Depression

Accelerated Intermittent Theta Burst Stimulation for Adolescent and Young Adult Depression With Elevated Suicide Risk

Ziprasidone vs. Sertraline/Haloperidol in Psychotic Depression

Treatment of Diabetes and Depression in Hispanics and African Americans and Its Effect on A1c and Quality of Life.

Assessing Treatment Emergent Suicidal Ideation in Patients With Major Depression

Radicle Revive 24: A Study of Health and Wellness Products on Menopausal Health and Related Health Outcomes

Antidepressant Therapy for Bipolar II Major Depression

Integrated Treatment for Youth With Mood Disorders

Long-term Observation of Participants With Mood Disorders

Safety, Efficacy, and Tolerability of Vilazodone in Major Depressive Disorder

Treating Chronic Pain in Buprenorphine Patients in Primary Care Settings

Study of DHT-Gel to Treat the Symptoms of Low Testosterone in Men 55-80

fMRI Accelerated TMS Depression

Open Label - Personalized Therapeutic Neuromodulation for Anhedonic Depression

Adapted Cognitive Behavioral Treatment for Depression in Patients With Moderate to Severe Traumatic Brain Injury

Initiating and Maintaining Physical Activity in Depressed Individuals