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ClinicalTrials.gov public records Last synced Oct 30, 2026, 10:57 AM EDT

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Showing 73–96 of 4,837 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Depressed Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Biological CVD Risk Factors in Older Depressed Patients

NCT00318864
View directory record Official record
Conditions
Depression, Hypertension, Hypercholesterolemia
Interventions
Cognitive behavioral therapy
Behavioral
Lead sponsor
Stanford University
Other
Eligibility
55 Years and older
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2002 – 2005
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Apr 27, 2006 · Synced Oct 30, 2026, 10:57 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Rosie the Chatbot: Leveraging Automated and Personalized Health Information Communication

NCT06053515
View directory record Official record
Conditions
Pregnancy, Postpartum Depression, Infant Development, Infant Conditions
Interventions
Rosie the Chatbot
Behavioral
Lead sponsor
University of Maryland, College Park
Other
Eligibility
14 Years to 99 Years · Female only
Enrollment
400 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
College Park, Maryland
Source: ClinicalTrials.gov public record
Updated May 5, 2026 · Synced Oct 30, 2026, 10:57 AM EDT
Completed Not applicable Interventional Results available

Enhancing Transdiagnostic Mechanisms of Cognitive Dyscontrol

NCT04912089
View directory record Official record
Conditions
Anxiety Disorders, Depression, Posttraumatic Stress Disorder
Interventions
COGENT
Behavioral
Lead sponsor
University of California, San Diego
Other
Eligibility
21 Years to 55 Years
Enrollment
73 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Jul 23, 2025 · Synced Oct 30, 2026, 10:57 AM EDT
Active, not recruiting No phase listed Observational Accepts healthy volunteers

Analyze Previously Collected Biopsy Samples From Participants Who Completed the "SPLASH: Split-Body Randomized Clinical Trial of Poly-L-Lactic Acid for Adipogenesis and Volumization of the Hip Dell" Study

NCT06656923
View directory record Official record
Conditions
Lateral Gluteal Depression
Interventions
Biopsies
Diagnostic Test
Lead sponsor
Goldman, Butterwick, Fitzpatrick and Groff
Other
Eligibility
Female only
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Apr 18, 2025 · Synced Oct 30, 2026, 10:57 AM EDT
Completed Not applicable Interventional

Process and Outcomes in CBT for Anxious and Depressed Youth

NCT03100279
View directory record Official record
Conditions
Anxiety Disorders, Depression
Interventions
Coping Cat/CAT Project, Primary and Secondary Coping Enhancement Therapy
Behavioral
Lead sponsor
Rutgers University
Other
Eligibility
7 Years to 17 Years
Enrollment
247 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2020
U.S. locations
1
States / cities
Piscataway, New Jersey
Source: ClinicalTrials.gov public record
Updated Jul 17, 2026 · Synced Oct 30, 2026, 10:57 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

SSIs for Mental Health and Loneliness

NCT05687162
View directory record Official record
Conditions
Loneliness, Mental Health Issue, Distress, Emotional, Depression, Anxiety, Stress
Interventions
Overcoming Loneliness three-week intervention, Overcoming Loneliness single-session intervention, Single-session "Sharing Feelings" program, The Blu Surfer program: a popular online content-based intervention for psychological distress, The Action Brings Change (ABC) Program (TEAM Lab version), Online help-seeking as usual, The Lonely Blu Surfer program: a popular online content-based intervention for loneliness, Overcoming loneliness SSI 8-minute version
Behavioral
Lead sponsor
University of California, Irvine
Other
Eligibility
16 Years and older
Enrollment
4,370 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Irvine, California
Source: ClinicalTrials.gov public record
Updated Jul 22, 2024 · Synced Oct 30, 2026, 10:57 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Virtual Reality Exercise on Promoting Physical Activity and Health Among College Students

NCT06902727
View directory record Official record
Conditions
Physical Activity Levels, Cardiovascular Fitness, Body Composition, Situational Motivation, Situational Interest, Mood States, Depressive Symptoms
Interventions
VR-based exercise bike, Usual routine
Device · Other
Lead sponsor
The University of Tennessee, Knoxville
Other
Eligibility
18 Years to 35 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 30, 2025 · Synced Oct 30, 2026, 10:57 AM EDT
Completed No phase listed Observational

Understanding Treatment Adherence Among Individuals With Rapid Cycling Bipolar Disorder

NCT00183703
View directory record Official record
Conditions
Bipolar Disorder
Interventions
Not listed
Lead sponsor
Case Western Reserve University
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2007
U.S. locations
2
States / cities
Beachwood, Ohio • Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 6, 2019 · Synced Oct 30, 2026, 10:57 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

A Study of Pregnant and Postpartum Women With and Without Mood Disorders

NCT03615794
View directory record Official record
Conditions
Bipolar Disorder, Major Depressive Disorder, Postpartum Depression, Postpartum Psychosis
Interventions
Not listed
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 50 Years
Enrollment
300 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2024
U.S. locations
2
States / cities
Baltimore, Maryland • Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Dec 30, 2025 · Synced Oct 30, 2026, 10:57 AM EDT
Withdrawn Not applicable Interventional

Integrated Smoking Cessation and Mood Management for ACS Patients

NCT03029923
View directory record Official record
Conditions
Acute Coronary Syndrome, Tobacco Use
Interventions
Experimental: Behavioral Activation Treatment for Cardiac Smokers (BAT-CS), Smoking cessation plus Health and Wellness
Behavioral
Lead sponsor
The Miriam Hospital
Other
Eligibility
18 Years to 75 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Aug 29, 2017 · Synced Oct 30, 2026, 10:57 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluation of a Yoga Intervention for Post-Traumatic Stress Disorder

NCT00962403
View directory record Official record
Conditions
Post-Traumatic Stress Disorder
Interventions
Yoga treatment
Behavioral
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years and older
Enrollment
108 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2012
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 20, 2013 · Synced Oct 30, 2026, 10:57 AM EDT
Terminated Not applicable Interventional

Video Directly Observed Therapy (VDOT) to Improve Medication Adherence

NCT03970642
View directory record Official record
Conditions
Depression
Interventions
Video directly observed therapy
Other
Lead sponsor
UConn Health
Other
Eligibility
18 Years and older
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Farmington, Connecticut
Source: ClinicalTrials.gov public record
Updated Feb 1, 2022 · Synced Oct 30, 2026, 10:57 AM EDT
Completed No phase listed Observational

Long Term Follow Up KET-PD

NCT06164756
View directory record Official record
Conditions
Parkinson's Disease, Depression
Interventions
Cognitive Behavior Therapy (CBT), Treatment As Usual (TAU)
Other
Lead sponsor
Yale University
Other
Eligibility
40 Years to 80 Years
Enrollment
49 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Sep 28, 2026 · Synced Oct 30, 2026, 10:57 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Effect of Food, Gender, and Age on the Pharmacokinetic Profile of SUVN-911 in Healthy Subjects

NCT03551288
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
SUVN-911
Drug
Lead sponsor
Suven Life Sciences Limited
Industry
Eligibility
18 Years and older
Enrollment
28 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated Aug 9, 2018 · Synced Oct 30, 2026, 10:57 AM EDT
Terminated Phase 1 Interventional

Assessment of the Safety and Effectiveness of Cortical Stimulation in Subjects With Major Depressive Disorder

NCT00380042
View directory record Official record
Conditions
Depression, Depressive Disorder
Interventions
Cortical Stimulation, Sham
Device
Lead sponsor
Northstar Neuroscience
Industry
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2009
U.S. locations
3
States / cities
Boston, Massachusetts • Pittsburgh, Pennsylvania • Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Dec 31, 2009 · Synced Oct 30, 2026, 10:57 AM EDT
Terminated Not applicable Interventional

Nu-V3 Non-Invasive Nerve Stimulation Device Trial for Chronic Pain, Anxiety, Depression, Sleeplessness

NCT05335980
View directory record Official record
Conditions
Chronic Pain, Anxiety, Depression, Sleeplessness
Interventions
Nu-V3
Device
Lead sponsor
Nu-Life Solutions
Industry
Eligibility
18 Years and older
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Apr 20, 2022 · Synced Oct 30, 2026, 10:57 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

Clinical Study to Investigate the Effect of the Combination of Psychotropic Drugs and an Opioid on Ventilation

NCT04310579
View directory record Official record
Conditions
Hypercapnia, Ventilatory Depression
Interventions
Oxycodone and Midazolam, Oxycodone, Paroxetine, and Quetiapine
Drug
Lead sponsor
Food and Drug Administration (FDA)
Federal
Eligibility
18 Years to 50 Years
Enrollment
55 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
West Bend, Wisconsin
Source: ClinicalTrials.gov public record
Updated May 21, 2024 · Synced Oct 30, 2026, 10:57 AM EDT
Terminated Phase 2 Interventional Results available

Adjunctive Isradipine for the Treatment of Bipolar Depression

NCT01784666
View directory record Official record
Conditions
Bipolar Disorder
Interventions
Isradipine, Placebo
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 20, 2017 · Synced Oct 30, 2026, 10:57 AM EDT
Completed Phase 2 Interventional

Clinical Trial of Felbamate for Treatment-Resistant Bipolar Depression

NCT00034229
View directory record Official record
Conditions
Bipolar Disorder
Interventions
Felbamate
Drug
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
Not listed
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2006
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 4, 2008 · Synced Oct 30, 2026, 10:57 AM EDT
Completed Not applicable Interventional

Clinical Outcomes of a Digital Mental Health Intervention for Moderate/Severe Depression and Anxiety

NCT07081061
View directory record Official record
Conditions
Depression, Anxiety, Mental Health Issue, Mental Health Wellness 2
Interventions
BetterHelp
Other
Lead sponsor
Teladoc Health
Industry
Eligibility
18 Years and older
Enrollment
86 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
San Jose, California
Source: ClinicalTrials.gov public record
Updated Aug 26, 2026 · Synced Oct 30, 2026, 10:57 AM EDT
Completed Not applicable Interventional

Affect Treatment for Depression and Anxiety

NCT05203861
View directory record Official record
Conditions
Depression, Anxiety
Interventions
Positive Affect Treatment, Negative Affect Treatment
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 65 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
2
States / cities
Los Angeles, California • Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Apr 25, 2025 · Synced Oct 30, 2026, 10:57 AM EDT
Completed Not applicable Interventional

Invasive Decoding and Stimulation of Altered Reward Computations in Depression Patients

NCT05239780
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Brain stimulation
Procedure
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years to 80 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 20, 2026 · Synced Oct 30, 2026, 10:57 AM EDT
Completed No phase listed Observational

Reward-Related Processes and Brain Function

NCT00029588
View directory record Official record
Conditions
Depression
Interventions
Not listed
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
9 Years to 40 Years
Enrollment
241 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2017
U.S. locations
2
States / cities
Washington D.C., District of Columbia • Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 6, 2017 · Synced Oct 30, 2026, 10:57 AM EDT
Completed No phase listed Observational

The Effect of Magnesium on Maternal Mood, Cognitive Function, and Birth Experience

NCT02454322
View directory record Official record
Conditions
Depression, Postpartum
Interventions
Magnesium Sulfate
Drug
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older · Female only
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2021
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 5, 2022 · Synced Oct 30, 2026, 10:57 AM EDT