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ClinicalTrials.gov public records Last synced Nov 5, 2026, 8:36 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 937–960 of 4,844 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Depressed Clear all

Conditions: Depression, Anxiety, Substance Use, Stress, Psychological, Stress, Emotional, Alcohol Use, Unspecified, Drug Use, Covid19
Interventions: Mindfulness Based Cognitive Therapy for Resilience During COVID-19 plus CHAMindWell, Internet Cognitive Behavioral Therapy plus CHAMindWell, CHAMindWell; Behavioral
Lead sponsor: Cambridge Health Alliance; Other
Eligibility: 18 Years to 70 Years
Enrollment: 113 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: Cambridge, Massachusetts

Conditions: Depression
Interventions: venlafaxine XR plus aripiprazole, venlafaxine plus placebo; Drug
Lead sponsor: University of Pittsburgh; Other
Eligibility: 60 Years and older
Enrollment: 468 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2014
U.S. locations: 2
States / cities: St Louis, Missouri • Pittsburgh, Pennsylvania

Conditions: Substance Use, Conduct Disorder, Depression, Anxiety
Interventions: Family Check-Up; Behavioral
Lead sponsor: University of Oregon; Other
Eligibility: Not listed
Enrollment: 593 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2011
U.S. locations: 1
States / cities: Portland, Oregon

Conditions: Depression, Macular Degeneration
Interventions: Problem Solving Treatment, Control; Behavioral
Lead sponsor: Thomas Jefferson University; Other
Eligibility: 65 Years and older
Enrollment: 206 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2001 – 2006
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Chronic Low-back Pain, Depression
Interventions: Psilocybin, Methylphenidate; Drug
Lead sponsor: Johns Hopkins University; Other
Eligibility: 21 Years to 80 Years
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Depression, Mood Disorders, Healthy (Controls)
Interventions: Whole Body Hyperthermia, Cold Water Plunge; Procedure
Lead sponsor: Barry Sandler; Other
Eligibility: 18 Years to 65 Years
Enrollment: 162 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2027
U.S. locations: 1
States / cities: Edwards, Colorado

Conditions: Stress, Depression, Anxiety and Worry
Interventions: Mindfulness meditation training; Behavioral
Lead sponsor: Sandraluz Lara-Cinisomo; Other
Eligibility: 18 Years and older
Enrollment: 30 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2017
U.S. locations: 1
States / cities: Champaign, Illinois

Conditions: Depression, Anxiety, Major Depressive Disorder
Interventions: CYB003, Placebo; Drug
Lead sponsor: Ohio State University; Other
Eligibility: 21 Years to 65 Years
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Fatigue Syndrome, Chronic, Healthy, Mood Disorders
Interventions: Not listed
Lead sponsor: National Institute of Mental Health (NIMH); NIH
Eligibility: Not listed
Enrollment: 60 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 1995 – 2000
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Pain, Anxiety State, Depressive State
Interventions: Breath Counting, Body Scan, Mindful Breathing, Mindfulness of Pain, Mindful Savoring; Behavioral
Lead sponsor: University of Utah; Other
Eligibility: 18 Years and older
Enrollment: 823 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2025
U.S. locations: 1
States / cities: Salt Lake City, Utah

Conditions: Depression - Major Depressive Disorder, Treatment-resistant Depression (TRD), rTMS, Ketamine, fMRI
Interventions: TMS, Ketamine; Device · Drug
Lead sponsor: Weill Medical College of Cornell University; Other
Eligibility: 18 Years to 70 Years
Enrollment: 27 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: New York, New York

Conditions: Depression - Major Depressive Disorder
Interventions: Mediterranean Diet, Time-Restricted Eating; Behavioral
Lead sponsor: University of California, San Diego; Other
Eligibility: 18 Years and older
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: La Jolla, California

Conditions: Anxiety Disorder, Worry, Uncertainty, Sleep Disorders, Insomnia, Fatigue, Pain, Depression, Cognitive-behavioral Therapy, Psychological Intervention, Esophageal Cancer, Pancreatic Cancer, Leukemia, Lung Cancer, Multiple Myeloma, Ovarian Neoplasm, Stage III or IV Cervical or Uterine Cancer, Stage IIIB, IIIC, or IV Breast Cancer, Glioblastoma Multiforme, Relapsed Lymphoma, Stage III or IV Colorectal Cancer, Stage IIIC or IV Melanoma
Interventions: Cognitive-behavioral therapy for worry, uncertainty & insomnia; Behavioral
Lead sponsor: Ohio State University Comprehensive Cancer Center; Other
Eligibility: 18 Years and older
Enrollment: 33 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2014
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Premature Birth, Obstetric Labor, Premature
Interventions: Family Nurture Intervention, Standard Care; Behavioral
Lead sponsor: Columbia University; Other
Eligibility: 26 Weeks to 34 Weeks
Enrollment: 461 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2022
U.S. locations: 2
States / cities: New York, New York • San Antonio, Texas

Conditions: Depression, Pain
Interventions: Duloxetine Hydrochloride; Drug
Lead sponsor: Eli Lilly and Company; Industry
Eligibility: 18 Years and older
Enrollment: 286 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2002 – 2003
U.S. locations: 25
States / cities: Peoria, Arizona • Burbank, California • Fresno, California + 22 more

Conditions: Crohn's Disease (CD), Ulcerative Colitis (UC), Inflammatory Bowel Diseases (IBD), Anxiety, Depression
Interventions: Group Psychotherapy Intervention; Behavioral
Lead sponsor: University of Chicago; Other
Eligibility: 18 Years and older
Enrollment: 16 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Adolescent Behavior
Interventions: As Safe As Possible, Brite, Treatment as Usual; Behavioral
Lead sponsor: University of Pittsburgh; Other
Eligibility: 12 Years to 17 Years
Enrollment: 68 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2017
U.S. locations: 2
States / cities: Pittsburgh, Pennsylvania • Dallas, Texas

Conditions: Binge Eating, Depression
Interventions: Duloxetine, Placebo; Drug
Lead sponsor: University of Cincinnati; Other
Eligibility: 18 Years to 65 Years
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2009
U.S. locations: 1
States / cities: Cincinnati, Ohio

Conditions: Chronic Fatigue Syndrome, Anxiety, Depression, Cancer
Interventions: Movement to rhythm; Behavioral
Lead sponsor: Duke University; Other
Eligibility: 25 Years to 65 Years
Enrollment: 17 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: Started 2014
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Depression
Interventions: IPT-AST, Group Counseling; Behavioral
Lead sponsor: Children's Hospital of Philadelphia; Other
Eligibility: 12 Years to 17 Years
Enrollment: 185 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2017
U.S. locations: 2
States / cities: Piscataway, New Jersey • Philadelphia, Pennsylvania

Conditions: Major Depressive Disorder
Interventions: Ropanicant; Drug
Lead sponsor: Suven Life Sciences Limited; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 41 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024
U.S. locations: 10
States / cities: Bellflower, California • Orange, California • Torrance, California + 7 more

Conditions: Subarachnoid Hemorrhage, Cognitive Impairment, Quality of Life, Depression, Anxiety
Interventions: brainHQ by Posit Science; Device
Lead sponsor: DHR Health Institute for Research and Development; Other
Eligibility: 18 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Edinburg, Texas

Conditions: Substance Abuse
Interventions: Family Spirit curriculum; Behavioral
Lead sponsor: Johns Hopkins University; Other
Eligibility: 12 Years to 24 Years
Enrollment: 320 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2002 – 2005
U.S. locations: 5
States / cities: Fort Defiance, Arizona • Tuba City, Arizona • Whiteriver, Arizona + 2 more

Conditions: Suicidal Behaviors, Suicide Ideation, Depression/Anxiety
Interventions: Aviva; Behavioral
Lead sponsor: University of Memphis; Other
Eligibility: 18 Years and older
Enrollment: 400 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2027
U.S. locations: 1
States / cities: Colorado Springs, Colorado

Search by objective public record fields.

Remotely Delivered Programs Targeting COVID-19 Stress-Related Depression and Substance Use

Incomplete Response in Late Life Depression: Getting to Remission (IRL GREY)

A Family Intervention for Adolescent Problem Behavior (AKA Project Alliance 2)

Preventing Depression in Patients With Macular Degeneration

Psilocybin in Chronic Low Back Pain and Depression

Cold and Heat Investigation to Lower Levels of Depression

The Veteran Caregiver Reducing Stress Time (VetCareReST) Study

A Mechanistic Study to Assess a Single Dose of CYB003 in Participants With Depression and Anxiety

Study of the Hypothalmic-Pituitary-Adrenal (HPA) Axis and Its Role in Major Depression

App Delivered Brief Mindfulness Intervention for Surgical Patients

Biomarker-Guided Antidepressant Selection

Nutritional Intervention for College Students With Depression

Cognitive-Behavioral Intervention for Worry, Uncertainty, and Insomnia for Cancer Survivors

Family Nurture Intervention in the NICU

Subject Information and Consent Form F1J-US-HMCB Duloxetine Once-Daily Dosing Versus Placebo in Patients With Major Depression and Pain

Virtual Group Therapy for IBD Patients With Anxiety and Depression

Brief Intervention for Suicide Risk Reduction in High Risk Adolescents

Study of Duloxetine vs Placebo in Treatment of Binge Eating Disorder With Depression

Traditional African Healing Ceremony in a U.S. Population

Depression Prevention Initiative - A Study of Interpersonal Psychotherapy-Adolescent Skills Training (IPT-AST) in School Settings

Study Evaluating Safety and Efficacy of Ropanicant in MDD Patients

Online Spanish Cognitive Intervention Program for Spanish-Speaking Latino/Hispanic Subarachnoid Hemorrhage Patients

Family Spirit Study

Examining the Efficacy of a Digital Therapeutic to Prevent Suicidal Behaviors