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ClinicalTrials.gov public records Last synced Nov 7, 2026, 5:19 AM EST

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Showing 1201–1224 of 4,844 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Depressed Clear all
Terminated Phase 4 Interventional Results available

Postpartum Depression: Transdermal Estradiol Versus Sertraline

NCT00744328
View directory record Official record
Conditions
Postpartum Depression
Interventions
Transdermal Estradiol, Sertraline, Placebo
Drug · Other
Lead sponsor
Northwestern University
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
85 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2013
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 10, 2019 · Synced Nov 7, 2026, 5:19 AM EST
Not yet recruiting Phase 2 Interventional

A Study of the Safety and Exploratory Efficacy of Oral AFA-281 in Patients with Alcohol Use Disorder

NCT06710431
View directory record Official record
Conditions
Alcohol Abuse, Alcohol Abuse/addiction, Anxiety, Pain Threshold, Depression Disorders, Sleep Disorder
Interventions
AFA-281
Drug
Lead sponsor
Afasci Inc
Industry
Eligibility
21 Years to 65 Years
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Nov 29, 2024 · Synced Nov 7, 2026, 5:19 AM EST
Recruiting Not applicable Interventional

Mind-body Resilience Program for Cardiac Arrest Survivors and Their Caregivers: Recovering Together After Cardiac Arrest

NCT07143357
View directory record Official record
Conditions
Emotional Distress, Cardiac Arrest (CA), Anxiety, Depression, Caregivers, Survivorship, Resilience, Mindfulness
Interventions
Recovering Together after Cardiac Arrest 1, Recovering Together after Cardiac Arrest 2
Behavioral · Other
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years and older
Enrollment
84 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
2
States / cities
Boston, Massachusetts • New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 7, 2026 · Synced Nov 7, 2026, 5:19 AM EST
Recruiting Not applicable Interventional

WellPATH-PREVENT: A Mobile Intervention for Middle-Aged and Older Adults Hospitalized for Suicidal Ideation or Attempt

NCT05183230
View directory record Official record
Conditions
Suicide, Attempted, Suicidal Ideation, Depression
Interventions
WellPATH-PREVENT, Optimized WellPATH-PREVENT
Behavioral
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
50 Years to 90 Years
Enrollment
115 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
2
States / cities
New York, New York • White Plains, New York
Source: ClinicalTrials.gov public record
Updated Sep 23, 2026 · Synced Nov 7, 2026, 5:19 AM EST
Completed Phase 2 Interventional

An Investigation of the Antidepressant Efficacy of the 5-HT2A Antagonist, M100907, in Combination With Citalopram in Treatment Resistant Depression

NCT00070694
View directory record Official record
Conditions
Depressive Disorder
Interventions
MDL100.907
Drug
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
Not listed
Enrollment
96 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2004
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 4, 2008 · Synced Nov 7, 2026, 5:19 AM EST
Completed Not applicable Interventional

Mindful Response to Adversity: A Brief Stress Resilience Training

NCT04064372
View directory record Official record
Conditions
Loneliness, Depression
Interventions
Mindful response to adversity brief training, Strengths-based response to adversity brief training
Behavioral
Lead sponsor
Carnegie Mellon University
Other
Eligibility
18 Years and older
Enrollment
114 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 3, 2020 · Synced Nov 7, 2026, 5:19 AM EST
Completed Phase 1Phase 2 Interventional

Pharmacodynamic/Pharmacokinetic Study of AQW051 in Schizophrenia

NCT00825539
View directory record Official record
Conditions
Schizophrenia
Interventions
AQW051, Placebo
Drug
Lead sponsor
Novartis Pharmaceuticals
Industry
Eligibility
18 Years to 60 Years
Enrollment
68 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
7
States / cities
Los Angeles, California • Chicago, Illinois • Baltimore, Maryland + 4 more
Source: ClinicalTrials.gov public record
Updated Dec 24, 2020 · Synced Nov 7, 2026, 5:19 AM EST
Completed Not applicable Interventional Accepts healthy volunteers Results available

Internet and Telephone Support Intervention for Stroke Caregivers

NCT04348851
View directory record Official record
Conditions
Depression, Quality of Life, Recovery of Function, Self Efficacy, Stress
Interventions
Caregiver problem-solving, Attention Control
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
53 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jun 2, 2020 · Synced Nov 7, 2026, 5:19 AM EST
Recruiting No phase listed Observational

Natural History of Depression, Bipolar Disorder and Suicide Risk

NCT06462196
View directory record Official record
Conditions
Behavioral Symptoms, Suicide, Self-Injurious Behavior, Sensory System Agents, Analgesics, Peripheral Nervous System Agents, Physiological Effects of Drugs, Anesthetics, Dissociative, Anesthetics, General, Anesthetics, Central Nervous System Depressants, Excitatory Amino Acid Antagonists, Excitatory Amino Acid Agents, Neurotransmitter Agents, Molecular Mechanisms of Pharmacological Action, Ketamine, Depression, Unipolar, Depressive Symptoms, Treatment Resistant Depression, Major Depressive Disorder, Depression, Bipolar
Interventions
Not listed
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
18 Years to 120 Years
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2030
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Nov 3, 2026 · Synced Nov 7, 2026, 5:19 AM EST
Terminated Not applicable Interventional Results available

Assessment of a Oral Endotracheal Tube Fastener on Patients Intubated With Oral Endotracheal Tubes

NCT02760927
View directory record Official record
Conditions
Respiratory Depression, Respiratory Failure, Ventilatory Depression
Interventions
Endotracheal Tube Fastener
Device
Lead sponsor
Hollister Incorporated
Industry
Eligibility
18 Years and older
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016
U.S. locations
3
States / cities
Gresham, Oregon • Portland, Oregon • Vancouver, Washington
Source: ClinicalTrials.gov public record
Updated Sep 6, 2018 · Synced Nov 7, 2026, 5:19 AM EST
Completed Not applicable Interventional

Taking Time to Connect: A Study of Programs for Hispanic Mothers Diagnosed With Cancer and Their Children

NCT03951454
View directory record Official record
Conditions
Cancer Survivorship
Interventions
Conexiones, Taking Time
Behavioral
Lead sponsor
New Mexico State University
Other
Eligibility
18 Years to 60 Years · Female only
Enrollment
43 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
5
States / cities
Las Cruces, New Mexico • El Paso, Texas • San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Feb 22, 2023 · Synced Nov 7, 2026, 5:19 AM EST
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Imaging SV2A in Mood Disorders

NCT02734602
View directory record Official record
Conditions
Major Depressive Disorder, Post-Traumatic Stress Disorder
Interventions
Ketamine
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years to 70 Years
Enrollment
130 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2027
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jun 8, 2026 · Synced Nov 7, 2026, 5:19 AM EST
Completed No phase listed Observational Accepts healthy volunteers

Assessing Anterior Cingulate Brain Activity in People With Late-Life Depression

NCT00926653
View directory record Official record
Conditions
Depression
Interventions
Escitalopram
Drug
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
60 Years to 85 Years
Enrollment
76 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2010
U.S. locations
1
States / cities
White Plains, New York
Source: ClinicalTrials.gov public record
Updated Aug 11, 2015 · Synced Nov 7, 2026, 5:19 AM EST
Terminated Not applicable Interventional Accepts healthy volunteers

Mindfulness Based Cognitive Therapy (MBCT) During Pregnancy

NCT03809572
View directory record Official record
Conditions
Maternal Psychological Distress, Postpartum Depression, Prenatal Stress
Interventions
Mindfulness Based Cognitive Therapy
Behavioral
Lead sponsor
Oregon Health and Science University
Other
Eligibility
21 Years to 45 Years · Female only
Enrollment
56 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Dec 20, 2021 · Synced Nov 7, 2026, 5:19 AM EST
Completed Not applicable Interventional

A Nature-based Physical Activity Therapy Group for College Students

NCT07399457
View directory record Official record
Conditions
Depression and Anxiety Symptom
Interventions
Moving Naturally Through Challenges group therapy
Behavioral
Lead sponsor
Kansas State University
Other
Eligibility
18 Years and older
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
1
States / cities
Manhattan, Kansas
Source: ClinicalTrials.gov public record
Updated Feb 10, 2026 · Synced Nov 7, 2026, 5:19 AM EST
Completed Not applicable Interventional Accepts healthy volunteers Results available

Screening Wizard- Phase 2

NCT04646369
View directory record Official record
Conditions
Depression, Suicidal Ideation
Interventions
"screening as usual", Screening Wizard 2.0, Screening Wizard 2.0 + SOVA
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
12 Years to 26 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
2
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 7, 2022 · Synced Nov 7, 2026, 5:19 AM EST
Completed Not applicable Interventional

ICU Doulas Providing Psychological Support

NCT03736954
View directory record Official record
Conditions
Illness, Critical, Anxiety, Depression, Post Traumatic Stress Disorder, Cognitive Impairment
Interventions
positive suggestion
Behavioral
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 8, 2022 · Synced Nov 7, 2026, 5:19 AM EST
Not listed Phase 1 Interventional

Motivational and Cognitive Intervention for College Drinkers

NCT01204229
View directory record Official record
Conditions
Alcohol Consumption, Anxiety, Depression
Interventions
Motivational and Cognitive Intervention for Drinkers (MCID), Brief Motivational Intervention (BMI)
Behavioral
Lead sponsor
University of Cincinnati
Other
Eligibility
18 Years to 25 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2010
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 22, 2011 · Synced Nov 7, 2026, 5:19 AM EST
Terminated Not applicable Interventional Results available

Feasibility - Beta Adrenergic Blockade (BB) in Cervical Cancer (CX)

NCT01902966
View directory record Official record
Conditions
Cervical Cancer
Interventions
Propranolol, Diary, Relaxation Audio Recording, Questionnaires
Drug · Behavioral
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2020
U.S. locations
2
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Oct 12, 2021 · Synced Nov 7, 2026, 5:19 AM EST
Completed Not applicable Interventional Accepts healthy volunteers

The Effects of a Life Coaching Seminar on Gratitude and Psychological Well-Being

NCT04172051
View directory record Official record
Conditions
Psychological, Depression, Anxiety, Psychological Stress, Mental Health Wellness 1, Mental Stress, Mental Depression
Interventions
Tony Robbins Date with Destiny
Behavioral
Lead sponsor
Applied Science & Performance Institute
Industry
Eligibility
18 Years to 80 Years
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
3
States / cities
Stanford, California • Tampa, Florida • West Palm Beach, Florida
Source: ClinicalTrials.gov public record
Updated Jul 14, 2020 · Synced Nov 7, 2026, 5:19 AM EST
Enrolling by invitation Not applicable Interventional

Effectiveness of mHealth Post-discharge Intervention for Patients With Severe Mental Illness

NCT05703412
View directory record Official record
Conditions
Bipolar Disorder, Major Depression, Schizophrenia
Interventions
Transition-FOCUS mHealth Intervention, Check-In
Behavioral
Lead sponsor
Butler Hospital
Other
Eligibility
18 Years and older
Enrollment
180 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Sep 29, 2026 · Synced Nov 7, 2026, 5:19 AM EST
Completed Phase 2 Interventional Results available

Omega-3 for Depression and Other Cardiac Risk Factors - 2

NCT02021669
View directory record Official record
Conditions
Depression
Interventions
Omega-3 supplement, Placebo
Drug
Lead sponsor
Washington University School of Medicine
Other
Eligibility
25 Years and older
Enrollment
144 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Sep 4, 2019 · Synced Nov 7, 2026, 5:19 AM EST
Completed No phase listed Observational Accepts healthy volunteers

Mechanisms of Anxiety and Depression Study

NCT03135756
View directory record Official record
Conditions
Depression, Anxiety
Interventions
Not listed
Lead sponsor
Palo Alto University
Other
Eligibility
18 Years to 55 Years
Enrollment
63 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2018
U.S. locations
2
States / cities
Los Altos, California • Stanford, California
Source: ClinicalTrials.gov public record
Updated May 11, 2018 · Synced Nov 7, 2026, 5:19 AM EST
Completed Not applicable Interventional

Cognitive Behavioral Therapy for the Treatment of Depression-Related Insomnia

NCT00255905
View directory record Official record
Conditions
Depression
Interventions
Cognitive behavioral therapy (CBT) for insomnia, Clinician monitoring
Behavioral
Lead sponsor
University of Rochester
Other
Eligibility
25 Years to 65 Years
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2007
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Jun 28, 2013 · Synced Nov 7, 2026, 5:19 AM EST