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ClinicalTrials.gov public records Last synced Nov 7, 2026, 8:46 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1417–1440 of 4,844 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Depressed Clear all

Conditions: Obesity, Hypertension, Hyperlipidemia, Depression
Interventions: Self-care CVD risk reduction, Referral to primary care provider for CVD risk management; Behavioral · Other
Lead sponsor: Debra Moser; Other
Eligibility: 21 Years and older
Enrollment: 330 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2016
U.S. locations: 1
States / cities: Lexington, Kentucky

Conditions: Anxiety Disorder, Breast Cancer, Depression, Fatigue, Hot Flashes, Pain, Sleep Disorders
Interventions: acupuncture therapy, sham intervention; Procedure
Lead sponsor: University of Maryland, Baltimore; Other
Eligibility: 18 Years and older · Female only
Enrollment: 51 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2011
U.S. locations: 2
States / cities: Baltimore, Maryland

Conditions: PTSD, Depression, Substance Use Disorder, Traumatic Brain Injury
Interventions: WEB-ED+ Treatment Arm; Behavioral
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: Not listed
Enrollment: 1,312 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2023
U.S. locations: 1
States / cities: Iowa City, Iowa

Conditions: Depression, Anxiety, Cancer
Interventions: Beating the Blues (BtB), Entertain Me Well (EMW), Coaching; Behavioral
Lead sponsor: University of Michigan Rogel Cancer Center; Other
Eligibility: 15 Years to 25 Years
Enrollment: 9 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2021
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Major Depressive Disorder
Interventions: Transcranial Magnetic Stimulation; Device
Lead sponsor: Washington University School of Medicine; Other
Eligibility: 18 Years to 50 Years
Enrollment: 4 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2013
U.S. locations: 1
States / cities: St Louis, Missouri

Conditions: Major Depression With Psychotic Features
Interventions: quetiapine; Drug
Lead sponsor: Rush University Medical Center; Other
Eligibility: 18 Years to 75 Years
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2007
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Schizophrenia, Schizoaffective Disorder, Major Depression, Bipolar Disorder, Anxiety Disorder
Interventions: Thinking Skills for Work Program, Supported Employment; Behavioral
Lead sponsor: Dartmouth-Hitchcock Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 110 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2011
U.S. locations: 2
States / cities: Chicago, Illinois • Manchester, New Hampshire

Conditions: Alcohol Use Disorder, Inflammatory Response, Craving, Depressed Mood
Interventions: Placebo, Endotoxin; Drug · Biological
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 21 Years to 45 Years
Enrollment: 20 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Depression, Alcohol Use
Interventions: Integrated Cognitive Behavioral Therapy, Standard Care; Behavioral
Lead sponsor: Brown University; Other
Eligibility: 12 Years to 18 Years
Enrollment: 114 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2017
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Postoperative Complications
Interventions: Alaris ETCO2 monitor - cont. resp. rate, & apnea events; Device
Lead sponsor: Texas Health Resources; Other
Eligibility: 18 Years and older
Enrollment: 60 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2006 – 2007
U.S. locations: 1
States / cities: Dallas, Texas

Conditions: Depression, Anxiety, Post-traumatic Stress Disorder
Interventions: Not listed
Lead sponsor: Boston Children's Hospital; Other
Eligibility: 6 Years to 20 Years
Enrollment: 166 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2010
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Depressive Disorder, Major
Interventions: Esketamine, Aripiprazole; Drug
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years to 74 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023
U.S. locations: 26
States / cities: Tuscaloosa, Alabama • Phoenix, Arizona • Little Rock, Arkansas + 22 more

Conditions: Depression, Stress, Conflict Resolution
Interventions: Internet-based psychological support; Behavioral
Lead sponsor: Dartmouth-Hitchcock Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 500 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2031
U.S. locations: 1
States / cities: Lebanon, New Hampshire

Conditions: Cancer Diagnosis, Non-Metastatic Neoplasm, Anxiety, Anxiety Disorders, Depression, Depressive Disorder, Depression, Anxiety, Desmoid
Interventions: Promoting Resilience in Stress Management Program; Behavioral
Lead sponsor: Dana-Farber Cancer Institute; Other
Eligibility: 18 Years to 39 Years
Enrollment: 13 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: Brighton, Massachusetts

Conditions: Depression
Interventions: Not listed
Lead sponsor: Duke University; Other
Eligibility: 13 Years and older
Enrollment: 35 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2026
U.S. locations: 1
States / cities: Nashville, Tennessee

Conditions: Depression - Major Depressive Disorder, Older Adults (65 Years and Older), Behavioral Activation Treatment, Virtual Reality Therapy
Interventions: VR-Enhanced BA; Behavioral
Lead sponsor: Stanford University; Other
Eligibility: 65 Years and older
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Stanford, California

Conditions: Depression, Spinal Cord Injuries
Interventions: Acceptance and commitment therapy (ACT); Behavioral
Lead sponsor: University of South Florida; Other
Eligibility: 18 Years and older
Enrollment: 137 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: Tampa, Florida

Conditions: Bipolar Disorder NOS
Interventions: Interpersonal and social rhythm therapy; Other
Lead sponsor: University of Pittsburgh; Other
Eligibility: 18 Years to 65 Years
Enrollment: 16 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2014
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Depression, Alcoholism, Drug Abuse
Interventions: Interpersonal and Social Rhythm Therapy (ISRT), Bipolar-Specific Cognitive Behavioral Therapy (CBT), Mindfulness-Based Stress Reduction (MBSR), Psycho-education & Understanding Bipolar Medications Therapy; Behavioral
Lead sponsor: Emory University; Other
Eligibility: 18 Years to 64 Years
Enrollment: 130 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2026
U.S. locations: 1
States / cities: Atlanta, Georgia

Conditions: Depression, Mood, Sleep, Physical Activity
Interventions: Intern Health Study behavioral change mobile notification; Behavioral
Lead sponsor: University of Michigan; Other
Eligibility: 18 Years and older
Enrollment: 2,562 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Treatment Resistant Depression
Interventions: Neuro-navigated Transcranial Magnetic Stimulation (TMS); Device
Lead sponsor: Soterix Medical; Industry
Eligibility: 18 Years to 60 Years
Enrollment: 22 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2025
U.S. locations: 1
States / cities: Woodbridge, New Jersey

Conditions: Depressive Disorder, Major, Depression
Interventions: Non-Invasive Transcranial Focused Ultrasound; Device
Lead sponsor: University of Arizona; Other
Eligibility: 18 Years to 50 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2024
U.S. locations: 1
States / cities: Tucson, Arizona

Conditions: Major Depressive Disorder
Interventions: Sertraline; Drug
Lead sponsor: Mclean Hospital; Other
Eligibility: 55 Years to 89 Years
Enrollment: 43 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2004 – 2008
U.S. locations: 1
States / cities: Belmont, Massachusetts

Conditions: Bipolar Depression
Interventions: Lamotrigine; Drug
Lead sponsor: Mclean Hospital; Other
Eligibility: 60 Years and older
Enrollment: 69 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2006 – 2011
U.S. locations: 1
States / cities: Belmont, Massachusetts

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Improving Heart Health in Appalachia

Acupuncture in Reducing Muscle and Bone Symptoms in Women Receiving Letrozole, Exemestane, or Anastrozole for Stage 0, Stage I, Stage II, or Stage III Breast Cancer

Online and Shared Decision-Making Interventions to Engage Service Men and Women in Post-Deployment Mental Health Care

Evaluating a Tailored Cognitive Behavioral Therapy for Adolescent and Young Adult Cancer Patients

Repetitive Transcranial Magnetic Stimulation for Treating Depression: A Functional Magnetic Resonance Imaging Study

Treatment of Depression With Quetiapine

Thinking Skills for Work in Severe Mental Illness

An Inflammatory Challenge Using Endotoxin

Community-Based Integrated Treatment for Adolescents

Application of Capnography Monitoring on the General Care Nursing Unit

The Implantable Cardioverter-defibrillators (ICD)/Device Expectations, Adaptations, and Successes Study

VA Aripiprazole vs Esketamine for Treatment Resistant Depression

Internet Based Psychological Support

PRISM for Depression and Anxiety in Young Adults With Cancer

Latino Teen Depression Treatment Study

Virtual Reality-Enhanced Behavioral Activation for Older Adults With Depression

Acceptance and Commitment Therapy for Depressed People With Spinal Cord Injuries

Pilot Study of Interpersonal and Social Rhythm Therapy for Subthreshold Bipolar

Suicidal Behavior in Patients Diagnosed With Bipolar Disorder

Intern Health Study 2022 and 2023

Virtual Neuro-Navigation System for Personalized Community Based TMS

Altering Default Mode Network Activity With Transcranial Focused Ultrasound to Reduce Depressive Symptoms

Magnetic Resonance Imaging Study of Geriatric Depression

Lamotrigine Therapy in Geriatric Bipolar Depression