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ClinicalTrials.gov public records Last synced Nov 7, 2026, 9:51 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1537–1560 of 4,844 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Depressed Clear all

Conditions: Major Depression, PTSD
Interventions: System level depression care quality improvement; Procedure
Lead sponsor: US Department of Veterans Affairs; Federal
Eligibility: 18 Years and older
Enrollment: 750 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2003 – 2006
U.S. locations: 3
States / cities: Sepulveda, California • Cleveland, Ohio • Seattle, Washington

Conditions: Major Depressive Episode
Interventions: Text Messaging Intervention; Other
Lead sponsor: University of Massachusetts, Worcester; Other
Eligibility: 16 Years to 45 Years · Female only
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: Worcester, Massachusetts

Conditions: Major Depressive Disorder, Bipolar Disorder, Healthy
Interventions: [18F]FPEB, [11C]APP311; Radiation
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 80 Years
Enrollment: 79 participants
Timeline: 2017 – 2024
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Depression / Major Depressive Disorder, Mood, Sleep, Physical Activity
Interventions: Intern Health Study behavioral change mobile notification; Behavioral
Lead sponsor: University of Michigan; Other
Eligibility: 18 Years and older
Enrollment: 1,000 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Sleep, Sleep Disturbance, Insufficient Sleep
Interventions: SPP, Sleep Psychoeducation; Behavioral
Lead sponsor: University of Pittsburgh; Other
Eligibility: 12 Years to 18 Years
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Major Depressive Disorder, Major Depressive Disorder, Recurrent, Major Depressive Disorder, Remitted
Interventions: Not listed
Lead sponsor: Mayo Clinic; Other
Eligibility: 13 Years to 21 Years
Enrollment: 57 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2017
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Suicidal Ideation
Interventions: Transdermal Estradiol + Placebo, Oral Micronized Progesterone + Placebo, Placebos; Drug
Lead sponsor: University of Illinois Chicago; Other
Eligibility: 18 Years to 45 Years · Female only
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2021
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Depression
Interventions: organized care program for chronic or recurrent depression; Behavioral
Lead sponsor: Kaiser Permanente; Other
Eligibility: 18 Years and older
Enrollment: 302 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: Started 2009
U.S. locations: 2
States / cities: Seattle, Washington

Conditions: Major Depressive Disorder, Alcohol Abuse, Alcohol Dependence
Interventions: acamprosate, escitalopram, Medical management, Placebo; Drug · Behavioral
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years to 64 Years
Enrollment: 23 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2010
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Concussion (Diagnosis), Concussion, Mild Traumatic Brain Injury, Treatment, Sleep Health, Depression, Anxiety
Interventions: Sleep Intervention; Behavioral
Lead sponsor: University of Colorado, Denver; Other
Eligibility: 10 Years to 19 Years
Enrollment: 54 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Aurora, Colorado

Conditions: Anxiety, Depression, Hematopoietic and Lymphatic System Neoplasm, Metastatic Malignant Solid Neoplasm
Interventions: Psychotherapy, Psilocybin, Survey Administration; Behavioral · Drug · Other
Lead sponsor: University of Washington; Other
Eligibility: 18 Years to 85 Years
Enrollment: 16 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Cancer, Depression
Interventions: Behavioral Activation Therapy App, Telehealth Delivered Behavioral Activation; Behavioral
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years and older
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Treatment Resistant Depression
Interventions: ALA-3000, Placebo, escitalopram, sertraline, duloxetine or venlafaxine XR; Drug
Lead sponsor: Alar Pharmaceuticals Inc.; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 37 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025
U.S. locations: 4
States / cities: Little Rock, Arkansas • St Louis, Missouri • Eatontown, New Jersey + 1 more

Conditions: Parkinson's Disease, Depression
Interventions: Repetitive transcranial magnetic stimulation (rTMS); Device
Lead sponsor: Beth Israel Deaconess Medical Center; Other
Eligibility: 21 Years to 85 Years
Enrollment: 61 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2014
U.S. locations: 5
States / cities: Los Angeles, California • Gainesville, Florida • Boston, Massachusetts + 2 more

Conditions: HIV, Depression, HIV Infections
Interventions: Cognitive behavioral therapy (CBT) for adherence and depression (CBT-AD), Life-steps adherence treatment, Information and supportive psychotherapy (ISP) for adherence and depression (ISP-AD); Behavioral
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years and older
Enrollment: 240 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2013
U.S. locations: 4
States / cities: Boston, Massachusetts • Providence, Rhode Island

Conditions: Depression
Interventions: Sertraline; Drug
Lead sponsor: University of Pittsburgh; Other
Eligibility: 18 Years to 45 Years · Female only
Enrollment: 300 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2003 – 2006
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Depression
Interventions: telephone depression care management; Behavioral
Lead sponsor: Butler Hospital; Other
Eligibility: 18 Years to 65 Years
Enrollment: 38 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2008
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Major Depressive Disorder, Recurrent
Interventions: TMS positively correlated DLPFC, TMS to negatively correlated DLPFC; Device · Procedure
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years to 50 Years
Enrollment: 45 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2018
U.S. locations: 1
States / cities: Charlestown, Massachusetts

Conditions: Dementia, Alzheimer Disease (AD), Depression Chronic, Caregiver Burden of People With Dementia, Cognitive Impairments
Interventions: Receptive Music Therapy; Behavioral
Lead sponsor: Florida SouthWestern State College; Other
Eligibility: 25 Years to 90 Years
Enrollment: 25 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022
U.S. locations: 1
States / cities: Fort Myers, Florida

Conditions: Hiv, Depression in Old Age, Isolation, Social, Aging
Interventions: Virtual Village; Other
Lead sponsor: University of California, Riverside; Other
Eligibility: 50 Years and older
Enrollment: 80 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Riverside, California

Conditions: Major Depressive Disorder
Interventions: GeneSight Psychotropic test, Canadian Network for Mood and Anxiety Treatment (CANMAT) Best Practice Guidelines; Other
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years to 65 Years
Enrollment: 201 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2022
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Anxiety, Depression
Interventions: PARTNER II; Behavioral
Lead sponsor: University of Pittsburgh; Other
Eligibility: 18 Years and older
Enrollment: 848 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2019
U.S. locations: 2
States / cities: Erie, Pennsylvania • Pittsburgh, Pennsylvania

Conditions: Depressive Disorder
Interventions: Saredutant succinate (SR48968C); Drug
Lead sponsor: Sanofi; Industry
Eligibility: 18 Years to 64 Years
Enrollment: 460 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2007
U.S. locations: 1
States / cities: Bridgewater, New Jersey

Conditions: End Stage Renal Disease, Sexual Dysfunction, Physiological, Pain, Depression
Interventions: Symptom management nurse intervention, Feedback intervention; Behavioral
Lead sponsor: US Department of Veterans Affairs; Federal
Eligibility: 18 Years and older
Enrollment: 315 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2012
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

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Evaluation Study of TIDES Depression Care Quality Improvement Intervention

A Text Messaging Intervention to Reduce Perinatal Depression Risk

Imaging mGluR5 and Synaptic Density in Psychiatric Disorders

Intern Health Study 2026

Sleep Promotion Program Primary Care

Glutamate Probes in Adolescent Depression

Unique Effects of Perimenstrual Estradiol or Progesterone Supplementation on Perimenstrual Suicidality

Organized Self-Management Support Services for Chronic Depression

Acamprosate Added to Escitalopram and Behavioral Treatment for Comorbid Depression and Alcoholism

Multidimensional Sleep Health Intervention to Optimize Concussion Recovery

Group Retreat Psilocybin Therapy for the Treatment of Anxiety and Depression in Patients With Metastatic Solid Tumors or Incurable Hematologic Malignancies

Optimizing Care for Cancer Survivors With Depression: Project 3

Multiple Ascending Dose Phase 1 Study of ALA-3000

rTMS for Motor and Mood Symptoms of Parkinson's Disease

Therapy Targeting Depression and HIV Treatment Adherence (The TRIAD Study)

Sertraline for the Prevention of Recurrent Postpartum Depression

Culturally Sensitive Depression Care Management for Latino Primary Care Patients

Investigation of Brain Network Dynamics in Depression

Impact of Musical Therapeutic Intervention on Depression in Dementia Patients and Caregiver Burden

Creating a Virtual Village for People Aging With HIV During COVID-19

Comparative Effectiveness of Pharmacogenomics for Treatment of Depression

PARTNER II: Improving Patient and Family Centered Care in Advanced Critical Illness

An Eight-week Study to Evaluate the Efficacy and Safety of Saredutant in Patients With Depression

Pain, Sexual Dysfunction, and Depression in Hemodialysis Patients