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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Depression/Anxiety Clear all
Recruiting Phase 1Phase 2 Interventional

Acceptance and Commitment Therapy for Adolescents and Young Adults With Sickle Cell Disease

NCT05685368
View directory record Official record
Conditions
Race-related Stress, Depression, Anxiety, Quality of Life, Stress Reaction
Interventions
ACT for SCD
Behavioral
Lead sponsor
Children's Hospital Los Angeles
Other
Eligibility
14 Years to 21 Years
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated May 5, 2026 · Synced Sep 24, 2026, 1:24 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Strategies for Coping With Negative Thoughts

NCT05566691
View directory record Official record
Conditions
Depressive Symptoms, Anxiety, Negative Thinking
Interventions
Positive thinking, Positive thinking + Mood induction, Thought reevaluation, Thought reevaluation + Mood induction
Other
Lead sponsor
Ohio State University
Other
Eligibility
18 Years and older
Enrollment
301 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 8, 2023 · Synced Sep 24, 2026, 1:24 PM EDT
Completed Not applicable Interventional

Evaluating a Novel Method of Generalizing Emotion Regulation

NCT01653548
View directory record Official record
Conditions
Problems With Emotion Regulation, Psychological Distress, Difficulties Coping With Negative Emotions, Anxiety, Depression, Borderline Personality Disorder
Interventions
Habituation Reminder Training, Habituation Reminder, Habituation
Behavioral
Lead sponsor
Duke University
Other
Eligibility
18 Years to 55 Years
Enrollment
372 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 22, 2016 · Synced Sep 24, 2026, 1:24 PM EDT
Not yet recruiting Not applicable Interventional

Identification of Depressive and Anxiety Symptoms Among a Sample of Emergency Department Patients Using Artificial Intelligence (AI) Technology

NCT06473558
View directory record Official record
Conditions
Artificial Intelligence (AI)
Interventions
Biometrics (or AI Biomaker)
Device
Lead sponsor
University Hospitals Cleveland Medical Center
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027 – 2028
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 14, 2026 · Synced Sep 24, 2026, 1:24 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Clinical Research Study to Evaluate Selegiline in the Treatment of Borderline Personality Disorder

NCT01912391
View directory record Official record
Conditions
Borderline Personality Disorder
Interventions
Selegiline, Placebo (for Selegiline)
Drug
Lead sponsor
Mood and Anxiety Research, Inc
Other
Eligibility
18 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2015
U.S. locations
1
States / cities
Fresno, California
Source: ClinicalTrials.gov public record
Updated Oct 7, 2015 · Synced Sep 24, 2026, 1:24 PM EDT
Completed Not applicable Interventional

Treatment Study for Non-Suicidal Self-Injury

NCT02060448
View directory record Official record
Conditions
Self Injurious Behavior Without Suicidal Intent
Interventions
Emotion awareness training, Cognitive reappraisal
Behavioral
Lead sponsor
Boston University Charles River Campus
Other
Eligibility
18 Years and older
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 20, 2017 · Synced Sep 24, 2026, 1:24 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Digital Data in Mental Health Therapy

NCT04011540
View directory record Official record
Conditions
Depressive Symptoms, Anxiety Generalized
Interventions
Digital data
Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 80 Years
Enrollment
115 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 27, 2024 · Synced Sep 24, 2026, 1:24 PM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

A Study Examining Adolescents With Non-Suicidal Self-Injury

NCT02947308
View directory record Official record
Conditions
Self-Injurious Behavior, Deliberate Self-Harm
Interventions
Not listed
Lead sponsor
University of Minnesota
Other
Eligibility
12 Years to 16 Years · Female only
Enrollment
168 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2023
U.S. locations
3
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 16, 2026 · Synced Sep 24, 2026, 1:24 PM EDT
Enrolling by invitation No phase listed Observational

Mental Health, Intellectual and Neurodevelopmental Disorder Detection With Artificial Intelligence Models

NCT06792175
View directory record Official record
Conditions
Autism Spectrum Disorder, Depression - Major Depressive Disorder, Anxiety, Generalized, Bipolar Disorder (BD), Attention Deficit Hyperactivity Disorder (ADHD), Schizophrenia Spectrum &Amp; Other Psychotic Disorders, Post Traumatic Stress Disorder, Obsessive Compulsive Disorder (OCD)
Interventions
Solicue Machine Learning Models, Mercuria Machine Learning Models
Diagnostic Test
Lead sponsor
Psyrin Inc.
Industry
Eligibility
13 Years to 60 Years
Enrollment
500 participants
Timeline
2025 – 2026
U.S. locations
2
States / cities
Brookline, Massachusetts • Zanesville, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 2, 2025 · Synced Sep 24, 2026, 1:24 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Growth Mindset Psychoeducation for Modifiable Risk Factors for CMD

NCT03707522
View directory record Official record
Conditions
Depression, Anxiety
Interventions
Growth mindset, Modifiable risk factor (MRF) information, Control
Behavioral
Lead sponsor
University of Nevada, Reno
Other
Eligibility
18 Years to 65 Years
Enrollment
162 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Reno, Nevada
Source: ClinicalTrials.gov public record
Updated Aug 11, 2019 · Synced Sep 24, 2026, 1:24 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Improving Physical and Psychosocial Well-being of African American Older Adults

NCT03716037
View directory record Official record
Conditions
Physical Activity, Psychosocial Stressors
Interventions
Physical Activity for Life (PAL)
Other
Lead sponsor
University of Alabama, Tuscaloosa
Other
Eligibility
65 Years to 100 Years
Enrollment
41 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Uniontown, Alabama
Source: ClinicalTrials.gov public record
Updated May 28, 2024 · Synced Sep 24, 2026, 1:24 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Mindfulness and Meditation Based Lactation Education on Maternal Breastmilk in the Neonatal ICU

NCT07351799
View directory record Official record
Conditions
Lactation, Mindfulness, NICU, Breastmilk, Neonatal, Meditation, Pumping, Breast, Cortisol, Oxytocin, Anxiety, Depression
Interventions
Standard of Care, Mindfulness-based Intervention
Behavioral
Lead sponsor
Mayo Clinic
Other
Eligibility
20 Years and older · Female only
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 19, 2026 · Synced Sep 24, 2026, 1:24 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effect of SKY Breath Meditation on Health and Well-being

NCT05523414
View directory record Official record
Conditions
Stress, Stress, Psychological, Stress, Physiological, Anxiety, Mental Well Being, Happiness, Resilience
Interventions
SKY
Behavioral
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
21 Years to 99 Years
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Mar 1, 2026 · Synced Sep 24, 2026, 1:24 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Ascertaining Diagnosis Classification With Elicited Speech

NCT05601063
View directory record Official record
Conditions
Schizophrenia Spectrum and Other Psychotic Disorders, Bipolar and Related Disorders, Depressive Disorder, Anxiety Disorders, Personality Disorders, Attention Deficit Hyperactivity Disorder
Interventions
Winterlight Speech Assessment
Behavioral
Lead sponsor
Northwell Health
Other
Eligibility
14 Years to 50 Years
Enrollment
255 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Glen Oaks, New York
Source: ClinicalTrials.gov public record
Updated Oct 31, 2022 · Synced Sep 24, 2026, 1:24 PM EDT
Completed Early Phase 1 Interventional Results available

Caffeine and Neurologic Recovery Following Surgery and General Anesthesia

NCT03577730
View directory record Official record
Conditions
Pain, Postoperative
Interventions
Caffeine Citrate, Dextrose Water
Drug
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
71 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Oct 5, 2021 · Synced Sep 24, 2026, 1:24 PM EDT
Not listed Phase 1Phase 2 Interventional Accepts healthy volunteers

Evaluation of Re-Entry Values and Mindfulness Program (REVAMP) With Jail Inmates

NCT01378923
View directory record Official record
Conditions
Impulsive Behavior, Substance Abuse, HIV Risk Behavior, Anxiety, Depression, Criminogenic Thinking
Interventions
REVAMP, TAU
Behavioral
Lead sponsor
George Mason University
Other
Eligibility
18 Years and older · Male only
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2013
U.S. locations
1
States / cities
Fairfax, Virginia
Source: ClinicalTrials.gov public record
Updated May 6, 2013 · Synced Sep 24, 2026, 1:24 PM EDT
Recruiting Not applicable Interventional

Family Spirit Strengths

NCT05836090
View directory record Official record
Conditions
Depressive Symptoms, Anxiety Disorders and Symptoms, Substance Use, Mental Health Issue
Interventions
Family Spirit Strengths (FSS), Family Spirit Nurture
Behavioral
Lead sponsor
Johns Hopkins Bloomberg School of Public Health
Other
Eligibility
14 Years and older · Female only
Enrollment
188 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
3
States / cities
Chinle, Arizona • Pokagon, Michigan • Shiprock, New Mexico
Source: ClinicalTrials.gov public record
Updated Apr 12, 2026 · Synced Sep 24, 2026, 1:24 PM EDT
Completed No phase listed Observational

Biobehavioral Correlates of Cancer-related Cognitive Dysfunction and Its Co-occurring Symptoms

NCT04611620
View directory record Official record
Conditions
Survivorship, Cognitive Dysfunction, Pain, Depression, Anxiety, Fatigue, Sleep Disturbance
Interventions
Cognitive Dysfunction
Behavioral
Lead sponsor
Indiana University
Other
Eligibility
21 Years and older
Enrollment
682 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Feb 21, 2023 · Synced Sep 24, 2026, 1:24 PM EDT
Terminated Phase 3 Interventional Results available

Quetiapine Extended Release (XR) Treatment of Major Depressive Disorder With Comorbid Generalized Anxiety Disorder

NCT00868374
View directory record Official record
Conditions
Major Depressive Disorder, Generalized Anxiety Disorder
Interventions
Quetiapine XR, Placebo
Drug
Lead sponsor
Keming Gao
Other
Eligibility
18 Years to 70 Years
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Dec 28, 2016 · Synced Sep 24, 2026, 1:24 PM EDT
Completed Not applicable Interventional

Acute Psychiatric Care at Home for Lower-risk Patients With Acute Psychiatric Illness Who Require Inpatient Care

NCT07364825
View directory record Official record
Conditions
Psychosis, Anxiety, Depression, Behavioral and Psychiatric Symptoms of Dementia
Interventions
Behavioral Health Home Hospital
Other
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years and older
Enrollment
41 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
4
States / cities
Belmont, Massachusetts • Boston, Massachusetts • Jamaica Plain, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 6, 2026 · Synced Sep 24, 2026, 1:24 PM EDT
Completed Not applicable Interventional

Randomized Controlled Trial of Virtual Reality Assisted Guided Imagery (VRAGI) for Pain in Advanced Cancer Patients.

NCT05348174
View directory record Official record
Conditions
Cancer Pain, Oncology, Virtual Reality, Depression, Anxiety
Interventions
Virtual Reality Assisted Guided Imagery (VRAGI)
Behavioral
Lead sponsor
Prisma Health-Upstate
Other
Eligibility
18 Years to 65 Years
Enrollment
41 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
3
States / cities
Clemson, South Carolina • Columbia, South Carolina • Greenville, South Carolina
Source: ClinicalTrials.gov public record
Updated Mar 18, 2025 · Synced Sep 24, 2026, 1:24 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Latent Structure of Multi-level Assessments and Predictors of Outcomes in Psychiatric Disorders

NCT02450240
View directory record Official record
Conditions
Depression, Anxiety, Eating Disorders, Drug Use Disorders
Interventions
standardized diagnostic assessment, self-report questionnaires, behavioral tasks, physiological measurements, structural and functional magnetic resonance imaging and EEG, biomarker and microbiome assessments, blood to derive induced pluripotent stem cells, genetic and epigenetic assessments
Behavioral · Other
Lead sponsor
Laureate Institute for Brain Research, Inc.
Other
Eligibility
18 Years to 55 Years
Enrollment
1,271 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2020
U.S. locations
1
States / cities
Tulsa, Oklahoma
Source: ClinicalTrials.gov public record
Updated Jul 6, 2020 · Synced Sep 24, 2026, 1:24 PM EDT
Completed Not applicable Interventional

A Tailored and Digital Approach to Address Equity and Support Well-being for Healthcare Workers in the Era of COVID

NCT05931432
View directory record Official record
Conditions
Depression, Anxiety, Satisfaction, Well-being
Interventions
Comprehensive Well-Being Intervention
Other
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
293 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 7, 2026 · Synced Sep 24, 2026, 1:24 PM EDT
Completed Not applicable Interventional

BBTI vs PSR in Musculoskeletal Orofacial Pain Adults

NCT04897581
View directory record Official record
Conditions
Myofascial Pain, Myalgia
Interventions
Brief Behavioral Therapy for Insomnia, BBTI, Physical Self-Regulation, PSR
Behavioral
Lead sponsor
Ian Boggero, PhD
Other
Eligibility
18 Years and older
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Jun 16, 2026 · Synced Sep 24, 2026, 1:24 PM EDT