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ClinicalTrials.gov public records Last synced Oct 12, 2026, 4:37 PM EDT

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Showing 217–240 of 245 matching trials from the live ClinicalTrials.gov search.
Filters: "digital intervention" Condition: Depression Clear all
Recruiting Not applicable Interventional

The Oh Happy Day Class - Digital Connections (OHDC-DC): A Pilot Study

NCT06206226
View directory record Official record
Conditions
Depression, Depressive Disorder, Depressive Symptoms
Interventions
OHDC-DC
Behavioral
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Sep 29, 2026 · Synced Oct 12, 2026, 4:37 PM EDT
Completed Phase 3 Interventional Results available

Active Reference (Fluoxetine) Fixed-dose Study of Vortioxetine in Paediatric Patients Aged 12 to 17 Years With Major Depressive Disorder (MDD)

NCT02709746
View directory record Official record
Conditions
Depressive Disorder, Major
Interventions
Vortioxetine 10 mg/day, Vortioxetine 20 mg/day, Fluoxetine 20 mg/day, Placebo
Drug · Other
Lead sponsor
H. Lundbeck A/S
Industry
Eligibility
12 Years to 17 Years
Enrollment
784 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
42
States / cities
Dothan, Alabama • Tucson, Arizona • Little Rock, Arkansas + 37 more
Source: ClinicalTrials.gov public record
Updated Aug 19, 2020 · Synced Oct 12, 2026, 4:37 PM EDT
Completed Not applicable Interventional

LoveYourBrain Yoga for Multiple Sclerosis

NCT03827928
View directory record Official record
Conditions
Multiple Sclerosis
Interventions
Yoga/meditation
Behavioral
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
Lebanon, New Hampshire
Source: ClinicalTrials.gov public record
Updated Feb 5, 2020 · Synced Oct 12, 2026, 4:37 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Glucose Variability and Cognition in Prediabetes

NCT04201600
View directory record Official record
Conditions
Glucose Metabolism Disorders (Including Diabetes Mellitus), Cognitive Decline, Functional Status, PreDiabetes, Aging, Depression
Interventions
Continuous Glucose Monitoring System (CGMS)
Device
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
50 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 30, 2025 · Synced Oct 12, 2026, 4:37 PM EDT
Terminated Not applicable Interventional

Digital Therapeutic for Adolescent Depressive Symptoms in Cardiology and Gastroenterology

NCT05461599
View directory record Official record
Conditions
Depressive Symptoms, Major Depressive Disorder, Depression, Cardiology, Gastrointestinal Diseases, Depressive Disorder, Depressive Episode, Adolescent Behavior, Adolescent - Emotional Problem
Interventions
SparkRx Mobile App
Device
Lead sponsor
Limbix Health, Inc.
Industry
Eligibility
13 Years to 22 Years
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated May 19, 2023 · Synced Oct 12, 2026, 4:37 PM EDT
Recruiting Not applicable Interventional

SUpport From PEeRs to Expand Access Study - Community

NCT07186816
View directory record Official record
Conditions
Depression, Anxiety
Interventions
Behavioral: Supported dCBT, Behavioral: Unsupported dCBT
Device
Lead sponsor
University of California, Berkeley
Other
Eligibility
18 Years to 100 Years
Enrollment
213 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Sep 22, 2025 · Synced Oct 12, 2026, 4:37 PM EDT
Completed Not applicable Interventional Results available

Home-based tDCS in Major Depressive Disorder

NCT04799405
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
tDCS
Device
Lead sponsor
Hebrew SeniorLife
Other
Eligibility
50 Years and older
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 24, 2022 · Synced Oct 12, 2026, 4:37 PM EDT
Terminated Phase 4 Interventional Results available

A Trial to Measure the Difference in All-cause Hospitalizations for Participants Who Are Using Abilify MyCite Versus Virtual Matched Controls in Adults With Schizophrenia, Bipolar 1 Disorder, and Major Depressive Disorder

NCT03643159
View directory record Official record
Conditions
Schizophrenia, Bipolar 1 Disorder, Major Depressive Disorder
Interventions
Abilify MyCite - Digital Medicine System, Aripiprazole or other oral antipsychotics
Combination Product · Drug
Lead sponsor
Otsuka Pharmaceutical Development & Commercialization, Inc.
Industry
Eligibility
18 Years to 63 Years
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018
U.S. locations
5
States / cities
Santa Rosa, California • Decatur, Georgia • Smyrna, Georgia + 2 more
Source: ClinicalTrials.gov public record
Updated Nov 8, 2019 · Synced Oct 12, 2026, 4:37 PM EDT
Completed Not applicable Interventional Results available

Study of a PST-Trained Voice-Enabled Artificial Intelligence Counselor(SPEAC) for Adults With Emotional Distress (Phase 2)

NCT05603923
View directory record Official record
Conditions
Depression, Anxiety
Interventions
Lumen Coached PST Intervention., Human Coached PST Intervention., Optional (delayed) Lumen Coached PST (Waitlist control).
Behavioral
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
2
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 23, 2026 · Synced Oct 12, 2026, 4:37 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Digital Data in Mental Health Therapy

NCT04011540
View directory record Official record
Conditions
Depressive Symptoms, Anxiety Generalized
Interventions
Digital data
Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 80 Years
Enrollment
115 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 28, 2024 · Synced Oct 12, 2026, 4:37 PM EDT
Recruiting Not applicable Interventional

Cognitive Rehabilitation for Veterans With MDD-related Cognitive Functioning Deficits

NCT06728774
View directory record Official record
Conditions
Major Depressive Disorder (MDD), Cognitive Dysfunction
Interventions
Motivationally Enhanced Compensatory Cognitive Training for Major Depressive Disorder (ME-CCT-MDD), Goal-focused Supportive Contact
Behavioral
Lead sponsor
Portland VA Medical Center
Federal
Eligibility
18 Years and older
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Jun 6, 2025 · Synced Oct 12, 2026, 4:37 PM EDT
Recruiting Not applicable Interventional

Low Voltage Electrical Stimulation for Depression in Parkinson's Patients

NCT06467695
View directory record Official record
Conditions
Parkinson Disease, Depressive Symptoms
Interventions
BIOPAC Stimsola, BIOPAC Stimsola Sham (zero amps)
Device
Lead sponsor
University of South Alabama
Other
Eligibility
19 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Mobile, Alabama
Source: ClinicalTrials.gov public record
Updated Apr 6, 2026 · Synced Oct 12, 2026, 4:37 PM EDT
Not yet recruiting Not applicable Interventional

Feasibility and Acceptability of a Novel Digital Intervention For Perinatal Men Who Have Depression or Anxiety

NCT07742566
View directory record Official record
Conditions
Paternal Postpartum Depression, Postpartum Anxiety
Interventions
Together in Parenting
Behavioral
Lead sponsor
Women and Infants Hospital of Rhode Island
Other
Eligibility
18 Years and older
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Aug 7, 2026 · Synced Oct 12, 2026, 4:37 PM EDT
Completed Not applicable Interventional

An Interactive Mobile Health (mHealth) App as Intervention for High Anxiety and Depression in College Students

NCT07017569
View directory record Official record
Conditions
Anxiety, Depression - Major Depressive Disorder, Stress
Interventions
Mobile health application
Behavioral
Lead sponsor
Texas A&M University
Other
Eligibility
18 Years and older
Enrollment
125 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
College Station, Texas
Source: ClinicalTrials.gov public record
Updated Jun 12, 2025 · Synced Oct 12, 2026, 4:37 PM EDT
Completed Not applicable Interventional

Rise Study for Depression

NCT06003361
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Digital CBT, Waitlist
Device · Other
Lead sponsor
Big Health Inc.
Industry
Eligibility
22 Years and older
Enrollment
61 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jan 17, 2024 · Synced Oct 12, 2026, 4:37 PM EDT
Not yet recruiting Not applicable Interventional

The Use of SmartPhone App (Kandoo) to Enhance Efficacy of Brief Behavioral Activation in Reducing Mood Disorder Symptoms

NCT06825637
View directory record Official record
Conditions
Depression Disorders
Interventions
Kandoo
Device
Lead sponsor
Child Mind Institute
Other
Eligibility
13 Years to 25 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 13, 2025 · Synced Oct 12, 2026, 4:37 PM EDT
Completed Not applicable Interventional

Investigating LIFUP in Anhedonic Depression

NCT06285474
View directory record Official record
Conditions
Depression, Anhedonia
Interventions
Low Intensity Focused Ultrasound Pulsation (LIFUP)
Device
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 65 Years
Enrollment
56 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jan 30, 2025 · Synced Oct 12, 2026, 4:37 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Engaging Black Youth in Depression and Suicide Prevention Treatment Within Urban Schools

NCT03940508
View directory record Official record
Conditions
Depression, Suicidal Ideation
Interventions
Making Connections Intervention, IPT-A
Behavioral
Lead sponsor
New York University
Other
Eligibility
12 Years to 20 Years
Enrollment
29 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
2
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 15, 2025 · Synced Oct 12, 2026, 4:37 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Using Technology to Optimize Collaborative Care Management of Depression in Urban and Rural Cancer Centers, SCOPE

NCT05012124
View directory record Official record
Conditions
Depression, Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm
Interventions
Collaborative care, Interview or Focus Group, Media/technology Intervention with collaborative care, Survey Administration
Other
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
297 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
4
States / cities
Auburn, Washington • Gig Harbor, Washington • Seattle, Washington + 1 more
Source: ClinicalTrials.gov public record
Updated Apr 16, 2026 · Synced Oct 12, 2026, 4:37 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Evaluating the Impact of Psychotherapeutic Advertising Claims on Cannabis Purchasing

NCT07216911
View directory record Official record
Conditions
Anxiety, Depression, Cannabis Use
Interventions
CC, PAC, WL
Behavioral
Lead sponsor
Trustees of Dartmouth College
Other
Eligibility
21 Years and older
Enrollment
2,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Lebanon, New Hampshire
Source: ClinicalTrials.gov public record
Updated Aug 4, 2026 · Synced Oct 12, 2026, 4:37 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Mobile Health and COVID-19

NCT05074693
View directory record Official record
Conditions
Anxiety Depression
Interventions
EASE app, INSIGHT (Control) App
Other
Lead sponsor
University of Houston
Other
Eligibility
18 Years and older
Enrollment
822 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
2
States / cities
Oklahoma City, Oklahoma • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jun 12, 2026 · Synced Oct 12, 2026, 4:37 PM EDT
Not yet recruiting Not applicable Interventional

Evaluating the Impact of Digital Behavioral Interventions to Address Insomnia and Depression in Breast Cancer Survivors Using an Adaptive Design

NCT07721064
View directory record Official record
Conditions
Insomnia, Depression
Interventions
Digital Insomnia Program, Digital Mental Health Program, Psychoeducation
Behavioral
Lead sponsor
University of Virginia
Other
Eligibility
18 Years and older · Female only
Enrollment
747 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Jul 24, 2026 · Synced Oct 12, 2026, 4:37 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Feasibility and Acceptability of a Novel Digital Intervention to Prevent Paternal Postpartum Depression

NCT07594743
View directory record Official record
Conditions
Paternal Postpartum Depression, Postpartum Anxiety
Interventions
Together in Parenting
Behavioral
Lead sponsor
Women and Infants Hospital of Rhode Island
Other
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jul 13, 2026 · Synced Oct 12, 2026, 4:37 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Brief Online Help-seeking Barrier Reduction Intervention

NCT03633825
View directory record Official record
Conditions
Crisis Intervention, Suicide and Depression
Interventions
Brief help-seeking barrier reduction intervention
Behavioral
Lead sponsor
Harvard University
Other
Eligibility
Not listed
Enrollment
39,450 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
1
States / cities
Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 12, 2023 · Synced Oct 12, 2026, 4:37 PM EDT