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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: "digital intervention" Condition: Depression Clear all
Completed Not applicable Interventional

Adaptive Messaging to Support Depression Self-Management

NCT06458192
View directory record Official record
Conditions
Depression
Interventions
Adaptive Messaging Intervention, Non-Adaptive Messaging Intervention, Psychoeducation-Only Control
Behavioral
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 12, 2026 · Synced Jul 24, 2026, 7:45 AM EDT
Recruiting Not applicable Interventional

Enhancing Brain And Mental Health Through Breathing Practice

NCT07369752
View directory record Official record
Conditions
Depressive Disorder, Anxiety, Adolescent
Interventions
Breathing Intervention
Behavioral
Lead sponsor
Mayo Clinic
Other
Eligibility
12 Years to 17 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
2
States / cities
Albert Lea, Minnesota • Eau Claire, Wisconsin
Source: ClinicalTrials.gov public record
Updated Apr 2, 2026 · Synced Jul 24, 2026, 7:45 AM EDT
Recruiting Not applicable Interventional

Health And Response: Digital Markers for Outcomes in Perinatal Depression Treatment Study

NCT07577947
View directory record Official record
Conditions
Depression, Perinatal Depression
Interventions
Perinatal depression online cognitive-behavioral therapy course, Clinical care (psychotherapy sessions)
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older · Female only
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jul 5, 2026 · Synced Jul 24, 2026, 7:45 AM EDT
Recruiting Not applicable Interventional

RXWell to Decrease Post-Operative Opioid Use in Total Knee or Hip Arthroplasty

NCT05658796
View directory record Official record
Conditions
Mood Disorders, Anxiety, Depressive Symptoms, Depression, Anxiety Disorders, Anxiety Depression
Interventions
-RxWell
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years to 100 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
3
States / cities
Monroeville, Pennsylvania • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 2, 2026 · Synced Jul 24, 2026, 7:45 AM EDT
Completed Not applicable Interventional

An Interactive Mobile Health (mHealth) App as Intervention for High Anxiety and Depression in College Students

NCT07017569
View directory record Official record
Conditions
Anxiety, Depression - Major Depressive Disorder, Stress
Interventions
Mobile health application
Behavioral
Lead sponsor
Texas A&M University
Other
Eligibility
18 Years and older
Enrollment
125 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
College Station, Texas
Source: ClinicalTrials.gov public record
Updated Jun 11, 2025 · Synced Jul 24, 2026, 7:45 AM EDT
Recruiting Not applicable Interventional

Examining the Efficacy of a Digital Therapeutic to Prevent Suicidal Behaviors

NCT06318962
View directory record Official record
Conditions
Suicidal Behaviors, Suicide Ideation, Depression/Anxiety
Interventions
Aviva
Behavioral
Lead sponsor
University of Memphis
Other
Eligibility
18 Years and older
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Colorado Springs, Colorado
Source: ClinicalTrials.gov public record
Updated May 4, 2026 · Synced Jul 24, 2026, 7:45 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Project HOPEFUL: A PN-RCT With Implementation Science

NCT07475039
View directory record Official record
Conditions
Older Adults (50-90 Years), Mental Health, Depression and Suicide Ideation, Social Functioning, Quality of Life, Thwarted Belongingness, Perceived Burdensomeness
Interventions
Standardized and manualized warm calls from providers trained in the BE training, Standardized and manualized warm calls from providers trained in the BE training + ASIST training
Behavioral
Lead sponsor
University of Florida
Other
Eligibility
55 Years and older
Enrollment
400 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2030
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Mar 15, 2026 · Synced Jul 24, 2026, 7:45 AM EDT
Recruiting Phase 2 Interventional

The Efficacy of Psilocybin Therapy for Depression in Parkinson's Disease

NCT07610369
View directory record Official record
Conditions
Depression, Parkinson's Disease (PD)
Interventions
Psilocybin (drug)
Drug
Lead sponsor
Yale University
Other
Eligibility
40 Years to 80 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jul 19, 2026 · Synced Jul 24, 2026, 7:45 AM EDT
Completed Phase 2 Interventional Results available

Exploratory Trial to Assess the Functionality of an Integrated Call Center for the Digital Medicine System

NCT02722967
View directory record Official record
Conditions
Schizophrenia, Major Depressive Disorder, Bipolar I Disorder
Interventions
Aripiprazole + IEM (Ingestible Event Marker)
Drug
Lead sponsor
Otsuka Pharmaceutical Development & Commercialization, Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
49 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016
U.S. locations
4
States / cities
Granada Hills, California • Rochester, New York • Durham, North Carolina + 1 more
Source: ClinicalTrials.gov public record
Updated May 22, 2018 · Synced Jul 24, 2026, 7:45 AM EDT
Recruiting Not applicable Interventional

Get ActivE Study for At-risk Youth

NCT06829953
View directory record Official record
Conditions
Anhedonia, Depression and Suicide Ideation
Interventions
GET ActivE, Treatment As Usual
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
12 Years to 18 Years
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
2
States / cities
Philadelphia, Pennsylvania • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 3, 2026 · Synced Jul 24, 2026, 7:45 AM EDT
Completed Not applicable Interventional Results available

Toward Understanding Drivers of Patient Engagement With Digital Mental Health Interventions - Part I

NCT05360901
View directory record Official record
Conditions
Depression, Anxiety
Interventions
IntelliCare with automated motivational messaging
Behavioral
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years to 80 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 17, 2023 · Synced Jul 24, 2026, 7:45 AM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

The University of Oregon ACCESS Project

NCT07264621
View directory record Official record
Conditions
School Attendance, School Climate, School Engagement, School Exclusion, Externalizing Behavior, Disparities, Teacher-student Relationships, Stress, Emotional Regulation, Depression
Interventions
Inclusive Skill-building Learning Approach (ISLA), Family Check-Up Online (FCU-O), FCU-Online with telehealth coaching
Behavioral
Lead sponsor
University of Oregon
Other
Eligibility
11 Years and older
Enrollment
1,440 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2030
U.S. locations
13
States / cities
Cottage Grove, Oregon • Eugene, Oregon • Springfield, Oregon
Source: ClinicalTrials.gov public record
Updated Dec 3, 2025 · Synced Jul 24, 2026, 7:45 AM EDT
Completed Not applicable Interventional

A Treatment for Depression Via a Gamified Mobile Phone Application Based on a New Cognitive Model

NCT05685758
View directory record Official record
Conditions
Depression, Depressive Disorder, Clinical Depression, Major Depressive Disorder
Interventions
FTP-based therapeutic mobile-app
Other
Lead sponsor
Hedonia Ltd
Industry
Eligibility
20 Years to 50 Years
Enrollment
117 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 12, 2023 · Synced Jul 24, 2026, 7:45 AM EDT
Completed Not applicable Interventional

Single-Session Intervention Targeting Emotional Awareness, Clarity, and Acceptance to Reduce Depression/Anxiety

NCT05109507
View directory record Official record
Conditions
Depression, Anxiety
Interventions
Visitor Mindset, Relaxing with Nature
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
530 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Dec 28, 2021 · Synced Jul 24, 2026, 7:45 AM EDT
Not yet recruiting Not applicable Interventional

Reduction of Depression in People With Disabilities Through Dual Treatment: Digital CBT & NBHWC Coaching

NCT07195292
View directory record Official record
Conditions
Hearing Disability, Depression, Mobility Disability
Interventions
Sham Digital Program - General health education and interactive quizzes unrelated to depression or CBT., Toivoa-002 - A digital Cognitive Behavioral Therapy program combined with NBHWC-certified coaching.
Device
Lead sponsor
Toivoa Inc
Industry
Eligibility
22 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
4
States / cities
Dover, Delaware • East Orange, New Jersey • Cleveland, Ohio + 1 more
Source: ClinicalTrials.gov public record
Updated Jul 19, 2026 · Synced Jul 24, 2026, 7:45 AM EDT
Completed Not applicable Interventional

A Tailored and Digital Approach to Address Equity and Support Well-being for Healthcare Workers in the Era of COVID

NCT05931432
View directory record Official record
Conditions
Depression, Anxiety, Satisfaction, Well-being
Interventions
Comprehensive Well-Being Intervention
Other
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
293 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 7, 2026 · Synced Jul 24, 2026, 7:45 AM EDT
Not listed No phase listed Observational

Validation of myStrength's Macropersonalization Engine

NCT05417178
View directory record Official record
Conditions
Depression, Anxiety, Trauma
Interventions
myStrength Macropersonalization Enginge
Other
Lead sponsor
Teladoc Health
Industry
Eligibility
18 Years to 85 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Menlo Park, California
Source: ClinicalTrials.gov public record
Updated Jun 13, 2022 · Synced Jul 24, 2026, 7:45 AM EDT
Completed Not applicable Interventional Results available

Technology Enabled Services to Enhance Depression Care

NCT05406791
View directory record Official record
Conditions
Depression, Anxiety
Interventions
VIRA App, Mood Education App
Other
Lead sponsor
Northwestern University
Other
Eligibility
13 Years and older
Enrollment
130 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 8, 2025 · Synced Jul 24, 2026, 7:45 AM EDT
Completed Not applicable Interventional Results available

Mobile Mental Health Apps for Suicide Prevention

NCT04536935
View directory record Official record
Conditions
Depression, Anxiety, Emotional Regulation
Interventions
Mobile Mental Health App - 1, Mobile Mental Health App - 2, Mobile Mental Health App - 3, Mobile Mental Health App - 4
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
19 Years and older
Enrollment
838 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Oct 19, 2022 · Synced Jul 24, 2026, 7:45 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Brief Online Help-seeking Barrier Reduction Intervention

NCT03633825
View directory record Official record
Conditions
Crisis Intervention, Suicide and Depression
Interventions
Brief help-seeking barrier reduction intervention
Behavioral
Lead sponsor
Harvard University
Other
Eligibility
Not listed
Enrollment
39,450 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
1
States / cities
Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 11, 2023 · Synced Jul 24, 2026, 7:45 AM EDT
Completed Not applicable Interventional Results available

Digital Behavioral Interventions in Inflammatory Bowel Disease

NCT04861597
View directory record Official record
Conditions
Crohn Disease, Ulcerative Colitis, Inflammatory Bowel Diseases, Stress, Psychological, Depression, Anxiety
Interventions
Internet based cognitive behavioral therapy, Digital mood tracking
Behavioral
Lead sponsor
Montefiore Medical Center
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Sep 18, 2024 · Synced Jul 24, 2026, 7:45 AM EDT
Completed Not applicable Interventional

Digital Therapeutic for Major Depressive Disorder (MDD) and Generalized Anxiety Disorder (GAD)

NCT05016050
View directory record Official record
Conditions
Major Depressive Disorder, Generalized Anxiety Disorder
Interventions
HPDT-DA-013
Device
Lead sponsor
Happify Inc.
Industry
Eligibility
22 Years and older
Enrollment
367 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 31, 2023 · Synced Jul 24, 2026, 7:45 AM EDT
Terminated Not applicable Interventional Results available

Radiosurgical Neuromodulation for Refractory Depression

NCT01403441
View directory record Official record
Conditions
Bipolar Disorder
Interventions
Radiosurgical Neuromodulation using the Cyberknife
Device
Lead sponsor
Stanford University
Other
Eligibility
22 Years to 65 Years
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Sep 4, 2017 · Synced Jul 24, 2026, 7:45 AM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Mobile Application Mindfulness

NCT07550166
View directory record Official record
Conditions
Stress, Anxiety, Depression, Psychological Distress, Mindfulness
Interventions
AI-Enabled Mobile App-Based Mindfulness Intervention
Behavioral
Lead sponsor
University of South Florida
Other
Eligibility
60 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
2
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Apr 23, 2026 · Synced Jul 24, 2026, 7:45 AM EDT