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ClinicalTrials.gov public records Last synced Oct 14, 2026, 1:32 PM EDT

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Showing 505–528 of 2,950 matching trials from the live ClinicalTrials.gov search.
Filters: "major depressive disorder" Condition: Depression Clear all
Completed No phase listed Observational Accepts healthy volunteers

Identifying Biological Markers for Severe Depression

NCT01831882
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Not listed
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 70 Years
Enrollment
210 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2020
U.S. locations
3
States / cities
Irvine, California • Stanford, California • New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 21, 2020 · Synced Oct 14, 2026, 1:32 PM EDT
Terminated Phase 3 Interventional Results available

Study to Evaluate the Efficacy, Safety and Tolerability of an Oral Aripiprazole/Escitalopram Combination Therapy in Participants With Major Depressive Disorder (MDD)

NCT01111552
View directory record Official record
Conditions
Major Depressive Disorder (MDD)
Interventions
Escitalopram, Aripiprazole, Placebo
Drug
Lead sponsor
Otsuka Pharmaceutical Development & Commercialization, Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
237 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
20
States / cities
Birmingham, Alabama • Little Rock, Arkansas • Carson, California + 16 more
Source: ClinicalTrials.gov public record
Updated Oct 26, 2021 · Synced Oct 14, 2026, 1:32 PM EDT
Terminated Phase 4 Interventional

Combinatorial Pharmacogenomics Testing in Treatment-Naïve Major Depressive Disorder

NCT03537547
View directory record Official record
Conditions
Major Depressive Disorder, Depression, Depressive Disorder, Depressive Episode, Depression, Unipolar
Interventions
GeneSight Psychotropic test, FDA-approved antidepressant or antipsychotic treatment
Other · Drug
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years to 65 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jun 5, 2020 · Synced Oct 14, 2026, 1:32 PM EDT
Completed Phase 2 Interventional Results available

A Phase II Study of PDC-1421 Capsule to Evaluate the Safety and Efficacy in Patients With Major Depressive Disorder

NCT02395978
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
PDC-1421 Capsule, placebo
Drug
Lead sponsor
BioLite, Inc.
Industry
Eligibility
20 Years to 65 Years
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jul 22, 2021 · Synced Oct 14, 2026, 1:32 PM EDT
Completed Not applicable Interventional Results available

Perioperative Mental Health in Orthopedic Surgery

NCT05697835
View directory record Official record
Conditions
Orthopedic Surgery, Older Adults, Depression, Anxiety
Interventions
Behavioral activation, Medication optimzation, Care as usual
Behavioral · Other
Lead sponsor
Washington University School of Medicine
Other
Eligibility
60 Years and older
Enrollment
116 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Apr 9, 2026 · Synced Oct 14, 2026, 1:32 PM EDT
Completed Phase 3 Interventional Results available

Escitalopram (Lexapro) for Depression MS or ALS

NCT00965497
View directory record Official record
Conditions
Major Depression, Multiple Sclerosis, Amyotrophic Lateral Sclerosis
Interventions
escitalopram
Drug
Lead sponsor
University of South Carolina
Other
Eligibility
18 Years to 70 Years
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
1
States / cities
Columbia, South Carolina
Source: ClinicalTrials.gov public record
Updated May 1, 2019 · Synced Oct 14, 2026, 1:32 PM EDT
Active, not recruiting Phase 1 Interventional Accepts healthy volunteers

Integrating Ketamine Effects on Neuronal Molecular Signatures and the Brain Functional and Structural Connectome

NCT06698848
View directory record Official record
Conditions
Depression, Suicide
Interventions
ketamin
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 50 Years
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2030
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 22, 2026 · Synced Oct 14, 2026, 1:32 PM EDT
Terminated Phase 2 Interventional Results available

A Randomised, Double-Blind, Placebo-Controlled Study Evaluating the Efficacy and Safety of Orvepitant in Subjects With Major Depressive Disorder

NCT00880048
View directory record Official record
Conditions
Depressive Disorder
Interventions
orvepitant, Placebo
Drug · Other
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years to 64 Years
Enrollment
343 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
27
States / cities
Phoenix, Arizona • Little Rock, Arkansas • Orange, California + 23 more
Source: ClinicalTrials.gov public record
Updated Oct 13, 2017 · Synced Oct 14, 2026, 1:32 PM EDT
Not listed Not applicable Interventional

FIT-ATOMIC Exercise Feasibility Trial

NCT06870968
View directory record Official record
Conditions
Neuroinflammatory Diseases, Multiple Sclerosis
Interventions
Exercise Training, Mobility and Flexibility Training
Behavioral
Lead sponsor
The Hospital for Sick Children
Other
Eligibility
11 Years to 25 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
2
States / cities
La Jolla, California • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 21, 2025 · Synced Oct 14, 2026, 1:32 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Latina Friends Motivating the Soul (ALMA)

NCT03749278
View directory record Official record
Conditions
Stress, Depression, Anxiety
Interventions
Latina Friends Motivating the Soul (ALMA)
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older · Female only
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
2
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated May 10, 2023 · Synced Oct 14, 2026, 1:32 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

An Evaluation of Safety and Feasibility Using Repetitive Transcranial Magnetic Stimulation (rTMS) in Adolescents With Depression

NCT00587639
View directory record Official record
Conditions
Depression
Interventions
rTMS Treatment
Device
Lead sponsor
Mayo Clinic
Other
Eligibility
13 Years to 18 Years
Enrollment
8 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2009
U.S. locations
3
States / cities
Chicago, Illinois • Rochester, Minnesota • Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Mar 12, 2012 · Synced Oct 14, 2026, 1:32 PM EDT
Completed Not applicable Interventional

Comparing Differing Financial Incentive Structures for Increasing Antidepressant Adherence Among Adults

NCT03441399
View directory record Official record
Conditions
Depression
Interventions
Financial incentives
Other
Lead sponsor
University of Pennsylvania
Other
Eligibility
21 Years to 64 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 15, 2019 · Synced Oct 14, 2026, 1:32 PM EDT
Completed Phase 3 Interventional

The Study of Olanzapine Plus Fluoxetine in Combination for Treatment of Treatment Resistant Depression

NCT00035321
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Olanzapine, Fluoxetine
Drug
Lead sponsor
Eli Lilly and Company
Industry
Eligibility
18 Years to 65 Years
Enrollment
600 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2005
U.S. locations
30
States / cities
Oceanside, California • San Marcos, California • Torrance, California + 27 more
Source: ClinicalTrials.gov public record
Updated Jul 24, 2006 · Synced Oct 14, 2026, 1:32 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

MBCT for People With Parkinson's Disease and Caregivers

NCT04469049
View directory record Official record
Conditions
Parkinson Disease, Anxiety, Depression
Interventions
Mindfulness-based cognitive therapy (MBCT)
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
28 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Oct 5, 2021 · Synced Oct 14, 2026, 1:32 PM EDT
Terminated Phase 4 Interventional Results available

Study of Probiotic GanedenBC30 for Irritable Bowel Syndrome and Major Depressive Disorder

NCT01337609
View directory record Official record
Conditions
Major Depressive Disorder, Irritable Bowel Syndrome
Interventions
Ganeden BC30, Placebo (sugar pill), Ganeden BC30, Placebo (sugar pill)
Drug · Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
2
States / cities
Burlington, Massachusetts • Westborough, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 9, 2013 · Synced Oct 14, 2026, 1:32 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Treating Adolescents With CBT and OBH

NCT04760938
View directory record Official record
Conditions
Anxiety Disorders, Depressive Disorder, Substance Use Disorders
Interventions
Outdoor Behavioral Healthcare (OBH), Cognitive Behavioral Therapy (CBT)
Behavioral
Lead sponsor
University of New Hampshire
Other
Eligibility
13 Years to 17 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Durham, New Hampshire
Source: ClinicalTrials.gov public record
Updated Feb 18, 2022 · Synced Oct 14, 2026, 1:32 PM EDT
Completed Not applicable Interventional Results available

Transcranial Laser Therapy for Major Depressive Disorder

NCT01538199
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Near-infrared radiation via Transcranial LED Therapy, Sham device
Device
Lead sponsor
Paolo Cassano
Other
Eligibility
18 Years to 65 Years
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
2
States / cities
Boston, Massachusetts • Chelsea, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 29, 2017 · Synced Oct 14, 2026, 1:32 PM EDT
Completed Not applicable Interventional Results available

Bright Light: An Adjunct Treatment for Combat Posttraumatic Stress Disorder (PTSD)

NCT00701064
View directory record Official record
Conditions
Posttraumatic Stress Disorder
Interventions
Bright Light Exposure, Negative Ion Generator
Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 60 Years
Enrollment
71 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2019
U.S. locations
1
States / cities
Columbia, Arizona
Source: ClinicalTrials.gov public record
Updated Sep 24, 2019 · Synced Oct 14, 2026, 1:32 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Northern-Manhattan Hispanic Caregiver Intervention Effectiveness Study

NCT02092987
View directory record Official record
Conditions
Depressive Symptoms, Burden
Interventions
Social work support, Educational material, NYU caregiver counseling intervention, REACH OUT counseling intervention
Other · Behavioral
Lead sponsor
Columbia University
Other
Eligibility
18 Years to 90 Years
Enrollment
221 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 9, 2021 · Synced Oct 14, 2026, 1:32 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Targeting Adolescent Depressive Symptoms Via Brief, Web-Based Interventions

NCT04066985
View directory record Official record
Conditions
Depression, Depressive Disorder, Behavioral Symptoms, Mood Disorders, Mental Disorders
Interventions
Growth Mindset Online Single-Session Program, Self-Kindness Online Single-Session Program, Supportive Therapy Online Single-Session Program (Control)
Behavioral
Lead sponsor
Child Mind Institute
Other
Eligibility
11 Years to 17 Years
Enrollment
501 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 4, 2019 · Synced Oct 14, 2026, 1:32 PM EDT
Completed Not applicable Interventional Results available

Loving-Kindness Meditation for PTSD

NCT01962714
View directory record Official record
Conditions
Posttraumatic Stress Disorder, Depression
Interventions
Loving-Kindness Meditation, Cognitive Processing Therapy
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
184 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Mar 17, 2020 · Synced Oct 14, 2026, 1:32 PM EDT
Completed Not applicable Interventional Results available

Adding Exercise to Antidepressant Medication Treatment for Depression

NCT00076258
View directory record Official record
Conditions
Depression
Interventions
SSRI + LD, SSRI + PHD
Behavioral
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 70 Years
Enrollment
126 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2007
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Sep 23, 2020 · Synced Oct 14, 2026, 1:32 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Role of Social Determinants in Cardiovascular Health and Vascular Function

NCT05772221
View directory record Official record
Conditions
Social Determinants of Health, Major Depressive Disorder, Cardiovascular Diseases
Interventions
Screening
Other
Lead sponsor
Baylor Research Institute
Other
Eligibility
18 Years and older
Enrollment
105 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jan 26, 2026 · Synced Oct 14, 2026, 1:32 PM EDT
Completed Not applicable Interventional

Telephone Care as a Substitute for Routine Psychiatric Medication

NCT00105885
View directory record Official record
Conditions
Major Depression, Posttraumatic Stress Disorders, Anxiety Disorders
Interventions
telephone care
Procedure
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
18 Years and older
Enrollment
324 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2008
U.S. locations
1
States / cities
White River Junction, Vermont
Source: ClinicalTrials.gov public record
Updated Feb 10, 2014 · Synced Oct 14, 2026, 1:32 PM EDT