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ClinicalTrials.gov public records Last synced Oct 27, 2026, 11:45 PM EDT

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Showing 649–672 of 5,331 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Depression Clear all
Completed Not applicable Interventional

Acceptance and Commitment Therapy for Depressed Individuals Living With Spinal Cord Injury Sustained Within 5 Years

NCT05725161
View directory record Official record
Conditions
Depression, Spinal Cord Injuries
Interventions
Acceptance and commitment therapy (ACT), Wait-list control group with psychoeducation materials provided
Behavioral
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years and older
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Feb 25, 2025 · Synced Oct 27, 2026, 11:45 PM EDT
Completed No phase listed Observational

Treatment Outcome of Vascular Depression

NCT00045773
View directory record Official record
Conditions
Depressive Disorder, Depression
Interventions
Sertraline
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
60 Years and older
Enrollment
208 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2006
U.S. locations
2
States / cities
St Louis, Missouri • Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 31, 2017 · Synced Oct 27, 2026, 11:45 PM EDT
Completed Phase 2 Interventional

The MEADOW PROJECT (Mending the Effects of Alcohol and Depression on Women) and The Bridge Program (Connecting Recovery Treatment and Behavioral Health)

NCT00851669
View directory record Official record
Conditions
Alcohol Dependence, Depression
Interventions
Interpersonal Psychotherapy for Co-occurring Alcohol Dependence and Major Depression (IPT-ADMD), Treatment as Usual
Behavioral
Lead sponsor
University of Rochester
Other
Eligibility
18 Years to 65 Years
Enrollment
91 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Jul 16, 2013 · Synced Oct 27, 2026, 11:45 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Depression, Experiential Diversity, and Behavioral Novelty

NCT05767554
View directory record Official record
Conditions
Depression
Interventions
Brief modified behavioral activation
Behavioral
Lead sponsor
University of Texas at Austin
Other
Eligibility
18 Years to 25 Years
Enrollment
77 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Aug 12, 2024 · Synced Oct 27, 2026, 11:45 PM EDT
Completed Not applicable Interventional

Mindful Movement Program in Improving Quality of Life in Older Female Breast Cancer Survivors

NCT00903474
View directory record Official record
Conditions
Anxiety Disorder, Breast Cancer, Cancer Survivor, Cognitive/Functional Effects, Depression, Psychosocial Effects of Cancer and Its Treatment
Interventions
questionnaire administration, study of socioeconomic and demographic variables, CAM exercise therapy, psychosocial assessment and care, quality-of-life assessment, stress management therapy
Other · Procedure
Lead sponsor
City of Hope Medical Center
Other
Eligibility
50 Years and older · Female only
Enrollment
49 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
1
States / cities
Duarte, California
Source: ClinicalTrials.gov public record
Updated Jun 8, 2015 · Synced Oct 27, 2026, 11:45 PM EDT
Completed Not applicable Interventional Results available

Minnesota Community-Based Cognitive Training in Early Psychosis

NCT03079024
View directory record Official record
Conditions
Schizophrenia, Psychosis, Schizoaffective Disorder, Schizophreniform Disorders, Psychosis NOS, Depression Psychotic Feature, Bipolar Disorder With Psychotic Features, Unspecified Psychosis
Interventions
Targeted Cognitive Training, General Cognitive Exercises, Coordinated Specialty Care for First Episode Psychosis
Device · Other
Lead sponsor
University of Minnesota
Other
Eligibility
16 Years to 35 Years
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 23, 2025 · Synced Oct 27, 2026, 11:45 PM EDT
Recruiting Early Phase 1 Interventional

Probiotic Administration for Adolescent Depression

NCT06898788
View directory record Official record
Conditions
Depression
Interventions
Visbiome, Placebo
Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
15 Years to 24 Years
Enrollment
77 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jul 14, 2026 · Synced Oct 27, 2026, 11:45 PM EDT
Completed Not applicable Interventional Results available

Acupuncture for Sedation in the Intensive Care Unit (ICU)

NCT01362270
View directory record Official record
Conditions
Delirium, Respiratory Depression, Overmedication
Interventions
Verum Acupuncture, Sham Acupuncture
Device
Lead sponsor
Oregon Health and Science University
Other
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Mar 20, 2020 · Synced Oct 27, 2026, 11:45 PM EDT
Not listed Not applicable Interventional

Safety and Efficacy Study of Deep Transcranial Magnetic Stimulation in Bipolar Depression

NCT01566591
View directory record Official record
Conditions
Bipolar Depression
Interventions
Deep TMS Treatment, Sham Treatment
Device
Lead sponsor
Brainsway
Industry
Eligibility
22 Years to 68 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2021
U.S. locations
9
States / cities
Juno Beach, Florida • Palm Beach, Florida • Royal Palm Beach, Florida + 6 more
Source: ClinicalTrials.gov public record
Updated Feb 4, 2021 · Synced Oct 27, 2026, 11:45 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

TRIAD Project: Qualitative Study of Adolescent Depression and Smoking

NCT00592696
View directory record Official record
Conditions
Adolescent - Emotional Problem, Smoking
Interventions
Not listed
Lead sponsor
Drexel University College of Medicine
Other
Eligibility
12 Years to 19 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2010
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 31, 2014 · Synced Oct 27, 2026, 11:45 PM EDT
Withdrawn Not applicable Interventional

An Open Label Study of the Genecept™ Assay in Treatment Resistant Depression

NCT01438242
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Genecept Assay
Device
Lead sponsor
Genomind, LLC
Industry
Eligibility
18 Years to 65 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Chalfont, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 23, 2015 · Synced Oct 27, 2026, 11:45 PM EDT
Completed Not applicable Interventional Results available

Healthy Hearts Healthy Minds

NCT03373110
View directory record Official record
Conditions
Cardiovascular Diseases, Depression
Interventions
Online Mindfulness Based Cognitive Therapy, Online Cognitive Behavioral Therapy, Fitbit Alone
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
506 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 2, 2022 · Synced Oct 27, 2026, 11:45 PM EDT
Completed Not applicable Interventional Results available

A Pilot Study on Repetitive Transcranial Magnetic Stimulation (rTMS) Treatment of Bipolar Depression

NCT00699218
View directory record Official record
Conditions
Mood Disorder, Bipolar Disorder, Major Depression, Depression
Interventions
Magnetic Stimulator Rapid2 made by Magstim Company Ltd. U.K.
Device
Lead sponsor
University of California, Davis
Other
Eligibility
18 Years to 65 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
1
States / cities
Davis, California
Source: ClinicalTrials.gov public record
Updated Jul 23, 2018 · Synced Oct 27, 2026, 11:45 PM EDT
Recruiting Phase 2 Interventional

A Study to Assess Change in Disease Activity and Adverse Events of Oral Icalcaprant in Adult Participants With Major Depressive Disorder

NCT07276997
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Icalcaprant, Placebo for Icalcaprant
Drug
Lead sponsor
AbbVie
Industry
Eligibility
18 Years to 65 Years
Enrollment
195 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
33
States / cities
Dothan, Alabama • Phoenix, Arizona • Little Rock, Arkansas + 27 more
Source: ClinicalTrials.gov public record
Updated Jun 15, 2026 · Synced Oct 27, 2026, 11:45 PM EDT
Completed Phase 2 Interventional Results available

Safety Study of Ziprasidone (Geodon) for the Depressive Mixed State

NCT00490542
View directory record Official record
Conditions
Bipolar Disorder, Bipolar Depression, Depression
Interventions
ziprasidone (Geodon), placebo
Drug
Lead sponsor
Tufts Medical Center
Other
Eligibility
18 Years to 65 Years
Enrollment
73 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2009
U.S. locations
4
States / cities
Chicago, Illinois • Boston, Massachusetts • Cambridge, Massachusetts + 1 more
Source: ClinicalTrials.gov public record
Updated Jul 29, 2016 · Synced Oct 27, 2026, 11:45 PM EDT
Completed Not applicable Interventional

Treatment of Post Traumatic Stress Disorder in Patients With Other Mental Illnesses

NCT00053690
View directory record Official record
Conditions
Stress Disorders, Post-Traumatic
Interventions
Cognitive Behavior Treatment
Behavioral
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
18 Years to 65 Years
Enrollment
88 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2004
U.S. locations
1
States / cities
Claremont, New Hampshire
Source: ClinicalTrials.gov public record
Updated Sep 10, 2013 · Synced Oct 27, 2026, 11:45 PM EDT
Completed No phase listed Observational

Evaluation of Pharmacogenetic Testing In a Mental Health Population and Economic Outcomes

NCT02474680
View directory record Official record
Conditions
Major Depressive Disorder 1
Interventions
Pharmacogenetic testing
Genetic
Lead sponsor
Avera McKennan Hospital & University Health Center
Other
Eligibility
18 Years and older
Enrollment
84 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Sioux Falls, South Dakota
Source: ClinicalTrials.gov public record
Updated May 3, 2017 · Synced Oct 27, 2026, 11:45 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Timing of Opioid Administration and Postoperative Respiratory Depression.

NCT07227389
View directory record Official record
Conditions
Respiratory Complications, Opioid Induced Respiratory Depression, Postoperative Respiratory Complications
Interventions
Respiratory volume monitoring
Diagnostic Test
Lead sponsor
Wayne State University
Other
Eligibility
18 Years to 85 Years
Enrollment
52 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2029
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Jul 16, 2026 · Synced Oct 27, 2026, 11:45 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Consequences of Conjugal Bereavement in Adults

NCT00001659
View directory record Official record
Conditions
Bereavement, Depressive Disorder, Immunologic Disease, Mental Disorder, Sleep Disorder
Interventions
Not listed
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
Not listed
Enrollment
210 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
1997 – 2002
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 4, 2008 · Synced Oct 27, 2026, 11:45 PM EDT
Recruiting Phase 2 Interventional

Cognitive Dysfunction and Inflammation in Depression: Experimental Inhibition Via Infliximab

NCT06136546
View directory record Official record
Conditions
Depressive Disorder, Major, Inflammation
Interventions
Infliximab, Placebo
Drug · Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
25 Years to 50 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 27, 2026 · Synced Oct 27, 2026, 11:45 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Intervention to Reduce Diaper Need and Increase Use of Pediatric Preventive Care

NCT03490045
View directory record Official record
Conditions
Diaper Dermatitis, Urinary Tract Infections, Infection, Depressive Symptoms, Stress
Interventions
Diaper Incentive, Conditional Cash Transfer Condition
Other
Lead sponsor
Yale University
Other
Eligibility
18 Years and older · Female only
Enrollment
77 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
2
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Apr 24, 2023 · Synced Oct 27, 2026, 11:45 PM EDT
Completed Phase 3 Interventional Results available

Study Evaluating Desvenlafaxine Succinate Sustained Release (DVS SR) vs. Escitalopram in Postmenopausal Women

NCT00406640
View directory record Official record
Conditions
Depression, Depressive Disorder, Depressive Disorder, Major
Interventions
Desvenlafaxine succinate sustained-release (DVS SR), Escitalopram
Drug
Lead sponsor
Wyeth is now a wholly owned subsidiary of Pfizer
Industry
Eligibility
40 Years to 70 Years · Female only
Enrollment
595 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
52
States / cities
Peoria, Arizona • Pasadena, California • San Diego, California + 46 more
Source: ClinicalTrials.gov public record
Updated Dec 28, 2023 · Synced Oct 27, 2026, 11:45 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Healthy Lifestyle Intervention for High-Risk Minority Pregnant Women

NCT03416010
View directory record Official record
Conditions
Emotional Disturbances, Depression, Pregnancy Late, Post-Partum Depression, Anxiety, Nutritional Deficiency
Interventions
COPE-P
Behavioral
Lead sponsor
Ohio State University
Other
Eligibility
18 Years to 40 Years · Female only
Enrollment
299 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2023
U.S. locations
3
States / cities
The Bronx, New York • Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 18, 2025 · Synced Oct 27, 2026, 11:45 PM EDT
Enrolling by invitation Not applicable Interventional

Behavioral Telehealth in Low-resource Primary Care Settings for Anxiety and Depression in Youth

NCT06273982
View directory record Official record
Conditions
Depression, Anxiety
Interventions
STEP-UP (transdiagnostic behavioral therapy for pediatric anxiety and depression), ARC (assisted referral to community care)
Behavioral
Lead sponsor
San Diego State University
Other
Eligibility
8 Years to 16 Years
Enrollment
220 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Apr 13, 2026 · Synced Oct 27, 2026, 11:45 PM EDT