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ClinicalTrials.gov public records Last synced Oct 29, 2026, 10:48 PM EDT

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Showing 1705–1728 of 5,335 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Depression Clear all
Completed Phase 1 Interventional Accepts healthy volunteers

Oral Tyramine Pressor Response Study of CX157 Tablets in Healthy Male Volunteers

NCT01633437
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
CX157, Placebo
Drug · Other
Lead sponsor
CeNeRx BioPharma Inc.
Industry
Eligibility
18 Years to 50 Years · Male only
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010
U.S. locations
1
States / cities
Miramar, Florida
Source: ClinicalTrials.gov public record
Updated Jul 4, 2012 · Synced Oct 29, 2026, 10:48 PM EDT
Completed Phase 2 Interventional

Evaluation of Repetitive Transcranial Magnetic Stimulation (rTMS) in the Treatment of Mood Disorders

NCT00001545
View directory record Official record
Conditions
Bipolar Disorder, Mood Disorder, Unipolar Depression
Interventions
Magstim Super Rapid Magnetic Stimulator, Cadwell MES-10
Device
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
18 Years to 90 Years
Enrollment
91 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1996 – 2006
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 13, 2006 · Synced Oct 29, 2026, 10:48 PM EDT
Recruiting Not applicable Interventional

Telehealth Behavioral Activation for Teens

NCT06273995
View directory record Official record
Conditions
Depression, Suicide and Self-harm, Depression in Adolescence, Depression Mild, Depression Moderate, Depression Severe
Interventions
Behavioral Activation
Other
Lead sponsor
Baylor College of Medicine
Other
Eligibility
12 Years to 18 Years
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2029
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Aug 4, 2026 · Synced Oct 29, 2026, 10:48 PM EDT
Completed Phase 1 Interventional Results available

Psilocybin-assisted CBT for Depression

NCT05227612
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Psilocybin, Cognitive behavioral therapy
Drug · Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
21 Years to 60 Years
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated May 19, 2026 · Synced Oct 29, 2026, 10:48 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Reducing Stigma and Increasing Treatment Seeking Intentions Among Adolescents

NCT06222528
View directory record Official record
Conditions
Stigma, Social, Mental Health Disorder, Adolescent Behavior, Depression
Interventions
Brief video intervention (Black Girl), Brief video intervention (Black Boy), Brief video intervention (Latinx Girl), Brief video intervention (Latinx Boy), Brief video intervention (White Girl), Brief video intervention (White Boy), Brief video intervention (Nonbinary or transgender), Control Condition
Behavioral
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
14 Years to 18 Years
Enrollment
1,200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 4, 2024 · Synced Oct 29, 2026, 10:48 PM EDT
Active, not recruiting Not applicable Interventional

DBS for Depression

NCT03437928
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Directional Deep Brain Stimulation
Device
Lead sponsor
Baylor College of Medicine
Other
Eligibility
22 Years to 70 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2027
U.S. locations
2
States / cities
Dallas, Texas • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Oct 1, 2026 · Synced Oct 29, 2026, 10:48 PM EDT
Completed Not applicable Interventional

VA Home-Based Emotional Learning With Practical Skills

NCT01685528
View directory record Official record
Conditions
Anxiety, Depression
Interventions
CBT
Behavioral
Lead sponsor
Baylor College of Medicine
Other
Eligibility
18 Years and older
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Apr 7, 2016 · Synced Oct 29, 2026, 10:48 PM EDT
Completed No phase listed Observational

Effectiveness and Acceptability of Stellate Ganglion Block for Posttraumatic Stress Disorder Symptoms - Acceptability

NCT03302312
View directory record Official record
Conditions
Posttraumatic Stress Disorder
Interventions
Not listed
Lead sponsor
RTI International
Other
Eligibility
18 Years and older
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
2
States / cities
Honolulu, Hawaii • Fort Bragg, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 30, 2018 · Synced Oct 29, 2026, 10:48 PM EDT
Withdrawn Not applicable Interventional

Expanding and Testing VA Collaborative Care Models for Depression

NCT00119028
View directory record Official record
Conditions
Major Depression, Post-Traumatic Stress Disorder
Interventions
Depression Care Quality Improvement Implementation
Procedure
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
Not listed
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2009
U.S. locations
6
States / cities
Long Beach, California • Shreveport, Louisiana • Minneapolis, Minnesota + 3 more
Source: ClinicalTrials.gov public record
Updated Apr 24, 2012 · Synced Oct 29, 2026, 10:48 PM EDT
Completed Phase 3 Interventional

Effects Of Antidepressants On Sexual Functioning In Adults

NCT00051272
View directory record Official record
Conditions
Major Depressive Disorder (MDD)
Interventions
Extended-release Bupropion Hydrochloride
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years and older
Enrollment
425 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2004
U.S. locations
24
States / cities
Phoenix, Arizona • Scottsdale, Arizona • Berkeley, California + 19 more
Source: ClinicalTrials.gov public record
Updated Mar 29, 2011 · Synced Oct 29, 2026, 10:48 PM EDT
Terminated Phase 2 Interventional

Multicentre Trial to Evaluate the Safety and Efficacy of CP-316,311 in Major Depressive Disorder

NCT00143091
View directory record Official record
Conditions
Depressive Disorder, Major
Interventions
CP-316,311, Placebo, Sertraline
Drug
Lead sponsor
Pfizer
Industry
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2006
U.S. locations
2
States / cities
Bellevue, Washington • Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Mar 24, 2008 · Synced Oct 29, 2026, 10:48 PM EDT
Completed Not applicable Interventional Results available

Opioid Treatment and Recovery Through a Safe Pain Management Program

NCT03889418
View directory record Official record
Conditions
Depression, Opioid Use, Chronic Pain, Anxiety
Interventions
Electronic medical recorded clinical decision support [EMR CDS], Stepped opioid collaborative care model [CCM]
Behavioral
Lead sponsor
Ochsner Health System
Other
Eligibility
18 Years and older
Enrollment
490 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
New Orleans, Louisiana
Source: ClinicalTrials.gov public record
Updated Apr 6, 2026 · Synced Oct 29, 2026, 10:48 PM EDT
Completed No phase listed Observational

Imaging mGluR5 and Synaptic Density in Psychiatric Disorders

NCT03898297
View directory record Official record
Conditions
Major Depressive Disorder, Bipolar Disorder, Healthy
Interventions
[18F]FPEB, [11C]APP311
Radiation
Lead sponsor
Yale University
Other
Eligibility
18 Years to 80 Years
Enrollment
79 participants
Timeline
2017 – 2024
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Sep 3, 2026 · Synced Oct 29, 2026, 10:48 PM EDT
Recruiting Not applicable Interventional

Antidepressant Adherence for Depressed Adults in Primary Care

NCT06496646
View directory record Official record
Conditions
Depression
Interventions
Arm 1 intervention, Arm 2 Intervention
Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
21 Years to 64 Years
Enrollment
525 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 26, 2025 · Synced Oct 29, 2026, 10:48 PM EDT
Completed Not applicable Interventional Results available

Brief Digital Intervention to Increase COVID-19 Vaccination Among Individuals With Anxiety or Depression

NCT06119854
View directory record Official record
Conditions
Misinformation, Vaccine Hesitancy, Anxiety, Depression, COVID-19
Interventions
Attitudinal inoculation, Cognitive-behavioral therapy-informed intervention, Conventional public health messaging
Behavioral
Lead sponsor
City University of New York, School of Public Health
Other
Eligibility
18 Years and older
Enrollment
1,419 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 11, 2025 · Synced Oct 29, 2026, 10:48 PM EDT
Completed Phase 3 Interventional

Duloxetine Versus Placebo for Fibromyalgia

NCT00489073
View directory record Official record
Conditions
Fibromyalgia
Interventions
duloxetine, placebo
Drug
Lead sponsor
Eli Lilly and Company
Industry
Eligibility
18 Years and older · Female only
Enrollment
345 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2003
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Jun 21, 2007 · Synced Oct 29, 2026, 10:48 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Interventions for Depressed Low Income Mothers and Their Infants

NCT00105573
View directory record Official record
Conditions
Depression
Interventions
Maternal interpersonal psychotherapy (IP), Infant-parent psychotherapy, Informational meetings plus treatment as usual
Behavioral
Lead sponsor
University of Rochester
Other
Eligibility
18 Years to 44 Years · Female only
Enrollment
218 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2010
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Apr 30, 2013 · Synced Oct 29, 2026, 10:48 PM EDT
Recruiting No phase listed Observational

Evaluate the Effects of Long-term Use of Psychotropic Medications on Eye Movement Patterns With the Gaize Device

NCT07389473
View directory record Official record
Conditions
ADHD, Depression Disorders, Mood Disorders, Anxiety Disorder Generalized, Bipolar Disorder (BPD)
Interventions
Prescription Psychotropic Medications
Drug
Lead sponsor
Gaize
Industry
Eligibility
18 Years to 65 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 5, 2026 · Synced Oct 29, 2026, 10:48 PM EDT
Not yet recruiting Not applicable Interventional

EEG-Guided Transcranial Magnetic Stimulation for Adults With Depression

NCT07862205
View directory record Official record
Conditions
Major Depressive Disorder (MDD), Treatment Resistant Depression, Major Depression
Interventions
MagVenture TMS Therapy System with Localite Navigation System and actiCHamp EEG
Device
Lead sponsor
Mayo Clinic
Other
Eligibility
22 Years to 60 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 16, 2026 · Synced Oct 29, 2026, 10:48 PM EDT
Recruiting Not applicable Interventional

Teenthrive 2: Treatments for Improving Mood in Teens

NCT07475845
View directory record Official record
Conditions
Depression in Adolescence
Interventions
Yoga-Based Intervention, group CBT
Behavioral
Lead sponsor
Butler Hospital
Other
Eligibility
12 Years to 18 Years
Enrollment
96 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
2
States / cities
Boston, Massachusetts • Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 26, 2026 · Synced Oct 29, 2026, 10:48 PM EDT
Completed No phase listed Observational

NeuroStar TMS Therapy System: Utilization and Outcomes

NCT01114477
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Not listed
Lead sponsor
Neuronetics
Other
Eligibility
Not listed
Enrollment
307 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
44
States / cities
Phoenix, Arizona • Berkeley, California • Beverly Hills, California + 38 more
Source: ClinicalTrials.gov public record
Updated Nov 13, 2015 · Synced Oct 29, 2026, 10:48 PM EDT
Recruiting Not applicable Interventional

RISE Versus Advocacy-based Enhanced Care as Usual for Patients Experiencing IPV

NCT06906302
View directory record Official record
Conditions
Intimate Partner Violence (IPV)
Interventions
RISE, Advocacy-based ECAU
Behavioral
Lead sponsor
Boston University
Other
Eligibility
18 Years and older
Enrollment
172 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2030
U.S. locations
3
States / cities
Boston, Massachusetts • Minneapolis, Minnesota • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 30, 2026 · Synced Oct 29, 2026, 10:48 PM EDT
Completed Phase 2 Interventional

BezafibrateTreatment for Bipolar Depression: A Proof of Concept Study

NCT02481245
View directory record Official record
Conditions
Bipolar Disorder, Depressive Episode
Interventions
Bezafibrate
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 24, 2026 · Synced Oct 29, 2026, 10:48 PM EDT
Completed Phase 2Phase 3 Interventional

Supraphysiological Doses of Levothyroxine as Adjunctive Therapy in Bipolar Depression

NCT01528839
View directory record Official record
Conditions
Bipolar Disorder
Interventions
L-Thyroxine, Placebo
Drug
Lead sponsor
Charite University, Berlin, Germany
Other
Eligibility
18 Years to 65 Years
Enrollment
74 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2008
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Feb 8, 2012 · Synced Oct 29, 2026, 10:48 PM EDT