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Showing 1–24 of 2,380 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Depression Disorders and Symptoms Clear all
Completed Phase 2Phase 3 Interventional

Treating Negative Affect in Low Back Pain Patients

NCT04747314
View directory record Official record
Conditions
Chronic Low Back Pain, Negative Affectivity
Interventions
Antidepressant, Enhanced Fear Avoidance Rehabilitation
Drug · Other
Lead sponsor
Ajay Wasan, MD, Msc
Other
Eligibility
18 Years to 75 Years
Enrollment
308 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
3
States / cities
Chestnut Hill, Massachusetts • Rochester, Minnesota • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 20, 2026 · Synced Jun 10, 2026, 7:37 AM EDT
Completed Phase 4 Interventional Results available

Combination Treatment Study for Memory Impairment and Depression

NCT01658228
View directory record Official record
Conditions
Depression, Mild Cognitive Impairment
Interventions
Donepezil, Placebo, Citalopram, Venlafaxine
Drug
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
55 Years to 95 Years
Enrollment
86 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2016
U.S. locations
2
States / cities
New York, New York • Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 16, 2017 · Synced Jun 10, 2026, 7:37 AM EDT
Suspended Early Phase 1 Interventional

Effect of Kava on Anxiety and Stress in Cancer Survivors

NCT06213298
View directory record Official record
Conditions
Kava, Anxiety, Stress, Cancer, Depression, Sleep
Interventions
Kava, Placebo
Drug · Dietary Supplement
Lead sponsor
Masonic Cancer Center, University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
43 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Feb 10, 2026 · Synced Jun 10, 2026, 7:37 AM EDT
Recruiting Not applicable Interventional

BTL-699-2 and HPM-6000UF Devices for the Improvement of Depressive Symptoms and Urinary Incontinence in Postpartum and Early Post-Childbirth Women

NCT07413692
View directory record Official record
Conditions
Depressive Symptoms, Urinary Incontinence
Interventions
EXOMIND (BTL-699-2) ActiveTreatment, EMSELLA (HPM-6000UF) ActiveTreatment, EXOMIND (BTL-699-2) Sham Treatment, EMSELLA (HPM-6000UF) Sham Treatment
Device
Lead sponsor
BTL Industries Ltd.
Industry
Eligibility
22 Years to 60 Years · Female only
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
3
States / cities
Garfield Heights, Ohio • Oklahoma City, Oklahoma • Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Feb 16, 2026 · Synced Jun 10, 2026, 7:37 AM EDT
Completed Not applicable Interventional

Randomized Controlled Trial of Project Body Neutrality

NCT06172452
View directory record Official record
Conditions
Depression, Eating Disorders, Body Image
Interventions
Project Body Neutrality SSI, Supportive Therapy SSI
Behavioral
Lead sponsor
Northwestern University
Other
Eligibility
13 Years to 17 Years
Enrollment
220 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 18, 2024 · Synced Jun 10, 2026, 7:37 AM EDT
Completed Phase 4 Interventional Results available

Ketamine Infusion for Adolescent Depression and Anxiety

NCT02579928
View directory record Official record
Conditions
Major Depressive Disorder, Anxiety Disorder
Interventions
Ketamine, Midazolam
Drug
Lead sponsor
Yale University
Other
Eligibility
13 Years to 17 Years
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
2
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jul 13, 2020 · Synced Jun 10, 2026, 7:37 AM EDT
Completed Phase 2 Interventional

Specialized Pro-resolving Lipid Mediators and Treatment Resistant Depression

NCT05774665
View directory record Official record
Conditions
Treatment Resistant Depression, Inflammation, Overweight
Interventions
Omega 3, Placebo
Drug · Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
3
States / cities
Atlanta, Georgia • Boston, Massachusetts • Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated May 5, 2026 · Synced Jun 10, 2026, 7:37 AM EDT
Terminated Not applicable Interventional

Effects of 'R' (Electro-kinetic Beverage) on Insomnia, Fatigue, and Depression in Breast Cancer Patients Having Adjuvant Chemo

NCT02217033
View directory record Official record
Conditions
Breast Cancer
Interventions
'R' (Electro-kinetically altered beverage), Placebo (water)
Other
Lead sponsor
South Sound Care Foundation
Other
Eligibility
18 Years and older · Female only
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
6
States / cities
Bonney Lake, Washington • Federal Way, Washington • Gig Harbor, Washington + 3 more
Source: ClinicalTrials.gov public record
Updated Apr 17, 2017 · Synced Jun 10, 2026, 7:37 AM EDT
Enrolling by invitation No phase listed Observational

Pediatric Behavioral Health Integrated Care: Indiana Statewide Strategic Plan to Address the Growing Mental Health Crisis

NCT07216638
View directory record Official record
Conditions
Implementation Research, Depressive Disorder, ANXIETY DISORDERS (or Anxiety and Phobic Neuroses), Conduct Disorders in Children, Pediatric Mental Health Services
Interventions
Not listed
Lead sponsor
Indiana University
Other
Eligibility
5 Years and older
Enrollment
575 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Oct 13, 2025 · Synced Jun 10, 2026, 7:37 AM EDT
Terminated Phase 2 Interventional

Efficacy and Safety of Lu AA39959 in Patients With Bipolar Depression

NCT00771134
View directory record Official record
Conditions
Bipolar Disorder
Interventions
Lu AA39959, Placebo, Quetiapine
Drug
Lead sponsor
H. Lundbeck A/S
Industry
Eligibility
18 Years to 65 Years
Enrollment
105 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated May 27, 2014 · Synced Jun 10, 2026, 7:37 AM EDT
Recruiting Not applicable Interventional

Collaborative Care for Anxiety and Depression in Epilepsy

NCT05559749
View directory record Official record
Conditions
Epilepsy, Anxiety, Depression
Interventions
collaborative care, usual neurology care
Behavioral
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 1, 2026 · Synced Jun 10, 2026, 7:37 AM EDT
Completed Phase 4 Interventional Results available

Vilazodone for Treatment of Geriatric Depression

NCT01608295
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Vilazodone; Viibryd, Paroxetine; Paxil
Drug
Lead sponsor
University of California, Los Angeles
Other
Eligibility
60 Years and older
Enrollment
65 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated May 10, 2018 · Synced Jun 10, 2026, 7:37 AM EDT
Completed No phase listed Observational

Physiological Brain Atlas Development

NCT01210534
View directory record Official record
Conditions
Parkinson Disease, Dystonia, Tremors, Obsessive Compulsive Disorder, Depression
Interventions
No intervention
Other
Lead sponsor
Ohio State University
Other
Eligibility
7 Years to 90 Years
Enrollment
456 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2021
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 12, 2023 · Synced Jun 10, 2026, 7:37 AM EDT
Completed Not applicable Interventional Results available

Multiple Treatment Study Using Low Field Magnetic Stimulation for Bipolar Depression

NCT01929681
View directory record Official record
Conditions
Bipolar Depression
Interventions
Low Field Magnetic Stimulation
Device
Lead sponsor
Mclean Hospital
Other
Eligibility
21 Years to 65 Years
Enrollment
53 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 25, 2017 · Synced Jun 10, 2026, 7:37 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Social Media Intervention for Postpartum Depression

NCT02355067
View directory record Official record
Conditions
Postpartum Depression, Parenting
Interventions
Social Media Intervention, Traditional In-Person Intervention
Behavioral
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
15 Years and older · Female only
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 8, 2021 · Synced Jun 10, 2026, 7:37 AM EDT
Completed Not applicable Interventional

Electronic Media and Its Application in Psychotherapy

NCT03712267
View directory record Official record
Conditions
Anxiety Disorders, Depression, Electronic Media
Interventions
Electronic Media Enhanced, Treatment as Usual
Behavioral
Lead sponsor
Mclean Hospital
Other
Eligibility
14 Years to 85 Years
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2023
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 4, 2025 · Synced Jun 10, 2026, 7:37 AM EDT
Active, not recruiting Not applicable Interventional

Testing FIRST in Youth Outpatient Psychotherapy

NCT04725721
View directory record Official record
Conditions
Anxiety, Depression, Trauma, Behavior Problem
Interventions
FIRST, Usual Care
Behavioral
Lead sponsor
Harvard University
Other
Eligibility
7 Years to 15 Years
Enrollment
212 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
2
States / cities
Cambridge, Massachusetts • Austin, Texas
Source: ClinicalTrials.gov public record
Updated Apr 16, 2026 · Synced Jun 10, 2026, 7:37 AM EDT
Completed Not applicable Interventional

Programs to Support You During Chemotherapy (Pro-You)

NCT02148406
View directory record Official record
Conditions
Depressive Symptoms, Fatigue, Psychosocial Effects of Cancer and Its Treatment, Stage IIA Colon Cancer, Stage IIA Rectal Cancer, Stage IIB Colon Cancer, Stage IIB Rectal Cancer, Stage IIC Colon Cancer, Stage IIC Rectal Cancer, Stage IIIA Colon Cancer, Stage IIIA Rectal Cancer, Stage IIIB Colon Cancer, Stage IIIB Rectal Cancer, Stage IIIC Colon Cancer, Stage IIIC Rectal Cancer, Stage IVA Colon Cancer, Stage IVA Rectal Cancer, Stage IVB Colon Cancer, Stage IVB Rectal Cancer
Interventions
Yoga Skills Training (YST), questionnaire administration, fatigue and depressive symptom assessment and management, psychological stress assessment, laboratory biomarker analysis, Attention Control
Behavioral · Other
Lead sponsor
Vanderbilt-Ingram Cancer Center
Other
Eligibility
18 Years and older
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jun 22, 2015 · Synced Jun 10, 2026, 7:37 AM EDT
Completed Phase 3 Interventional

Efficacy, Safety and Tolerability of Agomelatine Sublingual Tablets in the Treatment of Major Depressive Disorder (MDD)

NCT01110902
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Agomelatine (AGO178C), Placebo
Drug
Lead sponsor
Novartis Pharmaceuticals
Industry
Eligibility
18 Years to 70 Years
Enrollment
589 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
43
States / cities
Birmingham, Alabama • Costa Mesa, California • El Centro, California + 39 more
Source: ClinicalTrials.gov public record
Updated Dec 23, 2020 · Synced Jun 10, 2026, 7:37 AM EDT
Completed Not applicable Interventional Results available

Care Outcomes for Chiropractic Outpatient Veterans

NCT03254719
View directory record Official record
Conditions
Low Back Pain, PTSD, Depression, Anxiety
Interventions
Study assessments
Other
Lead sponsor
Palmer College of Chiropractic
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018
U.S. locations
4
States / cities
Coralville, Iowa • Davenport, Iowa • Iowa City, Iowa + 1 more
Source: ClinicalTrials.gov public record
Updated May 17, 2020 · Synced Jun 10, 2026, 7:37 AM EDT
Completed Phase 2 Interventional Results available

Safety and Efficacy of Cariprazine As Adjunctive Therapy In Major Depressive Disorder

NCT00854100
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Antidepressant + placebo, Antidepressant + cariprazine (0.1-0.3 mg/day), Antidepressant + cariprazine (1-2 mg/d)
Drug
Lead sponsor
Forest Laboratories
Industry
Eligibility
18 Years to 65 Years
Enrollment
231 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
41
States / cities
Phoenix, Arizona • Scottsdale, Arizona • Arcadia, California + 35 more
Source: ClinicalTrials.gov public record
Updated Mar 4, 2019 · Synced Jun 10, 2026, 7:37 AM EDT
Completed Not applicable Interventional

Integrating Solution Focused Interventions in Integrated Care

NCT05838222
View directory record Official record
Conditions
Depression, Diabetes Mellitus, Hypertension, Anxiety Disorders
Interventions
Solution Focused Intervention, Treatment as Usual
Behavioral · Other
Lead sponsor
University of Georgia
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
1
States / cities
Athens, Georgia
Source: ClinicalTrials.gov public record
Updated Oct 17, 2023 · Synced Jun 10, 2026, 7:37 AM EDT
Completed Not applicable Interventional

Diet and Depression

NCT06252701
View directory record Official record
Conditions
Depression, Major Depressive Disorder, Weight Gain, Obesity, Metabolic Syndrome
Interventions
Reduction of Ultra-processed foods
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 80 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Nov 20, 2025 · Synced Jun 10, 2026, 7:37 AM EDT
Completed Not applicable Interventional Results available

Reward Function and Therapy for Late-Life Depression

NCT03688139
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Engage Therapy, Supportive Therapy
Behavioral
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
60 Years and older
Enrollment
65 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
1
States / cities
White Plains, New York
Source: ClinicalTrials.gov public record
Updated Nov 13, 2024 · Synced Jun 10, 2026, 7:37 AM EDT