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Showing 1–24 of 3,942 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Depression Symptoms Clear all
Completed Not applicable Interventional

Feasibility of an Exercise Intervention

NCT01984060
View directory record Official record
Conditions
HIV
Interventions
HOME-EX
Other
Lead sponsor
University of Rochester
Other
Eligibility
45 Years to 80 Years
Enrollment
74 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated May 11, 2016 · Synced Sep 9, 2026, 9:06 AM EDT
Terminated Phase 4 Interventional Results available

Study on Allopregnanolone and Depression in Perimenopausal Women

NCT05329779
View directory record Official record
Conditions
Depression
Interventions
brexanolone, placebo
Drug
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
40 Years to 60 Years · Female only
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 21, 2026 · Synced Sep 9, 2026, 9:06 AM EDT
Completed Phase 4 Interventional

Treatment Trial for Psychogenic Nonepileptic Seizures

NCT00835627
View directory record Official record
Conditions
Convulsion, Non-Epileptic, Conversion Disorder, Depression, Stress Disorders, Post-Traumatic, Dissociative Disorders
Interventions
sertraline, CBT-ip, Combined (sertraline + CBT-ip), Standard Care
Drug · Behavioral · Other
Lead sponsor
Rhode Island Hospital
Other
Eligibility
18 Years to 95 Years
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2013
U.S. locations
3
States / cities
Stanford, California • Cincinnati, Ohio • Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Nov 9, 2014 · Synced Sep 9, 2026, 9:06 AM EDT
Completed Not applicable Interventional Results available

Efficacy and Safety of Cranial Electrical Stimulation (CES) for Major Depressive Disorder (MDD)

NCT01325532
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Active CES, Sham CES
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2015
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 31, 2016 · Synced Sep 9, 2026, 9:06 AM EDT
Completed Not applicable Interventional

Motivating Our Mothers 2

NCT02938598
View directory record Official record
Conditions
Depression, Maternal Care Patterns
Interventions
Maternal Depression Education and Care-Seeking Motivation
Behavioral
Lead sponsor
University of California, Davis
Other
Eligibility
21 Years to 65 Years · Female only
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Apr 12, 2021 · Synced Sep 9, 2026, 9:06 AM EDT
Not yet recruiting Phase 3 Interventional

Morphine or Ketamine for Analgesia

NCT06835504
View directory record Official record
Conditions
Abdominal Pain, Isolated Extremity Fracture, Pain, Pediatrics
Interventions
Ketamine hydrochloride, Morphine sulphate
Drug
Lead sponsor
Columbia University
Other
Eligibility
6 Years to 17 Years
Enrollment
1,010 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
8
States / cities
Los Angeles, California • Sacramento, California • Wilmington, Delaware + 5 more
Source: ClinicalTrials.gov public record
Updated Jun 8, 2026 · Synced Sep 9, 2026, 9:06 AM EDT
Completed Phase 1Phase 2 Interventional

Comparison of Two Psychotherapy Treatments for Depressed Women With a History of Sexual Abuse

NCT00257400
View directory record Official record
Conditions
Depression
Interventions
Interpersonal Psychotherapy (IPT), Individual Psychotherapy
Behavioral
Lead sponsor
University of Rochester
Other
Eligibility
18 Years and older · Female only
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2007
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Jan 2, 2014 · Synced Sep 9, 2026, 9:06 AM EDT
Completed Phase 2 Interventional

Single IV Dose of GLYX-13 in Patients With Treatment-Resistant Depression

NCT01234558
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
GLYX-13
Drug
Lead sponsor
Naurex, Inc, an affiliate of Allergan plc
Industry
Eligibility
18 Years to 65 Years
Enrollment
115 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
Evanston, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 11, 2012 · Synced Sep 9, 2026, 9:06 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Noninvasive Physiologic Sensors to Assess Depression

NCT02568865
View directory record Official record
Conditions
Depression, Major Depressive Disorder
Interventions
Physiological Sensors, Sleep Monitoring Device, Vocal Monitoring, Mobile Phone
Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 70 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2020
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 24, 2020 · Synced Sep 9, 2026, 9:06 AM EDT
Completed Not applicable Interventional

UCSF TARA Study: Training for Awareness, Resilience and Action

NCT02480257
View directory record Official record
Conditions
Depression, Anxiety
Interventions
TARA
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
14 Years to 18 Years
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Mar 21, 2022 · Synced Sep 9, 2026, 9:06 AM EDT
Completed Phase 2 Interventional Results available

Ketamine and Nitroprusside for Depression

NCT03102736
View directory record Official record
Conditions
Depression
Interventions
Placebos, Ketamine, Nitroprusside
Drug
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
21 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 1, 2020 · Synced Sep 9, 2026, 9:06 AM EDT
Completed Phase 2 Interventional Results available

Pilot Study of Open-label Placebo to Treat Major Depressive Disorder

NCT01103271
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Open-label Placebo
Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 60 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 13, 2013 · Synced Sep 9, 2026, 9:06 AM EDT
Completed No phase listed Observational

Quantified Mobile Sensing for Improving Diagnosis and Measuring Disease Progression

NCT02742064
View directory record Official record
Conditions
Depression, Bipolar Disorder
Interventions
Cogito Companion Mobile Phone Application
Other
Lead sponsor
Cogito Health Inc
Industry
Eligibility
18 Years and older
Enrollment
899 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 16, 2018 · Synced Sep 9, 2026, 9:06 AM EDT
Completed Phase 2 Interventional Results available

Depressed Mood Improvement Through Nicotine Dosing 2

NCT04433767
View directory record Official record
Conditions
Depressive Disorder
Interventions
Transdermal Nicotine patch
Drug
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
60 Years and older
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Dec 5, 2023 · Synced Sep 9, 2026, 9:06 AM EDT
Completed Not applicable Interventional

Loving-kindness Meditation for Posttraumatic Stress Disorder (PTSD)

NCT01607632
View directory record Official record
Conditions
Posttraumatic Stress Disorder
Interventions
loving-kindness meditation
Behavioral
Lead sponsor
Seattle Institute for Biomedical and Clinical Research
Other
Eligibility
18 Years and older
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated May 29, 2012 · Synced Sep 9, 2026, 9:06 AM EDT
Completed Not applicable Interventional Results available

The "Light for the Brain" Study

NCT02677987
View directory record Official record
Conditions
Hematopoietic Stem Cell Transplantation, Cognitive Impairments, Sleep, Depression, Fatigue, Quality of Life
Interventions
Intervention systematic light exposure, Comparison systematic light exposure
Device
Lead sponsor
Northwestern University
Other
Eligibility
21 Years and older
Enrollment
47 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2021
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 17, 2022 · Synced Sep 9, 2026, 9:06 AM EDT
Completed Not applicable Interventional Results available

Mechanism of Action of tACS for the Treatment of MDD

NCT03994081
View directory record Official record
Conditions
Major Depressive Disorder, MDD
Interventions
tACS, Sham tACS
Device
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 70 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 18, 2024 · Synced Sep 9, 2026, 9:06 AM EDT
Recruiting Not applicable Interventional

Amplification of Positivity for Alcohol Use

NCT06030154
View directory record Official record
Conditions
Alcohol Use Disorder, Anxiety, Depression
Interventions
Cognitive Behavioral Therapy, Amplification of Positivity Therapy, Surveys and Interviews
Behavioral
Lead sponsor
Laureate Institute for Brain Research, Inc.
Other
Eligibility
18 Years to 65 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Tulsa, Oklahoma
Source: ClinicalTrials.gov public record
Updated Jul 17, 2025 · Synced Sep 9, 2026, 9:06 AM EDT
Recruiting No phase listed Observational

Depression and Driving

NCT05446805
View directory record Official record
Conditions
Depression, Drive
Interventions
F 18 AV-1451 (Flortaucipir), [11C]-Pittsburgh Compound B ([11C]PiB)
Drug
Lead sponsor
Washington University School of Medicine
Other
Eligibility
65 Years and older
Enrollment
150 participants
Timeline
2021 – 2027
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jun 7, 2026 · Synced Sep 9, 2026, 9:06 AM EDT
Completed Phase 2 Interventional

Cytidine and Omega-3 Fatty Acids in Bipolar Disorder

NCT00854737
View directory record Official record
Conditions
Bipolar Disorder
Interventions
cytidine, omega-3 fatty acids, placebo
Dietary Supplement · Drug
Lead sponsor
Mclean Hospital
Other
Eligibility
18 Years to 55 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2010
U.S. locations
2
States / cities
Belmont, Massachusetts • Neptune City, New Jersey
Source: ClinicalTrials.gov public record
Updated Apr 19, 2012 · Synced Sep 9, 2026, 9:06 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Feasibility of Egg-Based Diet Interventions and Assessing Perinatal Mental Health

NCT05619445
View directory record Official record
Conditions
Depression, Anxiety, Stress
Interventions
Whole Liquid Egg, Plant-based Egg Substitute
Other
Lead sponsor
University of Idaho
Other
Eligibility
19 Years and older · Female only
Enrollment
1 participant
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Moscow, Idaho
Source: ClinicalTrials.gov public record
Updated Dec 5, 2024 · Synced Sep 9, 2026, 9:06 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Pitt Center for Emergency Responder Wellness

NCT05357586
View directory record Official record
Conditions
Posttraumatic Stress Disorder, Depression, Anxiety, Alcohol Use Disorder
Interventions
Unified Protocol for Transdiagnostic Treatment of Emotional Disorders
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years and older
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 19, 2024 · Synced Sep 9, 2026, 9:06 AM EDT
Terminated Not applicable Interventional Results available

rTMS for Depressed Teens: A Sham-Controlled Trial, Part 1

NCT01804270
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Repetitive transcranial magnetic stimulation (rTMS)
Device
Lead sponsor
Paul E. Croarkin
Other
Eligibility
12 Years to 21 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
2
States / cities
Rochester, Minnesota • Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Jan 18, 2022 · Synced Sep 9, 2026, 9:06 AM EDT
Completed Not applicable Interventional

Cognitive-Behavioral Therapy and Tai Chi Chih for Patients With Rheumatoid Arthritis

NCT00072657
View directory record Official record
Conditions
Rheumatoid Arthritis
Interventions
Cognitive Behavioral Therapy, Tai Chi Chih, Health Education Seminar
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older
Enrollment
106 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2009
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Apr 3, 2013 · Synced Sep 9, 2026, 9:06 AM EDT