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ClinicalTrials.gov public records Last synced Oct 15, 2026, 7:36 AM EDT

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Showing 649–672 of 1,044 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Depression and Anxiety Symptoms Clear all
Completed Not applicable Interventional

An Attachment Based Approach for Anxiety and Depression

NCT04719780
View directory record Official record
Conditions
Depression, Anxiety
Interventions
Emotionally Focused Therapy for Individuals, Self-Help CBT Training
Behavioral
Lead sponsor
Saint Paul University
Other
Eligibility
18 Years and older
Enrollment
88 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Feb 9, 2024 · Synced Oct 15, 2026, 7:36 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Unmute's CARE Framework: A Novel Approach to Strengthen the Therapeutic Alliance and Reduce Treatment Disparities

NCT06625502
View directory record Official record
Conditions
Depression Scale Score, Anxiety Symptoms, Functioning, Psychosocial, Working Alliance
Interventions
Culturally-Affirming Racial Equity Framework
Behavioral
Lead sponsor
New York University
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
2
States / cities
Chelsea, Massachusetts • New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 22, 2026 · Synced Oct 15, 2026, 7:36 AM EDT
Completed Early Phase 1 Interventional

Bio Electro Stimulation Therapy for Parkinson's Disease

NCT03014050
View directory record Official record
Conditions
Parkinson Disease
Interventions
e-Tapper TT-R1
Device
Lead sponsor
Boston University
Other
Eligibility
50 Years to 75 Years
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 3, 2020 · Synced Oct 15, 2026, 7:36 AM EDT
Completed Phase 3 Interventional Results available

Study of the Safety and Efficacy of Fixed-dose Brexpiprazole (OPC-34712) as Adjunctive Therapy in the Treatment of Adults With Major Depressive Disorder With and Without Anxious Distress

NCT02196506
View directory record Official record
Conditions
Depressive Disorder, Depression, Depressive Disorder, Major, Mood Disorders, Mental Disorders
Interventions
Placebo + ADT, Brexpiprazole +ADT
Drug
Lead sponsor
Otsuka Pharmaceutical Development & Commercialization, Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
837 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
30
States / cities
Birmingham, Alabama • Beverly Hills, California • Denver, Colorado + 27 more
Source: ClinicalTrials.gov public record
Updated Aug 21, 2018 · Synced Oct 15, 2026, 7:36 AM EDT
Completed Not applicable Interventional

Intervening Early: Key Adolescent Outcomes

NCT04168684
View directory record Official record
Conditions
Depressive Symptoms, Conduct Disorder, Anxiety Disorders
Interventions
Attachment and Biobehavioral Catch-up (ABC), Developmental Education for Families (DEF)
Behavioral
Lead sponsor
University of Delaware
Other
Eligibility
13 Years to 17 Years
Enrollment
128 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2026
U.S. locations
1
States / cities
Newark, Delaware
Source: ClinicalTrials.gov public record
Updated May 5, 2026 · Synced Oct 15, 2026, 7:36 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Pilot Study of Asynchronous and Synchronous Telepsychiatry for Skilled Nursing Facilities

NCT02537093
View directory record Official record
Conditions
Dementia, Depression, Mood Disorder, Anxiety Disorder, Substance Use Disorder
Interventions
Psychiatric Consultation
Behavioral
Lead sponsor
University of California, Davis
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
2
States / cities
Sacramento, California • Woodland, California
Source: ClinicalTrials.gov public record
Updated Jul 11, 2017 · Synced Oct 15, 2026, 7:36 AM EDT
Terminated Not applicable Interventional

MINDFUL-PC for Portuguese Speakers Pilot Study 2020

NCT04268355
View directory record Official record
Conditions
Depression, Anxiety Disorders, Stress Related Disorder, Adjustment Disorders, Chronic Illness
Interventions
Mindfulness Training for Primary Care
Behavioral
Lead sponsor
Cambridge Health Alliance
Other
Eligibility
18 Years to 70 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
1
States / cities
Somerville, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 11, 2021 · Synced Oct 15, 2026, 7:36 AM EDT
Completed Not applicable Interventional

Acceptance and Commitment Therapy for Depressed Individuals Living With Spinal Cord Injury Sustained Within 5 Years

NCT05725161
View directory record Official record
Conditions
Depression, Spinal Cord Injuries
Interventions
Acceptance and commitment therapy (ACT), Wait-list control group with psychoeducation materials provided
Behavioral
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years and older
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Feb 25, 2025 · Synced Oct 15, 2026, 7:36 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Confirmatory Efficacy of the Building a Strong Identity and Coping Skills Program

NCT05789446
View directory record Official record
Conditions
Chronic Stress, Anxiety, Depression
Interventions
Building a Strong Identity and Coping Skills
Behavioral
Lead sponsor
Penn State University
Other
Eligibility
11 Years and older
Enrollment
360 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2030
U.S. locations
5
States / cities
Harrisburg, Pennsylvania • Hershey, Pennsylvania • Spring Mills, Pennsylvania + 1 more
Source: ClinicalTrials.gov public record
Updated Sep 17, 2026 · Synced Oct 15, 2026, 7:36 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effect of Psychotherapy on Stress Biochemistry: An RCT of Psychotherapy and Emotional Freedom Techniques (EFT)

NCT00641394
View directory record Official record
Conditions
Stress, Depression, Anxiety
Interventions
Psychotherapy: Emotional Freedom Techniques (EFT), Cognitive Behavioral Therapy (CBT)
Behavioral
Lead sponsor
Soul Medicine Institute
Other
Eligibility
18 Years to 75 Years
Enrollment
83 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2010
U.S. locations
1
States / cities
Santa Rosa, California
Source: ClinicalTrials.gov public record
Updated Apr 25, 2018 · Synced Oct 15, 2026, 7:36 AM EDT
Completed Not applicable Interventional

A Ten-Week Online Acceptance and Commitment Therapy Intervention for Family Caregivers of People With Dementia

NCT05043441
View directory record Official record
Conditions
Depressive Symptoms
Interventions
Acceptance and commitment therapy (ACT), Psychoeducation
Behavioral
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years and older
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Oct 9, 2024 · Synced Oct 15, 2026, 7:36 AM EDT
Recruiting Not applicable Interventional

Facilitated Transitions From Postpartum to Primary Care Coordination for People With Chronic Conditions

NCT06557005
View directory record Official record
Conditions
Hypertension, Diabetes, Postpartum, Pregnancy, Anxiety, Depression, Obesity
Interventions
Facilitated Transition to Primary Care
Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older · Female only
Enrollment
1,320 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 13, 2026 · Synced Oct 15, 2026, 7:36 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Mindfulness Training in U.S. Army Cohorts

NCT03310112
View directory record Official record
Conditions
Psychological Stress, Anxiety, Post Traumatic Stress Disorder, Depression, Cognitive Change
Interventions
4-week MBAT, 2-week MBAT
Behavioral
Lead sponsor
University of Miami
Other
Eligibility
18 Years to 65 Years
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Coral Gables, Florida
Source: ClinicalTrials.gov public record
Updated Sep 18, 2018 · Synced Oct 15, 2026, 7:36 AM EDT
Completed Not applicable Interventional

Reducing Isolation and Feeling of Loneliness During Critical Illness

NCT05537311
View directory record Official record
Conditions
Critical Illness, Social Isolation, Anxiety, Depression, Post Intensive Care Unit Syndrome
Interventions
Social Engagement
Behavioral
Lead sponsor
Kirby Mayer
Other
Eligibility
18 Years to 99 Years
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Jul 14, 2023 · Synced Oct 15, 2026, 7:36 AM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Comparison of Vocal Biomarkers for Depression and Anxiety to Formal Clinical Assessments

NCT06464575
View directory record Official record
Conditions
Depression/Anxiety
Interventions
Not listed
Lead sponsor
Ellipsis Health
Industry
Eligibility
18 Years and older
Enrollment
540 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jun 18, 2024 · Synced Oct 15, 2026, 7:36 AM EDT
Recruiting Phase 2 Interventional Accepts healthy volunteers

Pharmaco-Neuroimaging Studies of Approach/Avoidance Behaviors and Post-Mortem Studies: Pharmacological Manipulation

NCT05232032
View directory record Official record
Conditions
Depressive Disorder, Major, Anxiety Disorder
Interventions
Nociceptin Receptor Antagonist, Aversive stimuli
Drug · Device
Lead sponsor
Mclean Hospital
Other
Eligibility
18 Years to 45 Years
Enrollment
112 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 18, 2026 · Synced Oct 15, 2026, 7:36 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Radicle Health1: A Study of Health and Wellness Formulations and Their Effects on Overall Health

NCT05783232
View directory record Official record
Conditions
Sleep, Pain, Depression, Anxiety
Interventions
Placebo Control Form 1 Capsules, Health Active Study Product 1.1 Capsules, Health Active Study Product 1.2 Capsules, Health Active Study Product 1.3 Capsules
Dietary Supplement
Lead sponsor
Radicle Science
Industry
Eligibility
21 Years to 105 Years
Enrollment
1,494 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Del Mar, California
Source: ClinicalTrials.gov public record
Updated Nov 22, 2023 · Synced Oct 15, 2026, 7:36 AM EDT
Not listed No phase listed Observational

Validation of myStrength's Macropersonalization Engine

NCT05417178
View directory record Official record
Conditions
Depression, Anxiety, Trauma
Interventions
myStrength Macropersonalization Enginge
Other
Lead sponsor
Teladoc Health
Industry
Eligibility
18 Years to 85 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Menlo Park, California
Source: ClinicalTrials.gov public record
Updated Jun 14, 2022 · Synced Oct 15, 2026, 7:36 AM EDT
Recruiting Not applicable Interventional

Valuation in Depressed Mood, Anhedonia, and Anxiety

NCT05384158
View directory record Official record
Conditions
Neurobehavioral Components of Reward and Loss Valuation
Interventions
cognitive behavioral therapy, valuation with instruction, valuation without instruction
Behavioral
Lead sponsor
Virginia Polytechnic Institute and State University
Other
Eligibility
25 Years to 50 Years
Enrollment
252 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
1
States / cities
Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated Aug 28, 2026 · Synced Oct 15, 2026, 7:36 AM EDT
Not listed No phase listed Observational

T.E.A.M. Feasibility and Efficacy Study 2.0

NCT03694106
View directory record Official record
Conditions
Depression, Anxiety
Interventions
TEAM PSYCHOTHERAPY
Behavioral
Lead sponsor
Feeling Good Institute
Other
Eligibility
18 Years and older
Enrollment
80 participants
Timeline
2019 – 2023
U.S. locations
1
States / cities
Mountain View, California
Source: ClinicalTrials.gov public record
Updated Mar 3, 2020 · Synced Oct 15, 2026, 7:36 AM EDT
Recruiting Not applicable Interventional

The Impact of Melatonin Lotion on Sleep and Mental Health

NCT06768749
View directory record Official record
Conditions
Sleep Problems, Depressive Disorder and Anxiety Disorders
Interventions
Melatonin lotion, Placebo lotion
Other
Lead sponsor
University of Redlands
Other
Eligibility
18 Years to 21 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Redlands, California
Source: ClinicalTrials.gov public record
Updated May 1, 2026 · Synced Oct 15, 2026, 7:36 AM EDT
Completed Not applicable Interventional

3D Maternal Fetal Bonding

NCT04540458
View directory record Official record
Conditions
Maternal-Fetal Relations, Paternal Behavior, Maternal Behavior
Interventions
3D printed model, Placebo
Other
Lead sponsor
Creighton University
Other
Eligibility
19 Years to 45 Years
Enrollment
288 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Mar 16, 2022 · Synced Oct 15, 2026, 7:36 AM EDT
Not yet recruiting Phase 1 Interventional Accepts healthy volunteers

Evaluating the Efficacy and Safety of PROSOMNIA Sleep Therapy™ in Patients With Sleep Deprivation and Chronic Insomnia

NCT06644573
View directory record Official record
Conditions
Chronic Insomnia, Sleep Deprivation, REM Behavior Disorder, REM Sleep Behavior Disorder, REM Sleep Measurement, Insomnia, Insomnia Related to Specified Disorder, Insomnia Due to Other Mental Disorder, Insomnia Comorbid to Psychiatric Disorder, Insomnia Due to Anxiety and Fear, Insomnia Related to Another Mental Condition, Insomnia Disorders, Idiopathic Hypersomnia, Sleep Disorders, Circadian Rhythm, Post Trauma Nightmares, PTSD - Post Traumatic Stress Disorder, Sleep Quality, Anesthesia, Anxiety, Depression, Mental Health, Alzheimer Disease or Associated Disorder, Parkinsons, Circadian Rhythm, Circadian Dysregulation, PTSD, Post-Traumatic, Post-Traumatic Stress Disorder Complex, Military Combat Stress Reaction, Sleep, Military Activity, Veterans, Shift Work Sleep Disorder, Menopause Related Conditions, Pain, Cancer Pain, Athletes
Interventions
PROSOMNIA Sleep Therapy™ (PSTx), Anesthesia-Induced Sleep Therapy, Diprivan (propofol), Astra-Zeneca, Continuous EEG Monitoring
Procedure · Drug · Device
Lead sponsor
Nyree Penn
Industry
Eligibility
18 Years to 65 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Aventura, Florida
Source: ClinicalTrials.gov public record
Updated May 28, 2025 · Synced Oct 15, 2026, 7:36 AM EDT
Completed Not applicable Interventional

Companion Dog Walking for ICU Survivor Health

NCT05820308
View directory record Official record
Conditions
Post Intensive Care Syndrome, Depression, Anxiety, Quality of Life
Interventions
Companion Dog Walking, Attention Control Group
Behavioral
Lead sponsor
University of Missouri, Kansas City
Other
Eligibility
18 Years and older
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
2
States / cities
Colorado Springs, Colorado
Source: ClinicalTrials.gov public record
Updated May 10, 2024 · Synced Oct 15, 2026, 7:36 AM EDT