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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Depression and Quality of Life Clear all
Completed Phase 1 Interventional

Phase I: At-Home Support for Rural Women Using Group Video Calling

NCT01672684
View directory record Official record
Conditions
Depression, Post-traumatic Stress Disorder, Recurrent Breast Cancer, Stage IA Breast Cancer, Stage IB Breast Cancer, Stage II Breast Cancer, Stage IIIA Breast Cancer, Stage IIIB Breast Cancer, Stage IIIC Breast Cancer, Stage IV Breast Cancer
Interventions
support group therapy, educational intervention
Procedure · Other
Lead sponsor
Stanford University
Other
Eligibility
21 Years and older · Female only
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
2
States / cities
Nevada City, California • Stanford, California
Source: ClinicalTrials.gov public record
Updated Oct 16, 2014 · Synced Sep 28, 2026, 9:27 PM EDT
Completed Not applicable Interventional Results available

SCI-VIP: Predictive Outcome Model Over Time for Employment (PrOMOTE)

NCT01141647
View directory record Official record
Conditions
Spinal Cord Injuries
Interventions
Vocational Rehabilitation
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 65 Years
Enrollment
1,047 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
7
States / cities
Palo Alto, California • Tampa, Florida • Boston, Massachusetts + 4 more
Source: ClinicalTrials.gov public record
Updated May 10, 2017 · Synced Sep 28, 2026, 9:27 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Improving Mood in Assisted Living Settings

NCT01763216
View directory record Official record
Conditions
Depressive Symptoms, Clinical Depression
Interventions
Road Tour, Boatload of Crosswords
Other
Lead sponsor
Marianne Smith
Other
Eligibility
55 Years and older
Enrollment
351 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2020
U.S. locations
32
States / cities
Amana, Iowa • Bettendorf, Iowa • Carlisle, Iowa + 17 more
Source: ClinicalTrials.gov public record
Updated Nov 8, 2020 · Synced Sep 28, 2026, 9:27 PM EDT
Completed Not applicable Interventional

Guided Eight-week Online Acceptance and Commitment Therapy for Distressed Family Caregivers of People With Dementia

NCT04847986
View directory record Official record
Conditions
Psychological Distress
Interventions
acceptance and commitment therapy (ACT), Control group
Behavioral
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years and older
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jun 27, 2022 · Synced Sep 28, 2026, 9:27 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Early Palliative Care With Standard Care or Standard Care Alone in Improving Quality of Life of Patients With Incurable Lung or Non-colorectal Gastrointestinal Cancer and Their Family Caregivers

NCT02349412
View directory record Official record
Conditions
Liver Cancer, Anxiety Disorder, Depression, Small Cell Lung Cancer, Extrahepatic Bile Duct Cancer, Malignant Mesothelioma, Pancreatic Cancer, Esophageal Cancer, Gastric Cancer, Non-small Cell Lung Cancer
Interventions
Early palliative care
Other
Lead sponsor
Alliance for Clinical Trials in Oncology
Other
Eligibility
18 Years and older
Enrollment
405 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2019
U.S. locations
23
States / cities
La Jolla, California • Honolulu, Hawaii • Chicago, Illinois + 20 more
Source: ClinicalTrials.gov public record
Updated Feb 6, 2025 · Synced Sep 28, 2026, 9:27 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Telephone Assessment and Skill-Building Intervention for Stroke Caregivers

NCT01275495
View directory record Official record
Conditions
Stroke, Family Caregivers
Interventions
Telephone Assessment and Skill-Building Kit (TASK II), Information, Support, and Referral (ISR)
Behavioral
Lead sponsor
Indiana University
Other
Eligibility
21 Years and older
Enrollment
254 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2014
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Mar 30, 2015 · Synced Sep 28, 2026, 9:27 PM EDT
Terminated No phase listed Observational

Factors Affecting Weight Gain in Women Receiving Adjuvant Chemotherapy for Breast Cancer

NCT00019643
View directory record Official record
Conditions
Depression, Stage I Breast Cancer, Stage IIIA Breast Cancer, Nutrition, Stage II Breast Cancer, Psychosocial Effects/Treatment, Quality of Life
Interventions
Not listed
Lead sponsor
National Institutes of Health Clinical Center (CC)
NIH
Eligibility
18 Years to 80 Years · Female only
Enrollment
26 participants
Timeline
1999 – 2007
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 30, 2023 · Synced Sep 28, 2026, 9:27 PM EDT
Not listed Not applicable Interventional

FOCUS for Pediatric Sickle Cell Disease and Cancer

NCT04075877
View directory record Official record
Conditions
Pediatric Cancer, Sickle Cell Disease, Quality of Life, Depressive Symptoms, Coping Skills
Interventions
FOCUS
Behavioral
Lead sponsor
Georgia State University
Other
Eligibility
12 Years to 18 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
2
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Nov 12, 2020 · Synced Sep 28, 2026, 9:27 PM EDT
Completed Not applicable Interventional Results available

Improving Quality of Life for Veterans With Stroke and Psychological Distress

NCT03645759
View directory record Official record
Conditions
Stroke, Depression, Anxiety
Interventions
I'm Whole, Education + usual care
Behavioral · Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jul 17, 2024 · Synced Sep 28, 2026, 9:27 PM EDT
Terminated No phase listed Observational

Psychological Outcomes in Isolated GnRH Deficiency

NCT02356172
View directory record Official record
Conditions
Hypogonadism
Interventions
Not listed
Lead sponsor
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NIH
Eligibility
18 Years to 200 Years
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 17, 2019 · Synced Sep 28, 2026, 9:27 PM EDT
Completed Not applicable Interventional

Problem-Solving Therapy for Depressive Symptoms and Quality of Life in Stroke Survivor-Caregiver Dyads

NCT04035681
View directory record Official record
Conditions
Stroke, Quality of Life, Depression
Interventions
Problem-Solving Therapy, Stroke-Related Health Education
Behavioral · Other
Lead sponsor
Allina Health System
Other
Eligibility
18 Years to 70 Years
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Sep 1, 2020 · Synced Sep 28, 2026, 9:27 PM EDT
Terminated No phase listed Observational

Study of Quality of Life in Freeman-Sheldon Syndrome and Related Conditions

NCT01307475
View directory record Official record
Conditions
Arthrogryposis, Craniofacial Abnormalities, Posttraumatic Stress Disorder, Depressive Disorder
Interventions
PTSD Checklist-Specific, Modified Flanagan Quality of Life Scale, Center for Epidemiologic Studies Depression Scale, Functional Enquiry Form, Strength, Joint ROM, Girth and Length Measurements, Study Physical Examination, PTSD, Depression, and FSS-Focused Examination, Freeman-Sheldon Specific Quality of Life Survey, Lactate, Glucose, and Adenosine Triphosphate Blood Levels
Other
Lead sponsor
Freeman-Sheldon Research Group, Inc.
Other
Eligibility
Not listed
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2017
U.S. locations
1
States / cities
Buckhannon, West Virginia
Source: ClinicalTrials.gov public record
Updated Apr 3, 2017 · Synced Sep 28, 2026, 9:27 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Acceptance Commitment Therapy for Caregivers of People with Memory Loss

NCT05749939
View directory record Official record
Conditions
Caregiver Burden, Behavioral and Psychiatric Symptoms of Dementia, Depressive Symptoms, Quality of Life, Psychological Flexibility, Sleep Quality, Positive Aspects of Caregiving
Interventions
Acceptance and Commitment Therapy
Behavioral
Lead sponsor
Utah State University
Other
Eligibility
18 Years and older
Enrollment
121 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Logan, Utah
Source: ClinicalTrials.gov public record
Updated Dec 5, 2024 · Synced Sep 28, 2026, 9:27 PM EDT
Completed Phase 2 Interventional Results available

Citalopram in Irritable Bowel Syndrome

NCT00477165
View directory record Official record
Conditions
Irritable Bowel Syndrome
Interventions
Citalopram, Placebo
Drug
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2009
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Apr 16, 2017 · Synced Sep 28, 2026, 9:27 PM EDT
Completed Not applicable Interventional

Palliative Care and Quality of Life in Idiopathic Pulmonary Fibrosis

NCT03981406
View directory record Official record
Conditions
Idiopathic Pulmonary Fibrosis, Depression, Anxiety, Depressive Disorder, Anxiety Disorders, Anxiety Depression
Interventions
Palliative Care, Standard of Care
Behavioral
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 28, 2020 · Synced Sep 28, 2026, 9:27 PM EDT
Active, not recruiting Not applicable Interventional

Collaborative Care for Anxiety and Depression in Epilepsy

NCT05559749
View directory record Official record
Conditions
Epilepsy, Anxiety, Depression
Interventions
collaborative care, usual neurology care
Behavioral
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 2, 2026 · Synced Sep 28, 2026, 9:27 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Drumming Groups for Parents of Autistic Children

NCT07375043
View directory record Official record
Conditions
Anxiety Acute, Stress, Depression and Quality of Life, Stress in Parents of Autistic Children
Interventions
Group Drumming
Behavioral
Lead sponsor
Arizona State University
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
Tempe, Arizona
Source: ClinicalTrials.gov public record
Updated Apr 30, 2026 · Synced Sep 28, 2026, 9:27 PM EDT
Completed Not applicable Interventional

Adjusting to Chronic Conditions Using Education Support and Skills

NCT00727155
View directory record Official record
Conditions
Anxiety, Depression
Interventions
Adjusting to Chronic Conditions Using Education Support and Skills
Behavioral
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
18 Years and older
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jul 9, 2009 · Synced Sep 28, 2026, 9:27 PM EDT
Completed Phase 4 Interventional Results available

Project to Improve Symptoms and Mood in People With Spinal Cord Injury

NCT00592384
View directory record Official record
Conditions
Major Depressive Disorder, Dysthymia, Spinal Cord Injuries
Interventions
venlafaxine XR, placebo
Drug
Lead sponsor
University of Washington
Other
Eligibility
18 Years to 64 Years
Enrollment
133 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2012
U.S. locations
6
States / cities
Birmingham, Alabama • Miami, Florida • Chicago, Illinois + 3 more
Source: ClinicalTrials.gov public record
Updated Dec 31, 2014 · Synced Sep 28, 2026, 9:27 PM EDT
Completed Phase 2 Interventional

Brief CBT for Anxiety and Advanced Cancer

NCT00706290
View directory record Official record
Conditions
Anxiety, Depression, Unspecified Adult Solid Tumor, Protocol Specific, Cancer, Cognitive Behavioral Therapy
Interventions
Brief Cognitive Behavioral Therapy
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
49 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 5, 2014 · Synced Sep 28, 2026, 9:27 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Support for Bereaved Cancer Caregivers

NCT06662409
View directory record Official record
Conditions
Bereavement, Cancer, Caregiver, Grief
Interventions
Nature-based healing meditation (NBHM) intervention
Other
Lead sponsor
Michigan State University
Other
Eligibility
18 Years and older
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
East Lansing, Michigan
Source: ClinicalTrials.gov public record
Updated Sep 17, 2026 · Synced Sep 28, 2026, 9:27 PM EDT
Completed Not applicable Interventional

Combined Illness Management and Psychotherapy in Treating Depressed Elders

NCT01337726
View directory record Official record
Conditions
Depression, Heart Failure, Chronic Obstructive Pulmonary Disease
Interventions
Combined Psychotherapy and Illness Management, Illness Management Only
Behavioral
Lead sponsor
University of Iowa
Other
Eligibility
55 Years and older
Enrollment
226 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2016
U.S. locations
2
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Apr 4, 2017 · Synced Sep 28, 2026, 9:27 PM EDT
Completed Phase 4 Interventional Results available

Effectiveness of Methylphenidate in Improving Cognition and Function in Older Adults With Depression

NCT00602290
View directory record Official record
Conditions
Depression
Interventions
Citalopram, Methylphenidate (MPH), Placebo
Drug
Lead sponsor
University of California, Los Angeles
Other
Eligibility
60 Years and older
Enrollment
181 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2013
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jan 10, 2018 · Synced Sep 28, 2026, 9:27 PM EDT
Completed Not applicable Interventional

Music Therapy and Dialysis: A Pilot Investigation Into the Effectiveness of Patient-Selected Music Interventions on Physiological, Psychological, and Quality-of-Life Outcomes

NCT03925168
View directory record Official record
Conditions
End Stage Renal Disease, Depression, Anxiety, Major Depressive Disorder, Generalized Anxiety Disorder, Compliance, Patient, Compliance, Medication, Mood, Pain, Energy Supply; Deficiency, Quality of Life, Blood Pressure, Heart Rate Fast
Interventions
Music therapy
Behavioral
Lead sponsor
Tulane University
Other
Eligibility
21 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
3
States / cities
New Orleans, Louisiana • Terrytown, Louisiana
Source: ClinicalTrials.gov public record
Updated Jan 14, 2021 · Synced Sep 28, 2026, 9:27 PM EDT