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ClinicalTrials.gov public records Last synced Oct 2, 2026, 1:51 AM EDT

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Showing 25–48 of 266 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Depression in Adolescence Clear all
Completed Phase 1 Interventional

Brief Intervention for Suicide Risk Reduction in High Risk Adolescents

NCT02272179
View directory record Official record
Conditions
Adolescent Behavior
Interventions
As Safe As Possible, Brite, Treatment as Usual
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
12 Years to 17 Years
Enrollment
68 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
2
States / cities
Pittsburgh, Pennsylvania • Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Dec 20, 2018 · Synced Oct 2, 2026, 1:51 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Family-Centered Treatment for Depression in Hispanic Youth

NCT05407051
View directory record Official record
Conditions
Depression, Family Research, Teen Depression
Interventions
Family Centered Treatment, Treatment as Usual
Behavioral
Lead sponsor
MetroHealth Medical Center
Other
Eligibility
18 Years and older
Enrollment
41 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 12, 2024 · Synced Oct 2, 2026, 1:51 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Implementing and Evaluating an Internet-based Cognitive Behavior Therapy Intervention in School Settings

NCT04928001
View directory record Official record
Conditions
Depression Anxiety and Co-occurring Rural Youth
Interventions
internet based iCBT program, Youth Thrive
Other
Lead sponsor
Montana State University
Other
Eligibility
13 Years to 19 Years
Enrollment
67 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Bozeman, Montana
Source: ClinicalTrials.gov public record
Updated Jan 30, 2025 · Synced Oct 2, 2026, 1:51 AM EDT
Terminated Not applicable Interventional Results available

rTMS for Depressed Teens: A Sham-Controlled Trial, Part 2

NCT01804296
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Repetitive transcranial magnetic stimulation (rTMS)
Device
Lead sponsor
Paul E. Croarkin
Other
Eligibility
12 Years to 21 Years
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
2
States / cities
Rochester, Minnesota • Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Jan 19, 2022 · Synced Oct 2, 2026, 1:51 AM EDT
Recruiting No phase listed Observational

Inflammatory and Glutamatergic Mechanisms of Sustained Threat in Adolescents With Depression

NCT05329441
View directory record Official record
Conditions
Depression in Adolescence
Interventions
Trier Social Stress Test (TSST)
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
14 Years to 21 Years
Enrollment
160 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated May 29, 2026 · Synced Oct 2, 2026, 1:51 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

RCT of a Brief Video Intervention Targeting Peer Inclusion to Reduce Depression-related Stigma in Adolescents

NCT06360107
View directory record Official record
Conditions
Depression, Adolescent - Emotional Problem, Stigma, Social, Help-Seeking Behavior
Interventions
brief video
Other
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
14 Years to 18 Years
Enrollment
645 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 6, 2025 · Synced Oct 2, 2026, 1:51 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Cognitive Behavioral vs. Interpersonal Therapy (IPT) Prevention of Depression in Adolescents

NCT00374439
View directory record Official record
Conditions
Depressive Symptoms
Interventions
Cognitive-behavioral, Interpersonal Therapy
Behavioral
Lead sponsor
Vanderbilt University
Other
Eligibility
12 Years to 17 Years
Enrollment
400 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2006
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Apr 10, 2017 · Synced Oct 2, 2026, 1:51 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Radical Openness for Adolescents Pilot

NCT05913557
View directory record Official record
Conditions
Anorexia Nervosa, Obsessive-Compulsive Disorder, Social Phobia, Depression, Anxiety
Interventions
Radically Open Dialectical Behavior Therapy (RO DBT)
Behavioral
Lead sponsor
Washington University School of Medicine
Other
Eligibility
13 Years to 21 Years · Female only
Enrollment
61 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jun 22, 2023 · Synced Oct 2, 2026, 1:51 AM EDT
Active, not recruiting No phase listed Observational Accepts healthy volunteers

Resilience in Adolescent Development

NCT03458936
View directory record Official record
Conditions
Risk Assessment, Resilience, Psychological, Depression, Mood Disorders, Anxiety Disorders, Mental Health
Interventions
Not listed
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
10 Years to 24 Years
Enrollment
1,500 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2032
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Sep 15, 2026 · Synced Oct 2, 2026, 1:51 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Family Spirit Study

NCT00356551
View directory record Official record
Conditions
Substance Abuse
Interventions
Family Spirit curriculum
Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
12 Years to 24 Years
Enrollment
320 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2002 – 2005
U.S. locations
5
States / cities
Fort Defiance, Arizona • Tuba City, Arizona • Whiteriver, Arizona + 2 more
Source: ClinicalTrials.gov public record
Updated Aug 1, 2016 · Synced Oct 2, 2026, 1:51 AM EDT
Completed Phase 1Phase 2 Interventional

Effects of Therapist Behavior on the Treatment of Depressed Adolescents

NCT00073359
View directory record Official record
Conditions
Depression, Depressive Disorder, Dysthymic Disorder
Interventions
Cognitive Behavioral Therapy
Behavioral
Lead sponsor
University of Denver
Other
Eligibility
13 Years to 18 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2005
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Apr 19, 2019 · Synced Oct 2, 2026, 1:51 AM EDT
Terminated Not applicable Interventional Results available

rTMS for Depressed Teens: A Sham-Controlled Trial, Part 1

NCT01804270
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Repetitive transcranial magnetic stimulation (rTMS)
Device
Lead sponsor
Paul E. Croarkin
Other
Eligibility
12 Years to 21 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
2
States / cities
Rochester, Minnesota • Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Jan 19, 2022 · Synced Oct 2, 2026, 1:51 AM EDT
Recruiting No phase listed Observational

Parent-Adolescent Relationships, Emotional Regulation, and HRV in Adolescents With Depression

NCT07430774
View directory record Official record
Conditions
Emotional Dysregulation, HRV, Adolescent, Family Relationship, Depression
Interventions
Not listed
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
12 Years to 18 Years
Enrollment
74 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Sep 21, 2026 · Synced Oct 2, 2026, 1:51 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Litebook EDGE™ Phototherapy on Academic Performance and Brain Activity

NCT05383690
View directory record Official record
Conditions
Sleepiness, Daytime
Interventions
LED bright light treatment device
Device
Lead sponsor
Mclean Hospital
Other
Eligibility
13 Years to 18 Years
Enrollment
26 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 20, 2022 · Synced Oct 2, 2026, 1:51 AM EDT
Active, not recruiting Not applicable Interventional

Intervention to Enhance Coping and Help-seeking Among Youth in Foster Care

NCT06019377
View directory record Official record
Conditions
Adolescent Behavior, Psychosocial Functioning, Coping Behavior, Help-Seeking Behavior, Utilization, Health Care, Depression, Anxiety, Stress Disorders, Post-Traumatic, Emotion Regulation, Child Welfare
Interventions
Stronger Youth Networks and Coping (SYNC)
Behavioral
Lead sponsor
Portland State University
Other
Eligibility
16 Years to 20 Years
Enrollment
106 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Jul 10, 2026 · Synced Oct 2, 2026, 1:51 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effects of a Single-session Implicit Theories of Personality Intervention on Early Adolescent Psychopathology

NCT03132298
View directory record Official record
Conditions
Anxiety Symptoms, Depressive Symptoms
Interventions
Implicit Theories of Personality Program, Control Program
Other
Lead sponsor
Harvard University
Other
Eligibility
12 Years to 15 Years
Enrollment
96 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 7, 2019 · Synced Oct 2, 2026, 1:51 AM EDT
Completed Not applicable Interventional

Depression & Insulin Sensitivity in Adolescents

NCT03263351
View directory record Official record
Conditions
Type2 Diabetes, Type 2 Diabetes Mellitus, Insulin Sensitivity, Insulin Resistance, Depression, Adolescent Obesity
Interventions
Cognitive-behavioral therapy group, Health education group
Behavioral
Lead sponsor
Colorado State University
Other
Eligibility
12 Years to 17 Years · Female only
Enrollment
147 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2025
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Sep 23, 2025 · Synced Oct 2, 2026, 1:51 AM EDT
Completed Phase 2 Interventional Results available

Pharmacokinetics and Tolerability of Vortioxetine (Lu AA21004) in Child and Adolescent Patients With Depressive or Anxiety Disorder

NCT01491035
View directory record Official record
Conditions
Depressive Disorder, Anxiety Disorder
Interventions
Vortioxetine
Drug
Lead sponsor
H. Lundbeck A/S
Industry
Eligibility
7 Years to 17 Years
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
4
States / cities
Washington D.C., District of Columbia • Wichita, Kansas • Cincinnatti, Ohio + 1 more
Source: ClinicalTrials.gov public record
Updated Mar 16, 2017 · Synced Oct 2, 2026, 1:51 AM EDT
Recruiting Not applicable Interventional

Mechanisms of Rumination Change in Adolescent Depression

NCT03859297
View directory record Official record
Conditions
Major Depressive Disorder, Mood Disorders
Interventions
Rumination-Focused CBT, Relaxation-based Therapy
Behavioral
Lead sponsor
Ohio State University
Other
Eligibility
14 Years to 17 Years
Enrollment
183 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2029
U.S. locations
3
States / cities
Columbus, Ohio • Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Aug 11, 2025 · Synced Oct 2, 2026, 1:51 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Doula Support for Young Mothers: A Randomized Trial

NCT01925664
View directory record Official record
Conditions
Parenting, Breastfeeding, Depression, Postpartum
Interventions
Doula
Behavioral
Lead sponsor
University of Chicago
Other
Eligibility
14 Years to 21 Years · Female only
Enrollment
248 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2001 – 2006
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 5, 2013 · Synced Oct 2, 2026, 1:51 AM EDT
Recruiting Not applicable Interventional

Phase II: Engagement and Clinical Impact of the Teleo Virtual Therapy Platform in Clinical Settings

NCT07155707
View directory record Official record
Conditions
Anxiety, Mood Disorders
Interventions
Teleo, Standard Videoconferencing
Other
Lead sponsor
Stanford University
Other
Eligibility
5 Years to 14 Years
Enrollment
156 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
2
States / cities
Monterey, California • Stanford, California
Source: ClinicalTrials.gov public record
Updated Jun 29, 2026 · Synced Oct 2, 2026, 1:51 AM EDT
Terminated Phase 1 Interventional

A Study of Seltorexant as Adjunctive Therapy to Antidepressants in Adolescents With Major Depressive Disorder Who Have an Inadequate Response to Selective Serotonin Reuptake Inhibitor (SSRI) and Psychotherapy

NCT04951609
View directory record Official record
Conditions
Depressive Disorder, Major
Interventions
Seltorexant, Placebo
Drug
Lead sponsor
Janssen Research & Development, LLC
Industry
Eligibility
12 Years to 17 Years
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
12
States / cities
Phoenix, Arizona • Anaheim, California • San Diego, California + 9 more
Source: ClinicalTrials.gov public record
Updated Apr 27, 2025 · Synced Oct 2, 2026, 1:51 AM EDT
Completed Not applicable Interventional Results available

Reducing Suicide Risk in Adolescents and Young Adults Via a Psychobehavioral Intervention to Regularize Daily Rhythms

NCT05317481
View directory record Official record
Conditions
Bipolar Disorder, Major Depressive Disorder, Mood Disorders, Suicide, Suicidal Ideation
Interventions
BE-SMART-DR, psychoeducational control comparator condition (CC)
Behavioral
Lead sponsor
Yale University
Other
Eligibility
16 Years to 29 Years
Enrollment
65 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
2
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Apr 13, 2026 · Synced Oct 2, 2026, 1:51 AM EDT
Completed Not applicable Interventional

A Family Intervention for Adolescent Problem Behavior (AKA Project Alliance 2)

NCT01490307
View directory record Official record
Conditions
Substance Use, Conduct Disorder, Depression, Anxiety
Interventions
Family Check-Up
Behavioral
Lead sponsor
University of Oregon
Other
Eligibility
Not listed
Enrollment
593 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2011
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Dec 12, 2011 · Synced Oct 2, 2026, 1:51 AM EDT