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Conditions: Hypogonadotropic Hypogonadism, Reproductive Disorder, Kallmann Syndrome, Delayed Puberty
Interventions: Not listed
Lead sponsor: Stephanie B. Seminara, MD; Other
Eligibility: 1 Year and older
Enrollment: 854 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2026
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Smith-Magenis Syndrome (SMS)
Interventions: Not listed
Lead sponsor: National Human Genome Research Institute (NHGRI); NIH
Eligibility: 1 Month to 115 Years
Enrollment: 593 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: Started 2001
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Cardiology, Infant Development, Development Delay
Interventions: NIDCAP Developmental Care; Behavioral
Lead sponsor: Boston Children's Hospital; Other
Eligibility: Up to 4 Months
Enrollment: 34 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2027
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Language Delay, Substance Use Disorders, Language Disorders in Children, Language Development, Prevention Intervention
Interventions: Comilia Group, Interaction Review Enhancement, Practical Support Enhancement; Behavioral
Lead sponsor: University of Oregon; Other
Eligibility: 18 Years and older
Enrollment: 244 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2029
U.S. locations: 1
States / cities: Eugene, Oregon

Conditions: Sarcoidosis
Interventions: Quality of Life; Diagnostic Test
Lead sponsor: University of Cincinnati; Other
Eligibility: 18 Years and older
Enrollment: 350 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2020
U.S. locations: 3
States / cities: Albany, New York • Cincinnati, Ohio • Cleveland, Ohio

Conditions: Developmental Disabilities, Developmental Delay
Interventions: PEM+; Behavioral
Lead sponsor: University of Illinois at Chicago; Other
Eligibility: 18 Years and older
Enrollment: 223 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Sarcoidosis, Diabetes Mellitus
Interventions: Venous blood sample, Ultrasound of pancreas; Diagnostic Test
Lead sponsor: University of Alabama at Birmingham; Other
Eligibility: 18 Years and older
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2020
U.S. locations: 1
States / cities: Birmingham, Alabama

Conditions: Neurodevelopmental Disorders, Intellectual Disability, Development Delay, ADHD, Autism Spectrum Disorder, Epilepsy
Interventions: Sulfonylurea; Drug
Lead sponsor: Royal Devon and Exeter NHS Foundation Trust; Other
Eligibility: 2 Years to 50 Years
Enrollment: 21 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2025
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Cerebral Palsy Infantile, Pre-Term, Motor Delay, Neurodevelopmental Disorders, Autism Spectrum Disorder
Interventions: Behavioral observation; Other
Lead sponsor: Ohio State University; Other
Eligibility: Up to 10 Days
Enrollment: 46 participants
Timeline: 2025 – 2030
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Neurodevelopmental Disorders, Neurodevelopmental Disorders (NDD), Neurodevelopmental Disorders and Developmental Abnormalities, Developmental Delay (Disorder), Cerebral Palsy (CP), Cerebral Palsy Hemiparetic Cerebral Palsy Spasticity Gait Disorders, Neurologic Postural Balance Impairment, Cerebral Palsy Infantile, Cerebral Palsy Spastic Hemiplegic, Cerebral Palsy, Dyskinetic, Autism Spectrum Disorder, Autism Spectrum Disorder (ASD, Hypoxic Ischemic Encephalopathy, Hypoxic Ischemic Encephalopathy (HIE), Traumatic Brain Injury (TBI), Sensory Processing Disorder, Chromosomal Abnormalities, Genetic Disorders, Down Syndrome (Trisomy 21), Fragile X Syndrome (FXS), RETT Syndrome With Proven MECP2 Mutation, Williams Syndrome, 22q11.2 Deletion Syndrome, Sensorimotor Integration
Interventions: Not listed
Lead sponsor: Healing Hope International; Other
Eligibility: 4 Years to 12 Years
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2036
U.S. locations: 1
States / cities: The Woodlands, Texas

Conditions: Child Development Disorder, Development Delay
Interventions: Young Children's Participation and Environment Measure (YC-PEM) electronic patient-reported outcome (e-PRO); Behavioral
Lead sponsor: University of Illinois at Chicago; Other
Eligibility: 3 Months to 36 Months
Enrollment: 76 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2022
U.S. locations: 1
States / cities: Denver, Colorado

Conditions: Cerebral Palsy
Interventions: Dynamic Supported Mobility, Conventional Therapy; Other
Lead sponsor: Children's Hospital of Philadelphia; Other
Eligibility: 12 Months to 36 Months
Enrollment: 42 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2020
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Autism Spectrum Disorder
Interventions: Pickleball Program (Community-Based); Behavioral
Lead sponsor: Penn State University; Other
Eligibility: 18 Years to 45 Years
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026
U.S. locations: 1
States / cities: Middletown, Pennsylvania

Conditions: Deafness, Hearing Loss
Interventions: cochlear implantation, hearing aids; Device
Lead sponsor: Stanford University; Other
Eligibility: 1 Day to 5 Years
Enrollment: 303 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2016
U.S. locations: 2
States / cities: Stanford, California • Houston, Texas

Conditions: Developmental Delays
Interventions: Therapist-Delivered Early Intervention Approach, Caregiver Coaching Early Intervention Approach, Parents Taking Action; Behavioral
Lead sponsor: Northwestern University; Other
Eligibility: 12 Months to 32 Months
Enrollment: 1,269 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2030
U.S. locations: 1
States / cities: Evanston, Illinois

Conditions: Behavior Problem, Developmental Delay, Emotional Disturbances, Family Conflict
Interventions: Nutrition and Play Intervention, Family Nurture Intervention; Behavioral
Lead sponsor: Columbia University; Other
Eligibility: 24 Months to 54 Months
Enrollment: 10 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018
U.S. locations: 1
States / cities: Stamford, Connecticut

Conditions: Post Operative Pain
Interventions: Pain and standard side effect management for PNCA with basal method., Pain and standard side effect management with PNCA without basal, Pain and standard side effect management with IV on an as needed basis method.; Other
Lead sponsor: Medical College of Wisconsin; Other
Eligibility: 4 Years to 18 Years
Enrollment: 94 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2010
U.S. locations: 1
States / cities: Milwaukee, Wisconsin

Conditions: Development; Delayed, Mental, Anxiety, Situational Anxiety, Fear of Other Medical Care, Behavior, Coping, Behavior Disorders, Psychological Disorder, Behavior Disorders in Children
Interventions: Not listed
Lead sponsor: Children's Hospital Medical Center, Cincinnati; Other
Eligibility: 3 Years to 21 Years
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2018
U.S. locations: 1
States / cities: Cincinnati, Ohio

Conditions: Endocrine Disease, Infertility, Hypogonadism, Amenorrhea, Adolescents
Interventions: Not listed
Lead sponsor: National Institute of Environmental Health Sciences (NIEHS); NIH
Eligibility: 14 Years to 100 Years
Enrollment: 111 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: Started 2012
U.S. locations: 2
States / cities: Bethesda, Maryland • Research Triangle Park, North Carolina

Conditions: Autism Spectrum Disorder, Moderate Language Delay
Interventions: Direct Instruction-Language for Learning (DI-LL) via telehealth (e.g., Zoom or WebEx), Standard of care delivered via telehealth (e.g., Zoom or WebEx); Behavioral
Lead sponsor: Emory University; Other
Eligibility: 4 Years to 7 Years
Enrollment: 137 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2020
U.S. locations: 1
States / cities: Atlanta, Georgia

Conditions: Genetic Disorder, Infertility, Hypogonadism, Amenorrhea
Interventions: Not listed
Lead sponsor: National Institute of Environmental Health Sciences (NIEHS); NIH
Eligibility: 6 Weeks to 120 Years
Enrollment: 850 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: Started 2012
U.S. locations: 2
States / cities: Bethesda, Maryland • Research Triangle Park, North Carolina

Conditions: Cerebral Palsy
Interventions: Not listed
Lead sponsor: University of Washington; Other
Eligibility: 18 Months to 12 Years
Enrollment: 724 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2017
U.S. locations: 4
States / cities: Atlanta, Georgia • Oklahoma City, Oklahoma • Philadelphia, Pennsylvania + 1 more

Conditions: Microcephaly, Hyperkinesis With Developmental Delay, Global Developmental Delay
Interventions: Acquire Therapy; Behavioral
Lead sponsor: Virginia Polytechnic Institute and State University; Other
Eligibility: 6 Months to 15 Years
Enrollment: 4 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2022
U.S. locations: 1
States / cities: Roanoke, Virginia

Conditions: Baker Gordon Syndrome, Rare Neurodevelopmental Conditions, Rare Neurogenetic Conditions, Syt-1 Disorder, Epilepsy, Seizure, Genetic Mutations, Autism in Children, Developmental Delay (Disorder)
Interventions: No Intervention: Observational Cohort; Other
Lead sponsor: University of Missouri-Columbia; Other
Eligibility: Up to 99 Years
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2028
U.S. locations: 1
States / cities: Columbia, Missouri

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The Molecular Basis of Inherited Reproductive Disorders

Natural History Study of Smith-Magenis Syndrome

Developmental Intervention for Hospitalized Newborns With Congenital Heart Disease

Prevent Language Delays and Disorders Among Children of Caregivers With Substance Use Disorders With Community Groups and Individualized Services

Patient Reported Outcome Instruments in Sarcoidosis

Exploratory Trial of a Pediatric Web-Based Care Planning Guide

A Suspected Association Between Sarcoidosis and Development of Diabetes Mellitus

Impact of Sulphonylureas on Neurodevelopmental Outcomes in KCNJ11-related Intermediate Developmental Delay, Epilepsy and Neonatal Diabetes (iDEND) Syndrome

Motor-voice Assessment in Infants (MAMI)

Intensive Multimodal Neurorehabilitation Targeting Neuroplasticity in Pediatric Neurodevelopmental and Chromosomal Disorders

Implementation of Electronic Shared Decision-Making Support for Early Intervention

Cerebral Palsy Early Mobility Training

Effect of an 8-Week Pickleball Program for Adults With Autism: A Feasibility Trial With a Delayed-Control Design

Outcomes In Children With Developmental Delay And Deafness

Empower EI: Comparing Early Intervention Approaches to Improve Communication in Toddlers With Developmental Delays

Stamford Group Family Nurture Intervention

Parent Nurse Controlled Analgesic in Pediatric Patients With Developmental Delay

Adaptive Care in the Perioperative Setting

Hormonal Regulation of Puberty and Fertility

Direct Instruction Language for Learning in Autism Spectrum Disorder

Inherited Reproductive Disorders

On Track: Monitoring Development of Children With Cerebral Palsy or Gross Motor Delay

Intensive Therapy for Children With Microcephaly, Hyperkinetic Movements, or Global Developmental Delay

Investigating Phenotypic, Epigenetic, and NeuroGenetic Traits in Rare and Ultra-rare Neurodevelopmental Disorders (Project PENGUIN)