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ClinicalTrials.gov public records Last synced Oct 8, 2026, 1:51 AM EDT

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Showing 121–144 of 406 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Diabetic Foot Disease Clear all
Completed Phase 2 Interventional

Clinical Trials of Footwear in Patients With Diabetes-Study Arm 2,3

NCT00013299
View directory record Official record
Conditions
Diabetic Foot Ulcers
Interventions
Prevention of Diabetic Ulcers
Device
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
18 Years and older
Enrollment
427 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2000 – 2001
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jan 21, 2009 · Synced Oct 8, 2026, 1:51 AM EDT
Completed Not applicable Interventional

Artacent Amniotic Tissue for Treatment of Chronic Lower Extremity Diabetic Ulcers.

NCT07219004
View directory record Official record
Conditions
Lower Extremity Chronic Ulcers in Diabetics, Diabetic Foot Ulcer (DFU)
Interventions
amniotic membrane
Other
Lead sponsor
Tides Medical
Industry
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
5
States / cities
North Port, Florida • Buffalo, New York • Monroeville, Pennsylvania + 2 more
Source: ClinicalTrials.gov public record
Updated Oct 21, 2025 · Synced Oct 8, 2026, 1:51 AM EDT
Completed Not applicable Interventional

Prospective, Comparitive, Randomized Study of Allograft Versus Skin Substitute in Non-healing Diabetic Foot Ulcers

NCT02870816
View directory record Official record
Conditions
Diabetic Foot Ulcer
Interventions
Tissue Engineered Skin Substitute, Offloading, Amnionic Membrane Graft
Procedure · Device
Lead sponsor
Professional Education and Research Institute
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
3
States / cities
Martinsville, Virginia • Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated Dec 8, 2021 · Synced Oct 8, 2026, 1:51 AM EDT
Completed Not applicable Interventional

A Prospective Trial of Non-healing Diabetic Foot Ulcers Treated With Standard Care With or Without BR-AC

NCT06511596
View directory record Official record
Conditions
Diabetic Foot Ulcer
Interventions
BR-AC, Standard Care
Other
Lead sponsor
BioStem Technologies
Industry
Eligibility
18 Years and older
Enrollment
71 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
11
States / cities
San Francisco, California • Sylmar, California • Torrance, California + 8 more
Source: ClinicalTrials.gov public record
Updated Jan 23, 2026 · Synced Oct 8, 2026, 1:51 AM EDT
Completed Not applicable Interventional Results available

Continuous Diffusion of Oxygen (CDO) Treatment for Healing of Diabetic Foot Ulcers

NCT02501538
View directory record Official record
Conditions
Foot Ulcer, Diabetic
Interventions
Transcutaneous O2 device
Device
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 89 Years
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2020
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jul 24, 2023 · Synced Oct 8, 2026, 1:51 AM EDT
Completed Not applicable Interventional

Pilot Study of PHOENIX Wound Matrix® Impact on Chronic DFU Wound Microbiome

NCT04437537
View directory record Official record
Conditions
Diabetic Foot Ulcer
Interventions
Bioresorbable 3D electrospun synthetic matrix
Device
Lead sponsor
RenovoDerm
Industry
Eligibility
18 Years and older
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
1
States / cities
Northampton, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 16, 2026 · Synced Oct 8, 2026, 1:51 AM EDT
Recruiting Phase 4 Interventional

Efficacy of Placental Membrane Dressings in Accelerating Diabetic Foot Healing

NCT07326553
View directory record Official record
Conditions
Diabete Mellitus, Foot Ulcer Chronic
Interventions
Placental Membrane
Biological
Lead sponsor
BioXTek
Industry
Eligibility
45 Years to 85 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
2
States / cities
Phoenix, Arizona • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jan 8, 2026 · Synced Oct 8, 2026, 1:51 AM EDT
Completed Not applicable Interventional Results available

PriMatrix for the Management of Diabetic Foot Ulcers

NCT03010319
View directory record Official record
Conditions
Diabetic Foot Ulcer
Interventions
PriMatrix Dermal Repair Scaffold, Secondary Dressings, Offloading device
Device
Lead sponsor
Integra LifeSciences Corporation
Industry
Eligibility
18 Years and older
Enrollment
226 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
17
States / cities
Carlsbad, California • Los Angeles, California • San Francisco, California + 13 more
Source: ClinicalTrials.gov public record
Updated Apr 29, 2022 · Synced Oct 8, 2026, 1:51 AM EDT
Completed Phase 2 Interventional

Pilot Study of the Safety and Clinical Efficacy of Topical Dermacyn™ Wound Care to Treat Mild Diabetic Foot Infections

NCT00516958
View directory record Official record
Conditions
Foot Ulcer, Diabetic
Interventions
Topical Dermacyn, Topical Dermacyn and Levofloxacin, Topical Saline and Levofloxacin
Drug
Lead sponsor
Oculus Innovative Sciences, Inc.
Industry
Eligibility
18 Years and older
Enrollment
65 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007
U.S. locations
16
States / cities
Tucson, Arizona • La Jolla, California • Los Angeles, California + 13 more
Source: ClinicalTrials.gov public record
Updated Jan 14, 2008 · Synced Oct 8, 2026, 1:51 AM EDT
Terminated Not applicable Interventional Results available

Dissolved Oxygen Dressing to Improve Chronic Wound Healing After Revascularization for Critical Limb Ischemia

NCT02046226
View directory record Official record
Conditions
Critical Limb Ischemia
Interventions
Oxygenesys(TM) Dissolved Oxygen Dressing
Device
Lead sponsor
Halyard Health
Industry
Eligibility
21 Years and older
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Oct 12, 2015 · Synced Oct 8, 2026, 1:51 AM EDT
Completed Not applicable Interventional

A Predictive Technology for Prevention of Diabetic Foot Ulcers

NCT04769115
View directory record Official record
Conditions
Diabetic Foot Ulcer
Interventions
Alert for temperature delta
Device
Lead sponsor
DAPS Health LLC
Other
Eligibility
35 Years and older
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
Annapolis, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 6, 2021 · Synced Oct 8, 2026, 1:51 AM EDT
Active, not recruiting No phase listed Observational

HEAL-4: Real-World Effectiveness of 4 Amniotic Allografts Adjunctive to Standard Care in DFU, VLU, and PU

NCT07223515
View directory record Official record
Conditions
Diabetic Foot Ulcer (DFU), Venous Leg Ulcers (VLUs), Pressure Ulcers, Bedsores, Decubitus Ulcer
Interventions
Not listed
Lead sponsor
Dynamic Medical Services dba Acesso Biologics
Industry
Eligibility
18 Years and older
Enrollment
2,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
2
States / cities
Novi, Michigan • Murfreesboro, Tennessee
Source: ClinicalTrials.gov public record
Updated Nov 3, 2025 · Synced Oct 8, 2026, 1:51 AM EDT
Completed No phase listed Observational

A Multicenter, Prospective, Observational Study With PriMatrix for the Treatment of Neuropathic Diabetic Foot Ulcers

NCT01228526
View directory record Official record
Conditions
Foot Ulcers, Diabetic
Interventions
PriMatrix
Device
Lead sponsor
Integra LifeSciences Corporation
Industry
Eligibility
18 Years and older
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
5
States / cities
Oakland, California • Rochester, Minnesota • New York, New York + 2 more
Source: ClinicalTrials.gov public record
Updated Aug 26, 2016 · Synced Oct 8, 2026, 1:51 AM EDT
Completed Not applicable Interventional Results available

Negative Pressure Wound Therapy as a Drug Delivery System

NCT02463487
View directory record Official record
Conditions
Diabetic Foot Ulcers
Interventions
Cardinal Pro +Simultaneous Irrigation (NPWTi), Cardinal Pro (NPWT) Therapy
Device
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
21 Years to 89 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2020
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jul 24, 2023 · Synced Oct 8, 2026, 1:51 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Omeza Products in Combination With Standard of Care for the Treatment of Diabetic Foot Ulcers

NCT05417425
View directory record Official record
Conditions
Diabetic Foot Ulcers
Interventions
Omeza collagen matrix, Omeza lidocaine lavage, Omeza skin protectant
Combination Product
Lead sponsor
Omeza, LLC
Industry
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Toledo, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 21, 2024 · Synced Oct 8, 2026, 1:51 AM EDT
No Longer Available No phase listed Expanded access Accepts healthy volunteers

Direct Antibiotic Delivery of Cefazolin Into Soft Tissue Infections Using Subcutaneous Injection and Ultrasonic Dispersion

NCT01238276
View directory record Official record
Conditions
Infection, Soft Tissue, Infection, Wound, Cellulitis, Diabetic Foot Ulcer
Interventions
Cefazolin, Silberg Tissue Preparation System
Drug · Device
Lead sponsor
Sonescence, Inc.
Industry
Eligibility
18 Years and older
Healthy volunteers
Accepts healthy volunteers
U.S. locations
1
States / cities
Sebastopol, California
Source: ClinicalTrials.gov public record
Updated Oct 23, 2018 · Synced Oct 8, 2026, 1:51 AM EDT
Recruiting Not applicable Interventional

Total Contact Soft Cast in Diabetic Foot Ulcers

NCT04210089
View directory record Official record
Conditions
Diabetic Foot Ulcer, Diabetes Mellitus, Foot Ulcer, Foot Ulcer, Diabetic, Ulcer, Ulcer Foot, Ulcer, Leg, Ankle Ulcer
Interventions
Total Contact Soft Cast, Cam Boot
Device
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2027
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 2, 2026 · Synced Oct 8, 2026, 1:51 AM EDT
Terminated Phase 3 Interventional

Phase III Study to Evaluate Efficacy and Safety of DSC127 in Diabetic Foot Ulcers

NCT01830348
View directory record Official record
Conditions
Diabetic Foot Ulcers
Interventions
DSC127, placebo vehicle gel
Drug
Lead sponsor
Integra LifeSciences Corporation
Industry
Eligibility
18 Years and older
Enrollment
266 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
25
States / cities
Mobile, Alabama • Fair Oaks, California • Fresno, California + 22 more
Source: ClinicalTrials.gov public record
Updated Dec 12, 2017 · Synced Oct 8, 2026, 1:51 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Non-Invasive Assessment of Wound Healing With Optical Methods

NCT00578604
View directory record Official record
Conditions
Diabetic Foot Ulcers
Interventions
diffuse near infrared spectroscopy measurements
Device
Lead sponsor
Drexel University College of Medicine
Other
Eligibility
18 Years to 65 Years
Enrollment
38 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2014
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 30, 2017 · Synced Oct 8, 2026, 1:51 AM EDT
Completed Not applicable Interventional

Effect of Fresh Amniotic Membrane in the Treatment of Diabetic Foot Ulcers

NCT02880592
View directory record Official record
Conditions
Diabetic Foot Ulcers
Interventions
Affinity Allograft, Standard of care
Other
Lead sponsor
Organogenesis
Industry
Eligibility
18 Years and older
Enrollment
89 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
8
States / cities
Miami Lakes, Florida • North Miami Beach, Florida • Clinton Township, Michigan + 5 more
Source: ClinicalTrials.gov public record
Updated Feb 19, 2020 · Synced Oct 8, 2026, 1:51 AM EDT
Terminated Not applicable Interventional Results available

Diabetic Foot Infection Antibiotic Study

NCT01539811
View directory record Official record
Conditions
Diabetic Foot Infections
Interventions
Surgical incision and drainage of diabetic foot infection, Short course antibiotics, Long course antibiotics
Procedure · Drug
Lead sponsor
Prisma Health-Upstate
Other
Eligibility
18 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012
U.S. locations
1
States / cities
Greenville, South Carolina
Source: ClinicalTrials.gov public record
Updated Jul 21, 2022 · Synced Oct 8, 2026, 1:51 AM EDT
Recruiting No phase listed Observational

A Real-World Registry of Chronic Wounds and Ulcers

NCT02280733
View directory record Official record
Conditions
Diabetic Foot, Pressure Ulcer, Surgical Wound Dehiscence, Vasculitis, Skin Ulcer, Leg Ulcer, Pyoderma, Peripheral Arterial Disease, Lymphedema, Surgical Complication, Venous Leg Ulcers (VLUs), Calciphylaxis, Sickle Cell Ulcer, Pressure Ulcer (PU), Diabetic Foot Ulcers (DFUs), Pressure Injury, Arterial Ulcers, Soft Tissue Radionecrosis (STRN), Traumatic Wounds, Chronic Ulcer
Interventions
Usual care
Other
Lead sponsor
U.S. Wound Registry
Other
Eligibility
Not listed
Enrollment
300,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2030
U.S. locations
1
States / cities
The Woodlands, Texas
Source: ClinicalTrials.gov public record
Updated Jul 16, 2025 · Synced Oct 8, 2026, 1:51 AM EDT
Completed Not applicable Interventional Results available

Electrical Stimulation to Accelerate Wound Healing

NCT03821675
View directory record Official record
Conditions
Diabetes, Diabetic Foot Ulcer, Peripheral Neuropathy, Peripheral Arterial Disease
Interventions
Electrical Stimulation - Active, Electrical Stimulation - Sham
Device
Lead sponsor
Baylor College of Medicine
Other
Eligibility
18 Years to 85 Years
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated May 9, 2022 · Synced Oct 8, 2026, 1:51 AM EDT
Completed No phase listed Observational

Monitoring Physiologic Parameters in Individuals With Diabetic Peripheral Neuropathy

NCT05613556
View directory record Official record
Conditions
Diabetic Foot, Diabetic Peripheral Neuropathy
Interventions
Orpyx SI® Sensory Insole System
Device
Lead sponsor
Orpyx Medical Technologies Inc.
Industry
Eligibility
18 Years to 100 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Circleville, Ohio
Source: ClinicalTrials.gov public record
Updated May 9, 2023 · Synced Oct 8, 2026, 1:51 AM EDT