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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Diet, Carbohydrate-Restricted Clear all
Terminated Not applicable Interventional

The Effects of a Low Carbohydrate, Non-Ketogenic Diet Versus Standard Diabetes Diet on Glycemic Control in Type 1 Diabetes

NCT03544892
View directory record Official record
Conditions
Diabetes Mellitus, Type 1
Interventions
Low carbohydrate diet, Standard of care diet
Other
Lead sponsor
University of Oklahoma
Other
Eligibility
18 Years to 30 Years
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Tulsa, Oklahoma
Source: ClinicalTrials.gov public record
Updated Jan 12, 2020 · Synced Sep 28, 2026, 3:14 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Diet and Migraine Study

NCT01859052
View directory record Official record
Conditions
Migraine, Obesity
Interventions
Low carbohydrate diet, Low calorie low fat diet, AHA diet recommendations
Other
Lead sponsor
Johns Hopkins University
Other
Eligibility
19 Years to 49 Years · Female only
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2015
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 1, 2015 · Synced Sep 28, 2026, 3:14 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Energy Balance Weight Regulation Study

NCT00619008
View directory record Official record
Conditions
Obesity
Interventions
Ad libitum low carbohydrate diet, Ad libitum High Complex Carbohydrate Diet, Energy-restricted high complex carbohydrate diet
Other
Lead sponsor
National Center for Complementary and Integrative Health (NCCIH)
NIH
Eligibility
21 Years to 65 Years
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2008
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Oct 2, 2008 · Synced Sep 28, 2026, 3:14 PM EDT
Terminated Phase 2 Interventional

Atkins Diet and Prostate Cancer Clinical Trial

NCT00932672
View directory record Official record
Conditions
Prostate Cancer
Interventions
Atkins Diet
Behavioral
Lead sponsor
Duke University
Other
Eligibility
18 Years and older · Male only
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2014
U.S. locations
3
States / cities
Los Angeles, California • Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Dec 6, 2015 · Synced Sep 28, 2026, 3:14 PM EDT
Completed Not applicable Interventional Results available

A Study to Determine Iatrogenic Hyperinsulinemia's Contribution to Insulin Resistance and Endothelial Dysfunction in Type 1 Diabetes

NCT04118374
View directory record Official record
Conditions
Diabetes Mellitus, Type 1
Interventions
Standard Carb Diet, Low Carb Diet
Other
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years to 60 Years
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Oct 27, 2025 · Synced Sep 28, 2026, 3:14 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

High Fat - High Protein Diet in the Treatment of Obesity

NCT00299273
View directory record Official record
Conditions
Obesity
Interventions
Low calorie high fat/protein diet
Behavioral
Lead sponsor
Rockefeller University
Other
Eligibility
25 Years to 50 Years · Female only
Enrollment
8 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2014
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 7, 2015 · Synced Sep 28, 2026, 3:14 PM EDT
Completed Phase 3 Interventional

Low Carbohydrate Diet Compared to Calorie and Fat Restricted Diet in Patients With Obesity and Type II Diabetes

NCT00108459
View directory record Official record
Conditions
Obesity, Type 2 Diabetes, Hyperlipidemia
Interventions
Low Carbohydrate Diet
Behavioral
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
18 Years and older
Enrollment
156 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2007
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 20, 2009 · Synced Sep 28, 2026, 3:14 PM EDT
Completed Not applicable Interventional

Comparison of Healthy Diets on Breast Cancer Markers

NCT02744079
View directory record Official record
Conditions
Breast Neoplasms
Interventions
Low carbohydrate diet, Low fat diet
Behavioral
Lead sponsor
Albert Einstein College of Medicine
Other
Eligibility
21 Years and older · Female only
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Aug 30, 2020 · Synced Sep 28, 2026, 3:14 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effects of Low Fat Versus Low Carbohydrate Diets on Energy Metabolism

NCT03878108
View directory record Official record
Conditions
Healthy, Healthy Volunteers
Interventions
LCHF diet, LFHC diet
Dietary Supplement
Lead sponsor
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NIH
Eligibility
18 Years to 50 Years
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 2, 2021 · Synced Sep 28, 2026, 3:14 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Low-Carbohydrate Dietary Pattern on Glycemic Outcomes Trial

NCT03675360
View directory record Official record
Conditions
Diabetes, PreDiabetes, Metabolic Disease, Hyperglycemia, Diet Modification, Glucose Intolerance, Glucose Metabolism Disorders (Including Diabetes Mellitus), Endocrine System Diseases
Interventions
Low-Carbohydrate Diet
Behavioral
Lead sponsor
Tulane University School of Public Health and Tropical Medicine
Other
Eligibility
40 Years to 70 Years
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2021
U.S. locations
1
States / cities
New Orleans, Louisiana
Source: ClinicalTrials.gov public record
Updated Feb 28, 2023 · Synced Sep 28, 2026, 3:14 PM EDT
Completed Not applicable Interventional

The Lifestyle Education About Prediabetes (Leap) Study

NCT05235425
View directory record Official record
Conditions
PreDiabetes
Interventions
Standard NDPP, Very low-carbohydrate diet
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
21 Years to 75 Years
Enrollment
304 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Dec 18, 2025 · Synced Sep 28, 2026, 3:14 PM EDT
Active, not recruiting Phase 1 Interventional Accepts healthy volunteers

Low-CArbohydrate Diet and SGLT2-INhibitOr to Achieve Moderate Ketosis in Healthy Volunteers

NCT05662865
View directory record Official record
Conditions
Ketones, Metabolism
Interventions
SGLT2 inhibitor, Controlled, Adaptive Study Diet
Drug · Other
Lead sponsor
AdventHealth Translational Research Institute
Other
Eligibility
18 Years to 60 Years
Enrollment
9 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
Orlando, Florida
Source: ClinicalTrials.gov public record
Updated Mar 29, 2026 · Synced Sep 28, 2026, 3:14 PM EDT
Completed Phase 1Phase 2 Interventional

The University of Michigan OWL (Online Wellness and Lifestyle) Study

NCT05010083
View directory record Official record
Conditions
Obesity
Interventions
diet and lifestyle program
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 25 Years
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Oct 23, 2022 · Synced Sep 28, 2026, 3:14 PM EDT
Terminated Not applicable Interventional

A Study of a Low-Carbohydrate Diet to Improve Maternal Health After Childbirth

NCT04045353
View directory record Official record
Conditions
Obesity, Postpartum Weight Retention, Insulin Sensitivity
Interventions
Low carbohydrate diet education, Low carbohydrate diet education with behavioral component
Behavioral
Lead sponsor
The University of Texas Medical Branch, Galveston
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Galveston, Texas
Source: ClinicalTrials.gov public record
Updated Apr 17, 2023 · Synced Sep 28, 2026, 3:14 PM EDT
Completed Not applicable Interventional Results available

Very Low Carbohydrate Diet as an Adjunctive Therapy for Youth Type 1 Diabetes

NCT04082884
View directory record Official record
Conditions
Type 1 Diabetes
Interventions
Very Low Carbohydrate Diet
Behavioral
Lead sponsor
Yale University
Other
Eligibility
13 Years to 25 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Feb 14, 2024 · Synced Sep 28, 2026, 3:14 PM EDT
Recruiting Not applicable Interventional

Very Low Carbohydrate Diets and Glucagon Response in T1DM

NCT04200391
View directory record Official record
Conditions
Type1diabetes
Interventions
Very low carbohydrate diet
Other
Lead sponsor
Boston Children's Hospital
Other
Eligibility
18 Years to 40 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 17, 2024 · Synced Sep 28, 2026, 3:14 PM EDT
Completed Not applicable Interventional Results available

Metabolic Changes Induced by a Very Low Carbohydrate Diet in Youth With Type 1 Diabetes

NCT04955691
View directory record Official record
Conditions
Type1diabetes, Low Carbohydrate Diet
Interventions
low carbohydrate diet, standard carbohydrate diet
Other
Lead sponsor
Yale University
Other
Eligibility
12 Years to 21 Years
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Oct 15, 2025 · Synced Sep 28, 2026, 3:14 PM EDT
Completed Not applicable Interventional

A Carbohydrate-restricted Diet to Reverse Fatty Liver in Adolescents With Obesity

NCT02787668
View directory record Official record
Conditions
Non-alcoholic Fatty Liver Disease, Childhood Obesity, Insulin Resistance
Interventions
Carbohydrate-restricted diet, Control, low-fat diet
Other
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
9 Years to 17 Years
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Feb 20, 2022 · Synced Sep 28, 2026, 3:14 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Egg Diet to Improve Metabolic Health and Function

NCT02760641
View directory record Official record
Conditions
Obesity
Interventions
Egg-based diet (EBD), Carbohydrate-based diet (CBD)
Other
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
60 Years to 75 Years
Enrollment
34 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Aug 20, 2017 · Synced Sep 28, 2026, 3:14 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Determination of the Effect of Extreme Dietary Carbohydrate Restriction on Hepatic Glucose Production

NCT01262326
View directory record Official record
Conditions
Non-Alcoholic Fatty Liver Disease
Interventions
Calorie and Carbohydrate Restriction
Other
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 65 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2011
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Nov 15, 2018 · Synced Sep 28, 2026, 3:14 PM EDT
Terminated Phase 2 Interventional

BREADS: Breast Adjuvant Diet Study

NCT04189263
View directory record Official record
Conditions
Breast Cancer
Interventions
Carbohydrate restricted dietary intervention, standard of care aromatase inhibitors
Other · Drug
Lead sponsor
Farin Amersi
Other
Eligibility
18 Years and older · Female only
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Apr 18, 2023 · Synced Sep 28, 2026, 3:14 PM EDT
Completed Not applicable Interventional

The Breakfast Study

NCT05986097
View directory record Official record
Conditions
Type 2 Diabetes
Interventions
Breakfast
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 80 Years
Enrollment
119 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Aug 31, 2026 · Synced Sep 28, 2026, 3:14 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Longitudinal Multi-Omic Profiles to Reveal Mechanisms of Obesity-Mediated Insulin Resistance

NCT05165706
View directory record Official record
Conditions
Diabetes Mellitus, Type 2, PreDiabetes, Insulin Resistance, Obesity, Nonalcoholic Steatohepatitis, Nonalcoholic Fatty Liver, Diet Modification
Interventions
Dietary Intervention Mediterranean Low Carbohydrate Diet, Dietary Intervention Standard Low Carbohydrate Diet, Dietary Intervention Standard Low Fat Diet
Behavioral
Lead sponsor
Stanford University
Other
Eligibility
35 Years to 65 Years
Enrollment
110 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2026
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Dec 3, 2024 · Synced Sep 28, 2026, 3:14 PM EDT
Completed Not applicable Interventional

The RECHARGE Low Carbohydrate Diet Trial for Metastatic Cancer

NCT00444054
View directory record Official record
Conditions
Cancer, Breast Cancer, Colon Cancer, Cervical Cancer, Uterine Cancer, Ovarian Cancer
Interventions
Very low carbohydrate diet (approximately 20 grams per day)
Behavioral
Lead sponsor
Albert Einstein College of Medicine
Other
Eligibility
21 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2012
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Oct 29, 2020 · Synced Sep 28, 2026, 3:14 PM EDT