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Conditions: Prader-Willi Syndrome, Hypothalamic Obesity, Obesity/Therapy
Interventions: Tirzepatide; Drug
Lead sponsor: Grace Kim; Other
Eligibility: 18 Years to 26 Years
Enrollment: 36 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 3
States / cities: Saint Paul, Minnesota • Nashville, Tennessee • Seattle, Washington

Conditions: Relapsing Multiple Sclerosis
Interventions: Remibrutinib, Teriflunomide; Drug
Lead sponsor: Novartis Pharmaceuticals; Industry
Eligibility: 18 Years to 55 Years
Enrollment: 1,000 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2030
U.S. locations: 52
States / cities: Phoenix, Arizona • Tucson, Arizona • Fort Smith, Arkansas + 47 more

Conditions: Prader-Willi Syndrome
Interventions: Repetitive Transcranial Magnetic Stimulation (rTMS); Device
Lead sponsor: Brigham and Women's Hospital; Other
Eligibility: 18 Years to 64 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2027
U.S. locations: 1
States / cities: Belmont, Massachusetts

Conditions: Spinal Cord Injuries, Traumatic Brain Injury, Spina Bifida, Cerebral Palsy, Stroke, Parkinson Disease, Multiple Sclerosis
Interventions: eM2M; Other
Lead sponsor: University of Alabama at Birmingham; Other
Eligibility: 18 Years to 70 Years
Enrollment: 108 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2025
U.S. locations: 1
States / cities: Birmingham, Alabama

Conditions: Obstructive Apnea
Interventions: Portable oxygen concentrator Inogen G5 model; Device
Lead sponsor: Children's Hospital Medical Center, Cincinnati; Other
Eligibility: 5 Years to 17 Years
Enrollment: 10 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2028
U.S. locations: 1
States / cities: Cincinnati, Ohio

Conditions: Pregnant Individuals, Aneuploidy, Down Syndrome (Trisomy 21), 22q11.2 Deletion Syndrome, Trisomy 13, Trisomy 18, Sex Chromosome Abnormalities
Interventions: Not listed
Lead sponsor: BillionToOne Inc.; Industry
Eligibility: Female only
Enrollment: 1,000 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 9
States / cities: Phoenix, Arizona • Riverside, California • West Covina, California + 5 more

Conditions: Multiple Sclerosis
Interventions: PACE-MS; Behavioral
Lead sponsor: Kessler Foundation; Other
Eligibility: 18 Years to 70 Years
Enrollment: 23 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: East Hanover, New Jersey

Conditions: Down Syndrome
Interventions: monitoring BIS in both groups; Device
Lead sponsor: Milton S. Hershey Medical Center; Other
Eligibility: 2 Years to 17 Years
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2017
U.S. locations: 1
States / cities: Hershey, Pennsylvania

Conditions: Down Syndrome, Sleep Disordered Breathing
Interventions: Adenotonsillectomy; Procedure
Lead sponsor: Brigham and Women's Hospital; Other
Eligibility: 3 Years to 13 Years
Enrollment: 26 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2021
U.S. locations: 6
States / cities: Ann Arbor, Michigan • Cincinnati, Ohio • Cleveland, Ohio + 3 more

Conditions: Down Syndrome, Alzheimer's Disease
Interventions: Not listed
Lead sponsor: Michael Rafii; Other
Eligibility: 30 Years to 60 Years
Enrollment: 12 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2017
U.S. locations: 1
States / cities: La Jolla, California

Conditions: Down Syndrome, Recurrent B Acute Lymphoblastic Leukemia
Interventions: 3-Dimensional Conformal Radiation Therapy, Asparaginase Erwinia chrysanthemi, Biospecimen Collection, Blinatumomab, Bone Marrow Aspiration, Bone Marrow Biopsy, Calaspargase Pegol, Cytarabine, Dexamethasone, Hydrocortisone Sodium Succinate, Lumbar Puncture, Mercaptopurine, Methotrexate, Nivolumab, Pegaspargase, Vincristine Sulfate; Radiation · Drug · Procedure + 1 more
Lead sponsor: National Cancer Institute (NCI); NIH
Eligibility: 1 Year to 30 Years
Enrollment: 461 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2028
U.S. locations: 211
States / cities: Birmingham, Alabama • Mobile, Alabama • Anchorage, Alaska + 151 more

Conditions: Multiple Sclerosis, Multiple Sclerosis, Relapsing-Remitting, Multiple Sclerosis, Chronic Progressive
Interventions: Cionic Neural Sleeve NS-100, Walking Program; Device · Behavioral
Lead sponsor: Cionic, Inc.; Industry
Eligibility: 22 Years to 75 Years
Enrollment: 14 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2026
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Autism Spectrum Disorder, Down Syndrome
Interventions: Bicycle Training Intervention; Behavioral
Lead sponsor: University of Michigan; Other
Eligibility: 9 Years to 18 Years
Enrollment: 155 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2012
U.S. locations: 3
States / cities: Southbend, Indiana • Ann Arbor, Michigan • Grand Rapids, Michigan

Conditions: Down Syndrome, Obstructive Sleep Apnea
Interventions: Oxygen; Drug
Lead sponsor: Brigham and Women's Hospital; Other
Eligibility: 5 Years to 18 Years
Enrollment: 230 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2027
U.S. locations: 7
States / cities: Los Angeles, California • Ann Arbor, Michigan • Cincinnati, Ohio + 4 more

Conditions: Down Syndrome
Interventions: Near-Infrared Transcranial Photobiomodulation, Sham Transcranial Photobiomodulation; Device
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 16 Years to 35 Years
Enrollment: 19 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2024
U.S. locations: 1
States / cities: Charlestown, Massachusetts

Conditions: Down Syndrome, Intellectual Disability, Sexuality, Parent-Child Relations
Interventions: Parent training; Behavioral
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: Not listed
Enrollment: 13 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2018
U.S. locations: 1
States / cities: Park Ridge, Illinois

Conditions: Cornelia de Lange Syndrome
Interventions: N-acetyl cysteine, Placebo; Drug · Other
Lead sponsor: Johns Hopkins University; Other
Eligibility: 13 Years to 35 Years
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Behavior Problem, Development Delay, Emotional Disturbances, Family Conflict, Relation, Mother-Child
Interventions: Family Nurture Intervention; Behavioral
Lead sponsor: Columbia University; Other
Eligibility: 24 Months to 78 Months
Enrollment: 38 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019
U.S. locations: 1
States / cities: Norwalk, Connecticut

Conditions: Down Syndrome, Down Syndrome, Partial Trisomy 21, Alzheimer Disease
Interventions: [18F]-FEOBV Radiotracer; Drug
Lead sponsor: Vanderbilt University Medical Center; Other
Eligibility: 18 Years to 55 Years
Enrollment: 30 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2027
U.S. locations: 1
States / cities: Nashville, Tennessee

Conditions: Obesity, Over-weight, Prader-Willi Syndrome
Interventions: ZGN-440 sterile diluent, 1.2 mg ZGN-440 for injectable suspension, 1.8 mg ZGN-440 for injectable suspension; Drug
Lead sponsor: Zafgen, Inc.; Industry
Eligibility: 16 Years to 65 Years
Enrollment: 17 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013
U.S. locations: 1
States / cities: Gainesville, Florida

Conditions: Down Syndrome
Interventions: High definition transcranial direct current stimulation; Device
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 18 Years to 45 Years
Enrollment: 5 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2016
U.S. locations: 1
States / cities: Madison, Wisconsin

Conditions: Down Syndrome
Interventions: Promoting Health through Parent Empowerment and the Activation of Routines, Enhanced Usual Care; Behavioral
Lead sponsor: University of Pittsburgh; Other
Eligibility: 12 Months and older
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Alzheimer Disease, Down Syndrome
Interventions: ION269; Drug
Lead sponsor: Ionis Pharmaceuticals, Inc.; Industry
Eligibility: 35 Years to 55 Years
Enrollment: 1 participant
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2025
U.S. locations: 5
States / cities: Indianapolis, Indiana • Kansas City, Kansas • Lexington, Kentucky + 2 more

Conditions: Fragile X Syndrome, Fragile X Syndrome (FXS)
Interventions: ZYN002, Placebo; Drug
Lead sponsor: Harmony Biosciences Management, Inc.; Industry
Eligibility: 3 Years to 29 Years
Enrollment: 257 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2025
U.S. locations: 18
States / cities: Phoenix, Arizona • Culver City, California • Irvine, California + 15 more

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Tirzepatide in PWS, HO and GNSO

Efficacy and Safety of Remibrutinib Compared to Teriflunomide in Participants With Relapsing Multiple Sclerosis (RMS) (REMODEL-1)

Cerebellar TMS and Satiety in Prader-Willi Syndrome

Movement-2-Music: Lakeshore Examination of Activity, Disability, and Exercise Response Study

Comparison of a Demand Oxygen Delivery

The ADVANCE (Assay Development and Validation for Pre-Natal and Obstetric Conditions) Study is the Largest U.S.-Based Prospective Study Demonstrating a Circulating Fetal Cell (CFC) Based Approach to Non-invasive Fetal Risk Assessment

Effects of Cycling and Virtual Reality on Thinking Speed in Persons With MS (PACE-MS)

Comparison of Bispectral Index Values in Patients With and Without Down's Syndrome

Healthy Sleep for Children With Down Syndrome

Down Syndrome Biomarker Initiative (DSBI)

A Study to Compare Blinatumomab Alone to Blinatumomab With Nivolumab in Patients Diagnosed With First Relapse B-Cell Acute Lymphoblastic Leukemia (B-ALL)

Impact of the Cionic Neural Sleeve on Mobility in Multiple Sclerosis

A Bicycle Training Intervention

Down Syndrome Obstructive Sleep Apnea

Transcranial Photobiomodulation With Near-Infrared Light for Language in Individuals With Down Syndrome

Parents as the Primary Sexuality Educators for Their Young Adults With Down Syndrome

Use of N-Acetylcysteine in the Treatment of Repetitive and Self-Injurious Behaviors in Cornelia de Lange Syndrome

Norwalk Feasibility Study

Cholinergic Integrity in Down Syndrome in Association With Aging, Alzheimer's Disease Pathology, and Cognition

An Efficacy, Safety, and Pharmacokinetics Study of Beloranib in Obese Subjects With Prader-Willi Syndrome

Feasibility and Dose Tolerability of HD-tDCS in Healthy Adults and Children With Down Syndrome

Promoting Health Through Parent Empowerment and the Activation of Routines (PrO-PEAR)

Hero: A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics (PK) and Pharmacodynamics (PD) of ION269 in Participants With Down Syndrome (DS) at Risk for Alzheimer's Disease (AD)

Clinical Study of Cannabidiol in Children, Adolescents, and Young Adults With Fragile X Syndrome