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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Filters: Condition: Disc Disease Clear all
Completed Phase 4 Interventional Results available

BIO4 Clinical Case Study: Cervical Spine

NCT03077204
View directory record Official record
Conditions
Degenerative Disc Disease, Trauma (Including Fractures), Spondylolisthesis
Interventions
1 or 2-Level ACDF utilizing BIO4 with Bio AVS Cervical Allograft (with graft window)., Aviator Anterior Cervical Plating System
Biological · Device
Lead sponsor
Seton Healthcare Family
Other
Eligibility
19 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Jan 13, 2022 · Synced Sep 20, 2026, 10:29 AM EDT
Completed No phase listed Observational

Natural Matrix Protein™ (NMP™) in Interbody Lumbar Fusion

NCT05972616
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
Natural Matrix Protein (NMP)
Biological
Lead sponsor
Induce Biologics USA Inc.
Industry
Eligibility
18 Years and older
Enrollment
53 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Shreveport, Louisiana
Source: ClinicalTrials.gov public record
Updated Oct 13, 2025 · Synced Sep 20, 2026, 10:29 AM EDT
Completed Not applicable Interventional

Comparison of Outcomes Between Early Physical Therapy Intervention and Usual Care Following Anterior Cervical Fusion Surgery

NCT01519115
View directory record Official record
Conditions
Cervical Spine Degenerative Disc Disease, Fusion of Spine, Cervical Region
Interventions
early physical therapy intervention, usual care
Other
Lead sponsor
Texas Woman's University
Other
Eligibility
30 Years to 70 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Tyler, Texas
Source: ClinicalTrials.gov public record
Updated Jan 12, 2015 · Synced Sep 20, 2026, 10:29 AM EDT
Terminated Phase 3 Interventional Results available

Comparison of Quadratus Lumborum Block Types

NCT04588389
View directory record Official record
Conditions
Pain, Opioid Use, Lumbar Disc Herniation
Interventions
Ropivacaine injection Location 1, Ropivacaine injection Location 2, Multimodal Pharmacological Management
Drug
Lead sponsor
University of Massachusetts, Worcester
Other
Eligibility
40 Years to 80 Years
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Worcester, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 27, 2025 · Synced Sep 20, 2026, 10:29 AM EDT
Completed Not applicable Interventional

Adipose Cells for Degenerative Disc Disease

NCT02097862
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
Adipose Stem Cells
Procedure
Lead sponsor
Bioheart, Inc.
Industry
Eligibility
18 Years to 85 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Sunrise, Florida
Source: ClinicalTrials.gov public record
Updated Mar 16, 2017 · Synced Sep 20, 2026, 10:29 AM EDT
Completed Phase 2 Interventional

Safety and Preliminary Efficacy Study of NeoFuse in Subjects Requiring Lumbar Interbody Fusion

NCT00996073
View directory record Official record
Conditions
Degenerative Disc Disease, Degenerative Spondylolisthesis, Spinal Stenosis
Interventions
Lumbar Interbody Fusion with Autograft, Lumbar Interbody Fusion with NeoFuse
Biological
Lead sponsor
Mesoblast, Ltd.
Industry
Eligibility
18 Years to 70 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2014
U.S. locations
5
States / cities
Santa Monica, California • Greenwood Village, Colorado • Loveland, Colorado + 2 more
Source: ClinicalTrials.gov public record
Updated Jun 28, 2020 · Synced Sep 20, 2026, 10:29 AM EDT
Completed Not applicable Interventional

A Randomized, Controlled Trial of Treatment for Disc Herniation With Radiating Leg Pain

NCT00220935
View directory record Official record
Conditions
Radiating Leg Pain, Disc Protrusion
Interventions
Orthotrac Pneumatic Vest
Device
Lead sponsor
Texas Back Institute
Other
Eligibility
21 Years to 55 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2006
U.S. locations
1
States / cities
Plano, Texas
Source: ClinicalTrials.gov public record
Updated Oct 4, 2006 · Synced Sep 20, 2026, 10:29 AM EDT
Withdrawn Not applicable Interventional

Proprio Spine Measurement Tool

NCT07023393
View directory record Official record
Conditions
Intervertebral Disc Degeneration, Intervertebral Disc Displacement, Spinal Curvatures, Spinal Osteochondrosis, Spinal Osteophytosis, Spinal Stenosis, Spondylitis, Spondylosis
Interventions
Intraoperative spinal measurement system
Device
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 22, 2026 · Synced Sep 20, 2026, 10:29 AM EDT
Terminated Not applicable Interventional

A Prospective Study of NuCel® in Cervical Spine Fusion

NCT02381067
View directory record Official record
Conditions
Spondylosis, Spinal Stenosis, Spondylolisthesis, Intervertebral Disc Disease, Intervertebral Disc Degeneration
Interventions
NuCel with Allograft Bone
Other
Lead sponsor
NuTech Medical, Inc
Industry
Eligibility
21 Years and older
Enrollment
61 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Marietta, Georgia
Source: ClinicalTrials.gov public record
Updated Jan 17, 2020 · Synced Sep 20, 2026, 10:29 AM EDT
Enrolling by invitation No phase listed Observational

Dose Responsiveness as a Measure of Clinical Effectiveness During Neuromonitored Spine Surgery

NCT05110833
View directory record Official record
Conditions
Intervertebral Disc Degeneration, Intervertebral Disc Displacement, Spinal Curvatures, Spinal Stenosis, Spondylitis, Spondylosis
Interventions
Not listed
Lead sponsor
Allina Health System
Other
Eligibility
18 Years and older
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2026
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 29, 2026 · Synced Sep 20, 2026, 10:29 AM EDT
Completed No phase listed Observational

Annex™ Adjacent Level System for Treatment of Adjacent Level Disease

NCT02108249
View directory record Official record
Conditions
Degenerative Disc Disease, Adjacent Level Disease
Interventions
Annex™ Adjacent Level System
Device
Lead sponsor
Spine Wave
Industry
Eligibility
18 Years to 85 Years
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2019
U.S. locations
1
States / cities
Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 21, 2020 · Synced Sep 20, 2026, 10:29 AM EDT
Terminated Not applicable Interventional Results available

Dexamethasone Versus Depo Medrol in Lumbar Epidurals

NCT01397552
View directory record Official record
Conditions
Lumbar Spine Disc Herniation, Lumbar Radiculitis, Lumbar Back Pain
Interventions
Dexamethasone, methylprednisolone acetate
Drug
Lead sponsor
State University of New York - Upstate Medical University
Other
Eligibility
21 Years to 89 Years
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2015
U.S. locations
1
States / cities
East Syracuse, New York
Source: ClinicalTrials.gov public record
Updated Nov 21, 2023 · Synced Sep 20, 2026, 10:29 AM EDT
Completed Phase 1 Interventional

AMG0103 in Subjects With Chronic Discogenic Lumbar Back Pain

NCT03263611
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
Placebo, AMG0103
Drug
Lead sponsor
AnGes, Inc.
Industry
Eligibility
18 Years to 75 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
6
States / cities
Los Angeles, California • San Diego, California • St. Petersburg, Florida + 2 more
Source: ClinicalTrials.gov public record
Updated Oct 11, 2021 · Synced Sep 20, 2026, 10:29 AM EDT
Completed Phase 3 Interventional Results available

PCM Cervical Disc System

NCT00578812
View directory record Official record
Conditions
Radiculopathy, Myelopathy
Interventions
Anterior Cervical Discectomy and Fusion (ACDF), PCM Cervical Disc
Device
Lead sponsor
NuVasive
Industry
Eligibility
18 Years to 65 Years
Enrollment
494 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2014
U.S. locations
23
States / cities
Beverly Hills, California • Greenwood Village, Colorado • Washington D.C., District of Columbia + 18 more
Source: ClinicalTrials.gov public record
Updated Jul 6, 2015 · Synced Sep 20, 2026, 10:29 AM EDT
Not listed Phase 3 Interventional

Wallis Mechanical Normalization System for Low Back Pain

NCT00134537
View directory record Official record
Conditions
Low Back Pain
Interventions
Interspinous process and dynamic stabilization, Conservative Care
Device
Lead sponsor
Zimmer Spine
Industry
Eligibility
18 Years to 60 Years
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2012
U.S. locations
17
States / cities
Phoenix, Arizona • Beverly Hills, California • Santa Monica, California + 13 more
Source: ClinicalTrials.gov public record
Updated Oct 3, 2011 · Synced Sep 20, 2026, 10:29 AM EDT
Completed No phase listed Observational

Osteocel® Plus in Transforaminal Lumbar Interbody Fusion (TLIF)

NCT00947583
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
Osteocel Plus
Biological
Lead sponsor
NuVasive
Industry
Eligibility
18 Years to 70 Years
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 23, 2025 · Synced Sep 20, 2026, 10:29 AM EDT
Not listed Phase 4 Interventional

A Prospective Study of the InterFuse T(tm),

NCT02678130
View directory record Official record
Conditions
Low Back Pain
Interventions
InterFuse T, Standard of Care TLIF (Stryker AVS Unilif)
Device
Lead sponsor
Vertebral Technologies, Inc.
Industry
Eligibility
18 Years to 89 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Nov 1, 2016 · Synced Sep 20, 2026, 10:29 AM EDT
Completed Not applicable Interventional

PREventing Pain After Surgery

NCT05306665
View directory record Official record
Conditions
Pain, Back, Spinal Stenosis, Disc Herniation, Spondylosis, Spondylolisthesis, Back Injuries
Interventions
ACT intervention
Behavioral
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
22 Years and older
Enrollment
125 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Chestnut Hill, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 18, 2026 · Synced Sep 20, 2026, 10:29 AM EDT
Terminated Not applicable Interventional

Patient Positioning in Lumbar Fusion Surgery and Its Impact on Spinal Sagittal Balance and Surgeon Satisfaction

NCT01326091
View directory record Official record
Conditions
Intervertebral Disk Degeneration
Interventions
Hyperlordotic Positioning
Other
Lead sponsor
Duke University
Other
Eligibility
18 Years to 65 Years
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 22, 2015 · Synced Sep 20, 2026, 10:29 AM EDT
Completed No phase listed Observational Results available

Patient Registry to Observe Outcomes Following Implantation of the VariLift Interbody Fusion Device

NCT01944345
View directory record Official record
Conditions
Prolapsed Lumbar Disc, Prolapsed Cervical Disc, Intervertebral Disc Degeneration, Spondylolisthesis, Grade 1, Intervertebral Disc Displacement
Interventions
Not listed
Lead sponsor
Wenzel Spine
Industry
Eligibility
18 Years to 99 Years
Enrollment
69 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
3
States / cities
Boston, Massachusetts • San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated May 16, 2016 · Synced Sep 20, 2026, 10:29 AM EDT
Withdrawn Phase 3 Interventional

Peri-Incisional Drug Injection in Lumbar Spine Surgery

NCT03513445
View directory record Official record
Conditions
Lumbar Disc Herniation, Degenerative Disc Disease, Spondylolisthesis
Interventions
Morphine, Epinephrine, naropin
Drug
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 18, 2022 · Synced Sep 20, 2026, 10:29 AM EDT
Not listed Phase 1Phase 2 Interventional

Pilot Study to Assess Safety/Preliminary Effectiveness of Prefix in Subjects With Degenerative Disc Disease (DDD) Undergoing Spine Fusion Surgery

NCT00798902
View directory record Official record
Conditions
Degenerative Disc Disease, Spondylolisthesis
Interventions
Prefix (AMPLEX) B2A Peptide Enhanced Ceramic Granules, Iliac crest autograft
Device · Other
Lead sponsor
BioSurface Engineering Technologies, Inc
Industry
Eligibility
18 Years to 70 Years
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
6
States / cities
Durango, Colorado • Washington D.C., District of Columbia • Kansas City, Kansas + 3 more
Source: ClinicalTrials.gov public record
Updated Mar 8, 2012 · Synced Sep 20, 2026, 10:29 AM EDT
Completed Not applicable Interventional Results available

Post-op Acetaminophen vs NSAID Use on Lumbar Spinal Fusion Outcomes

NCT02700451
View directory record Official record
Conditions
Lumbar Osteoarthritis, Spondylosis, Lumbar Disc Disease, Spinal Stenosis
Interventions
Ketorolac, Acetaminophen, Placebo
Drug
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years to 75 Years
Enrollment
178 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2023
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 9, 2023 · Synced Sep 20, 2026, 10:29 AM EDT
Active, not recruiting Not applicable Interventional

The Synergy Disc To Anterior Cervical Discectomy and Fusion

NCT04469231
View directory record Official record
Conditions
Cervical Degenerative Disc Disease
Interventions
Anterior Cervical Discectomy & Fusion
Device
Lead sponsor
Synergy Spine Solutions
Industry
Eligibility
18 Years to 70 Years
Enrollment
175 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2026
U.S. locations
20
States / cities
Phoenix, Arizona • Scottsdale, Arizona • Beverly Hills, California + 15 more
Source: ClinicalTrials.gov public record
Updated Nov 18, 2025 · Synced Sep 20, 2026, 10:29 AM EDT