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ClinicalTrials.gov public records Last synced Oct 17, 2026, 5:06 PM EDT

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Showing 1–24 of 173 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Discomfort Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Meibomian Gland Dysfunction Management With ZEST Protocol

NCT03968731
View directory record Official record
Conditions
Meibomian Gland Dysfunction, Dry Eye Syndromes, Ocular Surface Disease
Interventions
Zocular Eyelid System Treatment
Other
Lead sponsor
University of the Incarnate Word
Other
Eligibility
21 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Jul 14, 2022 · Synced Oct 17, 2026, 5:06 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Measuring the Feasibility and the Effects of Chair Massage on Pain and Discomfort in the Cardiac Sonographer

NCT00975026
View directory record Official record
Conditions
Overuse Injury, Repetitive Strain Injury
Interventions
Massages ± Stretches
Procedure
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 65 Years
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2009
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 5, 2012 · Synced Oct 17, 2026, 5:06 PM EDT
Terminated Phase 2 Interventional Results available

Myrbetriq™ (Mirabegron) to Reduce Pain and Discomfort Following Ureteral Stent Placement

NCT02462837
View directory record Official record
Conditions
Urinary Bladder, Overactive, Pain, Lower Urinary Tract Symptoms
Interventions
Mirabegron, Placebo
Drug
Lead sponsor
Southern Illinois University
Other
Eligibility
18 Years and older
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
1
States / cities
Springfield, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 13, 2023 · Synced Oct 17, 2026, 5:06 PM EDT
Recruiting Not applicable Interventional

J-Tip Use for Paracentesis in Adults With Ascites

NCT06996379
View directory record Official record
Conditions
Evaluate Patient Comfort Level During Paracentesis by Numbing Skin With a Needle-less Device, Instead of Using a Needle to Numb the Skin
Interventions
Experimental J-Tip Needle-Free Injection System, Control (Standard treatment)
Device
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 4, 2026 · Synced Oct 17, 2026, 5:06 PM EDT
Recruiting Phase 3 Interventional

Suzetrigine for Treatment and Reduction of Intense Discomfort After knEe Replacement PAIN

NCT07548385
View directory record Official record
Conditions
Total Knee Replacement Surgery, Post-operative Pain
Interventions
Suzetrigine, Placebo
Drug
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years to 85 Years
Enrollment
235 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 23, 2026 · Synced Oct 17, 2026, 5:06 PM EDT
Withdrawn Phase 1Phase 2 Interventional

Dorsal Penile Block for Post-Robotic Prostatectomy Foley Discomfort

NCT01565512
View directory record Official record
Conditions
Prostate Cancer, Robotic Prostatectomy, Foley Catheter Discomfort
Interventions
Bupivacaine, Saline
Drug
Lead sponsor
Columbia University
Other
Eligibility
40 Years to 80 Years · Male only
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 5, 2015 · Synced Oct 17, 2026, 5:06 PM EDT
Completed Not applicable Interventional

S&B Heat Stress Pilot Protocols

NCT06094764
View directory record Official record
Conditions
Thermal Discomfort
Interventions
Group A, Group B
Device
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years to 65 Years
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Oct 23, 2023 · Synced Oct 17, 2026, 5:06 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Punctal Plugs and Iodine Related Discomfort

NCT03396809
View directory record Official record
Conditions
Dry Eye Syndromes
Interventions
Punctal plug
Device
Lead sponsor
University of New Mexico
Other
Eligibility
18 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated Mar 13, 2024 · Synced Oct 17, 2026, 5:06 PM EDT
Terminated No phase listed Observational

The Evaluation of the Roles of New Cardiac Imaging in Patients With Chest Pain

NCT03800862
View directory record Official record
Conditions
Cardiology, Radiology, Stenoses
Interventions
CT-FFR and CTP
Device
Lead sponsor
Lancaster General Hospital
Other
Eligibility
45 Years to 85 Years
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Lancaster, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 27, 2022 · Synced Oct 17, 2026, 5:06 PM EDT
Completed Phase 2Phase 3 Interventional Results available

Functional Dyspepsia Treatment Trial

NCT00248651
View directory record Official record
Conditions
Dyspepsia and Other Specified Disorders of Function of Stomach
Interventions
Amitriptyline, Escitalopram, Placebo
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 75 Years
Enrollment
292 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2013
U.S. locations
7
States / cities
Scottsdale, Arizona • Jacksonville, Florida • Chicago, Illinois + 4 more
Source: ClinicalTrials.gov public record
Updated Jul 25, 2014 · Synced Oct 17, 2026, 5:06 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

BRIUS Vs FFA Efficiency

NCT04347018
View directory record Official record
Conditions
Dental Malocclusion, Angle Class II, Angle Class I, Crowding, Tooth
Interventions
BRIUS
Device
Lead sponsor
State University of New York at Buffalo
Other
Eligibility
10 Years to 17 Years
Enrollment
13 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Oct 4, 2024 · Synced Oct 17, 2026, 5:06 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Influence of Instaflex Advanced Supplement on Joint Function

NCT03041077
View directory record Official record
Conditions
Knee Discomfort
Interventions
Instaflex Advanced, Placebo
Dietary Supplement
Lead sponsor
Appalachian State University
Other
Eligibility
50 Years to 75 Years
Enrollment
66 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
1
States / cities
Kannapolis, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 23, 2018 · Synced Oct 17, 2026, 5:06 PM EDT
Withdrawn Phase 4 Interventional

Use of 5.0% Lifitegrast Ophthalmic Solution for the Treatment of Dry Eye Disease in Contact Lens Wearers

NCT03431272
View directory record Official record
Conditions
Contact Lens Dry Eye
Interventions
Lifitegrast
Drug
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Oct 25, 2018 · Synced Oct 17, 2026, 5:06 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Sensory Effects of Rapidly-Changing Magnetic Fields

NCT01632800
View directory record Official record
Conditions
Sensory Disorders
Interventions
High pulsed magnetic fields
Device
Lead sponsor
Weinberg Medical Physics LLC
Industry
Eligibility
18 Years and older
Enrollment
26 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011
U.S. locations
1
States / cities
Freeville, New York
Source: ClinicalTrials.gov public record
Updated Oct 8, 2019 · Synced Oct 17, 2026, 5:06 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Intra-operative Ketamine Infusions in Opioid-dependent Patients With Chronic Lower Back Pain

NCT00899600
View directory record Official record
Conditions
Chronic Low Back Pain
Interventions
Ketamine, Normal saline
Drug · Other
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
18 Years to 90 Years
Enrollment
102 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2009
U.S. locations
1
States / cities
Lebanon, New Hampshire
Source: ClinicalTrials.gov public record
Updated Oct 18, 2018 · Synced Oct 17, 2026, 5:06 PM EDT
Completed No phase listed Observational

Hemp Oil + User Experience Study

NCT04026672
View directory record Official record
Conditions
General Wellbeing, Gastrointestinal Health, Physical Discomfort, Sleep, Mood
Interventions
Not listed
Lead sponsor
Thorne HealthTech, Inc
Industry
Eligibility
18 Years and older
Enrollment
201 participants
Timeline
2020
U.S. locations
1
States / cities
Summerville, South Carolina
Source: ClinicalTrials.gov public record
Updated Feb 10, 2020 · Synced Oct 17, 2026, 5:06 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

The Effects of CBD Isolate on Menstrual-Related Symptoms

NCT05679830
View directory record Official record
Conditions
Menstrual Discomfort
Interventions
Cannabidiol
Drug
Lead sponsor
Canopy Growth Corporation
Industry
Eligibility
18 Years to 55 Years · Female only
Enrollment
33 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Harrisonburg, Virginia
Source: ClinicalTrials.gov public record
Updated Jan 11, 2023 · Synced Oct 17, 2026, 5:06 PM EDT
Completed Phase 4 Interventional Results available

CATHETER ANALGESIA TRIAL Phenazopyrdine vs. Placebo: a Randomized Controlled Trial

NCT00771173
View directory record Official record
Conditions
Catheter-related Bladder Discomfort
Interventions
phenazopyridine HCl, Placebo
Drug · Other
Lead sponsor
Loyola University
Other
Eligibility
18 Years and older · Female only
Enrollment
258 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
1
States / cities
Maywood, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 29, 2016 · Synced Oct 17, 2026, 5:06 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Development and Evaluation of "Period Kits" for Adolescents With Intellectual and Developmental Disabilities

NCT05497167
View directory record Official record
Conditions
Autistic Spectrum Disorder, Patient Empowerment, Menstrual Discomfort
Interventions
Period Kit
Other
Lead sponsor
Tufts Medical Center
Other
Eligibility
5 Years to 17 Years · Female only
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 31, 2024 · Synced Oct 17, 2026, 5:06 PM EDT
Completed Phase 4 Interventional Results available

Direct Application of Systane Complete to Contact Lenses

NCT03848221
View directory record Official record
Conditions
Dry Eye, Contact Lens Complication
Interventions
Systane Complete, Sensitive Eyes Rewetting Drops
Drug
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years and older
Enrollment
73 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
3
States / cities
Birmingham, Alabama • Babylon, New York • Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Oct 8, 2020 · Synced Oct 17, 2026, 5:06 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Multi-strain Probiotic Supplement for Digestive Comfort and Well-being in Healthy Women

NCT07831317
View directory record Official record
Conditions
Gastrointestinal Discomfort, Bloating
Interventions
Active: Multi-strain probiotic dietary supplement, Placebo: Placebo
Dietary Supplement
Lead sponsor
Daily Nouri
Industry
Eligibility
25 Years to 45 Years · Female only
Enrollment
160 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Sep 25, 2026 · Synced Oct 17, 2026, 5:06 PM EDT
Terminated Not applicable Interventional

Clinical Study of Chondro-Gide® for Large Chondral Lesions in the Knee

NCT04537013
View directory record Official record
Conditions
Knee Injuries, Cartilage Injury, Cartilage Disease, Knee Discomfort
Interventions
Microfracture, Microfracture plus placement of Chondro-Gide® ACC
Procedure · Device
Lead sponsor
Geistlich Pharma AG
Industry
Eligibility
18 Years to 55 Years
Enrollment
82 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
3
States / cities
Phoenix, Arizona • Stamford, Connecticut • Johns Creek, Georgia
Source: ClinicalTrials.gov public record
Updated Feb 13, 2026 · Synced Oct 17, 2026, 5:06 PM EDT
Recruiting Not applicable Interventional

NT-II™ Collagen for Joint Discomfort and Function

NCT07119645
View directory record Official record
Conditions
Activity-Related Knee Discomfort, Joint Discomfort, Functional Joint Pain, Functional Knee Pain, Knee Acute and Chronic Pain
Interventions
NT-II™ (240 mg), NT-II™ 480 mg, Glucosamine/Chondroitin
Dietary Supplement
Lead sponsor
Hofseth Biocare ASA
Industry
Eligibility
20 Years to 65 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated May 14, 2026 · Synced Oct 17, 2026, 5:06 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluate the Effects of a Marine Lipid Oil Concentrate Formulation on Inflammation/Discomfort

NCT04819646
View directory record Official record
Conditions
Inflammation
Interventions
Marine Lipid Oil Concentrate Formulation, Dietary Supplement
Dietary Supplement
Lead sponsor
Supplement Formulators, Inc.
Industry
Eligibility
35 Years to 75 Years
Enrollment
31 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Fort Lauderdale, Florida
Source: ClinicalTrials.gov public record
Updated Jan 13, 2023 · Synced Oct 17, 2026, 5:06 PM EDT