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Showing 1–24 of 961 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Distress Clear all
Completed Phase 1 Interventional Results available

Healthy Minds Program App Dosage

NCT05229406
View directory record Official record
Conditions
Depression, Anxiety, Psychological Distress
Interventions
HMP app
Behavioral
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years to 99 Years
Enrollment
92 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jul 31, 2023 · Synced Jul 20, 2026, 6:57 PM EDT
Not listed Not applicable Interventional

Online and Mobile Mindfulness Intervention to Reduce Distress

NCT04035304
View directory record Official record
Conditions
PTSD
Interventions
Mindfulness Coach
Other
Lead sponsor
VA Palo Alto Health Care System
Federal
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Menlo Park, California
Source: ClinicalTrials.gov public record
Updated Aug 19, 2019 · Synced Jul 20, 2026, 6:57 PM EDT
Completed Phase 1 Interventional Results available

Defibrotide Therapy for SARS-CoV2 (COVID-19) Acute Respiratory Distress Syndrome (ARDS)

NCT04530604
View directory record Official record
Conditions
COVID, Sars-CoV2, COVID-19, Acute Respiratory Distress Syndrome
Interventions
Defibrotide
Drug
Lead sponsor
Gregory Yanik
Other
Eligibility
18 Years to 70 Years
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated May 8, 2023 · Synced Jul 20, 2026, 6:57 PM EDT
Completed Not applicable Interventional Results available

The Care After Life-threatening Medical Events Study

NCT04589559
View directory record Official record
Conditions
Cardiac Arrest, Fear
Interventions
Heart Rate Variability Biofeedback Training
Behavioral
Lead sponsor
Columbia University
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 18, 2022 · Synced Jul 20, 2026, 6:57 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Measuring Distress in Prosthetic Joint Infection Using a Standardized Metric: CRUTCH Pathway Pilot.

NCT04762706
View directory record Official record
Conditions
Prosthetic Joint Infection
Interventions
CRUTCH Pathway
Behavioral
Lead sponsor
West Virginia University
Other
Eligibility
18 Years to 89 Years
Enrollment
9 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
1
States / cities
Morgantown, West Virginia
Source: ClinicalTrials.gov public record
Updated Jul 23, 2024 · Synced Jul 20, 2026, 6:57 PM EDT
Completed Not applicable Interventional Results available

Behavioral Approaches to Reducing Diabetes Distress and Improving Glycemic Control

NCT04016558
View directory record Official record
Conditions
Type 1 Diabetes, Diabetes Distress
Interventions
StreamLine, TunedIn, FixIt
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
19 Years and older
Enrollment
296 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Oct 27, 2025 · Synced Jul 20, 2026, 6:57 PM EDT
Not yet recruiting Phase 2 Interventional

Can Betamethasone Given After Birth Help Extremely Premature Babies Come Off Breathing Support Safely and Effectively?

NCT07447739
View directory record Official record
Conditions
Respiratory Distress Syndrome (RDS), Bronchopulmonary Dysplasia (BPD)
Interventions
Betamethasone
Drug
Lead sponsor
Khang Nguyen
Other
Eligibility
Up to 28 Weeks
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Valhalla, New York
Source: ClinicalTrials.gov public record
Updated Mar 2, 2026 · Synced Jul 20, 2026, 6:57 PM EDT
Active, not recruiting Not applicable Interventional

Improving Care, Accelerating Recovery and Education

NCT06233747
View directory record Official record
Conditions
Mental Health Disorder, Suicide Attempt, Suicidal Ideation, Emergency Psychiatric
Interventions
Improving Care, Accelerating Recovery & Education (ICARE)
Behavioral
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
12 Years to 17 Years
Enrollment
109 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
2
States / cities
Philadelphia, Pennsylvania • Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated Jun 3, 2026 · Synced Jul 20, 2026, 6:57 PM EDT
Active, not recruiting Not applicable Interventional

Clinical Trial of the Online OurRelationship Program for Veteran Couples

NCT05136651
View directory record Official record
Conditions
Relationship Distress
Interventions
OurRelationship
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Jun 1, 2026 · Synced Jul 20, 2026, 6:57 PM EDT
Completed Not applicable Interventional

Psychotherapy Treatment of Deployment-Related PTSD in Primary Care Settings

NCT00974402
View directory record Official record
Conditions
Post-Traumatic Stress Disorders, Stress Disorders, Combat Disorders
Interventions
Cognitive Behavioral Therapy
Behavioral
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
18 Years and older
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
3
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Sep 17, 2014 · Synced Jul 20, 2026, 6:57 PM EDT
Completed Phase 2 Interventional Results available

Covid-19 Infection and Pulmonary Distress Treatment With Zanubrutinib in Hospitalized Participants

NCT04382586
View directory record Official record
Conditions
COVID-19 Pulmonary Complications, COVID-19
Interventions
Zanubrutinib, Supportive Care, Placebo
Drug
Lead sponsor
BeiGene
Industry
Eligibility
18 Years and older
Enrollment
63 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
10
States / cities
Fullerton, California • Washington D.C., District of Columbia • Thomasville, Georgia + 6 more
Source: ClinicalTrials.gov public record
Updated Oct 25, 2024 · Synced Jul 20, 2026, 6:57 PM EDT
Completed Not applicable Interventional Results available

Targeting HIV Retention and Improved Viral Load Through Engagement ('THRIVE')

NCT04481373
View directory record Official record
Conditions
Human Immunodeficiency Virus, Depression, Anxiety
Interventions
THRIVE, Treatment as Usual
Behavioral · Other
Lead sponsor
Baylor College of Medicine
Other
Eligibility
18 Years to 80 Years
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Oct 13, 2025 · Synced Jul 20, 2026, 6:57 PM EDT
Not yet recruiting Not applicable Interventional

Self-directed Mobile Mindfulness to Address ICU Survivors' Psychological Distress

NCT07634419
View directory record Official record
Conditions
Critical Illness, Heart Failure, Sepsis, Ards, Pneumonia, Trauma Injury
Interventions
Lift mobile mindfulness, Enlighten Recovery education program
Behavioral
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
450 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027 – 2031
U.S. locations
3
States / cities
Los Angeles, California • Durham, North Carolina • Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Jul 7, 2026 · Synced Jul 20, 2026, 6:57 PM EDT
Recruiting Phase 4 Interventional

A Study of Zunveyl on Safety, Tolerability, Neuropsychiatric Symptoms, and Caregiver Distress in Alzheimer's Disease (RESOLVE)

NCT07633470
View directory record Official record
Conditions
Alzheimer Disease
Interventions
Zunveyl®
Drug
Lead sponsor
Alpha Cognition, Inc
Industry
Eligibility
50 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
5
States / cities
Miami, Florida • Port Orange, Florida • Palos Hills, Illinois + 2 more
Source: ClinicalTrials.gov public record
Updated Jul 19, 2026 · Synced Jul 20, 2026, 6:57 PM EDT
No Longer Available No phase listed Expanded access

Intermediate-size Expanded Access Program (EAP), Mesenchymal Stromal Cells (MSC) for Acute Respiratory Distress Syndrome (ARDS) Due to COVID-19 Infection

NCT04366830
View directory record Official record
Conditions
Moderate to Severe Acute Respiratory Distress Syndrome Associated With COVID-19
Interventions
Remestemcel-L
Drug
Lead sponsor
Mesoblast International Sàrl
Industry
Eligibility
18 Years and older
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 17, 2021 · Synced Jul 20, 2026, 6:57 PM EDT
Completed Not applicable Interventional Results available

Messy Memories: Mobile Application Therapy Following Critical Illness

NCT05849454
View directory record Official record
Conditions
Critical Illness, Psychological Distress, Health Behavior
Interventions
Messy Memories Intervention
Device
Lead sponsor
Columbia University
Other
Eligibility
18 Years and older
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 21, 2025 · Synced Jul 20, 2026, 6:57 PM EDT
Completed Not applicable Interventional Results available

Healthy And Positive Pathways for Young People With Type 1 Diabetes (HAPPY T1D)

NCT05413239
View directory record Official record
Conditions
Type 1 Diabetes
Interventions
Psychoeducation to reduce diabetes distress and improve glycemic outcomes
Behavioral
Lead sponsor
Joslin Diabetes Center
Other
Eligibility
14 Years to 25 Years
Enrollment
217 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
2
States / cities
Palo Alto, California • Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 11, 2026 · Synced Jul 20, 2026, 6:57 PM EDT
Not listed Not applicable Interventional

Crossover Comparison of Tidal Volume Delivery During Nasal Intermittent Positive Pressure Ventilation in Preterm Infants: Infant Cannula vs. Nasal Continuous Positive Airway Pressure Prongs

NCT04326270
View directory record Official record
Conditions
Respiratory Distress Syndrome in Premature Infant
Interventions
Nasal interface
Device
Lead sponsor
Arkansas Children's Hospital Research Institute
Other
Eligibility
Up to 28 Days
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Little Rock, Arkansas
Source: ClinicalTrials.gov public record
Updated Mar 29, 2020 · Synced Jul 20, 2026, 6:57 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Measuring Distress Tolerance With Functional MRI

NCT01038232
View directory record Official record
Conditions
Cocaine Dependence
Interventions
Not listed
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 55 Years
Enrollment
99 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2015
U.S. locations
2
States / cities
Baltimore, Maryland • College Park, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 11, 2019 · Synced Jul 20, 2026, 6:57 PM EDT
Active, not recruiting No phase listed Observational Accepts healthy volunteers

Financial Distress During Treatment for Pediatric Acute Lymphoblastic Leukemia in the United States

NCT04928599
View directory record Official record
Conditions
Acute Lymphoblastic Leukemia
Interventions
Electronic Health Record Review, Interview, Survey Administration
Other
Lead sponsor
Children's Oncology Group
Network
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2028
U.S. locations
39
States / cities
Oakland, California • Wilmington, Delaware • Fort Lauderdale, Florida + 31 more
Source: ClinicalTrials.gov public record
Updated Jan 7, 2026 · Synced Jul 20, 2026, 6:57 PM EDT
Completed No phase listed Observational

Distress Associated with Coronavirus Disease 2019 and Telehealth on Supportive Care Patients with Advanced Cancer

NCT05058339
View directory record Official record
Conditions
Advanced Malignant Solid Neoplasm, COVID-19 Infection, Hematopoietic and Lymphoid Cell Neoplasm, Locally Advanced Malignant Solid Neoplasm, Metastatic Malignant Solid Neoplasm, Recurrent Hematologic Malignancy, Recurrent Malignant Solid Neoplasm
Interventions
Survey Administration
Other
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
223 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Sep 18, 2024 · Synced Jul 20, 2026, 6:57 PM EDT
Recruiting Not applicable Interventional

Promoting Improved Functioning Among People Experiencing Stressful Situations

NCT06482567
View directory record Official record
Conditions
Acute Stress Reaction
Interventions
iCOVER, Physical Presence with Reassurance
Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 50 Years
Enrollment
450 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
5
States / cities
Belmont, Massachusetts • Worcester, Massachusetts • Detroit, Michigan + 2 more
Source: ClinicalTrials.gov public record
Updated Dec 8, 2025 · Synced Jul 20, 2026, 6:57 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Intervention to Prevent Behavioral Health Symptoms Among Pandemic Affected Children

NCT05639465
View directory record Official record
Conditions
Emotional Distress, Prosocial Behavior, Pandemic, COVID-19, Coping Skills, Social Support
Interventions
JoH-C19, Switch off Get Active
Behavioral
Lead sponsor
University of Illinois at Urbana-Champaign
Other
Eligibility
8 Years to 14 Years
Enrollment
800 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2027
U.S. locations
9
States / cities
Bradenton, Florida • Panama City, Florida • St. Petersburg, Florida + 5 more
Source: ClinicalTrials.gov public record
Updated Jan 22, 2026 · Synced Jul 20, 2026, 6:57 PM EDT
Terminated Not applicable Interventional

Distress Tolerance for Benzodiazepine Discontinuation

NCT05250570
View directory record Official record
Conditions
Substance Use Disorders
Interventions
Distress Tolerance - Benzodiazepine Discontinuation (DT-BD), Relaxation Therapy
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years and older
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
3
States / cities
Pittsburgh, Pennsylvania • Wilkinsburg, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 29, 2023 · Synced Jul 20, 2026, 6:57 PM EDT