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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Distress, Emotional Clear all
Recruiting Not applicable Interventional

Mind-body Resilience Program for Cardiac Arrest Survivors and Their Caregivers: Recovering Together After Cardiac Arrest

NCT07143357
View directory record Official record
Conditions
Emotional Distress, Cardiac Arrest (CA), Anxiety, Depression, Caregivers, Survivorship, Resilience, Mindfulness
Interventions
Recovering Together after Cardiac Arrest 1, Recovering Together after Cardiac Arrest 2
Behavioral · Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
84 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 22, 2025 · Synced Sep 29, 2026, 12:22 AM EDT
Completed Phase 2 Interventional

Low-intensity Stepped Care for Internalizing Distress

NCT05441111
View directory record Official record
Conditions
Depression, Anxiety, Emotion Regulation
Interventions
Common Elements Toolbox, Doing What Matters in Times of Stress: An Illustrated Guide, Guided self-help
Behavioral
Lead sponsor
Indiana University
Other
Eligibility
18 Years and older
Enrollment
275 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Bloomington, Indiana
Source: ClinicalTrials.gov public record
Updated May 6, 2024 · Synced Sep 29, 2026, 12:22 AM EDT
Recruiting Not applicable Interventional

Problem-Solving Training for Concussion

NCT05837676
View directory record Official record
Conditions
Brain Concussion
Interventions
Problem Solving Training for Concussion, Treatment as usual
Behavioral · Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
134 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Sep 7, 2025 · Synced Sep 29, 2026, 12:22 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Symptom Management for Rural-Urban Cancer Survivors and Caregivers

NCT05360498
View directory record Official record
Conditions
Cancer, Cancer Survivors, Informal Caregivers, Psychological Distress
Interventions
Adaptive Symptom Management and Survivorship Handbook (SMSH) and Telephone Interpersonal Counseling (TIP-C), NCI Brochure
Behavioral
Lead sponsor
University of Arizona
Other
Eligibility
18 Years and older
Enrollment
555 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
1
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated Feb 2, 2026 · Synced Sep 29, 2026, 12:22 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Yoga for Stress and Mental Health

NCT01652807
View directory record Official record
Conditions
Physiological Stress, Psychological Distress, Depression, Anxiety
Interventions
Hatha Yoga
Behavioral
Lead sponsor
Southern Methodist University
Other
Eligibility
25 Years to 45 Years · Female only
Enrollment
52 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2013
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jan 13, 2015 · Synced Sep 29, 2026, 12:22 AM EDT
Not listed Not applicable Interventional

Evaluating a New Program for Successfully Coping With Adversity

NCT05354492
View directory record Official record
Conditions
Trauma, Distress, Emotional, Psychological Distress
Interventions
Program to Support Well-Being after Adversity
Other
Lead sponsor
Wake Forest University
Other
Eligibility
18 Years and older
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 28, 2022 · Synced Sep 29, 2026, 12:22 AM EDT
Completed Not applicable Interventional

The Effect of Mirror Education for Women Undergoing Mastectomy

NCT01642628
View directory record Official record
Conditions
Emotional Distress, Anxiety, Depression
Interventions
Mirror Education
Other
Lead sponsor
Texas Woman's University
Other
Eligibility
18 Years and older · Female only
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
2
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Mar 31, 2014 · Synced Sep 29, 2026, 12:22 AM EDT
Completed Not applicable Interventional

Pain Coping Skills for Colorectal Cancer Survivors

NCT02706301
View directory record Official record
Conditions
Colorectal Cancer
Interventions
Telephone-Based Coping Skills Training (CST)
Behavioral
Lead sponsor
Duke University
Other
Eligibility
21 Years to 80 Years
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 16, 2019 · Synced Sep 29, 2026, 12:22 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Personalized Feedback for Distress Intolerant Smokers

NCT03918031
View directory record Official record
Conditions
Anxiety Disorders, Depression, Psychological Distress, Tobacco Dependence, Smoking, Tobacco, Smoking, Cigarette
Interventions
PFI for Smoking & Distress Tolerance, PFI for Smoking Only
Behavioral
Lead sponsor
University of Houston
Other
Eligibility
18 Years and older
Enrollment
121 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Nov 14, 2024 · Synced Sep 29, 2026, 12:22 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Reiki, Yoga, Meditation, on the Physical and Psychological Symptoms of Chemotherapy-Induced Peripheral Neuropathy

NCT01569269
View directory record Official record
Conditions
Peripheral Neuropathy
Interventions
Yoga Intervention, Meditation Intervention, Reiki, Holistic Education
Behavioral · Other
Lead sponsor
George Mason University
Other
Eligibility
18 Years to 90 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2012
U.S. locations
1
States / cities
Fairfax, Virginia
Source: ClinicalTrials.gov public record
Updated Apr 2, 2012 · Synced Sep 29, 2026, 12:22 AM EDT
Not yet recruiting Not applicable Interventional

Mind-Body Group Interventions for Psychological Distress in Young Breast Cancer Survivors

NCT07501637
View directory record Official record
Conditions
Breast Cancer
Interventions
Breath-Body-Mind (BBM), Survivorship education program (SEP)
Behavioral
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Sep 8, 2026 · Synced Sep 29, 2026, 12:22 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Mindfulness Based Cognitive Therapy (MBCT) During Pregnancy

NCT03809572
View directory record Official record
Conditions
Maternal Psychological Distress, Postpartum Depression, Prenatal Stress
Interventions
Mindfulness Based Cognitive Therapy
Behavioral
Lead sponsor
Oregon Health and Science University
Other
Eligibility
21 Years to 45 Years · Female only
Enrollment
56 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Dec 19, 2021 · Synced Sep 29, 2026, 12:22 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

General Psychological Distress, PTSD, and Co-Morbidities in Healthcare Workers Consequent to Occupational Trauma

NCT04626050
View directory record Official record
Conditions
Post-traumatic Stress Disorder, Moral Injury
Interventions
Medical Music, Narrative Writing, Prolonged Exposure Therapy, Interpersonal Psychotherapy
Behavioral
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2028
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 21, 2026 · Synced Sep 29, 2026, 12:22 AM EDT
Completed Not applicable Interventional Results available

Building Resiliency Among Caregivers of Curvivors and Metavivors

NCT05702723
View directory record Official record
Conditions
Stress, Cancer Diagnosis, Distress, Emotional
Interventions
Smart-3RP, Enhanced Usual Care
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
94 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 12, 2026 · Synced Sep 29, 2026, 12:22 AM EDT
Completed Not applicable Interventional Results available

Study of a PST-Trained Voice-Enabled Artificial Intelligence Counselor (SPEAC) for Adults With Emotional Distress (Phase 1)

NCT04524104
View directory record Official record
Conditions
Depression, Anxiety
Interventions
Lumen Treatment
Behavioral
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
18 Years and older
Enrollment
63 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
2
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jul 8, 2024 · Synced Sep 29, 2026, 12:22 AM EDT
Active, not recruiting Not applicable Interventional

The Development of an Integrated Physical Activity and Mental Health Intervention for Veterans With COPD, Emotion Distress, and Low Physical Activity

NCT04953806
View directory record Official record
Conditions
COPD, Depression, Anxiety
Interventions
Step-CBT
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
40 Years and older
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 2, 2026 · Synced Sep 29, 2026, 12:22 AM EDT
Completed Not applicable Interventional

Evaluating a Novel Method of Generalizing Emotion Regulation

NCT01653548
View directory record Official record
Conditions
Problems With Emotion Regulation, Psychological Distress, Difficulties Coping With Negative Emotions, Anxiety, Depression, Borderline Personality Disorder
Interventions
Habituation Reminder Training, Habituation Reminder, Habituation
Behavioral
Lead sponsor
Duke University
Other
Eligibility
18 Years to 55 Years
Enrollment
372 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 22, 2016 · Synced Sep 29, 2026, 12:22 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Well-being Promotion and Sleep Hygiene Education to Improve Sleep Quality

NCT04316663
View directory record Official record
Conditions
Poor Quality Sleep
Interventions
Well-Being Intervention, Sleep Hygiene
Behavioral
Lead sponsor
Columbia University
Other
Eligibility
18 Years to 65 Years
Enrollment
76 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 26, 2023 · Synced Sep 29, 2026, 12:22 AM EDT
Completed Not applicable Interventional Results available

A Needs-focused Palliative Care Intervention for Older Adults in ICUs

NCT04414787
View directory record Official record
Conditions
Palliative Care, Critical Illness, Aging, Care Delivery Model, Informal Caregivers, Psychological Distress
Interventions
PCplanner
Behavioral
Lead sponsor
Duke University
Other
Eligibility
50 Years and older
Enrollment
151 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 17, 2025 · Synced Sep 29, 2026, 12:22 AM EDT
Completed Not applicable Interventional Results available

Menadione Topical Lotion in Treating Skin Discomfort and Psychological Distress in Patients With Cancer Receiving Panitumumab, Erlotinib Hydrochloride, or Cetuximab

NCT01393821
View directory record Official record
Conditions
Dermatologic Complications, Malignant Neoplasm, Pain
Interventions
menadione topical lotion, placebo, questionnaire administration, management of therapy complications
Drug · Other · Procedure
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2018
U.S. locations
2
States / cities
Phoenix, Arizona • Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated May 15, 2025 · Synced Sep 29, 2026, 12:22 AM EDT
Not yet recruiting Not applicable Interventional

Feasibility of a Real-world, Financial Psycho-oncology Intervention to Address Cancer-related Financial Distress

NCT07724041
View directory record Official record
Conditions
Cancer, Financial Hardship, Psychological Distress
Interventions
Financial psycho-oncology intervention
Behavioral
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jul 22, 2026 · Synced Sep 29, 2026, 12:22 AM EDT
Completed Not applicable Interventional

Guided Eight-week Online Acceptance and Commitment Therapy for Distressed Family Caregivers of People With Dementia

NCT04847986
View directory record Official record
Conditions
Psychological Distress
Interventions
acceptance and commitment therapy (ACT), Control group
Behavioral
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years and older
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jun 27, 2022 · Synced Sep 29, 2026, 12:22 AM EDT
Completed No phase listed Observational

Checking Out Checking In: The Development and Validation of an Electronic Screening Tool for Pediatric Psychosocial Distress

NCT02423031
View directory record Official record
Conditions
Cancer
Interventions
Not listed
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
8 Years to 21 Years
Enrollment
178 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2021
U.S. locations
4
States / cities
Aurora, Colorado • Baltimore, Maryland • Bethesda, Maryland + 1 more
Source: ClinicalTrials.gov public record
Updated May 30, 2025 · Synced Sep 29, 2026, 12:22 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Piloting a School-Based Distress Tolerance Skills Program for Adolescents

NCT06638853
View directory record Official record
Conditions
Distress, Emotional, Internalizing Mental Health Symptoms
Interventions
Distress Tolerance Skills Training
Behavioral
Lead sponsor
Oregon Health and Science University
Other
Eligibility
11 Years to 14 Years
Enrollment
74 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Beaverton, Oregon
Source: ClinicalTrials.gov public record
Updated Mar 23, 2025 · Synced Sep 29, 2026, 12:22 AM EDT