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Showing 1–24 of 117 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Drinking Heavy Clear all
Completed Phase 4 Interventional Results available

Dutasteride for the Reduction of Alcohol Use in Male Drinkers

NCT01262287
View directory record Official record
Conditions
Alcoholism, Alcohol Abuse, Alcohol Dependence
Interventions
Dutasteride, Placebo
Drug
Lead sponsor
UConn Health
Other
Eligibility
18 Years to 65 Years · Male only
Enrollment
47 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
Farmington, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 19, 2017 · Synced Jul 21, 2026, 6:09 PM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers Results available

INIA Stress and Chronic Alcohol Interactions: Glucocorticoid Antagonists in Heavy Drinkers

NCT02989662
View directory record Official record
Conditions
Alcohol Use Disorder
Interventions
Mifepristone, Placebo - Cap
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
21 Years to 55 Years
Enrollment
65 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2024
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated May 29, 2025 · Synced Jul 21, 2026, 6:09 PM EDT
Completed Phase 1Phase 2 Interventional Results available

Varenicline to Reduce Alcohol Consumption in Heavy Drinkers

NCT00695500
View directory record Official record
Conditions
Alcohol Drinking
Interventions
Varenicline, Placebo
Drug
Lead sponsor
Vijay Ramchandani, Ph.D.
NIH
Eligibility
21 Years to 60 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2015
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 14, 2016 · Synced Jul 21, 2026, 6:09 PM EDT
Completed Phase 2 Interventional Results available

Study of the Medication Prazosin for Alcohol Dependence

NCT00762710
View directory record Official record
Conditions
Alcoholism
Interventions
Prazosin medication, Placebo medication
Drug
Lead sponsor
Seattle Institute for Biomedical and Clinical Research
Other
Eligibility
18 Years and older
Enrollment
92 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2014
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jun 3, 2020 · Synced Jul 21, 2026, 6:09 PM EDT
Completed Not applicable Interventional Results available

Web-Based Treatment of Heavy Drinking Among Women With a History of Sexual Trauma

NCT03111056
View directory record Official record
Conditions
Sexual Assault, Heavy Drinking
Interventions
Alc-ERDT
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older · Female only
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated May 13, 2026 · Synced Jul 21, 2026, 6:09 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Tailored Mobile Text Messaging to Reduce Problem Drinking

NCT01885312
View directory record Official record
Conditions
Alcohol-Related Disorders, Alcohol Use Disorders, Alcohol Drinking, Alcoholism, Alcohol Abuse
Interventions
Adaptive Tailored Intervention, Consequence-based Intervention, Tailored, not adaptive, based Intervention, Assessment only
Behavioral · Other
Lead sponsor
Northwell Health
Other
Eligibility
21 Years to 65 Years
Enrollment
174 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
Great Neck, New York
Source: ClinicalTrials.gov public record
Updated Oct 12, 2016 · Synced Jul 21, 2026, 6:09 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Cerebellar Involvement in Alcohol Use Disorder (AUD)

NCT05732207
View directory record Official record
Conditions
Alcohol Use Disorder
Interventions
cerebellar transcranial direct current stimulation
Procedure
Lead sponsor
Johns Hopkins University
Other
Eligibility
25 Years to 55 Years
Enrollment
122 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated May 10, 2026 · Synced Jul 21, 2026, 6:09 PM EDT
Completed Phase 1 Interventional Results available

Study of Olaparib With Radiation Therapy and Cetuximab in Advanced Head and Neck Cancer With Heavy Smoking History

NCT01758731
View directory record Official record
Conditions
Squamous Cell Carcinoma of the Head and Neck
Interventions
Olaparib, Cetuximab, Radiation Therapy
Drug · Radiation
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years and older
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2018
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Sep 22, 2019 · Synced Jul 21, 2026, 6:09 PM EDT
Withdrawn Not applicable Interventional

Personalized Approach Bias Modification in Heavy Drinking Veterans With Mild to Moderate Traumatic Brain Injury

NCT06380985
View directory record Official record
Conditions
Alcohol Use Disorder, Mild-Moderate Traumatic Brain Injury
Interventions
Personalized VR Alcohol Approach Bias Modification (ApBM) Condition, Sham Condition
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 65 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jun 26, 2024 · Synced Jul 21, 2026, 6:09 PM EDT
Completed Not applicable Interventional Results available

Emotion Regulation Interventions for Alcohol-Related Sexual Aggression

NCT03159468
View directory record Official record
Conditions
Sexual Aggression, Heavy Drinking
Interventions
Cognitive Restructuring, Mindfulness, Alcohol consumption
Behavioral · Other
Lead sponsor
University of Washington
Other
Eligibility
21 Years to 30 Years · Male only
Enrollment
209 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jul 25, 2019 · Synced Jul 21, 2026, 6:09 PM EDT
Withdrawn Phase 4 Interventional

Effects of Varenicline in Heavy Drinking Smokers

NCT02488889
View directory record Official record
Conditions
Cigarette Smoking, Alcohol Consumption
Interventions
Varenicline, Placebo pill (for varenicline), Alcohol, placebo beverage (for alcohol)
Drug
Lead sponsor
University of California, Los Angeles
Other
Eligibility
21 Years to 55 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated May 31, 2018 · Synced Jul 21, 2026, 6:09 PM EDT
Terminated Phase 2 Interventional Accepts healthy volunteers Results available

Does Oxytocin Alter Tolerance to or Motivation for Alcohol

NCT05312008
View directory record Official record
Conditions
Alcohol Use Disorder
Interventions
Intranasal oxytocin, Intranasal placebo
Drug
Lead sponsor
Indiana University
Other
Eligibility
21 Years to 60 Years
Enrollment
6 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Mar 3, 2025 · Synced Jul 21, 2026, 6:09 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Alcohol and Sex Risk Intervention for MSM Supplement

NCT03522948
View directory record Official record
Conditions
Heavy Drinking and Sexual Risk Behavior
Interventions
Brief intervention with text messaging to reduce sexual risk and heavy drinking among MSM
Behavioral
Lead sponsor
Boston University Charles River Campus
Other
Eligibility
21 Years to 50 Years · Male only
Enrollment
8 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 10, 2021 · Synced Jul 21, 2026, 6:09 PM EDT
Recruiting Not applicable Interventional

Virtual Incentive Treatment for Alcohol

NCT06265506
View directory record Official record
Conditions
Alcohol Use Disorder, Alcohol Drinking, Alcohol Abuse, Alcohol Dependence
Interventions
Contingency Management, Computer Based Training for Cognitive Behavioral Therapy for AUD (CBT4CBT)
Behavioral
Lead sponsor
Washington State University
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
Spokane, Washington
Source: ClinicalTrials.gov public record
Updated May 29, 2025 · Synced Jul 21, 2026, 6:09 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Reducing Alcohol Involved Sexual Violence in Higher Education

NCT05185440
View directory record Official record
Conditions
Sexual Violence, Drinking Heavy
Interventions
GIFTSS Training, Learning Collaborative, Provider Scripts
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years to 24 Years
Enrollment
2,400 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 3, 2026 · Synced Jul 21, 2026, 6:09 PM EDT
Completed Phase 1 Interventional Results available

Lacosamide Effects on Alcohol Self Administration and Craving in Heavy Drinkers

NCT03271528
View directory record Official record
Conditions
Alcohol Use Disorder
Interventions
Lacosamide, Placebo oral capsule
Drug
Lead sponsor
Boston Medical Center
Other
Eligibility
21 Years to 55 Years
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 2, 2021 · Synced Jul 21, 2026, 6:09 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Brief Web-Based Alcohol Reduction Intervention for Undergraduates

NCT01694082
View directory record Official record
Conditions
Alcohol Use, Heavy Drinking, Negative Consequences of Alcohol Use
Interventions
THRIVE, Brief brochure and assessment control
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years to 24 Years
Enrollment
207 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2014
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jun 15, 2014 · Synced Jul 21, 2026, 6:09 PM EDT
Completed Phase 2 Interventional

Evaluation of an School-based Alcohol Prevention Program for Middle School Students

NCT01847183
View directory record Official record
Conditions
Alcohol-related Disorders, Drinking and Driving, Neurological Impairment
Interventions
Click City®: Alcohol
Behavioral
Lead sponsor
Oregon Research Institute
Other
Eligibility
12 Years to 16 Years
Enrollment
2,300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
1
States / cities
Eugene, Oregon
Source: ClinicalTrials.gov public record
Updated Oct 5, 2016 · Synced Jul 21, 2026, 6:09 PM EDT
Completed Not applicable Interventional

A Web Application to Reduce Heavy Drinking in First-time DWI Offenders

NCT02071836
View directory record Official record
Conditions
Driving While Intoxicated, Driving Under the Influence, Heavy Drinking, Alcohol Abstinence
Interventions
Right Turns web application, Treatment as usual
Behavioral
Lead sponsor
Behavior Therapy Associates, LLP
Industry
Eligibility
18 Years and older
Enrollment
58 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated Jan 31, 2017 · Synced Jul 21, 2026, 6:09 PM EDT
Withdrawn Phase 2 Interventional

Oxytocin Treatment for Alcohol Use Disorders

NCT03636555
View directory record Official record
Conditions
Alcohol Use Disorder
Interventions
Oxytocin, Placebo
Drug
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
21 Years to 65 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 12, 2019 · Synced Jul 21, 2026, 6:09 PM EDT
Completed Phase 2Phase 3 Interventional Results available

Dutasteride Treatment for Reducing Heavy Drinking in AUD: Predictors of Efficacy

NCT04098302
View directory record Official record
Conditions
Alcohol Use Disorder
Interventions
Dutasteride Capsules, Placebo Capsules
Drug
Lead sponsor
UConn Health
Other
Eligibility
35 Years to 70 Years
Enrollment
180 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
1
States / cities
Farmington, Connecticut
Source: ClinicalTrials.gov public record
Updated May 8, 2025 · Synced Jul 21, 2026, 6:09 PM EDT
Terminated Phase 2 Interventional Results available

Topiramate to Reduce Heavy Drinking in HIV-Positive Heavy Drinkers

NCT01764685
View directory record Official record
Conditions
Heavy Drinking, HIV, Alcohol Dependence
Interventions
Topiramate, Medical Management, Placebo
Drug · Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 70 Years
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 14, 2016 · Synced Jul 21, 2026, 6:09 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Interactive Alcohol Decision-Making Programs

NCT05398315
View directory record Official record
Conditions
Heavy Drinking
Interventions
Empathic Statements/Reflections, Narrator Backstory, Male Narrator, Female Narrator, MI Techniques
Behavioral
Lead sponsor
Wayne State University
Other
Eligibility
18 Years and older
Enrollment
352 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Jun 5, 2023 · Synced Jul 21, 2026, 6:09 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

The iTAP Study for Veterans

NCT03804788
View directory record Official record
Conditions
Insomnia, Alcohol; Harmful Use
Interventions
Cognitive Behavioral Therapy for Insomnia, Sleep Hygeine
Behavioral
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
18 Years and older
Enrollment
71 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Jan 14, 2025 · Synced Jul 21, 2026, 6:09 PM EDT