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Showing 1–24 of 72 matching trials from the live ClinicalTrials.gov search.
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Completed Phase 4 Interventional

Quetiapine for Cocaine Use and Cravings

NCT00232336
View directory record Official record
Conditions
Cocaine-Related Disorders, Substance-Related Disorders
Interventions
quetiapine
Drug
Lead sponsor
Seattle Institute for Biomedical and Clinical Research
Other
Eligibility
18 Years to 65 Years
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2006
U.S. locations
1
States / cities
Tacoma, Washington
Source: ClinicalTrials.gov public record
Updated Apr 18, 2024 · Synced Sep 9, 2026, 4:43 PM EDT
Not listed Phase 2 Interventional

Sublingual Buprenorphine for Chronic Pain

NCT00612287
View directory record Official record
Conditions
Chronic Pain
Interventions
buprenorphine
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 70 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 6, 2009 · Synced Sep 9, 2026, 4:43 PM EDT
Terminated Phase 1 Interventional

Behavioral Therapy Development for Methamphetamine Abuse

NCT00252434
View directory record Official record
Conditions
Depression, Drug Abuse, Sexually Transmitted Diseases
Interventions
Cognitive Behavioral Therapy Development for Methamphetamine Abuse
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 65 Years · Male only
Timeline
2004 – 2007
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jan 26, 2016 · Synced Sep 9, 2026, 4:43 PM EDT
Completed No phase listed Observational

A Prospective Investigation of the Risks of Opioid Misuse, Abuse, and Addiction Among Patients Treated With Opioids for the Treatment of Chronic Pain

NCT02751762
View directory record Official record
Conditions
Opioid-Related Disorders, Opiate Addiction, Narcotic Abuse, Drug Abuse
Interventions
Observation Only
Other
Lead sponsor
Member Companies of the Opioid PMR Consortium
Industry
Eligibility
18 Years to 79 Years
Enrollment
3,600 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2023
U.S. locations
2
States / cities
Portland, Oregon • Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jan 28, 2025 · Synced Sep 9, 2026, 4:43 PM EDT
Completed Not applicable Interventional

CBT4CBT for Women in Residential Treatment for Substance Use Disorders

NCT03678051
View directory record Official record
Conditions
Substance Use Disorders, Drug Abuse, Drug Addiction, Substance Abuse, Drug Use Disorders, Drug Dependence, Substance Addiction
Interventions
Treatment as Usual (TAU), TAU+CBT4CBT
Behavioral
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years and older · Female only
Enrollment
63 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Feb 4, 2020 · Synced Sep 9, 2026, 4:43 PM EDT
Completed Phase 2 Interventional Results available

Lidocaine Infusion as a Treatment for Cocaine Relapse and Craving

NCT01929343
View directory record Official record
Conditions
Cocaine Addiction
Interventions
lidocaine following cue-induced craving, lidocaine following neutral stimulus, saline
Drug
Lead sponsor
Bryon Adinoff
Other
Eligibility
25 Years to 60 Years
Enrollment
84 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Dec 30, 2020 · Synced Sep 9, 2026, 4:43 PM EDT
Withdrawn Phase 4 Interventional

Comparison of Buprenorphine/Naloxone With Naltrexone in Opioid Dependent Adolescents

NCT01015066
View directory record Official record
Conditions
Opiate Addiction
Interventions
Buprenorphine/naloxone, Naltrexone
Drug
Lead sponsor
State University of New York at Buffalo
Other
Eligibility
16 Years to 25 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2014
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Jun 9, 2014 · Synced Sep 9, 2026, 4:43 PM EDT
Recruiting Not applicable Interventional

Neuroimaging of Adolescent Cannabis Use Treatment

NCT07340554
View directory record Official record
Conditions
Cannabis Use, Cannabis Dependence, Cannabis Use Disorder, Cannabis Abuse, Cannabis Intoxication, Cannabis Smoking, Cannabis Withdrawal, Cannabis-Related Disorder, Cannabis Abuse, in Remission, Cannabis Abuse, Episodic Use, Marijuana, Marijuana Abuse, Marijuana Use, Marijuana Smoking, Marijuana Dependence, Marijuana User, Marijuana-Related Disorder, Marijuana Use Disorder, Addiction, Addiction, Substance, Substance Use, Substance Use Disorders, Substance Dependence, Substance Abuse, Substance Related Problem, Substance Abuse Drug Chronic
Interventions
Contingency Management, Elastic Net Regression
Behavioral · Device
Lead sponsor
Indiana University
Other
Eligibility
14 Years to 17 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Jun 21, 2026 · Synced Sep 9, 2026, 4:43 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Web-delivery of Evidence-based, Psychosocial Treatment for Substance Use Disorders

NCT01104805
View directory record Official record
Conditions
Substance Abuse
Interventions
Therapeutic Education System (TES), Treatment-as-Usual (TAU)
Behavioral
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
18 Years to 75 Years
Enrollment
507 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2012
U.S. locations
10
States / cities
Danbury, Connecticut • Orlando, Florida • Waipahu, Hawaii + 7 more
Source: ClinicalTrials.gov public record
Updated Jul 10, 2017 · Synced Sep 9, 2026, 4:43 PM EDT
Completed Phase 2 Interventional Results available

Enhancing Disrupted Reconsolidation: Impact on Cocaine Craving

NCT01822587
View directory record Official record
Conditions
Cocaine Addiction
Interventions
Propranolol, 40 mg, Propranolol, 80 mg, Placebo
Drug
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years and older
Enrollment
181 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2018
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Dec 25, 2019 · Synced Sep 9, 2026, 4:43 PM EDT
Completed Phase 2Phase 3 Interventional Accepts healthy volunteers Results available

The Role of Sleep in the Treatment of Cannabis Use Disorders

NCT01685073
View directory record Official record
Conditions
Drug Addiction
Interventions
Zolpidem extended-release, MET/CBT
Drug · Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 55 Years
Enrollment
127 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2018
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated May 21, 2019 · Synced Sep 9, 2026, 4:43 PM EDT
Completed Not applicable Interventional

Contingency Management for Cocaine Dependence: Cash Versus Vouchers

NCT01366716
View directory record Official record
Conditions
Substance Related Disorders, Drug Addiction, Substance Abuse
Interventions
Cash CM, Voucher CM
Behavioral
Lead sponsor
Treatment Research Institute
Other
Eligibility
18 Years and older
Enrollment
352 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2013
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 27, 2023 · Synced Sep 9, 2026, 4:43 PM EDT
Completed Not applicable Interventional Results available

Personally-Tailored Opioid-overdose and Medication for Opioid Use Disorder (MOUD) Education (TOME) for Pregnant and Postpartum Persons in MOUD

NCT06262347
View directory record Official record
Conditions
Opioid Use Disorder, Pregnancy Related, Substance Use, Drug Abuse, Drug Abuse in Pregnancy, Drug Addiction
Interventions
Personally-Tailored Opioid-overdose and Medication for opioid use disorder (MOUD) Education (TOME), Control
Behavioral
Lead sponsor
T. John Winhusen, PhD
Other
Eligibility
18 Years and older · Female only
Enrollment
131 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
6
States / cities
Jacksonville, Florida • Pittsburgh, Pennsylvania • Charleston, South Carolina + 3 more
Source: ClinicalTrials.gov public record
Updated May 10, 2025 · Synced Sep 9, 2026, 4:43 PM EDT
Completed Not applicable Interventional Results available

Effect of Oxytocin on Craving and Therapy Response

NCT01827332
View directory record Official record
Conditions
Marijuana Dependence
Interventions
Oxytocin, Saline
Drug
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 65 Years
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Jan 1, 2017 · Synced Sep 9, 2026, 4:43 PM EDT
Completed Phase 1Phase 2 Interventional Results available

Medications Development for Drug Abuse Disorders

NCT01188421
View directory record Official record
Conditions
Opioid Related Disorders, Opioid Dependence, Opioid Addiction
Interventions
Buprenorphine/naloxone, Clonidine, Tramadol ER
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 60 Years
Enrollment
106 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2015
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 5, 2017 · Synced Sep 9, 2026, 4:43 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Effect of Product Characteristics on the Abuse Liability of Nicotine Pouches

NCT07165808
View directory record Official record
Conditions
Nicotine Addiction
Interventions
Nicotine pouch: Low dose, Nicotine pouch: High dose, Low pH, High pH
Other
Lead sponsor
Emory University
Other
Eligibility
21 Years to 35 Years
Enrollment
84 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2028
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Feb 26, 2026 · Synced Sep 9, 2026, 4:43 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Home-Based Program to Help Parents of Drug Abusing Adolescents

NCT01591239
View directory record Official record
Conditions
Substance-Related Disorders, Drug Addiction, Substance Abuse
Interventions
Home-Based Intervention, Educational Group
Behavioral
Lead sponsor
Treatment Research Institute
Other
Eligibility
12 Years to 19 Years
Enrollment
286 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2016
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 27, 2023 · Synced Sep 9, 2026, 4:43 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Safety, Tolerability and Abuse Liability Study of Intravenous NRP104 in Adults With Stimulant Abuse Histories

NCT00247572
View directory record Official record
Conditions
Attention Deficit Disorder With Hyperactivity, Amphetamine-Related Disorders, Substance-Related Disorders
Interventions
NRP104
Drug
Lead sponsor
New River Pharmaceuticals
Industry
Eligibility
18 Years to 55 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Nov 4, 2007 · Synced Sep 9, 2026, 4:43 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

90-Day Online Substance Use Program

NCT03069118
View directory record Official record
Conditions
Addictive Behavior, Alcohol Use Disorder, Alcohol Abuse, Drug Abuse, Drug Use Disorders
Interventions
Treatment - Workit Health Online Program, Control - Resource List
Behavioral
Lead sponsor
Workit Health
Industry
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Mar 12, 2017 · Synced Sep 9, 2026, 4:43 PM EDT
Completed Not applicable Interventional Results available

Effect of Oxytocin on Stress in Marijuana Users

NCT01335789
View directory record Official record
Conditions
Marijuana Dependence
Interventions
Oxytocin, Saline
Drug
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 65 Years
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Dec 13, 2015 · Synced Sep 9, 2026, 4:43 PM EDT
Completed Not applicable Interventional

Stage III Community-based Efficacy Trial for Mothering From the Inside Out

NCT02955199
View directory record Official record
Conditions
Addiction, Substance Abuse Drug Chronic, Child Neglect, Child Neglect Emotional, Child Abuse, Parenting, Parent-Child Problem, Parent-Child Relations, Parent / Child Problem, Parenteral Drug Abuse, Parents
Interventions
Mothering From the Inside Out (MIO), Parent Education
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years to 60 Years · Female only
Enrollment
97 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2020
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jul 13, 2021 · Synced Sep 9, 2026, 4:43 PM EDT
Terminated Phase 4 Interventional Results available

Buprenorphine as a Treatment in Opiate Dependent Pain Patients

NCT00552578
View directory record Official record
Conditions
Opiate Addiction, Refractory Pain
Interventions
buprenorphine/naloxone
Drug
Lead sponsor
State University of New York at Buffalo
Other
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Feb 16, 2011 · Synced Sep 9, 2026, 4:43 PM EDT
Completed Not applicable Interventional

Phone Interview to Prevent Recurring Opioid Overdoses

NCT02282306
View directory record Official record
Conditions
Overdose, Opioid-related Disorders, Drug Addiction, Drug Abuse, Substance Abuse, Opioid Use, Unspecified, Opioid Dependence, Drug Overdose
Interventions
TTIP-PRO
Behavioral
Lead sponsor
University of Cincinnati
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
2
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated May 27, 2015 · Synced Sep 9, 2026, 4:43 PM EDT
Completed No phase listed Observational

Medication Treatment for Opioid Use Disorder in Expectant Mothers: Infant Neurodevelopmental Outcomes Sub-study

NCT03911739
View directory record Official record
Conditions
Opioid-Related Disorders, Drug Addiction, Pregnancy Related, Substance Abuse, Drug Abuse, Neonatal Abstinence Syndrome, Neonatal Opiate Withdrawal Syndrome, Drug Abuse in Pregnancy
Interventions
Buprenorphine Injection, Buprenorphine Sublingual Product
Drug
Lead sponsor
T. John Winhusen, PhD
Other
Eligibility
Not listed
Enrollment
71 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
10
States / cities
Jacksonville, Florida • Boston, Massachusetts • Portland, Oregon + 6 more
Source: ClinicalTrials.gov public record
Updated Mar 15, 2026 · Synced Sep 9, 2026, 4:43 PM EDT