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ClinicalTrials.gov public records Last synced Oct 20, 2026, 7:20 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Showing 193–216 of 460 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Drug Abuse Clear all
Completed No phase listed Observational

Risk Perception in Drug-Dependent Adults With and Without Schizophrenia

NCT01031563
View directory record Official record
Conditions
Cocaine Dependence, Cannabis Dependence, Schizophrenia
Interventions
Not listed
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 64 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
Catonsville, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 2, 2017 · Synced Oct 20, 2026, 7:20 AM EDT
Completed Phase 2Phase 3 Interventional Results available

Memantine-enhanced Buprenorphine Treatment for Opioid-dependent Young Adults

NCT01052662
View directory record Official record
Conditions
Opioid Dependence
Interventions
Memantine, Placebo
Drug
Lead sponsor
University of Massachusetts, Worcester
Other
Eligibility
18 Years to 25 Years
Enrollment
87 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
1
States / cities
Worcester, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 1, 2015 · Synced Oct 20, 2026, 7:20 AM EDT
Recruiting Not applicable Interventional

Smartphone Services for Stimulant Use Disorder

NCT07092059
View directory record Official record
Conditions
Stimulant Use Disorder
Interventions
Smartphone digital therapeutic system
Device
Lead sponsor
DynamiCare Health
Industry
Eligibility
18 Years and older
Enrollment
270 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 29, 2025 · Synced Oct 20, 2026, 7:20 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Understanding Drug Abuse Treatment Outcomes

NCT01678833
View directory record Official record
Conditions
Drug Abuse/Dependence
Interventions
Not listed
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 60 Years · Male only
Enrollment
7 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2016
U.S. locations
2
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 5, 2018 · Synced Oct 20, 2026, 7:20 AM EDT
Completed Not applicable Interventional Results available

Personally-Tailored Opioid-overdose and Medication for Opioid Use Disorder (MOUD) Education (TOME) for Pregnant and Postpartum Persons in MOUD

NCT06262347
View directory record Official record
Conditions
Opioid Use Disorder, Pregnancy Related, Substance Use, Drug Abuse, Drug Abuse in Pregnancy, Drug Addiction
Interventions
Personally-Tailored Opioid-overdose and Medication for opioid use disorder (MOUD) Education (TOME), Control
Behavioral
Lead sponsor
T. John Winhusen, PhD
Other
Eligibility
18 Years and older · Female only
Enrollment
131 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
6
States / cities
Jacksonville, Florida • Pittsburgh, Pennsylvania • Charleston, South Carolina + 3 more
Source: ClinicalTrials.gov public record
Updated May 11, 2025 · Synced Oct 20, 2026, 7:20 AM EDT
Terminated Phase 4 Interventional Results available

Use of Xtampza ER to Overcome Difficulties in Swallowing Opioid Pills

NCT03588806
View directory record Official record
Conditions
Chronic Pain, Opioid Use, Deglutition
Interventions
Xtampza ER (oxycodone)
Drug
Lead sponsor
Ajay Wasan, MD, Msc
Other
Eligibility
21 Years to 65 Years
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 17, 2020 · Synced Oct 20, 2026, 7:20 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Linking Epigenomics With Prescription Opioid Abuse and High Impact Musculoskeletal Pain

NCT03947749
View directory record Official record
Conditions
Pain, Chronic, Prescription Drug Abuse (Not Dependent)
Interventions
Not listed
Lead sponsor
University of Florida
Other
Eligibility
18 Years and older
Enrollment
275 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
2
States / cities
Gainesville, Florida • Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Aug 14, 2023 · Synced Oct 20, 2026, 7:20 AM EDT
Completed Phase 2 Interventional Results available

Combined Treatment for Alcohol-Dependent Individuals With PTSD

NCT00262223
View directory record Official record
Conditions
Stress Disorders, Post-Traumatic, Alcohol Abuse, Substance-Related Disorders
Interventions
Seeking Safety, Sertraline, Pill placebo
Behavioral · Drug
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
18 Years to 65 Years
Enrollment
69 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2013
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 3, 2020 · Synced Oct 20, 2026, 7:20 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Modern Nicotine Oral Product Abuse Liability

NCT06777784
View directory record Official record
Conditions
Smoking, Tobacco Use
Interventions
Product A, Product B, Product C, Product D, Product E, Product F, Product G, Product N
Other
Lead sponsor
RAI Services Company
Industry
Eligibility
21 Years to 60 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
2
States / cities
Lexington, Kentucky • Knoxville, Tennessee
Source: ClinicalTrials.gov public record
Updated Dec 23, 2025 · Synced Oct 20, 2026, 7:20 AM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers Results available

The Effect of Prescription Medications in Marijuana Users

NCT00893074
View directory record Official record
Conditions
Marijuana Abuse
Interventions
Dronabinol 30mg/day, Dronabinol 60mg/day, Dronabinol 120mg/day, Placebo
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2011
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 3, 2017 · Synced Oct 20, 2026, 7:20 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Healthier You: Optimizing Screening, Brief Interventions, and Referral to Treatment (SBIRT) in the Emergency Department

NCT01113190
View directory record Official record
Conditions
Drug Abuse
Interventions
Computer-delivered Brief Intervention (CBI), Intervener-delivered Brief Intervention (IBI), Adapted Motivational Enhancement Therapy (AMET), Enhanced Usual Care (EUC)
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 60 Years
Enrollment
878 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2014
U.S. locations
1
States / cities
Flint, Michigan
Source: ClinicalTrials.gov public record
Updated Apr 7, 2016 · Synced Oct 20, 2026, 7:20 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Community Pharmacy-Based Prescription Drug Monitoring Program Opioid Risk Assessment Tool

NCT05706311
View directory record Official record
Conditions
Opioid Abuse, Prescription Opioid Abuse
Interventions
Clinical Decision Support Tool (Moderate Risk), Clinical Decision Support Tool (High Risk), Standard of Care
Behavioral · Other
Lead sponsor
University of Utah
Other
Eligibility
Not listed
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
2
States / cities
Cincinnati, Ohio • Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Jul 17, 2026 · Synced Oct 20, 2026, 7:20 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

A Study to Assess the Abuse Potential of Intranasal Cebranopadol

NCT06453265
View directory record Official record
Conditions
Abuse, Drug
Interventions
Cebranopadol- 600 ug, Cebranopadol- 800ug, Cebranopadol- 1000ug, Treatment A:, Treatment B, Treatment C, Qualification
Drug
Lead sponsor
Tris Pharma, Inc.
Industry
Eligibility
18 Years to 55 Years
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Dec 18, 2025 · Synced Oct 20, 2026, 7:20 AM EDT
Terminated Phase 1 Interventional

Behavioral Therapy Development for Methamphetamine Abuse

NCT00252434
View directory record Official record
Conditions
Depression, Drug Abuse, Sexually Transmitted Diseases
Interventions
Cognitive Behavioral Therapy Development for Methamphetamine Abuse
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 65 Years · Male only
Timeline
2004 – 2007
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jan 27, 2016 · Synced Oct 20, 2026, 7:20 AM EDT
Completed Phase 1 Interventional

Brief Interventions for Drop-out Re-engagement

NCT00350571
View directory record Official record
Conditions
Substance Abuse
Interventions
brief (behavioral therapy), Drop out re-engagement motivational intervention, standard care follow up
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years to 65 Years
Enrollment
299 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2009
U.S. locations
2
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Sep 17, 2014 · Synced Oct 20, 2026, 7:20 AM EDT
Recruiting Phase 1 Interventional Accepts healthy volunteers

Effect of Cannabis on Cigarette Use Behavior

NCT06609083
View directory record Official record
Conditions
Cannabis Use, Tobacco Use, Cigarette Smoking
Interventions
THC 30mg, THC 5mg, THC 0mg, Cigarette Full Nicotine, Cigarette Reduced Nicotine
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
21 Years and older
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2029
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jan 16, 2026 · Synced Oct 20, 2026, 7:20 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Abuse Potential Study of PF-00345439

NCT01986283
View directory record Official record
Conditions
Opioid Users
Interventions
Capsule, PF-00345439, oxycodone
Drug
Lead sponsor
Pain Therapeutics
Industry
Eligibility
18 Years to 55 Years
Enrollment
67 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Apr 4, 2016 · Synced Oct 20, 2026, 7:20 AM EDT
Completed Not applicable Interventional

Treatment for Psychological and Drug Abuse Problems

NCT01140334
View directory record Official record
Conditions
Substance Use Disorders
Interventions
Voucher Reinforcement, Standard Control
Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 65 Years
Enrollment
158 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 20, 2013 · Synced Oct 20, 2026, 7:20 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Abuse Liability of Suboxone Versus Subutex

NCT00710385
View directory record Official record
Conditions
Opioid-related Disorders
Interventions
Heroin, Naloxone, Low Bup Dose, High Bup Dose, Low Bup/Nal Dose, High Bup/Nal Dose, Placebo (PCB)
Drug
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
21 Years to 45 Years
Enrollment
19 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2008
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 5, 2016 · Synced Oct 20, 2026, 7:20 AM EDT
Completed Not applicable Interventional

No Opioids PrescrIptions On Discharge After Surgery

NCT04469868
View directory record Official record
Conditions
Opioid Use, Prescription Drug Abuse and Dependency, Surgery, Postoperative Pain
Interventions
No opioids at discharge
Behavioral
Lead sponsor
Albany Medical College
Other
Eligibility
18 Years and older
Enrollment
350 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2024
U.S. locations
1
States / cities
Albany, New York
Source: ClinicalTrials.gov public record
Updated Jul 31, 2024 · Synced Oct 20, 2026, 7:20 AM EDT
Completed Not applicable Interventional Results available

Contingency Management of Alcohol Abuse in the Severely Mentally ILL

NCT01567943
View directory record Official record
Conditions
Alcohol Abuse, Schizophrenia, Bipolar Disorder, Major Depressive Disorder
Interventions
Contingency Management
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
18 Years to 65 Years
Enrollment
123 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Feb 23, 2017 · Synced Oct 20, 2026, 7:20 AM EDT
Completed Phase 2 Interventional Results available

Lidocaine Infusion as a Treatment for Cocaine Relapse and Craving

NCT01929343
View directory record Official record
Conditions
Cocaine Addiction
Interventions
lidocaine following cue-induced craving, lidocaine following neutral stimulus, saline
Drug
Lead sponsor
Bryon Adinoff
Other
Eligibility
25 Years to 60 Years
Enrollment
84 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Dec 31, 2020 · Synced Oct 20, 2026, 7:20 AM EDT
Withdrawn Phase 2 Interventional

HIV Risk Reduction and Drug Abuse Treatment in Iran

NCT00398008
View directory record Official record
Conditions
Opiate Dependence, HIV Infections
Interventions
Buprenorphine/Subutex, Naltrexone, Drug counseling
Drug · Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years to 65 Years · Male only
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2008
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 30, 2020 · Synced Oct 20, 2026, 7:20 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Reinforcement-Based Treatment and Abstinence-Contingent Housing for Drug Abusers

NCT00685620
View directory record Official record
Conditions
Drug Abuse
Interventions
Reinforcement Based Treatment
Behavioral
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 65 Years
Enrollment
463 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2002 – 2007
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jan 11, 2017 · Synced Oct 20, 2026, 7:20 AM EDT