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Showing 1–24 of 53 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Drug Abuse Prevention Clear all
Not listed Not applicable Interventional Accepts healthy volunteers

A Trial of Connecting to Promote Foster Teen Well-Being

NCT03157895
View directory record Official record
Conditions
Relationship, Family (Foster), Substance Use Prevention
Interventions
Connecting
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
11 Years to 15 Years
Enrollment
220 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2020
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jul 30, 2019 · Synced Sep 7, 2026, 8:39 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Preventing HIV/STI in Urban Adolescents Via an mHealth Primary Care Intervention

NCT03368456
View directory record Official record
Conditions
HIV/AIDS and Infections, Drug Abuse, Adolescent Behavior, Drug Usage
Interventions
S4E, Usual Care
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
14 Years to 21 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Ypsilanti, Michigan
Source: ClinicalTrials.gov public record
Updated Aug 30, 2022 · Synced Sep 7, 2026, 8:39 AM EDT
Completed Phase 2 Interventional

Treatment Efficacy for Drug Abuse and AIDS Prevention - 2

NCT00000211
View directory record Official record
Conditions
Cocaine-Related Disorders, Heroin Dependence
Interventions
Buprenorphine
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
26 Years to 41 Years · Male only
Healthy volunteers
Healthy volunteers not accepted
Timeline
1989 – 1996
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 11, 2017 · Synced Sep 7, 2026, 8:39 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Hospital Visit as Opportunity for Prevention and Engagement for HIV-Infected Drug Users

NCT01612169
View directory record Official record
Conditions
HIV, AIDS, Substance Abuse, Inpatient
Interventions
Patient Navigation (PN) Group, Patient Navigator Plus Contingency Management (PN+CM) Group
Behavioral
Lead sponsor
Columbia University
Other
Eligibility
18 Years and older
Enrollment
801 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2015
U.S. locations
12
States / cities
Birmingham, Alabama • Torrance, California • Miami, Florida + 8 more
Source: ClinicalTrials.gov public record
Updated Mar 13, 2016 · Synced Sep 7, 2026, 8:39 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Preventing Drug Abuse Among Sexual Minority Youth

NCT03954535
View directory record Official record
Conditions
Substance Abuse
Interventions
Free2b, Attention-Placebo
Behavioral
Lead sponsor
Columbia University
Other
Eligibility
15 Years to 17 Years
Enrollment
1,216 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2024
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 25, 2025 · Synced Sep 7, 2026, 8:39 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A High School Program for Preventing Prescription Drug Misuse

NCT03219190
View directory record Official record
Conditions
Prescription Drug Abuse, Substance Abuse, Substance Use (Drugs, Alcohol)
Interventions
LST High School Hybrid
Behavioral
Lead sponsor
National Health Promotion Associates, Inc.
Industry
Eligibility
14 Years to 18 Years
Enrollment
1,804 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
White Plains, New York
Source: ClinicalTrials.gov public record
Updated Mar 9, 2026 · Synced Sep 7, 2026, 8:39 AM EDT
Completed Not applicable Interventional

Break the Cycle: Prevention for Reducing Initiation Into Injection Drug Use

NCT03502525
View directory record Official record
Conditions
Substance Abuse, Intravenous, Prevention and Control
Interventions
Break the Cycle Intervention, Bacterial Infection Prevention
Behavioral
Lead sponsor
New York University
Other
Eligibility
18 Years and older
Enrollment
402 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2022
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 24, 2025 · Synced Sep 7, 2026, 8:39 AM EDT
Recruiting Not applicable Interventional

Adaptation and Evaluation of Bright Horizons

NCT05743699
View directory record Official record
Conditions
Alcohol Abuse, Substance Use
Interventions
Bright Horizons, Case Management
Behavioral
Lead sponsor
Johns Hopkins Bloomberg School of Public Health
Other
Eligibility
10 Years to 24 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Whiteriver, Arizona
Source: ClinicalTrials.gov public record
Updated Jun 8, 2026 · Synced Sep 7, 2026, 8:39 AM EDT
Completed Not applicable Interventional Results available

Testing an Integrated Bio-Behavioral Primary HIV Prevention Intervention Among High-Risk People Who Use Drugs

NCT03282890
View directory record Official record
Conditions
Risk Behavior, HIV/AIDS, Medication Adherence, Substance Abuse
Interventions
CHRP-BB
Other
Lead sponsor
University of Connecticut
Other
Eligibility
18 Years and older
Enrollment
237 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2023
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Aug 16, 2025 · Synced Sep 7, 2026, 8:39 AM EDT
Completed Not applicable Interventional Results available

A Tailored, Peer-delivered Intervention to Reduce Recurring Opioid Overdoses

NCT02922959
View directory record Official record
Conditions
Drug Overdose, Opioid-Related Disorders, Drug Addiction, Drug Abuse, Substance Abuse
Interventions
Peer Intervention, naloxone nasal spray kit, Personally-tailored opioid overdose prevention education (information packet)
Behavioral · Drug
Lead sponsor
University of Cincinnati
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 23, 2020 · Synced Sep 7, 2026, 8:39 AM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers

Neurological Influences on Drug Prevention Intervention

NCT00198939
View directory record Official record
Conditions
Youths At-risk for Drug Use/Abuse
Interventions
Integrated Family and Cognitive-Behavioral Drug Prevention Intervention, Psychoeducation
Behavioral · Other
Lead sponsor
University of Florida
Other
Eligibility
11 Years to 15 Years
Enrollment
330 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2011
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 27, 2012 · Synced Sep 7, 2026, 8:39 AM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers

Healthy Teen Girls: HIV Risk Reduction

NCT00787696
View directory record Official record
Conditions
HIV-infection/Aids
Interventions
Cognitive-behavioral HIV/STD risk reduction
Behavioral
Lead sponsor
Mississippi State University
Other
Eligibility
13 Years to 18 Years · Female only
Enrollment
333 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2009
U.S. locations
1
States / cities
Columbia, Mississippi
Source: ClinicalTrials.gov public record
Updated Oct 19, 2011 · Synced Sep 7, 2026, 8:39 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Drug Abuse Prevention Among Girls Through a Mother-Daughter Intervention

NCT01236248
View directory record Official record
Conditions
Substance Use
Interventions
Prevention
Behavioral
Lead sponsor
Columbia University
Other
Eligibility
11 Years to 13 Years · Female only
Enrollment
916 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2012
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 17, 2017 · Synced Sep 7, 2026, 8:39 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Wakaya: Rising Up for Choctaw Youth Health

NCT05818384
View directory record Official record
Conditions
Obesity, Adolescent, Healthy Nutrition, Sedentary Behavior, Drug Abuse
Interventions
Wakaya: Rising Up for Choctaw Youth Curriculum
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
12 Years to 19 Years
Enrollment
176 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
2
States / cities
Durant, Oklahoma • Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Feb 19, 2025 · Synced Sep 7, 2026, 8:39 AM EDT
Completed Not applicable Interventional

Alcohol, Suicide and HIV Prevention for Teens in Mental Health Treatment

NCT02228044
View directory record Official record
Conditions
Suicide, Alcohol Abuse, Drug Abuse, HIV
Interventions
Prevention program
Behavioral
Lead sponsor
George Mason University
Other
Eligibility
13 Years to 18 Years
Enrollment
81 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2014
U.S. locations
1
States / cities
Fairfax, Virginia
Source: ClinicalTrials.gov public record
Updated Aug 27, 2014 · Synced Sep 7, 2026, 8:39 AM EDT
Withdrawn Phase 1Phase 2 Interventional

cSBIRT to Reduce Teen Tobacco, Alcohol and Drug Use

NCT01275391
View directory record Official record
Conditions
Tobacco Abuse, Alcohol Abuse, Drug Abuse
Interventions
Computer Screening, Brief Intervention, Referral toTreatment
Behavioral
Lead sponsor
Boston Children's Hospital
Other
Eligibility
12 Years to 21 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 6, 2016 · Synced Sep 7, 2026, 8:39 AM EDT
Completed Phase 2Phase 3 Interventional Results available

Voucher-Based Incentives in a Prevention Setting

NCT00607269
View directory record Official record
Conditions
Substance-related Disorders
Interventions
Voucher-Based Reinforcement Therapy
Behavioral
Lead sponsor
Friends Research Institute, Inc.
Other
Eligibility
18 Years to 65 Years · Male only
Enrollment
131 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2008
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jul 31, 2013 · Synced Sep 7, 2026, 8:39 AM EDT
Completed Phase 2 Interventional

Brief Voluntary Alcohol and Drug Intervention for Middle School Youth

NCT01081119
View directory record Official record
Conditions
Alcohol Drinking, Cigarette Smoking, Marijuana Smoking
Interventions
Project CHOICE
Behavioral
Lead sponsor
RAND
Other
Eligibility
11 Years to 15 Years
Enrollment
6,455 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2014
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jul 9, 2014 · Synced Sep 7, 2026, 8:39 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Familias Unidas: Preventing Drug Abuse and HIV in Hispanic First Offenders

NCT01257022
View directory record Official record
Conditions
Substance Use, Unsafe Sexual Behavior
Interventions
Familias Unidas
Behavioral
Lead sponsor
University of Miami
Other
Eligibility
12 Years to 17 Years
Enrollment
242 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2011
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Mar 4, 2014 · Synced Sep 7, 2026, 8:39 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Web-Based Intervention to Prevent Drug Abuse Among Adolescent Girls

NCT01813123
View directory record Official record
Conditions
Drug Abuse Prevention
Interventions
RealTeen
Behavioral
Lead sponsor
Columbia University
Other
Eligibility
13 Years to 14 Years · Female only
Enrollment
788 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2019
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 26, 2019 · Synced Sep 7, 2026, 8:39 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

First Years Away From Home: Letting Go and Staying Connected

NCT03227809
View directory record Official record
Conditions
Substance Abuse, Risk Reduction, RIsky Sexual Behavior
Interventions
Handbook condition, Handbook plus condition
Behavioral
Lead sponsor
Washington State University
Other
Eligibility
17 Years to 22 Years
Enrollment
910 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2021
U.S. locations
1
States / cities
Pullman, Washington
Source: ClinicalTrials.gov public record
Updated May 18, 2020 · Synced Sep 7, 2026, 8:39 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

NC Young Women's CoOp

NCT02965014
View directory record Official record
Conditions
Condomless Sex, Human Immunodeficiency Virus (HIV), Sexually Transmitted Infection (STI), Alcohol and Drug Use
Interventions
Face-to-Face Young Women's CoOp (YWC), mHealth Young Women's CoOp (YWC), HIV Counseling and Testing
Behavioral
Lead sponsor
RTI International
Other
Eligibility
18 Years to 25 Years · Female only
Enrollment
652 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2020
U.S. locations
4
States / cities
Durham, North Carolina • Greensboro, North Carolina • High Point, North Carolina + 1 more
Source: ClinicalTrials.gov public record
Updated Jan 7, 2025 · Synced Sep 7, 2026, 8:39 AM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Clinician Practice Companion to Address Youth Substance Use

NCT07725289
View directory record Official record
Conditions
Substance Use, Substance-Related Disorders, Adolescent Substance Use, Cannabis Use, Opioid Use Disorder, Drug Overdose, Overdose Prevention, Co-occurring Mental Health Conditions
Interventions
Practice Companion
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
14 Years to 24 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2027 – 2029
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 26, 2026 · Synced Sep 7, 2026, 8:39 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Drug Use Prevention Among Girls Through a Mother-Daughter Intervention

NCT00310258
View directory record Official record
Conditions
Adolescent Behavior
Interventions
Drug use prevention intervention
Behavioral
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
11 Years to 13 Years · Female only
Enrollment
2,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2006
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 10, 2017 · Synced Sep 7, 2026, 8:39 AM EDT