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Showing 1–24 of 164 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Drug Overdose Clear all
Completed Not applicable Interventional Accepts healthy volunteers Results available

Kentucky Communities and Researchers Engaging to Halt the Opioid Epidemic (CARE2HOPE)

NCT04134767
View directory record Official record
Conditions
Substance Use, HIV Infections, HCV Infection, Sexually Transmitted Infections (Not HIV or Hepatitis), Overdose, Drug, Opioid Use
Interventions
Health Linkage, Overdose Education
Behavioral
Lead sponsor
April M Young
Other
Eligibility
18 Years and older
Enrollment
234 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Dec 20, 2023 · Synced Jul 21, 2026, 11:59 AM EDT
Recruiting Phase 1 Interventional Accepts healthy volunteers

Single Dose Study, Pharmacokinetics of Oxycodone and PF614 Co-Administered With Nafamostat (PF614-MPAR-102)

NCT06500793
View directory record Official record
Conditions
Pharmacokinetics, Healthy Volunteer
Interventions
PF614 capsule, Nafamostat Mesylate
Drug
Lead sponsor
Ensysce Biosciences
Industry
Eligibility
18 Years to 55 Years
Enrollment
54 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated May 25, 2026 · Synced Jul 21, 2026, 11:59 AM EDT
Completed No phase listed Observational

Baseline Epidemiologic Assessment of Abuse-Deterrence of MorphaBond Extended Release (BEAD-MB)

NCT04033094
View directory record Official record
Conditions
Baseline Epidemiologic Assessment
Interventions
MorphaBond ER, Comparator Drug
Drug
Lead sponsor
Daiichi Sankyo
Industry
Eligibility
Not listed
Enrollment
17,566 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Basking Ridge, New Jersey
Source: ClinicalTrials.gov public record
Updated Mar 14, 2021 · Synced Jul 21, 2026, 11:59 AM EDT
Not yet recruiting Not applicable Interventional

Preventing Overdose and Promoting Recovery Through Court Navigation

NCT07700407
View directory record Official record
Conditions
Substance Use Disorder (SUD)
Interventions
CourtConnect, Information Only
Behavioral · Other
Lead sponsor
RTI International
Other
Eligibility
18 Years to 100 Years
Enrollment
600 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
2
States / cities
South Bend, Indiana • Research Triangle Park, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 13, 2026 · Synced Jul 21, 2026, 11:59 AM EDT
Terminated Phase 3 Interventional Results available

Virginia Opioid Overdose Treatment InitiatVE

NCT03818399
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
SUBLOCADE
Drug
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years and older
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated May 4, 2022 · Synced Jul 21, 2026, 11:59 AM EDT
Active, not recruiting No phase listed Observational

Health Insurance Instability and Mortality Among Patients Receiving Bup Tx for OUD

NCT05944133
View directory record Official record
Conditions
Opioid Use Disorder, Opioid Overdose, Death
Interventions
No intervention, observational retrospective study
Other
Lead sponsor
Kaiser Permanente
Other
Eligibility
16 Years and older
Enrollment
27,257 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Oct 16, 2024 · Synced Jul 21, 2026, 11:59 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Kentucky Outreach Service Kiosk (KyOSK): Reducing HIV, HCV, and Overdose Risk

NCT05657106
View directory record Official record
Conditions
Opioid-Related Disorders, Hepatitis C (HCV), Human Immunodeficiency Virus (HIV), Drug Overdose, Substance Abuse, Intravenous Drug Usage, Opiate Substitution Treatment, Sexually Transmitted Diseases
Interventions
Harm reduction kiosk
Behavioral
Lead sponsor
April M Young
Other
Eligibility
18 Years and older
Enrollment
752 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated May 5, 2026 · Synced Jul 21, 2026, 11:59 AM EDT
Not listed Not applicable Interventional

Naloxone Education in Total Joint Patients

NCT04868552
View directory record Official record
Conditions
Opioid Use, Pain, Musculoskeletal, Surgery, Overdose of Opiate
Interventions
Pre-hospital naloxone education
Other
Lead sponsor
Carilion Clinic
Other
Eligibility
18 Years and older
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated May 2, 2021 · Synced Jul 21, 2026, 11:59 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Tau PET Imaging in Opioid Use Disorder

NCT05651516
View directory record Official record
Conditions
Opioid-Related Disorders
Interventions
18F-PI-2620 PET/CT
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 60 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 8, 2026 · Synced Jul 21, 2026, 11:59 AM EDT
Completed No phase listed Observational Results available

Emergency Room Firearm and Medication Safety Intervention

NCT04797221
View directory record Official record
Conditions
Suicide, Firearm Injury, Overdose
Interventions
Not listed
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Aug 12, 2024 · Synced Jul 21, 2026, 11:59 AM EDT
Completed No phase listed Observational

Community and Familial Impacts of the Opioid Crisis

NCT05116852
View directory record Official record
Conditions
Opioid Use Disorder, Bereavement, Overdose of Opiate
Interventions
Survey
Other
Lead sponsor
Cambridge Health Alliance
Other
Eligibility
18 Years and older
Enrollment
578 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 3, 2025 · Synced Jul 21, 2026, 11:59 AM EDT
Completed Not applicable Interventional

Impact of Direct Outreach to Expand Access to Naloxone in the Context of Standing Orders

NCT03241771
View directory record Official record
Conditions
Opioid Abuse, Overdose, Risk Behavior
Interventions
Naloxone Navigator 1.0
Behavioral
Lead sponsor
Kaiser Permanente
Other
Eligibility
18 Years and older
Enrollment
325 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Aug 23, 2023 · Synced Jul 21, 2026, 11:59 AM EDT
Completed Phase 4 Interventional Results available

Project OOPEN: Opioid Overdose Prevention, Education and Intervention

NCT01788306
View directory record Official record
Conditions
Opioid Overdose
Interventions
OOPEN+BBCC
Drug
Lead sponsor
University of Washington
Other
Eligibility
18 Years to 70 Years
Enrollment
256 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2018
U.S. locations
3
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jan 10, 2022 · Synced Jul 21, 2026, 11:59 AM EDT
Active, not recruiting Not applicable Interventional

Supporting Treatment Access and Recovery Through Linkage and Support

NCT05713695
View directory record Official record
Conditions
Mental Health Disorders, Substance Use Disorders
Interventions
Full MISSION, Linkage Only Delivered by a Peer Specialist
Behavioral
Lead sponsor
University of Massachusetts, Worcester
Other
Eligibility
18 Years and older
Enrollment
208 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Worcester, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 12, 2026 · Synced Jul 21, 2026, 11:59 AM EDT
Completed No phase listed Observational

Prospective Cohort Study of Intravenous Lipid Emulsion for Resuscitating Critically-ill Poisoned Patients

NCT03107689
View directory record Official record
Conditions
Overdose
Interventions
administration of intravenous lipid emulsion
Other
Lead sponsor
University of Southern California
Other
Eligibility
Not listed
Enrollment
134 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2018
U.S. locations
2
States / cities
Phoenix, Arizona • Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Feb 29, 2024 · Synced Jul 21, 2026, 11:59 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Community Driven Substance Use Recovery for High Opioid Overdose Areas

NCT05260047
View directory record Official record
Conditions
Substance Use, Mental Health Issue, Opioid Use, Medication Assisted Treatment
Interventions
IMANI, Telehealth MAT, Traditional MAT plus Referral and Linkage
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
525 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
8
States / cities
Bridgeport, Connecticut • Hartford, Connecticut • New Britain, Connecticut + 1 more
Source: ClinicalTrials.gov public record
Updated Jun 7, 2026 · Synced Jul 21, 2026, 11:59 AM EDT
Completed Not applicable Interventional

Safety and Health Intervention Project

NCT02152397
View directory record Official record
Conditions
Drug Overdose, Opioid Related Disorders
Interventions
Therapist-led brief intervention (TBI)
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
139 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Waterford, Michigan
Source: ClinicalTrials.gov public record
Updated Apr 16, 2017 · Synced Jul 21, 2026, 11:59 AM EDT
Not listed Not applicable Interventional

Improving Availability of Intranasal Naloxone

NCT05877118
View directory record Official record
Conditions
Opioid Overdose
Interventions
Enhanced Overdose Education (EOE), Standard education
Behavioral
Lead sponsor
Hartford Hospital
Other
Eligibility
21 Years to 65 Years
Enrollment
84 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
2
States / cities
Hartford, Connecticut
Source: ClinicalTrials.gov public record
Updated Jun 6, 2024 · Synced Jul 21, 2026, 11:59 AM EDT
Terminated Phase 2 Interventional Results available

Meth-OD: A Study of IXT-m200 in Patients With Toxicity From Methamphetamine Overdose

NCT04715230
View directory record Official record
Conditions
Methamphetamine Intoxication (Disorder)
Interventions
IXT-m200, Lorazepam, Haloperidol
Biological · Drug
Lead sponsor
InterveXion Therapeutics, LLC
Industry
Eligibility
18 Years to 45 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
4
States / cities
Little Rock, Arkansas • Albuquerque, New Mexico • Everett, Washington + 1 more
Source: ClinicalTrials.gov public record
Updated Nov 17, 2023 · Synced Jul 21, 2026, 11:59 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Rapid Self-Testing to Prevent Fentanyl Overdose Among Young People Who Use Drugs

NCT03373825
View directory record Official record
Conditions
Accidental Overdose of Opiate
Interventions
Take home rapid drug test
Behavioral
Lead sponsor
Brown University
Other
Eligibility
18 Years to 35 Years
Enrollment
93 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jan 23, 2018 · Synced Jul 21, 2026, 11:59 AM EDT
Completed Not applicable Interventional Results available

Repeated-dose Behavioral Intervention to Reduce Opioid Overdose

NCT03838510
View directory record Official record
Conditions
Opioid-Related Disorders, Drug Overdose
Interventions
REBOOT
Behavioral
Lead sponsor
San Francisco Department of Public Health
Government
Eligibility
18 Years to 65 Years
Enrollment
268 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
2
States / cities
San Francisco, California • Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 14, 2025 · Synced Jul 21, 2026, 11:59 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

Pharmacodynamic Evaluation of Intramuscular Nalmefene Autoinjector 1.5 mg Compared to Intranasal Narcan 4 mg

NCT06719986
View directory record Official record
Conditions
Opioid Overdose
Interventions
Nalmefene HCl injection, Naloxone HCl intranasal
Drug
Lead sponsor
Purdue Pharma LP
Industry
Eligibility
18 Years to 55 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 2, 2025 · Synced Jul 21, 2026, 11:59 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Improving Access to Naloxone to Prevent Opioid Overdose Deaths (SAIA-Naloxone)

NCT05886712
View directory record Official record
Conditions
Overdose, Implementation as Usual
Interventions
Naloxone, Usual intervention
Other
Lead sponsor
RTI International
Other
Eligibility
18 Years and older
Enrollment
31 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
Berkeley, California
Source: ClinicalTrials.gov public record
Updated May 17, 2025 · Synced Jul 21, 2026, 11:59 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Naloxone Auto-injector as a Universal Precaution for Patients With Opioid Use Disorder

NCT02669901
View directory record Official record
Conditions
Opiate Antagonist Overdose, Opioid-Related Disorders
Interventions
Naloxone Auto-Injector
Behavioral
Lead sponsor
University of New Mexico
Other
Eligibility
18 Years and older
Enrollment
395 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2020
U.S. locations
1
States / cities
Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated Aug 11, 2024 · Synced Jul 21, 2026, 11:59 AM EDT