Independent directory Public ClinicalTrials.gov records United States
Clinical Trials Finder
Objective public record navigation
Search Results

Search by objective public record fields.

Search by query text, NCT ID, condition, intervention, sponsor, city, state, recruitment status, phase, study type, healthy volunteer eligibility, sex, or age. Results are retrieved from ClinicalTrials.gov and synchronized into the directory. Search pages remain noindex by default.

Clear filters
ClinicalTrials.gov public records Last synced Jul 22, 2026, 3:45 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 44 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Filters: Condition: Dual Tobacco Use Clear all
Recruiting Phase 2 Interventional Accepts healthy volunteers

Nicotine Regulation for Dual Users of E-cigarettes and Cigarettes

NCT06614504
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Varying the nicotine content of cigarettes, Varying the nicotine content of e-cigarettes
Other
Lead sponsor
University of Vermont
Other
Eligibility
21 Years and older
Enrollment
308 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2028
U.S. locations
2
States / cities
Providence, Rhode Island • Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated Jun 26, 2025 · Synced Jul 22, 2026, 3:45 AM EDT
Completed Phase 1 Interventional

Concurrent vs. Sequential Cessation of Dual Cigarette and E-cigarette Use

NCT06027840
View directory record Official record
Conditions
Cigarette Smoking, E-Cigarette Use, Smoking Cessation
Interventions
Varenicline, Counseling, Guided Self-Change Booklets
Drug · Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jun 7, 2026 · Synced Jul 22, 2026, 3:45 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Addictive Potential of LCCs in Dual Users

NCT03496077
View directory record Official record
Conditions
Tobacco Use Disorder, Dual Tobacco Use, Tobacco Dependence, Smoking, Smoking, Cigar, Smoking, Cigarette, Smoking, Tobacco
Interventions
Flavored and unflavored little cigars/cigarillos (LCCs)
Other
Lead sponsor
UConn Health
Other
Eligibility
18 Years to 34 Years
Enrollment
65 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Farmington, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 9, 2026 · Synced Jul 22, 2026, 3:45 AM EDT
Completed Phase 2 Interventional Results available

Formoterol Dose Ranging Study (ACHIEVE Duaklir USA Phase IIb)

NCT02796651
View directory record Official record
Conditions
Chronic Obstructive Pulmonary Disease - COPD
Interventions
Formoterol fumarate (6 μg), Formoterol furmarate (20 μg), Placebo for formoterol fumarate, Formoterol fumarate (12 μg), Formoterol fumarate (40 μg)
Drug
Lead sponsor
AstraZeneca
Industry
Eligibility
40 Years to 130 Years
Enrollment
132 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016
U.S. locations
20
States / cities
Glendale, Arizona • Phoenix, Arizona • Tempe, Arizona + 17 more
Source: ClinicalTrials.gov public record
Updated Feb 6, 2018 · Synced Jul 22, 2026, 3:45 AM EDT
Completed Phase 2Phase 3 Interventional Accepts healthy volunteers

Safety, Tolerability and Efficacy of the Nicotine Patch and Gum for the Treatment of Adolescent Tobacco Dependence

NCT01208935
View directory record Official record
Conditions
Tobacco Dependence
Interventions
Nicotine Patch, Nicotine Gum
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
13 Years to 17 Years
Enrollment
157 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
1999 – 2004
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jan 11, 2017 · Synced Jul 22, 2026, 3:45 AM EDT
Completed Phase 2 Interventional

Nicotinic Receptor Augmentation of SSRI Antidepressants

NCT00319319
View directory record Official record
Conditions
Depressive Disorder
Interventions
Mecamylamine hydrochloride (Inversine)
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years to 65 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2007
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Apr 18, 2007 · Synced Jul 22, 2026, 3:45 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Using Novel Behavioral Economic Measures to Characterize Dual Marijuana and Tobacco Use in Young Adults

NCT07398443
View directory record Official record
Conditions
Behavioral Economics, Cannabis Smoking, Tobacco Smoking
Interventions
Cue Reactivity
Behavioral
Lead sponsor
Brown University
Other
Eligibility
18 Years to 25 Years
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2028
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Mar 3, 2026 · Synced Jul 22, 2026, 3:45 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Smoking Cessation Self-Help for Dual Users of Tobacco Cigarettes and E-Cigarettes

NCT02416011
View directory record Official record
Conditions
Smoking Cessation
Interventions
GENERIC, eTARGET
Behavioral
Lead sponsor
H. Lee Moffitt Cancer Center and Research Institute
Other
Eligibility
18 Years and older
Enrollment
2,896 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2019
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Feb 22, 2022 · Synced Jul 22, 2026, 3:45 AM EDT
Recruiting No phase listed Observational

Measuring Communal Coping in Dual-smoking Couples Making a Quit Attempt

NCT07553962
View directory record Official record
Conditions
Smoking (Tobacco) Addiction, Smoking ( Cigarette), Tobacco, Tobacco Abstinence, Quitting Smoking, Smoking Cessation
Interventions
Not listed
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years and older
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated May 14, 2026 · Synced Jul 22, 2026, 3:45 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Preventing Relapse Following Involuntary Smoking Abstinence

NCT01374724
View directory record Official record
Conditions
Smoking, Smoking Cessation
Interventions
Tobacco Use Ban, Tailored Pamphlet, Informational Pamphlet, Relapse Prevention Intervention
Behavioral
Lead sponsor
University of Tennessee
Other
Eligibility
18 Years and older
Enrollment
23,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2017
U.S. locations
2
States / cities
Memphis, Tennessee • Lackland Air Force Base, Texas
Source: ClinicalTrials.gov public record
Updated Oct 31, 2016 · Synced Jul 22, 2026, 3:45 AM EDT
Completed Phase 3 Interventional Results available

Study to Determine the Efficacy and Safety of a Novel Nicotine Replacement Therapy

NCT02355665
View directory record Official record
Conditions
Tobacco Dependence
Interventions
Nicotine Spray, Placebo
Drug
Lead sponsor
McNeil Consumer Healthcare Division of McNEIL-PPC, Inc.
Industry
Eligibility
18 Years to 85 Years
Enrollment
1,198 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
8
States / cities
Scottsdale, Arizona • Burbank, California • Chicago, Illinois + 5 more
Source: ClinicalTrials.gov public record
Updated Jan 7, 2019 · Synced Jul 22, 2026, 3:45 AM EDT
Recruiting Not applicable Interventional

Pilot Study of Communication for Dual Users of Cigarettes and E-cigarettes

NCT07599462
View directory record Official record
Conditions
Tobacco Products, Cigarettes, Electronic Cigarettes
Interventions
communication
Other
Lead sponsor
UNC Lineberger Comprehensive Cancer Center
Other
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated May 19, 2026 · Synced Jul 22, 2026, 3:45 AM EDT
Completed No phase listed Observational

A Follow-up Study to Assess Long-term Immunogenicity and Safety of NicVAX/Placebo as an Aid to Smoking Cessation

NCT01304810
View directory record Official record
Conditions
Smoking Cessation, Nicotine Dependence
Interventions
NicVAX vaccine, Placebo
Biological
Lead sponsor
Nabi Biopharmaceuticals
Industry
Eligibility
18 Years to 65 Years
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011
U.S. locations
12
States / cities
Newport Beach, California • San Diego, California • Miami, Florida + 9 more
Source: ClinicalTrials.gov public record
Updated May 13, 2012 · Synced Jul 22, 2026, 3:45 AM EDT
Completed Phase 2 Interventional Results available

Effectiveness of GSK598809, a Selective D3 Antagonist, Added to CBT and NRT for Smoking Cessation and Relapse Prevention

NCT01188967
View directory record Official record
Conditions
Nicotine Dependence
Interventions
GSK598809, Placebo
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
84 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 22, 2017 · Synced Jul 22, 2026, 3:45 AM EDT
Recruiting Phase 1 Interventional Accepts healthy volunteers

A First in Human Single Ascending Dose (SAD) Study of ATI-1013 in Healthy Smokers

NCT07215923
View directory record Official record
Conditions
Thromboangiitis Obliterans (Buerger's Disease)
Interventions
ATI-1013 (0.2 g), ATI-1013 (0.8 g), ATI-1013 (3.2 g), Placebo
Biological · Other
Lead sponsor
Antidote Therapeutics, Inc
Industry
Eligibility
23 Years to 59 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Overland Park, Kansas
Source: ClinicalTrials.gov public record
Updated Oct 14, 2025 · Synced Jul 22, 2026, 3:45 AM EDT
Completed Not applicable Interventional Results available

An Intervention to Promote Smoking Cessation Among Adults With Food Insecurity

NCT05259852
View directory record Official record
Conditions
Smoking Cessation, Food Insecurity
Interventions
Food Assistance and Cessation Resources Navigation Plus Economic Assistance, Food Assistance and Cessation Resources Navigation
Behavioral
Lead sponsor
Case Western Reserve University
Other
Eligibility
21 Years and older
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 4, 2024 · Synced Jul 22, 2026, 3:45 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Quit Smoking Study for People Who Use E-Cigarettes

NCT04946825
View directory record Official record
Conditions
Nicotine Addiction, E-Cig Use, Quitting Smoking
Interventions
Nicotine replacement therapy patch, Nicotine replacement therapy lozenge, Quit electronic cigarettes, Continue electronic cigarettes
Drug · Behavioral
Lead sponsor
University of Vermont
Other
Eligibility
18 Years to 29 Years
Enrollment
396 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated May 21, 2025 · Synced Jul 22, 2026, 3:45 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Dual Use of ENDS and Combustible Cigarettes

NCT05280535
View directory record Official record
Conditions
Smoking, Cigarette, Electronic Cigarette Use
Interventions
Cue Reactivity Task, Computerized Visual Dot Probe, Choice Task
Behavioral
Lead sponsor
Brown University
Other
Eligibility
21 Years to 34 Years
Enrollment
82 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Sep 17, 2025 · Synced Jul 22, 2026, 3:45 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Impact of Cigar Flavor in Dual Users

NCT04487470
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Flavored filtered cigars, Unflavored filtered cigars
Other
Lead sponsor
UConn Health
Other
Eligibility
21 Years to 34 Years
Enrollment
89 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2024
U.S. locations
1
States / cities
Farmington, Connecticut
Source: ClinicalTrials.gov public record
Updated Oct 6, 2025 · Synced Jul 22, 2026, 3:45 AM EDT
Terminated Phase 3 Interventional Results available

Study to Determine if a New Nicotine Replacement Therapy Can Safely Help Smokers to Quit Smoking

NCT01296698
View directory record Official record
Conditions
Tobacco Dependence
Interventions
Placebo, Nicotine
Drug
Lead sponsor
McNeil Consumer Healthcare Division of McNEIL-PPC, Inc.
Industry
Eligibility
18 Years and older
Enrollment
257 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011
U.S. locations
19
States / cities
Muscle Shoals, Alabama • Oceanside, California • Griffin, Georgia + 16 more
Source: ClinicalTrials.gov public record
Updated Apr 22, 2012 · Synced Jul 22, 2026, 3:45 AM EDT
Completed Phase 4 Interventional

Varenicline Treatment in Alcohol and Nicotine Dependent Patients With Schizophrenia

NCT00727103
View directory record Official record
Conditions
Schizophrenia, Schizoaffective Disorder, Alcohol Dependence, Nicotine Dependence
Interventions
Varenicline, Placebo
Drug
Lead sponsor
State University of New York - Upstate Medical University
Other
Eligibility
18 Years to 69 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
1
States / cities
Syracuse, New York
Source: ClinicalTrials.gov public record
Updated Feb 7, 2024 · Synced Jul 22, 2026, 3:45 AM EDT
Completed Phase 3 Interventional

A Second Study of NicVAX/Placebo as an Aid for Smoking Cessation

NCT01102114
View directory record Official record
Conditions
Smoking Cessation
Interventions
NicVAX Vaccine, Placebo Vaccine
Biological
Lead sponsor
Nabi Biopharmaceuticals
Industry
Eligibility
18 Years to 65 Years
Enrollment
1,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
25
States / cities
Encino, California • Los Alamitos, California • Denver, Colorado + 22 more
Source: ClinicalTrials.gov public record
Updated May 8, 2012 · Synced Jul 22, 2026, 3:45 AM EDT
Completed Phase 2 Interventional Results available

CAN-DOSE Study: Cessation With Augmented Nicotine for Dual Use Of Smoking and E-cigarettes

NCT06087328
View directory record Official record
Conditions
Smoking Cessation, Electronic Cigarette Use, Cigarette Smoking
Interventions
Regular Nicotine patch and lozenge dose, Augmented Nicotine patch and lozenge dose
Drug
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years and older
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Nov 25, 2025 · Synced Jul 22, 2026, 3:45 AM EDT
Completed Phase 2 Interventional Results available

Effectiveness of GW468816, an NMDA Glycine Site Antagonist, for Prevention of Relapse to Smoking

NCT00218465
View directory record Official record
Conditions
Nicotine Dependence
Interventions
GW468816, Placebo Comparator: Placebo
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 65 Years · Female only
Enrollment
264 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2009
U.S. locations
2
States / cities
Belmont, Massachusetts • Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 23, 2017 · Synced Jul 22, 2026, 3:45 AM EDT