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Showing 1–21 of 21 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Dysfunction of Eustachian Tube Clear all
Completed Not applicable Interventional

Effect of Rate (Slope) of Compression on the Incidence of Symptomatic ETD and MEB: a Phase III Prospective Study.

NCT04804098
View directory record Official record
Conditions
Ear Barotrauma, Middle Ear Disease, Ear Diseases, Pressure Injury, Eustachian Tube Dysfunction, Middle Ear; Injury, Middle Ear Barotrauma
Interventions
Compression Profile/Schedule: 15 minute Non-Linear compression from start of the daily treatment until treatment pressure is reached (45 fsw), Compression Profile/Schedule: 15 minute Linear compression from start of the daily treatment until treatment pressure is reached (45 fsw)
Procedure
Lead sponsor
Northwell Health
Other
Eligibility
Not listed
Enrollment
1,553 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
Sleepy Hollow, New York
Source: ClinicalTrials.gov public record
Updated Jun 8, 2026 · Synced Jul 22, 2026, 3:45 AM EDT
Completed Not applicable Interventional

Balloon Dilation in Selected Subjects With Refractory Eustachian Tube Dysfunction

NCT02114762
View directory record Official record
Conditions
Eustachian Tube Dysfunction
Interventions
Balloon dilation of the Eustachian tube
Procedure
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years to 50 Years
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 10, 2017 · Synced Jul 22, 2026, 3:45 AM EDT
Not yet recruiting Not applicable Interventional

Active vs. Passive VR During Office-based ENT Procedures

NCT07599826
View directory record Official record
Conditions
Pain, Anxiety, Chronic Rhinosinusitis (CRS), Nasal Obstruction, Nasal Polyp, Eustachian Tube Dysfunction, Dysphonia, Subglottic Stenosis (SGS)
Interventions
Virtual reality headset or goggles
Device
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
18 Years and older
Enrollment
132 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated May 19, 2026 · Synced Jul 22, 2026, 3:45 AM EDT
Completed Phase 3 Interventional Results available

Short Term Relief of Eustachian Tube Dysfunction and Serous Otitis Media Using Intranasal Steroid Sprays

NCT00279916
View directory record Official record
Conditions
Otitis Media, Serous, Negative Middle Ear Pressure, Rhinitis, Otitis Media With Effusion, Otitis Media, Secretory
Interventions
Triamcinolone acetonide nasal spray, Placebo nasal spray
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
6 Years to 100 Years
Enrollment
91 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2009
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated May 29, 2017 · Synced Jul 22, 2026, 3:45 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Evaluating Changes in Middle Ear Pressure Caused by CPAP

NCT02882022
View directory record Official record
Conditions
Eustachian Tube Disorder
Interventions
Continuous positive airway pressure
Device
Lead sponsor
University of Virginia
Other
Eligibility
18 Years and older · Male only
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Mar 8, 2022 · Synced Jul 22, 2026, 3:45 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Gas Supply, Demand and Middle Ear Gas Balance -- Diagnosis of Eustachian Tube Dysfunction

NCT01974726
View directory record Official record
Conditions
Eustachian Tube Dysfunction
Interventions
ET Stress test, Sonotubometry, Forced Response Test (FRT), Inflation Deflation Test (IDT), Maneuver Sequence, 9-Step Test, Tubomanometry, Videoendoscopic assessment of ETF, Pressure chamber ET test
Other
Lead sponsor
University of Pittsburgh
Other
Eligibility
3 Years to 70 Years
Enrollment
95 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2019
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 7, 2020 · Synced Jul 22, 2026, 3:45 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Tubomanometry and EarPopper Devices for Eustachian Tube Function Testing

NCT03850197
View directory record Official record
Conditions
Eustachian Tube Dysfunction
Interventions
EarPopper, Tympanometry, Tubomanometry
Device
Lead sponsor
Cuneyt M. Alper
Other
Eligibility
5 Years to 60 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 12, 2020 · Synced Jul 22, 2026, 3:45 AM EDT
Recruiting Phase 2 Interventional Accepts healthy volunteers

Effect of Novel Exhalational Delivery System With Fluticasone (EDS-FLU) on Eustachian Tube Dysfunction (ETD)

NCT05275686
View directory record Official record
Conditions
Eustachian Tube Dysfunction
Interventions
Fluticasone Propionate 93 MCG/1 ACTUATION Nasal Spray, Placebo Nasal Spray
Drug · Other
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
18 Years to 80 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2027
U.S. locations
4
States / cities
Los Angeles, California • Sacramento, California • Indianapolis, Indiana + 1 more
Source: ClinicalTrials.gov public record
Updated Mar 10, 2026 · Synced Jul 22, 2026, 3:45 AM EDT
Completed Phase 2 Interventional Results available

Adult Study to Evaluate Placement of Tympanostomy Tubes In-office (ADEPT)

NCT03197558
View directory record Official record
Conditions
Barotrauma;Ear, OME - Otitis Media With Effusion, AOM - Acute Otitis Media, Eustachian Tube Dysfunction
Interventions
Tymbion Iontophoresis and Tube Delivery System (TDS)
Combination Product
Lead sponsor
Tusker Medical
Industry
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
8
States / cities
Roseville, California • San Jose, California • Louisville, Kentucky + 5 more
Source: ClinicalTrials.gov public record
Updated Jan 17, 2020 · Synced Jul 22, 2026, 3:45 AM EDT
Terminated Not applicable Interventional Results available

Exercises for Improving Soft Palate and Eustachian Tube Function in Children With Ear Tubes With or Without Cleft Palate

NCT03868891
View directory record Official record
Conditions
Cleft Palate, Tube Disorders Eustachian, Velopharyngeal Incompetence Due to Cleft Palate, Velopharyngeal Insufficiency
Interventions
EMST150
Device
Lead sponsor
Noel Jabbour
Other
Eligibility
6 Years to 17 Years
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 22, 2023 · Synced Jul 22, 2026, 3:45 AM EDT
Withdrawn Phase 4 Interventional

The Study of Eustachian Tube Dysfunction and Laryngopharyngeal Reflux

NCT02123498
View directory record Official record
Conditions
Eustachian Tube Dysfunction, Laryngopharyngeal Reflux
Interventions
Omeprazole, Ranitidine, Pantoprazole, 24-Hour Diagnostic pH-Probe Test, Laryngoscopy
Drug · Procedure
Lead sponsor
Loma Linda University
Other
Eligibility
18 Years to 80 Years
Healthy volunteers
Healthy volunteers not accepted
U.S. locations
2
States / cities
Loma Linda, California • Redlands, California
Source: ClinicalTrials.gov public record
Updated Sep 25, 2016 · Synced Jul 22, 2026, 3:45 AM EDT
Completed Not applicable Interventional Results available

XprESS Eustachian Tube Dilation Study

NCT02391584
View directory record Official record
Conditions
Eustachian Tube Dysfunction
Interventions
XprESS, Control
Device · Other
Lead sponsor
Entellus Medical, Inc.
Industry
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
5
States / cities
Denver, Colorado • North Platte, Nebraska • Sayre, Pennsylvania + 2 more
Source: ClinicalTrials.gov public record
Updated Oct 31, 2018 · Synced Jul 22, 2026, 3:45 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

SinuSonic for ETD and Facial Pain: Acoustic Vibration + Oscillating Expiratory Pressure

NCT04404036
View directory record Official record
Conditions
Eustachian Tube Dysfunction, Facial Pain
Interventions
SinuSonic Device
Device
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Feb 12, 2026 · Synced Jul 22, 2026, 3:45 AM EDT
Recruiting No phase listed Observational

AERA Pediatrics Registry

NCT07071298
View directory record Official record
Conditions
Dysfunction of Eustachian Tube
Interventions
Not listed
Lead sponsor
Integra LifeSciences Corporation
Industry
Eligibility
Up to 18 Years
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2031
U.S. locations
9
States / cities
Palo Alto, California • Boston, Massachusetts • West Bloomfield, Michigan + 6 more
Source: ClinicalTrials.gov public record
Updated Jul 6, 2026 · Synced Jul 22, 2026, 3:45 AM EDT
Withdrawn Not applicable Interventional

Refractory Eustachian Tube Dysfunction: Are the Symptoms Related to Endolymphatic Hydrops

NCT01661777
View directory record Official record
Conditions
Eustachian Tube Dysfunction, Endolymphatic Hydrops
Interventions
Nasal steroid, Myringotomy tube placement, Diuretic, Antihistamine, Low salt diet
Drug · Procedure · Behavioral
Lead sponsor
Vanderbilt University
Other
Eligibility
18 Years to 70 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated May 28, 2014 · Synced Jul 22, 2026, 3:45 AM EDT
Completed No phase listed Observational

Risk Factors and Potential Causes of Eustachian Tube Dysfunction in Adults

NCT01251432
View directory record Official record
Conditions
Eustachian Tube Dysfunction, Chronic Otitis Media
Interventions
Not listed
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years to 75 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2016
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 3, 2016 · Synced Jul 22, 2026, 3:45 AM EDT
Completed Not applicable Interventional

Effect of Total Compression Time and Rate (Slope) on Incidence of Symptomatic ETD and MEB: A Phase II Prospective Study.

NCT04776967
View directory record Official record
Conditions
Eustachian Tube Dysfunction, Middle Ear Barotrauma, Middle Ear Disease, Middle Ear; Injury, Pressure Injury, Ear Barotrauma
Interventions
Hyperbaric Compression Profile
Procedure
Lead sponsor
Northwell Health
Other
Eligibility
Not listed
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2021
U.S. locations
1
States / cities
Sleepy Hollow, New York
Source: ClinicalTrials.gov public record
Updated Aug 18, 2021 · Synced Jul 22, 2026, 3:45 AM EDT
Enrolling by invitation No phase listed Observational Accepts healthy volunteers

Diagnostic Precision and Accuracy Using the Teed Scoring System Versus the O'Neill Grading System

NCT04726306
View directory record Official record
Conditions
Otic Barotrauma, Pressure Injury, Ear Injury, Barotitis, Barotrauma
Interventions
Otic Barotrauma Grading System
Diagnostic Test
Lead sponsor
Northwell Health
Other
Eligibility
Not listed
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Sleepy Hollow, New York
Source: ClinicalTrials.gov public record
Updated Jun 9, 2026 · Synced Jul 22, 2026, 3:45 AM EDT
Completed Phase 2 Interventional Results available

Effect of Simethicone on Eustachian Tube Dysfunction

NCT01312038
View directory record Official record
Conditions
Otitis Media
Interventions
Simethicone, Placebo
Drug
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years to 50 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 26, 2016 · Synced Jul 22, 2026, 3:45 AM EDT
Completed No phase listed Observational

XprESS ET Registry

NCT04136977
View directory record Official record
Conditions
Eustachian Tube Dysfunction
Interventions
Eustachian tube dilation
Device
Lead sponsor
Entellus Medical, Inc.
Industry
Eligibility
18 Years and older
Enrollment
169 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
11
States / cities
Torrance, California • Colorado Springs, Colorado • Evans, Georgia + 7 more
Source: ClinicalTrials.gov public record
Updated Sep 29, 2020 · Synced Jul 22, 2026, 3:45 AM EDT
Completed Not applicable Interventional Results available

Study of Safety and Efficacy for the Eustachian Tube Balloon Catheter

NCT02087150
View directory record Official record
Conditions
Eustachian Tube Dysfunction
Interventions
Acclarent Eustachian Tube Balloon Catheter (ETBC)
Device
Lead sponsor
Integra LifeSciences Corporation
Industry
Eligibility
22 Years and older
Enrollment
323 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
21
States / cities
East Palo Alto, California • Washington D.C., District of Columbia • Boca Raton, Florida + 17 more
Source: ClinicalTrials.gov public record
Updated Jul 11, 2024 · Synced Jul 22, 2026, 3:45 AM EDT