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ClinicalTrials.gov public records Last synced Oct 21, 2026, 2:09 AM EDT

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Showing 49–72 of 85 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Dysphonia Clear all
Completed Not applicable Interventional

Biofeedback vs Laryngeal Control Therapy in Management of Paradoxical Vocal Fold Motion

NCT05770518
View directory record Official record
Conditions
Paradoxical Vocal Fold Motion, Vocal Cord Dysfunction
Interventions
Biofeedback, Laryngeal control therapy (LCT)
Behavioral
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years and older
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Dec 22, 2025 · Synced Oct 21, 2026, 2:09 AM EDT
Recruiting Not applicable Interventional

Deep Brain Stimulation in Laryngeal Dystonia and Voice Tremor

NCT05150093
View directory record Official record
Conditions
Laryngeal Dystonia, Spasmodic Dysphonia, Tremor, Dystonia
Interventions
Deep Brain Stimulation
Procedure
Lead sponsor
Massachusetts Eye and Ear Infirmary
Other
Eligibility
18 Years to 80 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 2, 2025 · Synced Oct 21, 2026, 2:09 AM EDT
Completed No phase listed Observational

Role of Neurotransmission and Functional CNS Networks in Spasmodic Dysphonia

NCT00713414
View directory record Official record
Conditions
Spasmodic Dysphonia, Focal Dystonia
Interventions
Not listed
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Eligibility
21 Years to 80 Years
Enrollment
37 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2016
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 5, 2018 · Synced Oct 21, 2026, 2:09 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Voice Tremor in Spasmodic Dysphonia: Central Mechanisms and Treatment Response

NCT01961297
View directory record Official record
Conditions
Spasmodic Dysphonia, Voice Tremor
Interventions
Sodium oxybate
Drug
Lead sponsor
Kristina Simonyan
Other
Eligibility
21 Years to 80 Years
Enrollment
53 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2017
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Nov 22, 2017 · Synced Oct 21, 2026, 2:09 AM EDT
Completed No phase listed Observational

Efficacy of Conversation Training Therapy (CTT)

NCT02441348
View directory record Official record
Conditions
Voice Disorders
Interventions
Conversation Training Therapy
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years to 60 Years
Enrollment
67 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 8, 2019 · Synced Oct 21, 2026, 2:09 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Study of Air Stream in Voice Production

NCT00015795
View directory record Official record
Conditions
Spastic Dysphonia, Healthy
Interventions
airway interruption test
Device
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Eligibility
Not listed
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2001 – 2003
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 4, 2008 · Synced Oct 21, 2026, 2:09 AM EDT
Terminated Phase 4 Interventional Results available

Safety and Efficacy of Lansoprazole 30mg Twice Daily in Treatment of Laryngitis Associated With Gastroesophageal Reflux

NCT00369265
View directory record Official record
Conditions
Laryngopharyngeal Reflux
Interventions
Lansoprazole, Sugar pill
Drug · Dietary Supplement
Lead sponsor
American Institute for Voice and Ear Research
Other
Eligibility
18 Years to 89 Years
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2009
U.S. locations
3
States / cities
Detroit, Michigan • Philadelphia, Pennsylvania • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Aug 24, 2012 · Synced Oct 21, 2026, 2:09 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Electrical Muscle Stimulation to Aid Swallowing in Dysphagia

NCT00001936
View directory record Official record
Conditions
Deglutition Disorder, Healthy
Interventions
Not listed
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Eligibility
Up to 90 Years
Enrollment
155 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 1999
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 2, 2017 · Synced Oct 21, 2026, 2:09 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Computational Cranial and Cervical Muscle Network in Normal and Disordered Voice

NCT04713033
View directory record Official record
Conditions
Dysphonia
Interventions
surface electromyogram (sEMG), flexible laryngoscopy
Diagnostic Test
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 88 Years
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 1, 2025 · Synced Oct 21, 2026, 2:09 AM EDT
Completed Phase 1 Interventional

Dextromethorphan to Treat Patients With Voice Spasms

NCT00055549
View directory record Official record
Conditions
Voice Disorders
Interventions
Dextromethorphan, Lorazepam
Drug
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Eligibility
18 Years to 80 Years
Enrollment
65 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2009
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 2, 2017 · Synced Oct 21, 2026, 2:09 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Brain Network Changes After Vibro-tactile Stimulation in Laryngeal Dystonia

NCT07443891
View directory record Official record
Conditions
Laryngeal Dystonia
Interventions
Vibrotactile Stimulation (VTS)
Device
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 75 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 19, 2026 · Synced Oct 21, 2026, 2:09 AM EDT
Completed Phase 1Phase 2 Interventional Results available

DaxibotulinumtoxinA Injection for Treatment of Adductor Spasmodic Dysphonia

NCT05158166
View directory record Official record
Conditions
Adductor Spasmodic Dysphonia, Voice Disorders, Spasmodic Dysphonia
Interventions
DaxibotulinumtoxinA
Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated May 18, 2026 · Synced Oct 21, 2026, 2:09 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

rTMS in Spasmodic Dysphonia

NCT02957942
View directory record Official record
Conditions
Spasmodic Dysphonia, Laryngeal Dystonia
Interventions
1Hz repetitive transcranial magnetic stimulation (rTMS)
Device
Lead sponsor
University of Minnesota
Other
Eligibility
21 Years to 75 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 1, 2020 · Synced Oct 21, 2026, 2:09 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Clinical Validation of DystoniaNet Deep Learning Platform for Diagnosis of Isolated Dystonia

NCT05317390
View directory record Official record
Conditions
Dystonia, Drug Induced Dystonia, Parkinson Disease, Essential Tremor, Dyskinesias, Myoclonus, Tic Disorders, Torticollis, Ulnar Nerve Entrapment, Temporomandibular Joint Disorders, Dysphonia
Interventions
DystoniaNet-based diagnosis of isolated dystonia
Diagnostic Test
Lead sponsor
Massachusetts Eye and Ear Infirmary
Other
Eligibility
Not listed
Enrollment
1,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2028
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 2, 2025 · Synced Oct 21, 2026, 2:09 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Brain Networks in Dystonia

NCT03042962
View directory record Official record
Conditions
Spasmodic Dysphonia, Singer's Dystonia, Writer's Cramp, Musician's Focal Hand Dystonia, Craniofacial Dystonia, Blepharospasm Oromandibular Dystonia
Interventions
MRI, Blood draw
Other · Procedure
Lead sponsor
Massachusetts Eye and Ear Infirmary
Other
Eligibility
21 Years to 80 Years
Enrollment
141 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 8, 2025 · Synced Oct 21, 2026, 2:09 AM EDT
Recruiting Phase 4 Interventional

The Mechanism Versus PPI Trial

NCT06999577
View directory record Official record
Conditions
Laryngopharyngeal Reflux, Cough, Throat Clearing, Dysphonia, Reflux
Interventions
Omeprazole 40 MG, Laryngeal Recalibration Therapy, GERD Lifestyle Recommendations
Drug · Behavioral
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years to 89 Years
Enrollment
160 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
San Deigo, California
Source: ClinicalTrials.gov public record
Updated Aug 1, 2025 · Synced Oct 21, 2026, 2:09 AM EDT
Withdrawn Not applicable Interventional

The Effects of Adding Expiratory Muscle Strength Training in Voice Therapy

NCT03692494
View directory record Official record
Conditions
Dysphonia, Unilateral Vocal Cord Paralysis
Interventions
Standard of care voice therapy, Expiratory muscle strength training (EMST)
Other
Lead sponsor
University of Miami
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Feb 7, 2025 · Synced Oct 21, 2026, 2:09 AM EDT
Completed Not applicable Interventional

Serial Platelet-Rich Plasma Injections for Vocal Fold Atrophy, Scar, and/or Sulcus Vocalis

NCT03749863
View directory record Official record
Conditions
Presbylarynx, Atrophy; Larynx, Dysphonia, Vocal Cord Atrophy, Presbylarynges, Vocal Fold Scar, Sulcus Vocalis of Vocal Cord
Interventions
Serial PRP injections
Procedure
Lead sponsor
University of Southern California
Other
Eligibility
18 Years and older
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated May 10, 2023 · Synced Oct 21, 2026, 2:09 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Study to Evaluate Effects of Gargle Phonation in Voice

NCT04766658
View directory record Official record
Conditions
Voice Disorders, Muscle Tension Dysphonia, Speech Therapy
Interventions
Gargle Phonation, Water swallow
Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 89 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
2
States / cities
Scottsdale, Arizona • Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 19, 2022 · Synced Oct 21, 2026, 2:09 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Characteristics of Idiopathic Familial Voice Disorders

NCT00001552
View directory record Official record
Conditions
Laryngeal Disease, Spastic Dysphonia, Voice Disorder
Interventions
Not listed
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Eligibility
Not listed
Enrollment
270 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 1996
U.S. locations
2
States / cities
Iowa City, Iowa • Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 2, 2017 · Synced Oct 21, 2026, 2:09 AM EDT
Not yet recruiting Not applicable Interventional

Active vs. Passive VR During Office-based ENT Procedures

NCT07599826
View directory record Official record
Conditions
Pain, Anxiety, Chronic Rhinosinusitis (CRS), Nasal Obstruction, Nasal Polyp, Eustachian Tube Dysfunction, Dysphonia, Subglottic Stenosis (SGS)
Interventions
Passive virtual reality headset or goggles, Active virtual reality headset or goggles
Device
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
18 Years and older
Enrollment
132 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Aug 17, 2026 · Synced Oct 21, 2026, 2:09 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Randomized Controlled Trial of Voice on Children With Vocal Nodules

NCT01255735
View directory record Official record
Conditions
Vocal Fold Nodules
Interventions
Not listed
Lead sponsor
Massachusetts Eye and Ear Infirmary
Other
Eligibility
6 Years to 10 Years
Enrollment
114 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2016
U.S. locations
3
States / cities
Boston, Massachusetts • Philadelphia, Pennsylvania • Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Dec 2, 2016 · Synced Oct 21, 2026, 2:09 AM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Central Mechanisms in Speech Motor Control Studied With H215O PET

NCT00001308
View directory record Official record
Conditions
Communication Disorder, Healthy, Stuttering, Tourette Syndrome, Voice Disorder
Interventions
Not listed
Lead sponsor
National Institute on Deafness and Other Communication Disorders (NIDCD)
NIH
Eligibility
18 Years to 85 Years
Enrollment
1,163 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
1992 – 2016
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 17, 2019 · Synced Oct 21, 2026, 2:09 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Effects of Neuromodulation in Laryngeal Dystonia

NCT05095740
View directory record Official record
Conditions
Laryngeal Dystonia, Focal Dystonia
Interventions
repetitive transcranial magnetic stimulation (rTMS), sham rTMS
Device
Lead sponsor
MGH Institute of Health Professions
Other
Eligibility
21 Years to 85 Years
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 20, 2026 · Synced Oct 21, 2026, 2:09 AM EDT