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ClinicalTrials.gov public records Last synced Oct 21, 2026, 1:37 AM EDT

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Showing 1–24 of 39 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Dysphoria Clear all
Completed No phase listed Observational Accepts healthy volunteers

The Strategic Use of Hyaluronic Acid Fillers and Neurotoxin to Influence Gender Perception in Transgender Individuals

NCT04478214
View directory record Official record
Conditions
Gender Dysphoria
Interventions
Not listed
Lead sponsor
Mountain Dermatology Specialists
Other
Eligibility
18 Years to 65 Years
Enrollment
2 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Chestnut Hill, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 20, 2020 · Synced Oct 21, 2026, 1:37 AM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Gender Identity and Own Body Perception

NCT04374708
View directory record Official record
Conditions
Gender Dysphoria
Interventions
fMRI
Diagnostic Test
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 40 Years
Enrollment
132 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2021
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Mar 22, 2023 · Synced Oct 21, 2026, 1:37 AM EDT
Recruiting No phase listed Observational

Gender Affirming Vaginoplasty With Tubularized Augmented Peritoneal Cap (TAPCap) Utilizing Fish Skin Xenograft (Kerecis™)

NCT07286123
View directory record Official record
Conditions
Gender Dysphoria, Adult
Interventions
Tubularized augmented peritoneal cap vaginoplasty, Biopsy
Procedure
Lead sponsor
University Hospitals Cleveland Medical Center
Other
Eligibility
19 Years to 99 Years · Male only
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Dec 16, 2025 · Synced Oct 21, 2026, 1:37 AM EDT
Terminated Phase 4 Interventional Accepts healthy volunteers

Comparison of PKs of 17-Beta-Estradiol Via Sublingual Placement Versus Swallowing in Male-to-Female Transgender Patients

NCT05428215
View directory record Official record
Conditions
Gender Dysphoria
Interventions
17beta Estradiol
Drug
Lead sponsor
MaineHealth
Other
Eligibility
18 Years and older · Male only
Enrollment
2 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Portland, Maine
Source: ClinicalTrials.gov public record
Updated Jul 27, 2023 · Synced Oct 21, 2026, 1:37 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

Evaluating Drug Interactions Between Doravirine With Estradiol and Spironolactone in Healthy Transgender Women

NCT04283656
View directory record Official record
Conditions
Transgender Health, Gender Dysphoria, Transgender Women, Human Immunodeficiency Virus
Interventions
Doravirine/Lamivudine/Tenofovir, Spironolactone 100mg, Estradiol 2mg, Placebo
Drug · Other
Lead sponsor
Thomas Jefferson University
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
8 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 26, 2025 · Synced Oct 21, 2026, 1:37 AM EDT
Terminated No phase listed Observational

Effect of Transgender Therapy on Muscle, Fat and Tissue Receptors

NCT04551144
View directory record Official record
Conditions
Gender Incongruence, Transgenderism
Interventions
testosterone cypionate, Estradiol Valerate
Drug
Lead sponsor
St. Louis University
Other
Eligibility
18 Years to 50 Years
Enrollment
4 participants
Timeline
2020 – 2023
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jan 8, 2024 · Synced Oct 21, 2026, 1:37 AM EDT
Completed Phase 4 Interventional Results available

The Effect of Pectoral Blocks on Perioperative Pain in Gender Affirmation Top Surgery

NCT04474366
View directory record Official record
Conditions
Gender Dysphoria, Opioid Use, Pain, Postoperative
Interventions
Ropivacaine 0.2% Injectable Solution, Saline (0.9%)
Drug · Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 65 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jul 3, 2023 · Synced Oct 21, 2026, 1:37 AM EDT
Completed Not applicable Interventional

Neuromodulation for Dysphoria

NCT05061745
View directory record Official record
Conditions
Dysphoria
Interventions
Guided Meditation VR for Wellness, Accelerated Transcranial Magnetic Stimulation: MagVenture Transcranial Magnetic Stimulation (Treatment Coil Cool B70 AP), Accelerated Transcranial Magnetic Stimulation: MagVenture Transcranial Magnetic Stimulation (Cool D-B80 AP)
Device
Lead sponsor
Florida State University
Other
Eligibility
18 Years and older
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Tallahassee, Florida
Source: ClinicalTrials.gov public record
Updated Apr 13, 2026 · Synced Oct 21, 2026, 1:37 AM EDT
Completed Phase 2 Interventional Results available

Ibudilast and Withdrawal-Related Dysphoria

NCT03489850
View directory record Official record
Conditions
Alcohol Use Disorder
Interventions
Ibudilast, Placebo
Drug · Other
Lead sponsor
University of California, Los Angeles
Other
Eligibility
21 Years to 45 Years
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Oct 7, 2021 · Synced Oct 21, 2026, 1:37 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Sleep and IR in Transgender Adolescents

NCT05489159
View directory record Official record
Conditions
Sleep Disorder, Insulin Resistance, Gender Dysphoria
Interventions
Not listed
Lead sponsor
Duke University
Other
Eligibility
12 Years to 18 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 16, 2025 · Synced Oct 21, 2026, 1:37 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Skeletal Health and Bone Marrow Composition Among Youth

NCT04203381
View directory record Official record
Conditions
Gender Dysphoria in Children, Puberty, Bone Development
Interventions
GnRH Agonist
Device
Lead sponsor
Amy DiVasta, MD
Other
Eligibility
9 Years to 14 Years
Enrollment
78 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2026
U.S. locations
2
States / cities
Boston, Massachusetts • Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 3, 2026 · Synced Oct 21, 2026, 1:37 AM EDT
Completed No phase listed Observational

Study of Premenstrual Syndrome and Premenstrual Dysphoria

NCT00001177
View directory record Official record
Conditions
Mood Disorder
Interventions
Not listed
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
18 Years to 50 Years · Female only
Enrollment
1,569 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 1984
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 18, 2026 · Synced Oct 21, 2026, 1:37 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Progestin (Progesterone-Like Hormones) Induced Dysphoria (Depressed Mood, Irritability, Anxiety)

NCT00001770
View directory record Official record
Conditions
Depressive Disorder, Mood Disorder, Psychomotor Agitation
Interventions
Not listed
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
Female only
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
1998 – 2003
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 4, 2008 · Synced Oct 21, 2026, 1:37 AM EDT
Active, not recruiting No phase listed Observational

Ovarian Tissue Cryopreservation in the Setting of Gender-affirming Therapy

NCT05863676
View directory record Official record
Conditions
Gender Dysphoria, Transgender
Interventions
Oophorectomy, Infectious Disease Testing
Procedure · Diagnostic Test
Lead sponsor
University of Pittsburgh
Other
Eligibility
9 Years and older · Female only
Enrollment
20 participants
Timeline
2020 – 2030
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 9, 2026 · Synced Oct 21, 2026, 1:37 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

The Effect of Sex Steroid Replacement Therapy in the Hypogonadism and Transgender Active-Duty Population

NCT06247267
View directory record Official record
Conditions
Hypogonadism, Gender Identity Dysphoria
Interventions
Fortesta, Estradiol
Drug
Lead sponsor
Walter Reed National Military Medical Center
Federal
Eligibility
18 Years to 65 Years
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2025
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 29, 2025 · Synced Oct 21, 2026, 1:37 AM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Transgender Cohort Study of Gender Affirmation and HIV-related Health

NCT03595956
View directory record Official record
Conditions
HIV/AIDS, STI, Gender Dysphoria, Transsexualism, Gender Identity, Depression, Anxiety
Interventions
Medical gender affirmation
Other
Lead sponsor
Fenway Community Health
Other
Eligibility
18 Years and older
Enrollment
4,500 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 18, 2020 · Synced Oct 21, 2026, 1:37 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Brain Health in Transgender Adults

NCT07624747
View directory record Official record
Conditions
Gender Dysphoria
Interventions
Magnetic Resonance Imaging, Cognition and Health Tests, Optional Exercise Test
Device · Other
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years to 45 Years
Enrollment
72 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jun 3, 2026 · Synced Oct 21, 2026, 1:37 AM EDT
Completed Not applicable Interventional Results available

A Pychoeducational Intervention for Women With Diabetes

NCT01185561
View directory record Official record
Conditions
Depression, Anxiety, Anger
Interventions
Psychoeducational intervention
Behavioral
Lead sponsor
Loyola University
Other
Eligibility
18 Years to 75 Years · Female only
Enrollment
74 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
1
States / cities
Maywood, Illinois
Source: ClinicalTrials.gov public record
Updated Dec 14, 2016 · Synced Oct 21, 2026, 1:37 AM EDT
Recruiting No phase listed Observational

Pubertal Blockade and Estradiol Effects on Cardiometabolic Health for Transitioning Youth

NCT04596592
View directory record Official record
Conditions
Transgenderism, Gender Dysphoria, Insulin Sensitivity
Interventions
Not listed
Lead sponsor
University of Colorado, Denver
Other
Eligibility
13 Years to 16 Years
Enrollment
90 participants
Timeline
2021 – 2026
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Jun 10, 2025 · Synced Oct 21, 2026, 1:37 AM EDT
Active, not recruiting No phase listed Observational

Testicular Tissue Cryopreservation in the Setting of Gender-Affirming Therapy

NCT05829928
View directory record Official record
Conditions
Gender Dysphoria, Transgender
Interventions
Infectious Disease Testing, Gonadal Tissue Removal
Diagnostic Test · Procedure
Lead sponsor
University of Pittsburgh
Other
Eligibility
9 Years and older · Male only
Enrollment
150 participants
Timeline
2019 – 2029
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 9, 2026 · Synced Oct 21, 2026, 1:37 AM EDT
Enrolling by invitation Phase 2Phase 3 Interventional

Polyethylene-glycol Assisted Nerve Repair in Phalloplasty

NCT05897086
View directory record Official record
Conditions
Gender Dysphoria
Interventions
Polyethylene Glycol 3350
Drug
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years and older · Female only
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2029
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Oct 20, 2025 · Synced Oct 21, 2026, 1:37 AM EDT
Recruiting Phase 3 Interventional

Development of Effective, Opioid Sparing Techniques for Peri-operative Pain Management of Transgender Patients Undergoing Gender Affirming Surgeries

NCT04979338
View directory record Official record
Conditions
Gender Dysphoria
Interventions
Ultrasound guided Continuous Infraclavicular Brachial Plexus Block, Ultrasound guided Continuous Femoral Nerve Block, Ultrasound guided Pudendal Nerve Block, Bupivacaine, Bilateral ultrasound guided Transversus Abdominis Plane Block, Bilateral spermatic cord block, Pecs I & II Block, Local anesthetic
Other · Drug
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
18 Years and older
Enrollment
640 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Sep 17, 2025 · Synced Oct 21, 2026, 1:37 AM EDT
Not yet recruiting No phase listed Observational

Can 3D Modeling Enhance Patient Understanding, Education, and Surgical Outcomes in Gender Affirming Peritoneal Vaginoplasty?

NCT07412509
View directory record Official record
Conditions
Vaginoplasty, Gender Dysphoria, Adult
Interventions
Use 3D printed patient specific models for patient education
Other
Lead sponsor
University of Chicago
Other
Eligibility
18 Years and older · Male only
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 21, 2026 · Synced Oct 21, 2026, 1:37 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Transgender Therapeutic Support Groups

NCT04217707
View directory record Official record
Conditions
Gender Dysphoria in Adolescents and Adults
Interventions
Pre- and Post-Surgical Transgender Therapeutic Support Group
Behavioral
Lead sponsor
Denver Health and Hospital Authority
Other
Eligibility
18 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Jul 5, 2022 · Synced Oct 21, 2026, 1:37 AM EDT