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ClinicalTrials.gov public records Last synced Nov 15, 2026, 5:21 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 241–264 of 373 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: E Cig Use Clear all

Conditions: Addiction Nicotine
Interventions: VapeAway filter system; Device
Lead sponsor: VapeAway; Industry
Eligibility: 21 Years and older
Enrollment: 70 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: New York, New York

Conditions: Nicotine Vaping, Nicotine Use Disorder
Interventions: quitSTART Mobile Application, Chatbot Feature in quitSTART Mobile Application; Device · Behavioral
Lead sponsor: Washington University School of Medicine; Other
Eligibility: 15 Years to 25 Years
Enrollment: 26 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: St Louis, Missouri

Conditions: Nicotine Dependence
Interventions: MarkTen and e-Go e-cigarettes; Device
Lead sponsor: Truth Initiative; Other
Eligibility: 18 Years to 65 Years
Enrollment: 80 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2018
U.S. locations: 2
States / cities: Washington D.C., District of Columbia • Richmond, Virginia

Conditions: Smoking Cessation, Obesity and Obesity-related Medical Conditions
Interventions: Electronic Cigarettes (EC), Nicotine replacement therapy (NRT); Other
Lead sponsor: Brown University; Other
Eligibility: 21 Years and older
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Tobacco Use
Interventions: Not listed
Lead sponsor: University of Oklahoma; Other
Eligibility: 18 Years to 50 Years
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019
U.S. locations: 1
States / cities: Oklahoma City, Oklahoma

Conditions: Tobacco Use Disorder
Interventions: E-cigarette and Heat not burn; Combination Product
Lead sponsor: University of Kansas Medical Center; Other
Eligibility: 21 Years and older
Enrollment: 22 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2021
U.S. locations: 1
States / cities: Kansas City, Missouri

Conditions: Smoking, Nicotine Dependence
Interventions: No intervention: observation only; Other
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 18 Years to 99 Years
Enrollment: 422 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2019
U.S. locations: 2
States / cities: Madison, Wisconsin • Milwaukee, Wisconsin

Conditions: Cigarette Smoking-Related Carcinoma, Tobacco-Related Carcinoma
Interventions: Cigarette, Nicotine Replacement, Questionnaire Administration, Survey Administration, Very Low Nicotine Content Cigarette, ECIG-Hi, ECIG-Lo; Drug · Other · Device
Lead sponsor: M.D. Anderson Cancer Center; Other
Eligibility: 21 Years to 65 Years
Enrollment: 213 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2025
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Tobacco Use Disorder
Interventions: Either normal nicotine content cigarettes (15.8mg/g) or reduced nicotine content cigarettes (0.4mg/g), E-Cigarettes; Other
Lead sponsor: Brown University; Other
Eligibility: 18 Years to 70 Years
Enrollment: 326 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2023
U.S. locations: 2
States / cities: Providence, Rhode Island • Burlington, Vermont

Conditions: Cigarette Smoking, E-cigarette Use
Interventions: Nicotine Content, Illegal cigarette price, E-cigarette price; Behavioral
Lead sponsor: Virginia Polytechnic Institute and State University; Other
Eligibility: 21 Years and older
Enrollment: 70 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Roanoke, Virginia

Conditions: E Cig Use
Interventions: Not listed
Lead sponsor: Ohio State University Comprehensive Cancer Center; Other
Eligibility: 18 Years to 25 Years
Enrollment: 115 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2024
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Nicotine Vaping, Nicotine, Vaping
Interventions: CA35, CM35, Cig; Other
Lead sponsor: Philip Morris Products S.A.; Industry
Eligibility: 24 Years to 65 Years
Enrollment: 36 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022
U.S. locations: 1
States / cities: High Point, North Carolina

Conditions: E Cigarette Use
Interventions: adapted vaping cessation intervention; Behavioral
Lead sponsor: Veterans Medical Research Foundation; Other
Eligibility: 18 Years to 30 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: San Diego, California

Conditions: Vaping, Cessation, Tobacco
Interventions: This is Quitting, Assessment only control, Waitlist control; Behavioral · Other
Lead sponsor: Truth Initiative; Other
Eligibility: 13 Years to 17 Years
Enrollment: 1,681 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: Washington D.C., District of Columbia

Conditions: Vaping
Interventions: Acted-Out Narrative Ads, Non-Acted-Out Narrative Testimonial Ads, Neutral Control Videos; Behavioral
Lead sponsor: UNC Lineberger Comprehensive Cancer Center; Other
Eligibility: 13 Years to 20 Years
Enrollment: 1,910 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2028
U.S. locations: 2
States / cities: Fairfield, Connecticut • Chapel Hill, North Carolina

Conditions: Tobacco Use
Interventions: Normal Nicotine Content Vape with all flavor e-liquids, Normal nicotine content vape with tobacco e-liquids, Low nicotine content vape with all flavor e-liquids, Low nicotine content vape with tobacco e-liquids; Other
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 21 Years and older
Enrollment: 69 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Winston-Salem, North Carolina

Conditions: Tobacco Dependence
Interventions: SWITCH IT, E-cig Provision Only; Behavioral · Other
Lead sponsor: Dartmouth-Hitchcock Medical Center; Other
Eligibility: 21 Years and older
Enrollment: 250 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2028
U.S. locations: 2
States / cities: Louisville, Kentucky • Providence, Rhode Island

Conditions: Substance Use Disorder, Alcohol Use Disorder
Interventions: Not listed
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: 18 Years to 99 Years
Enrollment: 10,000 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2047
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: E-cigarette Use
Interventions: Live Free From E-cigarettes; Behavioral
Lead sponsor: University of Southern California; Other
Eligibility: 18 Years to 24 Years
Enrollment: 105 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Electronic Cigarette Use
Interventions: Preferred ENDS, Preferred ENDS with HWL; Other
Lead sponsor: Florida International University; Other
Eligibility: 21 Years to 35 Years
Enrollment: 80 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2027
U.S. locations: 1
States / cities: Miami, Florida

Conditions: E-cigarette, Vaping, Tobacco, Nicotine, Adolescent Behavior, Video Information, Digital Education Interventions
Interventions: Working group, Focus group; Other
Lead sponsor: Boston Children's Hospital; Other
Eligibility: 13 Years and older
Enrollment: 46 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Tobacco Dependence, Schizophrenia, Bipolar Disorder, Schizoaffective Disorder
Interventions: E-cigarette; Behavioral
Lead sponsor: Dartmouth-Hitchcock Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 240 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2021
U.S. locations: 2
States / cities: Louisville, Kentucky • Lawrence, Massachusetts

Conditions: Electronic Cigarette Use
Interventions: Tobacco product administration and assessment, own brand cigarettes, Tobacco product administration and assessment, ECIG 30 Watts, 0 mg/ml nicotine, Tobacco product administration and assessment, ECIG 30 Watts, 8 mg/ml nicotine, Tobacco product administration and assessment, ECIG 30 Watts, 15 mg/ml nicotine, Tobacco product administration and assessment, ECIG 30 Watts, 30 mg/ml nicotine; Other
Lead sponsor: Virginia Commonwealth University; Other
Eligibility: 18 Years to 55 Years
Enrollment: 44 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: Richmond, Virginia

Conditions: Smoking Cessation, Electronic Cigarette Use, Cigarette Smoking
Interventions: Regular Nicotine patch and lozenge dose, Augmented Nicotine patch and lozenge dose; Drug
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years and older
Enrollment: 46 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2024
U.S. locations: 1
States / cities: Charleston, South Carolina

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The CONQUER Trial - Cessation Of Nicotine, QUitting With E-cigarette Reduction

Testing the Feasibility and Acceptability of Social Media and Digital Therapeutics to Decrease Vaping Behaviors

Lab to Real World Assessment of E-cigarette Abuse Liability and Appeal

Clinical Research Evaluating Smoking Cessation With E-Cigarettes and Nicotine Therapy

E-Cigarette and Cigarette Nicotine Delivery and Abuse Liability in Cigarette Smokers and Dual Users

Comparative Abuse Liability Among African American and White Smokers

E-Cigarettes: Dynamic Patterns of Use and Health Effects

Very Low Nicotine Content Cigarettes and E-Cigarettes in Promoting Smoking Cessation in Daily and Intermittent Cigarette Smokers

Low Nicotine Content Cigarettes in Vulnerable Populations: Affective Disorders

Effects of a Low Nicotine Standard and Tobacco Prices on Illegal Cigarette Purchasing

Young Adult EC Use and Respiratory Outcomes

Nicotine Pharmacokinetics Following Use of the P4M3 Gen 2.0 E-Cigarette Compared to Smoking Cigarettes

Adapting an Intervention for Vaping in Young Veterans

Text Message Quit Vaping Intervention for Adolescents

Evaluating Narrative Vaping Prevention Video Ads for Adolescents and Young Adults

Cigarette and E-cigarette Nicotine Content in an Electronic Tobacco Marketplace (ETM)

Harm Reduction for Smokers With Mental Illness

Screening, Evaluation and Assessment (SEA) Protocol at the NIDA IRP

An Online Intervention to Reduce E-cigarette Use and Susceptibility to Smoking in Young Adults

Developing and Testing Health Warning Labels on the ENDS Device

Understanding Vape Marketing Study

The Appeal and Impact of E-cigarettes in Smokers With SMI

Effects of E-Cigarette Nicotine Content in Smokers (Nicotine Flux Study)

CAN-DOSE Study: Cessation With Augmented Nicotine for Dual Use Of Smoking and E-cigarettes