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ClinicalTrials.gov public records Last synced Nov 15, 2026, 6:03 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 265–288 of 373 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: E Cig Use Clear all

Conditions: Nicotine Dependence, Transcranial Magnetic Stimulation, Vaping, Smoking Cessation, Smoking (Tobacco) Addiction
Interventions: Varenicline, Transcranial Magnetic Stimulation, Transcranial Magnetic Stimulation Sham, Nicotine Cessation Counseling, D-cycloserine; Drug · Device · Behavioral
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years to 65 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: E-cigarette Use
Interventions: E-cigarette cessation text-messaging intervention, Standard care control using standard national resources; Behavioral
Lead sponsor: Jovan Gwon, PhD, RN, FIAAN; Other
Eligibility: 18 Years to 24 Years
Enrollment: 50 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2026
U.S. locations: 1
States / cities: Milwaukee, Wisconsin

Conditions: Arterial Inflammation
Interventions: No drug or device, only a test. The test is called a PET/CT; Other
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 21 Years to 45 Years
Enrollment: 30 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2023
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Tobacco Use, Substance Use Disorders
Interventions: Switching to E-Cigarette, Quitting using Medication, Counseling; Behavioral · Drug
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 21 Years and older
Enrollment: 240 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2028
U.S. locations: 4
States / cities: Charleston, South Carolina • Conway, South Carolina • Greenville, South Carolina + 1 more

Conditions: Tobacco Use, Nicotine Pouch Self-Administration
Interventions: Nicotine Pouch Dosage; Other
Lead sponsor: William Middleton; Other
Eligibility: 18 Years and older
Enrollment: 1,360 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Lexington, Kentucky

Conditions: Cigarette Smoking, E-Cigarette Use, Smoking Cessation
Interventions: Varenicline, Counseling, Guided Self-Change Booklets; Drug · Behavioral
Lead sponsor: Yale University; Other
Eligibility: 18 Years and older
Enrollment: 19 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Cigarette Smoking, Nicotine Vaping
Interventions: All nicotine/ tobacco products at market price, Nicotine vaping products at 1/2 market price, Nicotine vaping products at 2x market price, Heated tobacco products at 1/2 market price., Heated tobacco products at 2x market price., Nicotine pouch products at 1/2 market price., Nicotine pouch products at 2x market price.; Other
Lead sponsor: Virginia Polytechnic Institute and State University; Other
Eligibility: 21 Years and older
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Roanoke, Virginia

Conditions: Smoking
Interventions: Usual Brand Cigarette, Electronic Cigarette #1, Electronic Cigarette #2, Leading U.S. Nicotine Gum; Other
Lead sponsor: R.J. Reynolds Vapor Company; Industry
Eligibility: 21 Years to 60 Years
Enrollment: 153 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2015
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Smoking, Healthy
Interventions: Cinnamaldehyde e-liquid, PG/VG e-liquid; Other
Lead sponsor: University of North Carolina, Chapel Hill; Other
Eligibility: 18 Years to 40 Years
Enrollment: 19 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2020
U.S. locations: 1
States / cities: Chapel Hill, North Carolina

Conditions: Nicotine Dependence
Interventions: nicotine, menthol; Drug
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 30 Years
Enrollment: 57 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2016
U.S. locations: 2
States / cities: West Haven, Connecticut

Conditions: Nicotine Dependence, Other Tobacco Product
Interventions: Nicotine, Low Dose Menthol, High Dose Menthol; Drug · Other
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 20 Years
Enrollment: 59 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2017
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Toxicant Exposure
Interventions: E-Cigarette Vs. Smoking as Usual; Other
Lead sponsor: California State University, San Marcos; Other
Eligibility: 21 Years and older
Enrollment: 187 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2019
U.S. locations: 2
States / cities: San Marcos, California • Kansas City, Missouri

Conditions: Tobacco Cessation
Interventions: This is Quitting, Assessment only Control; Other
Lead sponsor: Truth Initiative; Other
Eligibility: 18 Years to 24 Years
Enrollment: 2,588 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: Washington D.C., District of Columbia

Conditions: Cigarette Smoking-Related Carcinoma
Interventions: Not listed
Lead sponsor: UConn Health; Other
Eligibility: 16 Years to 45 Years · Female only
Enrollment: 182 participants
Timeline: 2018 – 2023
U.S. locations: 6
States / cities: Denver, Colorado • Farmington, Connecticut • Hartford, Connecticut + 2 more

Conditions: Electronic Cigarette Use
Interventions: Beverage with ethanol and E-cigarette liquid with ethanol, Beverage with ethanol and E-cigarette liquid without ethanol, Beverage without ethanol and E-cigarette liquid with ethanol, Beverage without ethanol and E-cigarette liquid without ethanol; Other
Lead sponsor: Virginia Commonwealth University; Other
Eligibility: 21 Years to 55 Years
Enrollment: 12 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2024
U.S. locations: 1
States / cities: Richmond, Virginia

Conditions: Tobacco Smoking, Psychiatric Disorders
Interventions: E-cigarette; Other
Lead sponsor: Fordham University; Other
Eligibility: 21 Years and older
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2024
U.S. locations: 1
States / cities: The Bronx, New York

Conditions: Electronic Cigarette Use, Smoking, Cigarette, Nicotine Dependence
Interventions: NJOY ACE e-cigarette; Other
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 50 Years and older
Enrollment: 15 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Lung Inflammation, HIV Seropositivity
Interventions: ECIGS, mobile contingency management (mCM), Usual brand; Other · Behavioral
Lead sponsor: Duke University; Other
Eligibility: 18 Years to 64 Years
Enrollment: 10 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2018
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Nicotine Dependence
Interventions: one time exposure to e-cig with nicotine, one time exposure to e-cig without nicotine, one time exposure to empty e-cig; Other
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 21 Years to 45 Years
Enrollment: 148 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2022
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Electronic Cigarettes
Interventions: JUUL electronic cigarette, IQOS electronic cigarette, Own Brand cigarette; Other
Lead sponsor: Virginia Commonwealth University; Other
Eligibility: 21 Years to 55 Years
Enrollment: 22 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Richmond, Virginia

Conditions: Nicotine Dependence
Interventions: Nicotine, Experimental Flavor, Menthol Flavor; Drug · Other
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 20 Years
Enrollment: 56 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2019
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Vaping
Interventions: An image resembling a social media post; Behavioral
Lead sponsor: University of Southern California; Other
Eligibility: 14 Years to 25 Years
Enrollment: 2,829 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: E-cigarette Use, Withdrawal
Interventions: Transdermal Nicotine Patch, Placebo Nicotine Patch; Drug
Lead sponsor: Johns Hopkins University; Other
Eligibility: 21 Years to 55 Years
Enrollment: 150 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2028
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Smoking
Interventions: E-cigarette/tobacco Smoking Exposure; Device
Lead sponsor: NYU Langone Health; Other
Eligibility: 21 Years to 40 Years
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2016
U.S. locations: 1
States / cities: New York, New York

Search by objective public record fields.

Varenicline and Accelerated Transcranial Magnetic Stimulation (TMS) for Quitting Nicotine Use (Pilot Study)

Vape-Free Text-Messaging: Pilot Study

Arterial Inflammation and E-Cigarettes

STEPS: Substance Use Trial of E-cigarettes or Pharmacotherapy for Smoking

Comparison of Demand and Substitution for Nicotine Pouches as a Function of Nicotine Dosage

Concurrent vs. Sequential Cessation of Dual Cigarette and E-cigarette Use

Comparison of the Substitution Between Different Tobacco/Nicotine Products as a Function of Tobacco-user Type

Assess Biomarkers of Tobacco Exposure and Nicotine Pharmacokinetics in Smokers After a 5-Day In-Clinic Confinement Switch to an Electronic Cigarette or Nicotine Gum

In-vivo Effects of E-cigarette Aerosol on Innate Lung Host Defense

The Effects of Menthol as Delivered by an Electronic Cigarette on the Desirability of Nicotine in Tobacco Users

Flavors and E-cigarette Effects in Adolescent Smokers- STUDY 1

Effects Among Smokers Who Use and Do Not Use E-Cigarettes

Text Message Quit Vaping Intervention for Young Adults

Electronic Cigarette Use During Pregnancy

The Impact of Oral Ethanol and Vaped Ethanol on the Evaluation of Impairment

The Effect of Electronic Cigarette Use on Smoking Behaviors Among Smokers Receiving Outpatient Psychiatric Treatment

Assessing E-Cigarettes for Tobacco Harm Reduction in the Context of Lung Cancer Screening

Effects of E-cigarettes (ECIGs) on Pulmonary Inflammation and Behavior in HIV Infected Smokers

E-cigarettes and Blood Vessel Function

Assessment of Two New Electronic Cigarettes in Cigarette Smokers

Flavors and E-cigarette Effects in Adolescent Smokers- STUDY 2

Social Media Influences on Perceptions of Alternative Nicotine and Nicotine-like Vaping Products Among Youth and Young Adults (AYA)

Evaluation of the Electronic Cigarette Withdrawal Syndrome

Effect of Electronic Cigarettes on Platelets, Endothelium and Inflammation