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ClinicalTrials.gov public records Last synced Nov 15, 2026, 6:52 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 337–360 of 373 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: E Cig Use Clear all

Conditions: E-cigarette Use
Interventions: Local heating + L-NAME (NG-nitro-L-arginine methyl ester; nitric oxide synthase inhibitor), Chronic estrogen exposure; Drug · Other
Lead sponsor: Anna Stanhewicz, PhD; Other
Eligibility: 18 Years to 24 Years
Enrollment: 80 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2026
U.S. locations: 1
States / cities: Iowa City, Iowa

Conditions: Dual Use of Cigarettes and E-cigarettes
Interventions: Text- and web-based support, Nicotine Replacement Therapy (NRT, nicotine patch), Nicotine replacement therapy lozenge; Behavioral · Drug
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years and older
Enrollment: 321 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2031
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Cigarette Smoking Behavior, E-Cigarette Use
Interventions: E-cigarette, Nicotine replacement therapy (patch, gum), both arms, CO-contingent financial incentives, both arms, Cessation counseling; Other · Drug · Behavioral
Lead sponsor: Thomas Jefferson University; Other
Eligibility: 21 Years and older
Enrollment: 44 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Healthy, Nicotine Addiction, Electronic Cigarette Use
Interventions: Lower nicotine e-liquid, Higher nicotine eliquid; Drug
Lead sponsor: Rochester Institute of Technology; Other
Eligibility: 21 Years and older
Enrollment: 72 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: Rochester, New York

Conditions: Smoking Cessation
Interventions: E-cigarette free access, E-cigarette/NRT/Zyban/Chantix Choice, Outcome Incentive arm, Loss framing incentive arm, Control; Behavioral
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years to 99 Years
Enrollment: 6,006 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2017
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Electronic Cigarette Use
Interventions: JUUL ENDS - Virginia Tobacco 5% nicotine strength, JUUL ENDS - Virginia Tobacco 3% nicotine strength, JUUL ENDS - Menthol 5% nicotine strength, JUUL ENDS - Menthol 3% nicotine strength, JUUL ENDS - Mint 5% nicotine strength, JUUL ENDS - Mint 3% nicotine strength, JUUL ENDS - Mango 5% nicotine strength, JUUL ENDS - Mango 3% nicotine strength; Other
Lead sponsor: Juul Labs, Inc.; Industry
Eligibility: 21 Years to 65 Years
Enrollment: 56 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2020
U.S. locations: 2
States / cities: Burbank, California • Baltimore, Maryland

Conditions: Tobacco Use, Opioid Use Disorder, Tobacco-Related Disorders
Interventions: E-cigarette, Control/Standard Advice; Other · Behavioral
Lead sponsor: University of Maryland, Baltimore; Other
Eligibility: 50 Years and older
Enrollment: 36 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: E-cigarette Use, Tobacco Use Cessation
Interventions: Computerized attentional bias modification training, Placebo attention control training; Behavioral
Lead sponsor: University of Wisconsin, Milwaukee; Other
Eligibility: 18 Years to 29 Years
Enrollment: 50 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2024
U.S. locations: 1
States / cities: Milwaukee, Wisconsin

Conditions: E-cigarette Use, Substance Use
Interventions: ENDS Prevention Intervention (TBD); Behavioral
Lead sponsor: University of Hawaii; Other
Eligibility: 10 Years to 14 Years
Enrollment: 500 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Honolulu, Hawaii

Conditions: Vaping Cessation
Interventions: Guided mindfulness meditation, Scenery video; Behavioral
Lead sponsor: University of Texas at Austin; Other
Eligibility: 18 Years to 29 Years
Enrollment: 12 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: New Orleans, Louisiana

Conditions: Tobacco Dependence
Interventions: Nicotine Containing ECIG with tobacco flavor, Nicotine Containing ECIG with Strawberry Vanilla Flavor, Placebo ECIG with Tobacco Flavor, Placebo ECIG with Strawberry Vanilla Flavor; Other
Lead sponsor: Milton S. Hershey Medical Center; Other
Eligibility: 21 Years to 60 Years
Enrollment: 19 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2024
U.S. locations: 1
States / cities: Hershey, Pennsylvania

Conditions: Nicotine Use Disorder
Interventions: Nicotine, Flavor; Drug
Lead sponsor: Yale University; Other
Eligibility: 21 Years to 50 Years
Enrollment: 130 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2023
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Nicotine Dependence, E-Cig Use
Interventions: Nicotine patch, Phone Counseling, Digital Coaching; Drug · Behavioral
Lead sponsor: Ohio State University; Other
Eligibility: 18 Years to 24 Years
Enrollment: 508 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Vaping, Vaping Cessation, Nicotine Dependence
Interventions: Social Media Intervention; Behavioral
Lead sponsor: University of California, San Francisco; Other
Eligibility: 13 Years and older
Enrollment: 60 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Sudden Cardiac Death, Prolonged QTc Interval
Interventions: EC with nicotine, EC without nicotine, control, TC with nicotine (own brand), research TC with very low level nicotine; Other
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 21 Years to 45 Years
Enrollment: 110 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2023
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Oxidative Stress, Tobacco Use, Electronic Cigarettes
Interventions: High temperature wattage setting on electronic cigarette, Low temperature wattage setting on electronic cigarette, High concentration of Propylene Glycol, Low concentration of Propylene Glycol; Other
Lead sponsor: Milton S. Hershey Medical Center; Other
Eligibility: 21 Years and older
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Hershey, Pennsylvania

Conditions: Electronic Cigarette Use, Tobacco Smoking
Interventions: JUUL ENDS, Combustible cigarette, comparator e-cigarette, Nicorette gum; Other
Lead sponsor: Juul Labs, Inc.; Industry
Eligibility: 21 Years to 65 Years
Enrollment: 137 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019
U.S. locations: 2
States / cities: Kansas City, Kansas • Lexington, Kentucky

Conditions: Vaping Teens, Vaping Behaviors, Vaping Cessation, Tobacco Use Disorder
Interventions: E-cigarette Cessation Manual; Behavioral
Lead sponsor: Florida International University; Other
Eligibility: 14 Years to 18 Years
Enrollment: 120 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Miami, Florida

Conditions: E-Cig Use
Interventions: ECIG own, ECIG Vuse; Other
Lead sponsor: Ohio State University Comprehensive Cancer Center; Other
Eligibility: 21 Years to 25 Years
Enrollment: 56 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2025
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Tobacco Use
Interventions: 3 mg/mL nicotine strength e-liquid, 6 mg/mL nicotine strength e-liquid, 12 mg/mL nicotine strength e-liquid, 24 mg/mL nicotine strength e-liquid; Drug
Lead sponsor: Virginia Polytechnic Institute and State University; Other
Eligibility: 18 Years and older
Enrollment: 81 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2021
U.S. locations: 1
States / cities: Roanoke, Virginia

Conditions: E-cigarette Use, Cigarette Smoking, Harm Reduction, Tobacco Use
Interventions: E-cigarettes, Oral nicotine pouches; Other
Lead sponsor: Abramson Cancer Center at Penn Medicine; Other
Eligibility: 21 Years and older
Enrollment: 200 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2028
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: E Cigarette Use, Vaping, Smoking, Tobacco Smoking, Nicotine Use Disorder, Qt Interval, Variation in, HIV I Infection, Oxidative Stress, Inflammation
Interventions: TCIG, ECIG, sham control; Other
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 21 Years to 45 Years
Enrollment: 37 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2023
U.S. locations: 2
States / cities: Los Angeles, California

Conditions: E-cigarette Use/Vaping Prevention, Nicotine Dependence Prevention, Adolescent Mental Health
Interventions: Virtual Reality E-Cigarette Prevention Program; Behavioral
Lead sponsor: Yale University; Other
Eligibility: 11 Years to 15 Years
Enrollment: 1,251 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Vaping
Interventions: Videos featuring influencers promoting e-cigarettes alongside healthy lifestyle activities; Other
Lead sponsor: University of Southern California; Other
Eligibility: 18 Years to 24 Years
Enrollment: 1,500 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023
U.S. locations: 1
States / cities: Los Angeles, California

Search by objective public record fields.

Sex Differences in the Vascular Effects of E-cigarette Use

DOSE-UP: Dose Optimization for Smoking and E-Cigarette Use Pharmacotherapy

Project E-Shift: A Harm Reduction Intervention for Chronically Unhoused Smokers.

Compensatory Behavior of E-cig Users in Response to Reduced Nicotine E-liquids

Randomized Clinical Trial to Reduce Harm From Tobacco

Study to Characterize Puffing Topography With Use of JUUL Electronic Nicotine Delivery Systems (ENDS) in Adult, Closed-System ENDS Consumers

E-cigarette Switching Older Adults

Attentional Bias Modification Training for E-cigarette Users

The Development and Evaluation of a Culturally Grounded ENDS Intervention for Rural Hawaiian Youth

Mindful Breaths: Mindfulness for Young Adult Vaping

Establishing the Effect of Flavor on the Addictive Potential of Electronic Cigarettes

Effects of E-Cigarette Flavors on Adults TCORS 2.0

Research and Innovation to Stop E-cigarette/Vaping in Young Adults

Social Media Support Groups for Adolescent Vaping Cessation

Smoking and Ventricular Repolarization

Impact of Electronic Cigarette Temperature and Solvent on Biomarkers

Characterize the Nicotine Uptake and Subjective Effects With Use of JUUL Electronic Nicotine Delivery Systems

Developing an E-Cigarette Cessation Intervention for Hispanic/Latina(o) Youth in Florida: The BReATHE Study

Respiratory Effects of E-Cigarettes in Obese Youth

Electronic Cigarette Unit Price Manipulations in the Experimental Tobacco Marketplace

Noncombustible Nicotine Delivery Systems as Potential Harm Reduction Tools for Persistent Cigarette Smokers

Acute Effects of TCIG vs ECIG in PLWH

A Virtual Reality E-cigarette Prevention and Emotion Regulation Intervention for Adolescents

Influencer Marketing: a Survey-based Experiment